Abstract:
:Human alpha interferon (IFN-alpha) and beta interferon (IFN-beta) showed antiviral and anticellular effects on human lymphoblastoid Daudi and P3HR-1 cells, but up to 1,000 units/ ml of gamma interferon (IFN-gamma) showed no such effect. Though a fairly high level of dsRNA-dependent 2'-5'-oligoadenylate synthetase (2-5A synthetase) was found in Daudi cells, treatment of these cells with IFN-alpha and beta enhanced the enzyme level in cells at least four-fold, but IFN-gamma did not show any such effect. Lymphoblastoid Raji cells were insensitive to the antiviral and anticellular activities of IFN-alpha, beta and gamma, but 2-5A synthetase was induced in cells by the treatment with IFN-alpha and beta, though the enzyme level was lower than that found in interferon-treated Daudi cells. Human leukemic K562 cells were completely insensitive to IFN-alpha, beta and at the same time to IFN-gamma with regard to the antiviral, anticellular activities and to the induction of 2-5A synthetase.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Tomita Y,Cantell K,Kuwata Tdoi
10.1002/ijc.2910300206subject
Has Abstractpub_date
1982-08-15 00:00:00pages
161-5issue
2eissn
0020-7136issn
1097-0215journal_volume
30pub_type
杂志文章abstract::We reported that tumor endothelial cells (TECs) differ from normal endothelial cells (NECs) in many aspects, such as gene expression profiles. Although CXCR7 is reportedly highly expressed in blood vessels of several tumors, its function in TECs is still unknown. To investigate this role, we isolated TECs from mouse t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29655
更新日期:2015-12-15 00:00:00
abstract::Antibodies to the 27 kDa heat shock protein (hsp27) are present in some women with ovarian and endometrial cancers but not in women with nonmalignant conditions or healthy women. The appearance of these antibodies suggests that the corresponding protein (hsp27) may be present in an extracellular form in gynecologic ca...
journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2002-12-10 00:00:00
abstract::Established cell lines derived from human malignant astrocytomas typically express a combination of platelet-derived growth factor (PDGF) and PDGF receptor which could form an autocrine loop. In this study, we screened for the essential components of a PDGF autocrine loop in fresh surgical isolates of human astrocytom...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910600206
更新日期:1995-01-17 00:00:00
abstract::Regular aspirin and non-aspirin nonsteroidal anti-inflammatory drug (NSAID) use is associated with a reduced risk of colorectal cancer. The effect of NSAIDs on the risk of other cancers remains unclear. To evaluate whether use of aspirin or other specific NSAIDs protects against lung cancer, we conducted a case-contro...
journal_title:International journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/ijc.22514
更新日期:2007-04-01 00:00:00
abstract::The human HBL-100 cell line harbours SV40 DNA integrated in tandem at a unique site. The SV40 T-antigen expressed in these cells is defective in a function essential to the replication of the viral genome. The integrated SV40 sequences were molecularly cloned in a bacteriophage, and a subclone (plasmid pSVHBI) contain...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910440230
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abstract::To assess the relation between air pollution with airway irritants, including sulfuric acid and lung cancer, a case-control study was performed near an industry producing sulfuric acid and fertilizers in Kedainiai county, central Lithuania. The county had the highest lung cancer rates of the country among men. Between...
journal_title:International journal of cancer
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doi:10.1002/ijc.10314
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abstract::Dietary information from a case-control study of pancreatic cancer conducted in Metropolitan Toronto between 1983 and 1986 is reported. A total of 249 cases and 505 population-based controls completed quantitative diet histories from which total caloric intake and the intake of a number of nutrients were estimated. A ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910450405
更新日期:1990-04-15 00:00:00
abstract::A displacement assay with tamoxifen, based on the relative binding affinity of tamoxifen and estradiol for the estrogen receptor (ER), was proposed in 1990 as prognostic indicator for breast-cancer patients. Validation of its predictive results in relation to the outcome of 73 patients with ER+ tumors is analyzed. ER,...
journal_title:International journal of cancer
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doi:10.1002/(sici)1097-0215(19971114)73:4<486::aid-ijc
更新日期:1997-11-14 00:00:00
abstract::We evaluated cell survival, DNA double strand breaks (dsbs), and DNA synthesis following camptothecin (CPT) alone or concurrent CPT and X-radiation treatments in exponential-phase cultures of a radioresistant human melanoma cell line. Cell survival was measured by a clonogenic assay. DNA dsbs were measured by pulsed-f...
journal_title:International journal of cancer
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更新日期:2001-10-20 00:00:00
abstract::Human germ cell tumors comprise a heterogeneous group of neoplasms. Those of the adult testis, known as TGCTs, originate from carcinoma in situ (CIS), which are initiated during intra-uterine development. We present here a molecular model for the development of TGCTs, including various parameters, such as apoptosis, c...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0215(19991210)83:6<809::aid-ijc
更新日期:1999-12-10 00:00:00
abstract::Very recently, BRAF mutations were found in about 2/3 of malignant melanomas and at lower frequencies in other human cancers. The BRAF gene codes for a protein in the mitogen-activated protein kinase (MAPK) pathway. All mutations identified to date are within the kinase domain, with a single missense mutation (V599E) ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11199
更新日期:2003-08-10 00:00:00
abstract::Epigenetic alterations play a major role in cancer. Recently we reported that stem cell Polycomb group targets (PcGTs) are up to 12-fold more likely to have cancer-specific promoter DNA hypermethylation than nontargets. To identify potential, prognostic DNA methylation markers in ovarian cancer we analyzed the DNA met...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23563
更新日期:2008-08-01 00:00:00
abstract::Two genome-wide association studies (GWAS) have identified 5p15.33 (TERT-CLPTM1L) as one of the susceptible regions for glioma in European background. A replication research of our group highlighted the association signals in the TERT gene of this region in a Chinese Han population. To comprehensively explore the regi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27417
更新日期:2012-10-01 00:00:00
abstract::The Swedish Family-Cancer Database was used to analyze second cancers after oral, esophageal, rectal, cervical, genital and skin (squamous cell carcinoma) cancers. A strong and consistent association of second cancers was observed at all these sites, in men and women. As a novel finding, an association of rectal cance...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1319
更新日期:2001-07-15 00:00:00
abstract::The epidermal growth factor receptor (EGFR) is frequently expressed in triple-negative breast cancer (TNBC) and is a marker of poor prognosis in this patient population. Because activating mutations in this kinase are very rare events in breast cancer, we screened breast tumor gene expression profiles to examine the d...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28295
更新日期:2013-12-01 00:00:00
abstract::Although a screening program for gastric cancer, using barium X-ray examination, has been carried out widely in Japan for the past 3 decades, there is insufficient evidence to confirm its effectiveness in terms of reducing mortality. To evaluate the effectiveness of the screening, a population-based case-control study...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910600106
更新日期:1995-01-03 00:00:00
abstract::Variants of human papillomavirus (HPV) type 31 have been shown to be related both to risk of cervical lesions and racial composition of a population. It is largely undetermined whether variants differ in their likelihood of persistence. Study subjects were women who participated in the ASCUS-LSIL Triage Study and who ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27689
更新日期:2013-02-01 00:00:00
abstract::Tumour necrosis factor alpha (TNF) mRNA is detected in the macrophage infiltrate surrounding the tumour, but the cellular/molecular interactions leading to TNF gene expression in macrophages are unknown. The in vitro system in which human blood monocytes are stimulated with human cancer cells for TNF release was used ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910560221
更新日期:1994-01-15 00:00:00
abstract::The clonotypic T-cell receptor (TCR) is a potential target antigen for specific immunotherapy of cutaneous T-cell lymphoma (CTCL). We identified T-cell epitopes from the rearranged TCR beta chain of the malignant T-cell population by the "reverse immunology" approach. Peptide-specific T-cell lines were generated again...
journal_title:International journal of cancer
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doi:10.1002/ijc.22113
更新日期:2006-11-15 00:00:00
abstract::We previously determined that human papillomavirus (HPV) virus-like particles (VLPs) and pseudovirions (PsV) did not, respectively, bind to or infect intact epithelium of the cervicovaginal tract. However, they strongly bound heparan sulfate proteoglycans (HSPG) on the basement membrane of disrupted epithelium and inf...
journal_title:International journal of cancer
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abstract::In order to evaluate whether the SCID mouse can provide the microenvironment for the growth of human immature T-cell leukemias and if in vivo growth alters their phenotype, we examined the behavior of 3 well-characterized T-cell acute lymphoblastic leukemia (T-ALL)-derived T-cell lines which are at different stages of...
journal_title:International journal of cancer
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更新日期:1994-02-15 00:00:00
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journal_title:International journal of cancer
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doi:10.1002/ijc.2910610616
更新日期:1995-06-09 00:00:00
abstract::Hereditary non-polyposis colorectal cancer, HNPCC, is an autosomal dominant condition predisposing to cancers of primarily the colorectum and the endometrium. The aim of our study was to identify persons at a high risk of hereditary colorectal cancer and to estimate their risk of colon and other HNPCC-associated tumou...
journal_title:International journal of cancer
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更新日期:2001-02-15 00:00:00
abstract::Resistance to anticancer drugs is the major problem in the treatment of many advanced cancers, including androgen-independent prostate cancer. Recently, increased expression of Id-1, a basic helix-loop-helix protein, is reported in several types of advanced cancer. It is suggested that high expression of Id-1 may prov...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21592
更新日期:2006-04-15 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980703)77:1<101::aid-ijc
更新日期:1998-07-03 00:00:00
abstract::In normal somatic cells, the methylation pattern of DNA is stably maintained by DNA (cytosine-5-)-methyltransferase (DNA methyltransferase). Increased expression of DNA methyltransferase has been detected in many types of human cancer and has been thought to play an important role in tumorigenesis. In our study, we de...
journal_title:International journal of cancer
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doi:10.1002/(sici)1097-0215(19990924)83:1<10::aid-ijc3
更新日期:1999-09-24 00:00:00
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journal_title:International journal of cancer
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abstract::The present study was undertaken to determine the role of the metalloproteinase MMP-9 in the invasive phenotype of squamous-cell carcinoma of the oral cavity and the regulation of its expression. Zymographic analysis of conditioned medium from 2 highly invasive squamous-cell-carcinoma cell lines indicated large amount...
journal_title:International journal of cancer
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journal_title:International journal of cancer
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更新日期:1997-05-16 00:00:00
abstract::Common genetic variations in genes involved in DNA repair or response to genotoxic stress may influence both cancer susceptibility and treatment response individually or interactively. However, in acute myeloid leukemia (AML), the relevance of these genetic variations remains to be fully established. In this study, we...
journal_title:International journal of cancer
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更新日期:2011-01-01 00:00:00