Nonsteroidal anti-inflammatory drugs and risk of lung cancer.


:Regular aspirin and non-aspirin nonsteroidal anti-inflammatory drug (NSAID) use is associated with a reduced risk of colorectal cancer. The effect of NSAIDs on the risk of other cancers remains unclear. To evaluate whether use of aspirin or other specific NSAIDs protects against lung cancer, we conducted a case-control study nested in a cohort of subjects 40-84 years old in 1995-2004, without a diagnosis of cancer before the study start date, and with at least 2 years of enrollment with a general practitioner providing data to the The Health Improvement Network (THIN) database in the UK. Patients who had a first diagnosis of primary lung cancer during the study period were considered cases. A random sample of 10,000 controls was frequency-matched to the cases for age, sex and calendar year. The index date for exposure definition was 1 year before the date of diagnosis for cases and 1 year before a random date within the study period for controls. Relative risks and 95% confidence intervals were estimated using conditional logistic regression stratified for matching factors. Factors such as smoking, chronic obstructive pulmonary disease, cardiovascular diseases and body mass index were introduced in the model. We identified 4,336 cases with primary incident lung cancer (incidence rate 7.6 per 10,000 person-years). Compared with subjects with no prescription of non-aspirin NSAID prior to the index date, the risk of lung cancer was 0.76 (0.61-0.94) among those who received a prescription the previous year and had a treatment duration of at least 1 year. The corresponding relative risk was 1.15 (0.99-1.34) for aspirin. In conclusion, prescription of non-aspirin NSAIDs for at least 1 year might be associated with a slightly reduced risk of lung cancer. Aspirin was not associated with a risk reduction, perhaps due to residual confounding.


Int J Cancer


Hernández-Díaz S,García Rodríguez LA




Has Abstract


2007-04-01 00:00:00












  • Human papillomavirus--the most significant risk determinant of cervical intraepithelial neoplasia.

    abstract::Sexual behavior has been consistently identified as a major risk factor for cervical cancer. Population-based studies have demonstrated that risk related to sexual activity is mediated by human papillomavirus (HPV) infection. We conducted a case-control study of 199 cases with low-grade squamous intraepithelial lesion...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kjaer SK,van den Brule AJ,Bock JE,Poll PA,Engholm G,Sherman ME,Walboomers JM,Meijer CJ

    更新日期:1996-03-01 00:00:00

  • Emerging roles of the host defense peptide LL-37 in human cancer and its potential therapeutic applications.

    abstract::Human cathelicidin LL-37, a host defense peptide derived from leukocytes and epithelial cells, plays a crucial role in innate and adaptive immunity. Not only does LL-37 eliminate pathogenic microbes directly but also modulates host immune responses. Emerging evidence from tumor biology studies indicates that LL-37 pla...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Wu WK,Wang G,Coffelt SB,Betancourt AM,Lee CW,Fan D,Wu K,Yu J,Sung JJ,Cho CH

    更新日期:2010-10-15 00:00:00

  • Allelic loss at 1p and 19q frequently occurs in association and may represent early oncogenic events in oligodendroglial tumors.

    abstract::The molecular mechanisms underlying the genesis and progression of oligodendroglial tumors are poorly understood, since only restricted information on loss of heterozygosity from isolated cases is available. The commonest alterations appear to involve deletion of 1p and 19q, while loss of heterozygosity for 9p, chromo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bello MJ,Leone PE,Vaquero J,de Campos JM,Kusak ME,Sarasa JL,Pestaña A,Rey JA

    更新日期:1995-06-22 00:00:00

  • Multiple primary cancers as a guide to heritability.

    abstract::There are approximately 100 genes which when mutated are known to predispose to one or more forms of cancer. Currently, genetic testing is offered for many of these, either as single genes or as multi-gene panels. Features of hereditary cancer include a positive family history of cancer, early age of onset and the app...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Cybulski C,Nazarali S,Narod SA

    更新日期:2014-10-15 00:00:00

  • Chemoprevention of glandular stomach carcinogenesis through duodenogastric reflux in rats by a COX-2 inhibitor.

    abstract::Duodenogastric reflux (DGR) causes glandular stomach carcinogenesis in rats without carcinogens. We aimed to investigate how this carcinogenesis might be prevented by a selective COX-2 inhibitor, meloxicam. A series of 188 Fisher 344 rats underwent a surgical DGR procedure and were divided into 2 groups. One group was...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Oba M,Miwa K,Fujimura T,Harada S,Sasaki S,Hattori T

    更新日期:2008-10-01 00:00:00

  • Development of a replication-deficient adenoviral vector-based vaccine candidate for the interception of HPV16- and HPV18-induced infections and disease.

    abstract::High-risk Human papilloma virus (HPV) types are the causative agents of cervical cancer and several other anogenital malignancies. The viral proteins expressed in the (pre)malignant cells are considered ideal targets for immunological intervention. Many approaches have been evaluated for this purpose, mostly aiming at...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Khan S,Oosterhuis K,Wunderlich K,Bunnik EM,Bhaggoe M,Boedhoe S,Karia S,Steenbergen RDM,Bosch L,Serroyen J,Janssen S,Schuitemaker H,Vellinga J,Scheper G,Zahn R,Custers J

    更新日期:2017-07-15 00:00:00

  • Cell cycle-related kinase supports ovarian carcinoma cell proliferation via regulation of cyclin D1 and is a predictor of outcome in patients with ovarian carcinoma.

    abstract::Our previous study has suggested that the cell cycle-related kinase (CCRK) is a putative candidate oncogene in glioblastoma tumorigenesis. The potential oncogenic role of CCRK and its clinical/prognostic significance, however, in ovarian carcinoma are unclear. In this study, CCRK expression was examined by immunohisto...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wu GQ,Xie D,Yang GF,Liao YJ,Mai SJ,Deng HX,Sze J,Guan XY,Zeng YX,Lin MC,Kung HF

    更新日期:2009-12-01 00:00:00

  • HER3 is required for the maintenance of neuregulin-dependent and -independent attributes of malignant progression in prostate cancer cells.

    abstract::HER3 (ERBB3) is a catalytically inactive pseudokinase of the HER receptor tyrosine kinase family, frequently overexpressed in prostate and other cancers. Aberrant expression and mutations of 2 other members of the family, EGFR and HER2, are key carcinogenic events in several types of tumors, and both are well- validat...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Soler M,Mancini F,Meca-Cortés O,Sánchez-Cid L,Rubio N,López-Fernández S,Lozano JJ,Blanco J,Fernández PL,Thomson TM

    更新日期:2009-12-01 00:00:00

  • Endoscopic screening for synchronous esophageal neoplasia among patients with incident head and neck cancer: Prevalence, risk factors, and outcomes.

    abstract::Esophageal squamous-cell neoplasia (ESCN) is a common second primary neoplasia found in patients with head-and-neck squamous-cell carcinoma (HNSCC). This study sought to identify the risk factors for synchronous ESCN and how they influence survival in HNSCC patient. Eight hundred and fifteen incident HNSCC patients we...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wang YK,Chuang YS,Wu TS,Lee KW,Wu CW,Wang HC,Kuo CT,Lee CH,Kuo WR,Chen CH,Wu DC,Wu IC

    更新日期:2017-11-15 00:00:00

  • Melphalan availability in hypoxia-inducible factor-1alpha+/+ and factor-1alpha-/- tumors is independent of tumor vessel density and correlates with melphalan erythrocyte transport.

    abstract::Many tumors are impervious to anticancer agents. Resistance due to lack of cytotoxic penetration into the tumor is often overlooked but can play a significant role in undermining therapy. Insufficient and irregular vascularization of tumors is a possible barrier to drug delivery, but there are others, e.g., impaired v...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wildiers H,Guetens G,de Boeck G,Landuyt W,Verbeken E,Highley M,de Bruijn EA,van Oosterom AT

    更新日期:2002-06-01 00:00:00

  • Correlation between the serum level of hepatitis C virus RNA and disease activities in acute and chronic hepatitis C.

    abstract::The influence of viremia on hepatic injury in patients infected with hepatitis C virus was examined by analysis of the relationship between alanine aminotransferase activity and the amount of hepatitis C virus RNA in sequential serum samples from I untreated patient with acute hepatitis C and 3 untreated patients with...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Gunji T,Kato N,Mori S,Ootsuyama Y,Hijikata M,Imawari M,Shimotohno K

    更新日期:1992-11-11 00:00:00

  • H-Ras selectively up-regulates MMP-9 and COX-2 through activation of ERK1/2 and NF-kappaB: an implication for invasive phenotype in rat liver epithelial cells.

    abstract::One of the most frequent events in carcinogenesis is uncontrolled activation of Ras signaling pathway. A previous study demonstrated that the introduction of H-Ras into the normal WB-F344 rat liver epithelial (WB) cell line and adult male F344 rats resulted in tumorigenicity. The present study investigated whether H-R...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lee KW,Kim MS,Kang NJ,Kim DH,Surh YJ,Lee HJ,Moon A

    更新日期:2006-10-15 00:00:00

  • Elevated apolipoprotein(a) levels in cancer patients.

    abstract::Elevated plasma lipoprotein(a) has been associated with an increased risk of cardiovascular disease. We report a significant elevation of total plasma apolipoprotein(a) levels in cancer patients compared with hospitalized control patients and normal healthy blood donors. Of the cancer patients studied, 48% had levels ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wright LC,Sullivan DR,Muller M,Dyne M,Tattersall MH,Mountford CE

    更新日期:1989-02-15 00:00:00

  • In vitro and in vivo anti-tumor activity of L-glutamic acid gamma-monohydroxamate against L1210 leukemia and B16 melanoma.

    abstract::A glutamine analogue, L-glutamic acid gamma-monohydroxamate (GAH) demonstrated complete cytotoxicity against L1210 cells in culture and marked anti-tumoral activity in vivo against L1210 leukemia and B16 melanoma. In vitro, GAH caused concentration-dependent inhibition of L1210 cell growth, with complete cell death be...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Vila J,Thomasset N,Navarro C,Doré JF

    更新日期:1990-04-15 00:00:00

  • Interleukin-10 production in malignant melanoma: preferential detection of IL-10-secreting tumor cells in metastatic lesions.

    abstract::IL-10 mRNA expression and protein production in established melanoma cell lines and freshly cultured primary and metastatic melanoma cells was examined. The in situ distribution of IL-10 in native melanoma tissue was also investigated by immunohistochemistry in primary tumors, metastases, benign melanocytic nevi and n...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Dummer W,Bastian BC,Ernst N,Schänzle C,Schwaaf A,Bröcker EB

    更新日期:1996-05-29 00:00:00

  • Studies on clonal heterogeneity in two spontaneously metastasizing mammary carcinomas of recent origin.

    abstract::We have studied the clonal heterogeneity of 2 spontaneously metastasizing mammary carcinomas which recently arose spontaneously in C3H/He female retired breeders. Cells of early (2nd to 5th) transplant generations of these tumors were cloned by a combination of semi-solid agarose colony formation and limiting dilution...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Brodt P,Parhar R,Sankar P,Lala PK

    更新日期:1985-02-15 00:00:00

  • Serum folate receptor alpha as a biomarker for ovarian cancer: Implications for diagnosis, prognosis and predicting its local tumor expression.

    abstract::Folate receptor alpha (FRA) is a GPI-anchored glycoprotein and encoded by the FOLR1 gene. High expression of FRA is observed in specific malignant tumors of epithelial origin, including ovarian cancer, but exhibits very limited normal tissue expression, making it as an attractive target for the ovarian cancer therapy....

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kurosaki A,Hasegawa K,Kato T,Abe K,Hanaoka T,Miyara A,O'Shannessy DJ,Somers EB,Yasuda M,Sekino T,Fujiwara K

    更新日期:2016-04-15 00:00:00

  • The role of mucin in colon-cancer metastasis.

    abstract::Mucinous colorectal cancer often presents at an advanced stage. We have previously observed that mucin production by human colon-cancer cells correlates with their ability to colonize the liver in experimental animal models. The present study was undertaken in order to further elucidate the mechanisms by which product...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Schwartz B,Bresalier RS,Kim YS

    更新日期:1992-08-19 00:00:00

  • Genome structure-based screening identified epigenetically silenced microRNA associated with invasiveness in non-small-cell lung cancer.

    abstract::MicroRNA (miRNA) expression is frequently altered in human cancers. To search for epigenetically silenced miRNAs in non-small-cell lung cancer (NSCLC), we mapped human miRNAs on autosomal chromosomes and selected 55 miRNAs in silico. We treated six NSCLC cell lines with the DNA methylation inhibitor 5-aza-2'-deoxycyti...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Watanabe K,Emoto N,Hamano E,Sunohara M,Kawakami M,Kage H,Kitano K,Nakajima J,Goto A,Fukayama M,Nagase T,Yatomi Y,Ohishi N,Takai D

    更新日期:2012-06-01 00:00:00

  • Risk factors for endometrial cancer according to familial susceptibility.

    abstract::Endometrial cancer (EC) shares some environmental or genetic risk factors with colorectal cancer (CRC). It represents a risk factor for CRC. Furthermore, EC is the most frequent extracolonic neoplasm in HNPCC (hereditary nonpolyposis colorectal cancer) and, in this syndrome, it has the same inheritance pattern as CRC....

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fornasarig M,Campagnutta E,Talamini R,Franceschi S,Boz G,Scarabelli C,Andreaus CM,Scozzari G,Valentini M

    更新日期:1998-07-03 00:00:00

  • Increased ether lipid cytotoxicity by reducing membrane cholesterol content.

    abstract::Ether-linked glycerophospholipids (ether lipids, EL) are selectively toxic and anti-proliferative agents against cancer cells in vitro. The reason for such selectivity is not completely clear. Their mechanism of action is mediated through an interaction with the plasma membrane and the membrane lipid composition may m...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Diomede L,Piovani B,Modest EJ,Noseda A,Salmona M

    更新日期:1991-09-30 00:00:00

  • Development of an intrinsic P-glycoprotein-mediated doxorubicin resistance in quiescent cell layers of large, multicellular prostate tumor spheroids.

    abstract::Growing multicellular prostate tumor spheroids develop quiescent cell subpopulations in central regions with features of intrinsic multicell-mediated drug resistance. Doxorubicin (dox) uptake was significantly reduced in large spheroids (diameter 400+/-70 microm), which consist predominantly of quiescent cells, as com...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wartenberg M,Frey C,Diedershagen H,Ritgen J,Hescheler J,Sauer H

    更新日期:1998-03-16 00:00:00

  • Upregulation of matrix metalloproteinases (MMPs) in breast cancer xenografts: a major induction of stromal MMP-13.

    abstract::In human breast cancer (HBC), as with many carcinoma systems, most matrix metalloproteinases (MMPs) are largely expressed by the stromal cells, whereas the tumour cells are relatively silent in MMP expression. To determine the tissue source of the most relevant MMPs, we xenografted HBC cell lines and HBC tissues into ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lafleur MA,Drew AF,de Sousa EL,Blick T,Bills M,Walker EC,Williams ED,Waltham M,Thompson EW

    更新日期:2005-04-20 00:00:00

  • SET domain containing 1B gene is mutated in primary hepatic neuroendocrine tumors.

    abstract::Primary hepatic neuroendocrine tumors (PHNETs) are extremely rare NETs originating from the liver. These tumors are associated with heterogeneous prognosis, and few treatment targets for PHNETs have been identified. Because the major genetic alterations in PHNET are still largely unknown, we performed whole-exome sequ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yang P,Huang X,Lai C,Li L,Li T,Huang P,Ouyang S,Yan J,Cheng S,Lei G,Wang Z,Yu L,Hong Z,Li R,Dong H,Wang C,Yu Y,Wang X,Li X,Wang L,Lv F,Yin Y,Yang H,Song J,Gao Q,Wang X,Zhang S

    更新日期:2019-12-01 00:00:00

  • Cell-mediated cytotoxicity for cultured autologous melanoma cells.

    abstract::Peripheral blood lymphocytes from 32 patients with malignant melanoma were tested for cell-mediated cytotoxicity (CMC) against cultured autologous melanoma cells. Effector cells were prepared from venous blood by defibrination, gel sedimentation, nylon column filtration, and lysis of remaining erythrocytes with NH4Cl....

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Livingston PO,Shiku H,Bean MA,Pinsky CM,Oettgen HF,Old LJ

    更新日期:1979-07-15 00:00:00

  • Glycated hemoglobin and cancer incidence and mortality in the Atherosclerosis in Communities (ARIC) Study, 1990-2006.

    abstract::Diabetes is a risk factor for many cancers; chronic hyperglycemia is hypothesized to be, in part, explanatory. We evaluated the association between glycated hemoglobin, a time-integrated glycemia measure, and cancer incidence and mortality in nondiabetic and diabetic men and women. We conducted a prospective study of ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Joshu CE,Prizment AE,Dluzniewski PJ,Menke A,Folsom AR,Coresh J,Yeh HC,Brancati FL,Platz EA,Selvin E

    更新日期:2012-10-01 00:00:00

  • Long-term exposure to fine particulate matter air pollution and the risk of lung cancer among participants of the Canadian National Breast Screening Study.

    abstract::Recently, air pollution has been classified as a carcinogen largely on the evidence of epidemiological studies of lung cancer. However, there have been few prospective studies that have evaluated associations between fine particulate matter (PM2.5 ) and cancer at lower concentrations. We conducted a prospective analys...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tomczak A,Miller AB,Weichenthal SA,To T,Wall C,van Donkelaar A,Martin RV,Crouse DL,Villeneuve PJ

    更新日期:2016-11-01 00:00:00

  • ERK inhibitor PD98059 enhances docetaxel-induced apoptosis of androgen-independent human prostate cancer cells.

    abstract::Anticancer drugs docetaxel and vinorelbine suppress cell growth by altering microtubule assembly and activating the proapoptotic signal pathway. Vinorelbine and docetaxel have been approved for treating several advanced cancers. However, their efficacy in the management of advanced hormone-refractory prostate cancer r...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zelivianski S,Spellman M,Kellerman M,Kakitelashvilli V,Zhou XW,Lugo E,Lee MS,Taylor R,Davis TL,Hauke R,Lin MF

    更新日期:2003-11-10 00:00:00

  • Effect of tunicamycin on synthesis and secretion of carcinoembryonic antigen by human colonic adenocarcinoma cells.

    abstract::The effect of the glycosylation inhibitor, tunicamycin, on synthesis and secretion of the membrane-associated glycoprotein carcinoembryonic antigen (CEA), was studied in the LS174T human colon cancer cell line. Tunicamycin treatment inhibited total cellular glycoprotein synthesis but did not affect CEA levels of cellu...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Miura S,Kim YS

    更新日期:1986-08-15 00:00:00

  • Kinetics of the immune response of tumor-bearing hamsters to two simian virus 40 coded non-structural polypeptides present in simian virus 40 tumor cells.

    abstract::The kinetics of the immune response of hamsters transplanted with virus-free SV40 tumor cells (TSV5) to two SV40-coded non-structural proteins of 94,000 daltons (T antigen) and 17,000 daltons (t antigen) was studied in order to determine if the variation in the immune reactivity of serum from tumor-bearing animals tow...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ransom JH,Thompson DL,Tevethia SS

    更新日期:1982-02-15 00:00:00