Nonsteroidal anti-inflammatory drugs and risk of lung cancer.

abstract：:Recently reported genome-wide association studies have identified more than 20 common low-penetrance colorectal cancer (CRC) susceptibility loci. Recent studies have reported that copy number variations (CNVs) are considered important human genomic variants related to cancer, while the contribution of CNVs remains unc...

journal_title：International journal of cancer

authors： Park C,Kim JI,Hong SN,Jung HM,Kim TJ,Lee S,Kim SJ,Kim HC,Kim DH,Cho B,Park JH,Sung J,Lee DS,Kang M,Son HJ,Kim YH

更新日期：2017-01-01 00:00:00

abstract：:The miR-34 family members are direct transcriptional targets of tumor suppressor p53, and loss of miR-34 function can impair p53-mediated cell cycle arrest and apoptosis. A potentially functional SNP rs4938723 (T > C) was found in the promoter region of pri-miR-34b/c (423 bp from the transcription start site), located...

journal_title：International journal of cancer

authors： Xu Y,Liu L,Liu J,Zhang Y,Zhu J,Chen J,Liu S,Liu Z,Shi H,Shen H,Hu Z

更新日期：2011-01-15 00:00:00

abstract：:Although the incidence of, and deaths due to, malignant melanoma are rising at a rapid rate, few experimental models mimic the highly metastatic properties associated with the pathogenesis of the human disease, making study of the disease difficult. Thus, new human models are required to understand melanoma biology, e...

journal_title：International journal of cancer

authors： Welch DR,Bisi JE,Miller BE,Conaway D,Seftor EA,Yohem KH,Gilmore LB,Seftor RE,Nakajima M,Hendrix MJ

更新日期：1991-01-21 00:00:00

abstract：:To evaluate renal pelvis and ureter (RPU) cancer risk in relation to lifetime use of analgesics, a population-based case-control study was carried out in 3 areas of the United States. Among 502 cases and 496 controls diagnosed and interviewed during 1983-1986, no significant increases in risk were found for any of the...

journal_title：International journal of cancer

authors： Linet MS,Chow WH,McLaughlin JK,Wacholder S,Yu MC,Schoenberg JB,Lynch C,Fraumeni JF Jr

更新日期：1995-07-04 00:00:00

abstract：:With the aim of identifying innovative therapeutic strategies for osteosarcoma patients who are refractory to conventional chemotherapy, we analyzed the in vitro effects of the blockage of autocrine circuits. Since the insulin-like growth factor-I receptor (IGF-IR)-mediated loop is relevant to the growth of osteosarco...

journal_title：International journal of cancer

authors： Benini S,Baldini N,Manara MC,Chano T,Serra M,Rizzi S,Lollini PL,Picci P,Scotlandi K

更新日期：1999-02-09 00:00:00

abstract：:Regulatory T cells (Treg) mediate amelioration of disease and immune homeostasis by inhibiting immune activation and maintaining peripheral immune tolerance. The suppressive mechanisms and clinical significance of Treg have not been completely elucidated in patients with acute myeloid leukemia (AML). Here, we demonstr...

journal_title：International journal of cancer

authors： Shenghui Z,Yixiang H,Jianbo W,Kang Y,Laixi B,Yan Z,Xi X

更新日期：2011-09-15 00:00:00

abstract：:With the improvement of treatments, a growing number of survivors with childhood or adolescent central nervous system (CNS) tumor are parenting their own children. We aimed to explore the risk of somatic diseases among children of these survivors compared to population controls. Children of survivors with CNS tumor be...

journal_title：International journal of cancer

authors： Huang W,Sundquist K,Sundquist J,Ji J

更新日期：2020-11-13 00:00:00

abstract：:Within the Netherlands Cohort Study on diet and cancer, we investigated associations between total alcohol consumption, specific alcoholic beverage consumption and risk of colorectal cancer (CRC) according to anatomical subsite. Hazard Ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional...

journal_title：International journal of cancer

authors： Bongaerts BW,van den Brandt PA,Goldbohm RA,de Goeij AF,Weijenberg MP

更新日期：2008-11-15 00:00:00

abstract：:We have previously shown that AEV infection of leukosis-free chickens provokes an erythroleukemia in the infected birds, and that the target cell for virus transformation is most likely an early pro-erythroblast comparable to the BFU-E. The virus infection correlates with a block in differentiation which was studied a...

journal_title：International journal of cancer

authors： Therwath A,Scherrer K

更新日期：1982-05-15 00:00:00

abstract：:In this study, a cell-penetrating peptide, the transactivating transcriptional factor (TAT) domain from HIV, was linked to a chitosan/doxorubicin (chitosan/DOX) conjugate to form a chitosan/DOX/TAT hybrid. The synthesized chitosan/DOX/TAT conjugate showed a different intracellular distribution pattern from a conjugate...

journal_title：International journal of cancer

authors： Lee JY,Choi YS,Suh JS,Kwon YM,Yang VC,Lee SJ,Chung CP,Park YJ

更新日期：2011-05-15 00:00:00

abstract：:Galunisertib (LY2157299), a promising small-molecule inhibitor of the transforming growth factor-beta (TGF-β) receptor, is currently in mono- and combination therapy trials for various cancers including glioblastoma, hepatocellular carcinoma and breast cancer. Using genetically modified mouse models, we investigated t...

journal_title：International journal of cancer

authors： Li W,Tibben M,Wang Y,Lebre MC,Rosing H,Beijnen JH,Schinkel AH

更新日期：2020-03-15 00:00:00

abstract：:The human bowel contains a large and dynamic bacterial population that is not only essential for intestinal health, but also critical for the development of diseases such as cancer. In this respect, the Gram-positive bacterium Streptococcus bovis has been associated with colon cancer for many years. To investigate the...

journal_title：International journal of cancer

authors： Tjalsma H,Schöller-Guinard M,Lasonder E,Ruers TJ,Willems HL,Swinkels DW

更新日期：2006-11-01 00:00:00

abstract：:A recent clinical trial found a protective role of niacinamide, a derivative of niacin, against skin cancer recurrence. However, there is no epidemiologic study to assess the association between niacin intake and risk of skin cancer [basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and melanoma]. We prospecti...

journal_title：International journal of cancer

authors： Park SM,Li T,Wu S,Li WQ,Weinstock M,Qureshi AA,Cho E

更新日期：2017-05-01 00:00:00

abstract：:Mucinous colorectal cancer often presents at an advanced stage. We have previously observed that mucin production by human colon-cancer cells correlates with their ability to colonize the liver in experimental animal models. The present study was undertaken in order to further elucidate the mechanisms by which product...

journal_title：International journal of cancer

authors： Schwartz B,Bresalier RS,Kim YS

更新日期：1992-08-19 00:00:00

abstract：:Drug-induced DNA demethylation in normal human cells and inherited localized hypomethylation in mitogen-stimulated lymphocytes from patients with a rare recessive disease (ICF: immunodeficiency, centromeric region instability, facial anomalies) are associated with karyotypic instability. This chromosomal recombination...

journal_title：International journal of cancer

authors： Narayan A,Ji W,Zhang XY,Marrogi A,Graff JR,Baylin SB,Ehrlich M

更新日期：1998-09-11 00:00:00

abstract：:We have shown earlier that extracellular GSH can exert a cell-specific growth-inhibitory effect on human tumor cells. In the present study, 2 human ovarian carcinoma cell lines (A2780 and IGROV-1) were used to investigate the biochemical basis of the GSH growth-inhibitory effect. Whereas cells were resistant, A2780 ce...

journal_title：International journal of cancer

authors： Perego P,Paolicchi A,Tongiani R,Pompella A,Tonarelli P,Carenini N,Romanelli S,Zunino F

更新日期：1997-04-10 00:00:00

abstract：:CD30 is selectively expressed on the tumor cells of a variety of malignant disorders of the immune system and can therefore be used as a target for an anti-CD30 antibody-based immunotherapy. However, CD30 is cleaved at the cell surface by tumor necrosis factor-alpha converting enzyme (TACE). This metalloproteinase rel...

journal_title：International journal of cancer

authors： Hansen HP,Matthey B,Barth S,Kisseleva T,Mokros T,Davies SJ,Beckett RP,Foelster-Holst R,Lange HH,Engert A,Lemke H

更新日期：2002-03-10 00:00:00

abstract：:Multidrug resistance, the phenomenon by which cells treated with a drug become resistant to the cytotoxic effect of a variety of other structurally and functionally unrelated drugs, is often associated with the expression of P-glycoprotein, an efflux membrane pump coded by the MDR1 (ABCB1) gene. Transcription from MDR...

journal_title：International journal of cancer

authors： Raguz S,Randle RA,Sharpe ER,Foekens JA,Sieuwerts AM,Meijer-van Gelder ME,Melo JV,Higgins CF,Yagüe E

更新日期：2008-03-01 00:00:00

abstract：:Epigenetic modification of gene expression plays an important role in the development of human cancers. The inactivation of SPARC through CpG island methylation was studied in colon cancers using oligonucleotide microarray analysis and methylation specific PCR (MSP). Gene expression of 7 colon cancer cell lines was ev...

journal_title：International journal of cancer

authors： Yang E,Kang HJ,Koh KH,Rhee H,Kim NK,Kim H

更新日期：2007-08-01 00:00:00

abstract：:Infection with erbB-2 (E) of Ha-ras (H) oncogene-transfected cells has been previously shown to cooperatively induce anchorage-independent growth of the MCF10A human mammary epithelial cell line in vitro, but not to induce nude mouse tumorigenicity. Here we show that oncogene-transformed MCF10A are able to halt in the...

journal_title：International journal of cancer

authors： Giunciuglio D,Culty M,Fassina G,Masiello L,Melchiori A,Paglialunga G,Arand G,Ciardiello F,Basolo F,Thompson EW

更新日期：1995-12-11 00:00:00

abstract：:The synthetic retinoid fenretinide [N-(4-hydroxyphenyl)retinamide, 4-HPR] has demonstrated growth inhibition and induction of apoptosis of various malignant cells, including lung cancer cell lines. 4-HPR is now being investigated in several clinical trials. In our study, we show that 4-HPR inhibits growth on a broad p...

journal_title：International journal of cancer

authors： Ohlmann CH,Jung C,Jaques G

更新日期：2002-08-10 00:00:00

abstract：:A case-control study of 374 patients with primary epithelial cancers of the oral cavity, oro- and hypopharynx, and larynx is reported, the controls being patients with selected other cancers, matched for age and sex. Of all eligible patients, 93% were interviewed. Increased risks were seen with alcohol consumption and...

journal_title：International journal of cancer

authors： Elwood JM,Pearson JC,Skippen DH,Jackson SM

更新日期：1984-11-15 00:00:00

abstract：:Numerous prospective and retrospective studies have clearly demonstrated a dose-related increased lung cancer risk associated with cigarette smoking, with evidence also for a genetic component to risk. In this study, using the two-stage clonal expansion stochastic model framework, for the first time we investigated th...

journal_title：International journal of cancer

authors： Deng L,Kimmel M,Foy M,Spitz M,Wei Q,Gorlova O

更新日期：2009-05-01 00:00:00

abstract：:Inhibition of programmed cell death (apoptosis) is associated with increased tumor aggressiveness. We hypothesized that a novel sensitive to apoptosis gene, SAG, may be expressed in tumors of patients with nonsmall cell lung cancer (NSCLC) and may affect their clinical outcome. Expression of SAG messenger RNA was eval...

journal_title：International journal of cancer

authors： Sasaki H,Yukiue H,Kobayashi Y,Moriyama S,Nakashima Y,Kaji M,Fukai I,Kiriyama M,Yamakawa Y,Fujii Y

更新日期：2001-11-20 00:00:00

abstract：:Seven human ocular melanoma cell lines were established in vitro and 3 of these, GU-4, LLN-40 and its subline C17-11, were characterized. Mice were immunized with these ocular melanoma cell lines, and 2 hybridomas producing monoclonal IgG1 antibodies (MAb) were produced. MAb 2/10SN recognizes a 44-kDa monomeric protei...

journal_title：International journal of cancer

authors： Safi N,Kantor RR,Atkinson B,Moratz C,Wilt AR,Pancake S,Reba R,Mathieson BJ,Desgrez A

更新日期：1992-07-09 00:00:00

abstract：:Differentiated thyroid carcinoma (TC) is threefold more common in women than in men and, therefore, a role of female hormones in the etiology of differentiated TC has been suggested. We assessed these hypotheses in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Among 345,157 women (mea...

journal_title：International journal of cancer

authors： Zamora-Ros R,Rinaldi S,Biessy C,Tjønneland A,Halkjaer J,Fournier A,Boutron-Ruault MC,Mesrine S,Tikk K,Fortner RT,Boeing H,Förster J,Trichopoulou A,Trichopoulos D,Papatesta EM,Masala G,Tagliabue G,Panico S,Tumino R,P

更新日期：2015-03-01 00:00:00

abstract：:In the last decade, mitochondrial DNA (mtDNA) haplogroups have been associated with the occurrence of breast cancer. However, the underlying mechanism is not known. Combining a case-control study with a large cohort of women from Southern China with breast cancer and functional analyses with trans-mitochondrial techno...

journal_title：International journal of cancer

authors： Ma L,Fu Q,Xu B,Zhou H,Gao J,Shao X,Xiong J,Gu Q,Wen S,Li F,Shen L,Chen G,Fang H,Lyu J

更新日期：2018-05-01 00:00:00

abstract：:A cyclin-dependent kinase inhibitor CDKN2A (p16/Ink4a) is a tumor suppressor and upregulated in cellular senescence. CDKN2A promoter methylation and gene silencing are associated with the CpG island methylator phenotype (CIMP) in colon cancer. However, prognostic significance of CDKN2A methylation or loss of CDKN2A (p...

journal_title：International journal of cancer

authors： Shima K,Nosho K,Baba Y,Cantor M,Meyerhardt JA,Giovannucci EL,Fuchs CS,Ogino S

更新日期：2011-03-01 00:00:00

abstract：:ECOG 1696 was a Phase II multi-center trial testing vaccination with melanoma peptides, gp100, MART-1 and tyrosinase delivered alone, with GM-CSF, IFN-α2b or both cytokines to HLA-A2(+) patients with metastatic melanoma. Here, the frequency of circulating CD8(+) tetramer(+) (tet(+) ) T cells and maturation stages of...

journal_title：International journal of cancer

authors： Schaefer C,Butterfield LH,Lee S,Kim GG,Visus C,Albers A,Kirkwood JM,Whiteside TL

更新日期：2012-08-15 00:00:00

abstract：:In previous studies, the antigen CSH-275 (RTNKEASIC) was found expressed in tissue specimens from colorectal cancer but not in normal colonic mucosa. It was also naturally expressed in the DHD-K12 experimental colorectal cancer in BDIX rats. In this study, we describe the effect of vaccination with the synthetic nonap...

journal_title：International journal of cancer

authors： Sinibaldi Vallebona P,Rasi G,Pierimarchi P,Bernard P,Guarino E,Guadagni F,Garaci E

更新日期：2004-05-20 00:00:00