Abstract:
:A population-based case-control study of risk factors for renal-cell carcinoma was conducted in Denmark from 1989 to 1992. A total of 368 histologically verified cases and 396 controls were included. Information on weight, height, physical activity and reproductive factors were collected in a structured interview, along with information on other suspected risk factors. A significant increase in risk was seen for obese women but not obese men. Although there was no clear gradient, the risk was highest among women with a relative weight in the upper 5% (OR 6.1; 95% CI, 2.3 to 16.1). The increased risk was most evident for high relative weight in ages 30 to 50. No association was observed for height or physical activity. Use of amphetamines was associated with increased risk but, because of the close link with obesity, we were unable to provide evidence that amphetamines are an independent risk factor. We found some evidence for an association with reproductive variables, including decreased risk for women with late menarche and first pregnancy and birth. We observed no association with number of pregnancies or age at menopause, or use of estrogen-containing medication.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Mellemgaard A,Engholm G,McLaughlin JK,Olsen JHdoi
10.1002/ijc.2910560113subject
Has Abstractpub_date
1994-01-02 00:00:00pages
66-71issue
1eissn
0020-7136issn
1097-0215journal_volume
56pub_type
杂志文章abstract::The relation between breast feeding and breast cancer was investigated in a multicentric case-control study conducted in Italy on 2,167 parous women with histologically confirmed breast cancer, diagnosed within 1 year, and 2,208 parous control women admitted to hospitals in the same catchment areas of cases for acute,...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/(SICI)1097-0215(19960717)67:2<161::AID-IJC
更新日期:1996-07-17 00:00:00
abstract::Transfer of the herpes simplex virus type I thymidine kinase (HSV-TK) gene into tumor cells using virus-based vectors in conjunction with ganciclovir (GCV) exposure provides a potential gene therapy strategy for the treatment of cancer. The possibility of using a novel targetable Sindbis virus expression vector contai...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990105)80:1<110::aid-ijc
更新日期:1999-01-05 00:00:00
abstract::ERK and RSK2 drive proliferation and invasion of many cancers. Phosphoprotein enriched in astrocytes 15 (PEA15) binds ERK and RSK2 and high PEA15 levels can impair ERK- and RSK2-dependent transcription. PEA15 expression also inversely correlates with cell motility and invasiveness. We therefore tested PEA15 effects on...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27415
更新日期:2012-10-01 00:00:00
abstract::High-grade serous epithelial ovarian cancer (HGS-EOC) is a systemic disease, with marked intra and interpatient tumor heterogeneity. The issue of spatial and temporal heterogeneity has long been overlooked, hampering the possibility to identify those genomic alterations that persist, before and after therapy, in the g...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32288
更新日期:2019-11-15 00:00:00
abstract::Long-term survival rates for advanced ovarian cancer patients have not changed appreciably over the past four decades; therefore, development of new, effective treatment modalities remains a high priority. Tumor Treating Fields (TTFields), a clinically active anticancer modality utilize low-intensity, intermediate fre...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30406
更新日期:2016-12-15 00:00:00
abstract::Cell populations resistant to high doses (30 microM) of 6-thioguanine (6-TG, 6-TG(r) cells) were selected from a human colon carcinoma cell line, LoVo. This cell line, which lacks hMSH2, a component of the human mismatch binding heterodimer hMutSalpha, is resistant to low doses of 6-TG. The level of activity of hypoxa...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990812)82:4<556::aid-ijc
更新日期:1999-08-12 00:00:00
abstract::Natural killer (NK) activity of human peripheral blood lymphocytes (HPBL) was studied in 32 alcoholics and 15 control subjects in a 4-h chromium release assay using K562 tumor target cells. The natural killer activity of human peripheral blood lymphocytes in alcoholics was significantly higher than the level found in ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910260405
更新日期:1980-10-15 00:00:00
abstract::Survival for breast cancer (BC) is lower in eastern than northern/central Europe, and in older than younger women. We analysed how comorbidities at diagnosis affected whether selected standard treatments (STs) were given, across Europe and over time, also assessing consequences for survival/relapse. We analysed 7581 s...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31974
更新日期:2019-05-01 00:00:00
abstract::The promoter variants of TNF-α, a major regulator of immune and inflammation responses, have been implicated in cancer development and prognosis. Thus, we investigated associations between four TNF-α promoter variants and risk of recurrence of squamous cell carcinoma of the oropharynx (SCCOP). We evaluated association...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28512
更新日期:2014-04-15 00:00:00
abstract::In a cohort of 11,663 participants in a breast-cancer screening program, height, weight, waist circumference and hip circumference were measured, and information about menstrual and reproductive history was obtained by questionnaire. After exclusion of 83 women with unclear menopausal status, the subjects were divided...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980529)76:5<647::aid-ijc
更新日期:1998-05-29 00:00:00
abstract::Insulin-like growth factor-1 receptor (IGF-1R) and human epidermal growth factor receptor-2 (HER2) receptor expression has been found to be a key regulator of tumorigenesis. The purpose of our study was to establish the prognostic significance of IGF-1R in esophageal cancer and to determine the effect of IGF-1R and HE...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25196
更新日期:2010-10-15 00:00:00
abstract::There is a growing evidence of the protective role of the Mediterranean diet (MD) on cancer. However, no prospective study has yet investigated its influence on lymphoma. We evaluated the association between adherence to the MD and risk of lymphoma and its subtypes in the European Prospective Investigation into Cancer...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32091
更新日期:2019-07-01 00:00:00
abstract::We have used immunoprecipitation to test tumor biopsies and normal adult and fetal human tissues for p97, a tumor-associated protein. Five of nine melanoma biopsies contained p97 in low to very high levels. Three of seven non-melanoma tumors contained p97, but in smaller amounts. No p97 was detected in any of the norm...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910270204
更新日期:1981-02-15 00:00:00
abstract::Folate receptor-alpha (FR-alpha) is generally over-expressed in non-mucinous human ovarian carcinomas. The meaning of FR-alpha over-expression and its role in the 5-methyltetrahydrofolic acid (N5-CH3-H4PteGlu) transport in such tumors is not clear, especially compared with the reduced folate carrier (RFC), the other k...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980105)75:1<125::aid-ijc
更新日期:1998-01-05 00:00:00
abstract::Fifty-two sporadic primary non-small-cell lung carcinomas (NSCLC) were examined for microsatellite instability. Six different microsatellite markers localized on chromosomes 2, 5, 8, 10, 11 and 17 were used. Genomic instability was observed in 35% (18/52) of NSCLC at single or multiple loci. The tumors were also analy...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19981123)78:5<606::aid-ijc
更新日期:1998-11-23 00:00:00
abstract::Conversion of solid sarcomas and carcinomas into ascites tumors depends on the in vivo selection of phenotypically altered tumor cell variants that can grow in the dissociated form. Once selected, they retain this property even after prolonged s.c. growth as solid tumors. From an s.c.-passaged subline of an ascites-co...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910450324
更新日期:1990-03-15 00:00:00
abstract::Deregulation of cell survival pathways and resistance to apoptosis are widely accepted to be fundamental aspects of tumorigenesis. As in many tumours, the aberrant growth and survival of colorectal tumour cells is dependent upon a small number of highly activated signalling pathways, the inhibition of which elicits po...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22917
更新日期:2007-11-15 00:00:00
abstract::Polyisoprenylated benzophenones derived from Garcinia xanthochymus have cytotoxic activity in vitro and antitumor activity in rodent models, but the mechanism is unknown. The purpose of our study was to examine in parallel molecular pathways that are targeted by 3 Garcinia-derived benzophenones-xanthochymol (X), gutti...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23515
更新日期:2008-08-01 00:00:00
abstract::Studies in human, animal and cellular systems suggest that phenols from virgin olive oil are capable of inhibiting several stages in carcinogenesis, including metastasis. The invasion cascade comprises cell attachment to extracellular matrix components or basement membrane, degradation of basement membrane by proteoly...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23148
更新日期:2008-02-01 00:00:00
abstract::As Phase 0 studies have proven to be reasonably predictive of therapeutic dose pharmacokinetics, the application of microdosing has expanded into metabolism, drug-drug interactions and now diagnostics. One potentially serious issue with this application of microdosing that has not been previously discussed is the poss...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.28773
更新日期:2015-04-01 00:00:00
abstract::Tumors need to acquire an angiogenic phenotype for outgrowth and metastasis formation. Limited information on the angiogenic potential of specific tissues, especially human breast tissues is available. Here we describe an in vivo model, using the dorsal skin fold chamber in immunodeficient nude mice, where various tis...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980729)77:3<455::aid-ijc
更新日期:1998-07-29 00:00:00
abstract::During 2000, marine antitumor pharmacology research aimed at the discovery of novel antitumor agents was published in 85 peer-reviewed articles. The purpose of this article is to present a structured review of the antitumor and cytotoxic properties of 143 marine natural products, many of them novel compounds that belo...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.11080
更新日期:2003-06-20 00:00:00
abstract::Since most intracellular proteins are expressed with their ligands, ligands of cancer-testis (CT) antigens may also be CT in their distribution. Applying Sperm protein 17 (Sp17) as the bait in a yeast 2-hybrid system of a testicular cDNA library, 17 interacting clones were isolated and all encoded Ropporin, a spermato...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22842
更新日期:2007-10-01 00:00:00
abstract::IL-15 is an immunostimulatory cytokine with IL-2-like activities. To exploit the potential role of IL-15 in cancer immuno-/gene therapy, we engineered murine TS/A cells with different IL-15 cDNA constructs. Significant IL-15 secretion was achieved only by the use of a modified cDNA encoding for an IL-15 pre-protein be...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:
更新日期:2000-08-15 00:00:00
abstract::Cytotoxic antibodies against glioblastoma-associated antigen(s) have been sought for in glioma patient sera. Complement-dependent cytotoxicity (CDC) I and antibody-dependent cell-mediated cytotoxicity (ADCC) assays were used to test sera from 80 patients using 51 Cr labelled target cells derived from eight different g...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910250209
更新日期:1980-02-15 00:00:00
abstract::By serologic identification of antigens by recombinant expression cloning (SEREX) analysis using an autologous lung adenocarcinoma cell line, OU-LU-6, as a cDNA library source, we demonstrated that XAGE-1 was the dominant antigen recognized by serum from a patient. By immunoscreening, we obtained 38 positive cDNA clon...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11587
更新日期:2004-02-10 00:00:00
abstract::gamma-L-glutaminyl-4-hydroxy-3-iodobenzene (I-GHB), a novel iodinated analog of gamma-L-glutaminyl-4-hydroxybenzene (GHB), demonstrates greater anti-tumor activity in human and in murine melanoma cell lines. These phenolic amides are substrates for gamma-glutamyltranspeptidase (GGTP; E.C. 2.3.2.2), a cell-membrane-ass...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910560620
更新日期:1994-03-15 00:00:00
abstract::We used oligonucleotide microarrays to investigate gene expression changes associated with multi-step human papillomavirus type 16 (HPV16)-mediated carcinogenesis in vitro. Gene expression profiles in 4 early passage HPV16-immortalized human keratinocyte (HKc) lines derived from different donors were compared with the...
journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2008-07-01 00:00:00
abstract::Daphnane-type diterpene gnidimacrin isolated from the Chinese plant Stellera chamaejasme L. is an antitumor agent that activates protein kinase C (PKC). The mechanism of antitumor action of gnidimacrin and the possible involvement of PKC were examined using sensitive K562 and refractory HLE cells. Gnidimacrin did bind...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980717)77:2<243::aid-ijc
更新日期:1998-07-17 00:00:00
abstract::Ten patients with bulky brain glioblastoma, recurring after surgery, radiotherapy or chemotherapy, underwent direct intralesional radioimmunotherapy (RIT) using a monoclonal antibody (MAb), BC-2, raised against tenascin and labelled with 131I. Tenascin, the BC-2-recognized glycoprotein, is an antigen expressed by the ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910510103
更新日期:1992-04-22 00:00:00