Abstract:
:During 2000, marine antitumor pharmacology research aimed at the discovery of novel antitumor agents was published in 85 peer-reviewed articles. The purpose of this article is to present a structured review of the antitumor and cytotoxic properties of 143 marine natural products, many of them novel compounds that belong to diverse structural classes, including polyketides, terpenes, steroids and peptides. The organisms yielding these bioactive compounds comprised a taxonomically diverse group of marine invertebrate animals, algae, fungi and bacteria. Antitumor pharmacological studies were conducted with 19 marine natural products in a number of experimental and clinical models that defined or further characterized their mechanisms of action. Potentially promising in vitro cytotoxicity data generated with murine and human tumor cell lines were reported for 124 novel marine chemicals with as yet undetermined mechanisms of action. Noteworthy is the fact that marine anticancer research clearly remains a multinational effort, involving researchers from Austria, Australia, Brazil, Canada, England, France, Germany, Greece, Indonesia, Italy, Japan, New Zealand, Russia, Spain, South Korea, Switzerland, Taiwan, the Netherlands and the United States. Finally, this 2000 overview of the marine pharmacology literature highlights the fact that the discovery of novel marine antitumor agents continued at the same high level of research activity as during 1998 and 1999.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Mayer AM,Gustafson KRdoi
10.1002/ijc.11080keywords:
subject
Has Abstractpub_date
2003-06-20 00:00:00pages
291-9issue
3eissn
0020-7136issn
1097-0215journal_volume
105pub_type
杂志文章,评审abstract::In vitro infection of EBV-negative lymphoma cell lines with immortalizing strains of Epstein-Barr virus induces the cell-surface expression of B-cell markers, such as the EBV receptor/CR2 (CD21) and the CD23 antigen. The non-immortalizing EBV variant, P3HRI, which carries a deletion encompassing the EBV nuclear antige...
journal_title:International journal of cancer
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doi:10.1002/ijc.2910460418
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abstract::Meibomian gland carcinoma (MGC) and basal cell carcinoma (BCC) are common eyelid carcinomas that exhibit highly dissimilar degrees of proliferation and prognoses. We address here the question of the differential mechanisms between these two eyelid cancers that explain their different outcome. A total of 102 confirmed ...
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journal_title:International journal of cancer
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doi:10.1002/ijc.2910190209
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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abstract::We have shown that modulation of intracellular calcium in EBV latently infected cells could induce the expression of viral antigens, and suggested that a protein kinase-C (PKC) may play a major role in the EBV genome activation. We now report further investigations on the role of PKC using 2 selective enzymatic inhibi...
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doi:10.1002/ijc.2910400624
更新日期:1987-12-15 00:00:00
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更新日期:1982-06-15 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910520328
更新日期:1992-09-30 00:00:00
abstract::Squamous cell carcinoma of the conjunctiva (SCCC) has been associated with HIV infection in equatorial Africa, but the evidence for association with HIV in developed countries, where SCCC is rarer, is controversial. We investigated the risk for SCCC and other eye cancers in the updated U.S. HIV/AIDS Cancer Match Regis...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23384
更新日期:2008-06-01 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22561
更新日期:2007-05-15 00:00:00
abstract::Sequence diversity over 2600 nucleotides of the upstream regulatory region (URR) and the E6 and E2/E4 genes of 34 human papillomavirus (HPV)16 cervical cancer isolates from Australia and New Caledonia was investigated. One 81 base duplication, 41 single base substitutions and 1 single base insertion were identified in...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10103
更新日期:2002-02-20 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.30063
更新日期:2016-08-01 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910400518
更新日期:1987-11-15 00:00:00
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journal_title:International journal of cancer
pub_type: 撤回出版物
doi:10.1002/ijc.32281
更新日期:2019-08-15 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2010-09-01 00:00:00
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更新日期:2006-09-15 00:00:00
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更新日期:1997-05-02 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910420319
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pub_type: 杂志文章
doi:10.1002/ijc.2910620308
更新日期:1995-07-28 00:00:00
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