Abstract:
:We report that the Rhesus (Rh)-negative phenotype is more prevalent in patients with small-cell lung cancer (SCLC) than in the normal Caucasian population (SCLC: 25% Rh-negative vs. 15% expected, p less than 0.0001). This finding has been validated for a Central and a Northern European population (Switzerland and UK). In contrast, the Rh-negative phenotype is no more frequent in non-small-cell lung cancer patients or in heavy smokers with coronary heart disease than in the general population. There was a normal distribution of the ABO blood group phenotype in all patients studied. Whilst the significance of this observation is unclear, we hypothesize that a genetic predisposition to the development of SCLC may be linked to a hitherto unidentified gene on chromosome 1p near the Rh locus. Our observation may perhaps allow further progress to be made in understanding genetic mechanisms of SCLC carcinogenesis.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Cerny T,Fey MF,Oppliger R,Castiglione M,Nachbur B,Gertsch M,Gasser A,Joss RA,Thatcher N,Lind Mdoi
10.1002/ijc.2910520328keywords:
subject
Has Abstract,Author List Incompletepub_date
1992-09-30 00:00:00pages
504-6issue
3eissn
0020-7136issn
1097-0215journal_volume
52pub_type
杂志文章abstract::Approximately 80% of bladder tumors are urothelial superficial papillary carcinomas (USPC). Despite a generally good prognosis, these tumors have a strong propensity to recur and about 1/3 of them compared to disease progression. Histological assessment of these superficial tumors is not sufficiently discriminator in ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11049
更新日期:2003-06-10 00:00:00
abstract::Previous studies have shown that the in vitro-selected adriamycin-resistant human small-cell lung-carcinoma cell line GLC4-ADR150 displays multidrug resistance as the result of 3-fold decreased DNA-topoisomerase II (topo II) activity and a 6-fold reduction in adriamycin accumulation. Not the MDR1 gene, but the MRP gen...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910610317
更新日期:1995-05-04 00:00:00
abstract::We have investigated the comparative initial DNA binding properties of 7 platinum-based anticancer drugs: 5 cis-oriented compounds, cisplatin, tetraplatin (Ormaplatin), JM118 [cis ammine dichloro (cyclohexylamine) platinum (II)], JM216 [bisacetato cis ammine dichloro (cyclohexylamine) platinum (IV)] and JM149 [cis amm...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910620612
更新日期:1995-09-15 00:00:00
abstract::PAX3 encodes a transcription factor, which with Zic1 is necessary for induction of the neural crest during early embryonic development. There are 7 human PAX3 isoforms (a-h). PAX3e is the full length isoform comprising 10 exons. PAX3c comprises 8 exons plus 5 codons of intron 8, while PAX3g has a truncated transactiva...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22316
更新日期:2007-03-15 00:00:00
abstract::MET is a master gene controlling a genetic program driving proliferation, apoptosis protection and invasion. The ROR1 pseudokinase acts as a MET substrate. However, its contribution to MET signaling and MET-dependent biological outcomes remains to be elucidated. By structure-function analysis of ROR1 mutants, we show ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28879
更新日期:2014-11-15 00:00:00
abstract::Incidence of upper gastrointestinal cancers of the oesophagus and stomach show a strong unexplained male predominance. Hormonal and reproductive factors have been associated with upper gastrointestinal cancers in women but there is little available data on men. To investigate this, we included 219,425 men enrolled in ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31375
更新日期:2018-08-15 00:00:00
abstract::Therapy-induced senescence (TIS) as a permanent growth arrest can be induced by various stimuli, including anticancer compounds. TIS emerged as a promising strategy to overcome resistance phenomena. However, senescent cancer cells might regain proliferation activity in vivo or even secrete tumor-promoting cytokines. T...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28350
更新日期:2014-01-01 00:00:00
abstract::Nitric oxide may serve as one cofactor for human papillomavirus (HPV)-induced development of cervical cancer. Therefore, we first assessed the levels of cervical fluid nitric oxide metabolite (NOx) in 283 women with and without high-risk (hr) HPV. The NOx level in women with hr HPV (48.4 μmol/L [95% CI: 39.4-56.6], n ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25637
更新日期:2011-06-15 00:00:00
abstract::There is an unexplained strong male predominance in the aetiology of oesophageal adenocarcinoma (OAC). The hypothesis that oestrogens are protective, deserves attention. A potential protective influence of exogenous oestrogen exposure, that is, hormone replacement therapy (HRT) and oral contraceptives (OC) has been ad...
journal_title:International journal of cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1002/ijc.28869
更新日期:2014-11-01 00:00:00
abstract::In a case-control study of gastric cancer (GC) in high-risk and low-risk areas of Italy, 923 GCs were systematically categorized by one pathologist according to the Lauren classification distinguishing 2 main histologic types, intestinal (55%) and diffuse (23%). Intestinal types outnumbered diffuse types by a 3 to 1 m...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910480310
更新日期:1991-05-30 00:00:00
abstract::These studies were designed to examine the role of neutrophils in transplantation immunity to syngeneic rat tumors. We have earlier reported that specific transplantation immunity to syngeneic transplanted tumors is abrogated by selective depletion of peripheral-blood neutrophils by administration of a monoclonal anti...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910540121
更新日期:1993-04-22 00:00:00
abstract::Lymphatic leukemia developed in C57BL/6 mice following inoculation of normal thymocytes that and been co-cultured on leukemic thymus epithelial reticulum monolayer cells. Using thymocytes genetically marked in Ly membrane antigens, we showed that the thymomas which developed were produced by the co-cultured thymocytes...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910210119
更新日期:1978-01-15 00:00:00
abstract::We have examined several types of tumor cell lines and shown that they invariably expressed little or no Egr-1, in contrast to their normal counterparts. We have previously shown that the expression of exogenous Egr-1 in human breast and other tumor cells markedly reduces transformed growth and tumorigenicity. We ther...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970703)72:1<102::aid-ijc
更新日期:1997-07-03 00:00:00
abstract::Murine macrophages from different anatomical sites were compared for their ability to become tumoricidal and to secrete interleukin-1 (IL-1) and tumor necrosis factor (TNF) following stimulation in vitro by several biological response modifiers (BRM). Peritoneal macrophages (PM), alveolar macrophages (AM), and tumor-i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910480513
更新日期:1991-07-09 00:00:00
abstract::A 42-kDa recombinant protein, PX141, consisting of the trans-activator protein encoded by human T-cell leukemia virus (HTLV-1) (tax1 antigen) and the amino-terminal fusion peptide of 12 amino acid residues of the alpha-peptide encoded by the plasmid pUC19 was produced. In order to investigate the immunogenicity of the...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910480423
更新日期:1991-06-19 00:00:00
abstract::PCNA and esophagin have been implicated in the multistep process of carcinogenesis, but simultaneous characterization of these proteins in the early stages of esophageal neoplastic progression has yet to be undertaken. In morphologically normal esophageal epithelium, esophagin stains the granular layer cells, principa...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20267
更新日期:2004-09-01 00:00:00
abstract::von Willebrand factor (vWF), a glycoprotein produced uniquely by endothelial cells and megakaryocytes, is routinely used to identify vessels in tissue sections. Vessel density in tumor specimens, as determined by immuno-histochemical staining for vWF or other endothelial cell markers, is a negative prognostic factor f...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(20000115)85:2<281::aid-ijc
更新日期:2000-01-15 00:00:00
abstract::A panel of human breast cancer specimens was examined for single base change mutations by DNA sequencing and for larger deletions using a PCR-based assay. In the cancer specimens examined, no sequencing variants were detected other than a previously characterized polymorphism. Although most of the specimens contained ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20001015)88:2<209::aid-ijc10>3.0
更新日期:2000-10-15 00:00:00
abstract::Somatic mutations in the TP53 gene are the most frequently observed genetic alterations in human malignancies, including breast cancer, which is one of the leading causes of death among women in Brazil. In our study, we determined the frequency and the pattern of TP53 mutations in malignant breast tumors from 120 pati...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10567
更新日期:2002-09-01 00:00:00
abstract::Human alpha interferon (IFN-alpha) and beta interferon (IFN-beta) showed antiviral and anticellular effects on human lymphoblastoid Daudi and P3HR-1 cells, but up to 1,000 units/ ml of gamma interferon (IFN-gamma) showed no such effect. Though a fairly high level of dsRNA-dependent 2'-5'-oligoadenylate synthetase (2-5...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910300206
更新日期:1982-08-15 00:00:00
abstract::Detectable post-therapy plasma Epstein-Barr virus (EBV) DNA predicts poor survival in non-metastatic nasopharyngeal carcinoma (NPC). However, some patients subsequently experience spontaneous remission of residual EBV DNA during follow-up and it was unclear whether these patients were still at high risk of disease fai...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32021
更新日期:2019-05-01 00:00:00
abstract::The influence of 4 murine monoclonal antibodies (MAbs) directed against surface determinants of a metastasizing rat adenocarcinoma (BSp73ASML) on metastatic spread was evaluated and compared to their in vivo binding as well as to the induction of a humoral anti-MAb response, especially with respect to the development ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910460528
更新日期:1990-11-15 00:00:00
abstract::The deleted in liver cancer 1 (DLC1) tumor suppressor is an important RhoGTP activating protein (RhoGAP) that plays a crucial role in many types of human cancers. Small GTPases regulate normal cellular processes but aberrant expression and activation of GTPases contribute to tumorigenesis. RhoGAP suppresses Rho activi...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.28505
更新日期:2014-07-15 00:00:00
abstract::Cancer-germline genes (CGGs) code for immunogenic antigens that are present on various human tumors but not on normal tissues. The importance of CGGs in cancer immunotherapy has led to detailed studies of their expression in a range of human tumors. We measured the levels of expression of 12 CGGs in various pediatric ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22118
更新日期:2007-01-01 00:00:00
abstract::High circulating glucose, insulin resistance and obesity appear to be associated with increased risk of breast cancer (BC). We sought further insight into the relation of these variables to BC. We assessed associations of BC risk with serum fasting glucose, insulin, homeostasis model assessment-insulin resistance (HOM...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26071
更新日期:2012-02-15 00:00:00
abstract::Analysis of the length of circulating DNA in plasma has been reported as a marker for solid tumor detection. We assessed the sensitivity and specificity of increased plasma DNA length to identify patients with head and neck squamous cell carcinoma (HNSCC) and monitor posttreatment disease status. Fifty-eight HNSCC pat...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22250
更新日期:2006-12-01 00:00:00
abstract::MUC18/MCAM is a cell-surface glycoprotein that is strongly expressed on advanced human melanomas. Transfection of 3 MCAM-negative melanoma cell lines with MCAM cDNA led to cell-surface expression and to a MCAM-dependent homotypic adhesion. This adhesion was independent of divalent cations and was inhibited at 4 degree...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19971127)73:5<769::aid-ijc
更新日期:1997-11-27 00:00:00
abstract::DNA copy number alterations (CNAs) are frequent in cancer, and recently developed CNA signatures revealed their value in molecular tumor stratification for patient prognosis and platinum resistance prediction in ovarian cancer. Head and neck squamous cell carcinoma (HNSCC) is also characterized by high CNAs. In this s...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32962
更新日期:2020-09-15 00:00:00
abstract::Three monoclonal antibodies (MAbs) against p53 protein (PAb 24o, DO-I and PAb1801) were used to define the immunophenotype of 13 melanoma cell lines. Immunoreactions could be detected in 12 out of 13 cell lines by using the indirect immunofluorescence technique. In 7 of these the majority of cells displayed cytoplasmi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910540427
更新日期:1993-06-19 00:00:00
abstract::Previous studies indicate that the triterpene glycoside actein from the herb black cohosh inhibits growth of human breast cancer cells. This study seeks to identify genes altered in human breast cancer cells by treatment with actein, using gene expression analysis. We treated MDA-MB-453 human breast cancer cells with ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22897
更新日期:2007-11-01 00:00:00