The growth inhibitory effect of actein on human breast cancer cells is associated with activation of stress response pathways.

abstract：:The aim of our study was to estimate uptake of prostate-specific antigen (PSA) testing in an entire country, including time trends and geographical differences. Data from the Swedish Cancer Register on prostate cancer incidence between 1980 and 2007 and published data from the Gothenburg branch of the European randomi...

journal_title：International journal of cancer

authors： Jonsson H,Holmström B,Duffy SW,Stattin P

更新日期：2011-10-15 00:00:00

abstract：:Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. To improve existing therapies and broaden the spectrum of cytotoxic agents that can be used in RMS treatment, we performed a phage-display-based screening for peptides that bind specifically to RMS cells. Two peptides binding to RMS and to othe...

journal_title：International journal of cancer

authors： Witt H,Hajdin K,Iljin K,Greiner O,Niggli FK,Schäfer BW,Bernasconi M

更新日期：2009-05-01 00:00:00

abstract：:Controlling adverse events (AEs) through dose reduction can enhance drug adherence and treatment response. Currently, there is no guide for sorafenib dosing. The aim of this study was to evaluate whether sorafenib dosing could affect treatment outcomes. A total of 782 hepatocellular carcinoma (HCC) patients treated wi...

journal_title：International journal of cancer

authors： Tak KY,Nam HC,Choi JY,Yoon SK,Kim CW,Kim HY,Lee SW,Lee HL,Chang UI,Song DS,Yang JM,Kwon JH,Yoo SH,Sung PS,Choi SW,Song MJ,Kim SH,Jang JW

更新日期：2020-10-01 00:00:00

abstract：:Routine pathological examination cannot distinctively predict the clinical course of meningiomas because even histologically benign tumors may recur after gross total resection. Numerous efforts have been made for the evaluation of different immunohistochemical assays in meningioma prognosis. We investigated the progn...

journal_title：International journal of cancer

authors： Korshunov A,Shishkina L,Golanov A

更新日期：2003-05-10 00:00:00

abstract：:Renewed interest in the use of therapeutic enzymes combined with an improved knowledge of cancer cell metabolism, has led to the translation of several arginine depletion strategies into early phase clinical trials. Arginine auxotrophic tumors are reliant on extracellular arginine, due to the downregulation of arginos...

journal_title：International journal of cancer

authors： Fultang L,Vardon A,De Santo C,Mussai F

更新日期：2016-08-01 00:00:00

abstract：:In STU mice bearing metastasizing SV40-transformed 51A-232B-M tumors, an immune response against a cellular 60kDa protein (p60) developed in about 50% of the tumor-bearing animals, in addition to the response against SV40 large T-antigen and cellular protein p53. The anti-p60 auto-immune response could be observed as ...

journal_title：International journal of cancer

authors： Manneck HE,Pfaff M,Anderer FA

更新日期：1988-12-15 00:00:00

abstract：:A human papillomavirus (HPV) was cloned from a patient with multiple squamous cell carcinomas (SCCs) and identified as HPV88, recently categorized into a new species within the genus Gamma. The HPV88 viral load in an SCC of the index patient exceeded 1 million copies/cell. By contrast, a survey of 447 skin lesions (79...

journal_title：International journal of cancer

authors： Kullander J,Handisurya A,Forslund O,Geusau A,Kirnbauer R,Dillner J

更新日期：2008-01-15 00:00:00

abstract：:To determine the relationship between p16MTS1/CDK4I expression, gene inactivation and 9p21 loss of heterozygosity (LOH) in the development of laryngeal carcinomas, we have examined p16MTS1/CDK4I protein and mRNA expression in a series of 7 normal and 36 tumoral tissues, and the presence of gene alterations and 9p21 LO...

journal_title：International journal of cancer

authors： Jares P,Nadal A,Fernández PL,Pinyol M,Hernández L,Cazorla M,Hernández S,Beà S,Cardesa A,Campo E

更新日期：1999-05-31 00:00:00

abstract：:Women affected by gross cystic disease of the breast have an increased risk of breast cancer. We report here the incidence of breast cancer by cyst type and intracystic epidermal growth factor (EGF) concentration. Our retrospective study included 504 women who had at least 1 cyst aspiration between 1985 and 1993. Cyst...

journal_title：International journal of cancer

authors： Boccardo F,Marenghi C,Ghione G,Pepe A,Parodi S,Rubagotti A

更新日期：2001-07-20 00:00:00

abstract：:There is little long-term follow-up information about how the number of melanoma deaths and case fatality vary over time according to the measured thickness of melanoma at diagnosis. This population-based longitudinal cohort study examines patterns and trends in case fatality among 44,531 people in Queensland (Austral...

journal_title：International journal of cancer

authors： Baade PD,Whiteman DC,Janda M,Cust AE,Neale RE,Smithers BM,Green AC,Khosrotehrani K,Mar V,Soyer HP,Aitken JF

更新日期：2020-09-01 00:00:00

abstract：:An orang-utan (Pongo pygmaeus) suspension line, CP81, was shown to lack myeloid markers of lysozyme activity an d phagocytosis but to be positive for lymphocytic N-alkaline phosphatase activity, and to release a B-cell-tropic herpesvirus. This herpesvirus, termed Herpesvirus pongo, had 30--40% DNA homology with EBV an...

journal_title：International journal of cancer

authors： Rabin H,Neubauer RH,Hopkins RF 3rd,Nonoyama M

更新日期：1978-06-15 00:00:00

abstract：:Peripheral blood leukocytes from patients with confirmed pulmonary neoplasia were tested for cytotoxicity against cultured cells derived from lung tumours of various histological types, foetal and normal adult lung tissue and tumours arising in organs other than the lung. Leukocytes from 73 percent of patients were cy...

journal_title：International journal of cancer

authors： Vose BM,Moore M,Jack GD

更新日期：1975-02-15 00:00:00

abstract：:The expression of the recently described rap genes, closely related in the effector region to the ras proto-oncogenes, was examined by Northern blot analysis in 41 primary human tumors. The structural and in vitro biological properties of the rap gene products suggest their possible antagonistic action in the same eff...

journal_title：International journal of cancer

authors： Culine S,Olofsson B,Gosselin S,Honore N,Tavitian A

更新日期：1989-12-15 00:00:00

abstract：:Breast cancer is one of the leading causes of cancer death in women. It is a complex and heterogeneous disease with different clinical outcomes. Stratifying patients into subgroups with different outcomes could help guide clinical decision making. In this study, we used two opposing groups of genes, Yin and Yang, to d...

journal_title：International journal of cancer

authors： Xu W,Jia G,Cai N,Huang S,Davie JR,Pitz M,Banerji S,Murphy L

更新日期：2017-03-15 00:00:00

abstract：:Adult T-cell leukemia (ATL) is a retrovirus-associated leukemia with poor prognosis and often has deletions of the p16INK4a and p15INK4b genes on chromosome 9p21. The gene for methylthioadenosine phosphorylase (MTAP), a purine and methionine metabolic enzyme, resides approximately 100 Kb telomeric to the p16INK4a gene...

journal_title：International journal of cancer

authors： Hori Y,Hori H,Yamada Y,Carrera CJ,Tomonaga M,Kamihira S,Carson DA,Nobori T

更新日期：1998-01-05 00:00:00

abstract：:Angiogenesis is essential for tumor growth and metastasis. In the process of angiogenesis, the interaction between adhesive proteins of endothelial cells and extracellular matrix components plays an important role by mediating cell attachment, which is indispensable for their motility, and by transmitting the regulato...

journal_title：International journal of cancer

authors： Trochon V,Mabilat C,Bertrand P,Legrand Y,Smadja-Joffe F,Soria C,Delpech B,Lu H

更新日期：1996-05-29 00:00:00

abstract：:Biopsies of 13 penile cancers (PC), from patients living in regions of Uganda with a high incidence of genital cancers, were studied for the presence, molecular characteristics and physical state of DNA related to that of human papillomavirus (HPV) types 6, 11, 16, 18, 31 and 33. HPV DNA sequences were detected in all...

journal_title：International journal of cancer

authors： Tornesello ML,Buonaguro FM,Beth-Giraldo E,Kyalwazi SK,Giraldo G

更新日期：1992-06-19 00:00:00

abstract：:The human HBL-100 cell line harbours SV40 DNA integrated in tandem at a unique site. The SV40 T-antigen expressed in these cells is defective in a function essential to the replication of the viral genome. The integrated SV40 sequences were molecularly cloned in a bacteriophage, and a subclone (plasmid pSVHBI) contain...

journal_title：International journal of cancer

authors： Saint-Ruf C,Nardeux P,Cebrian J,Lacasa M,Lavialle C,Cassingena R

更新日期：1989-08-15 00:00:00

abstract：:Epigenetic modification of gene expression plays an important role in the development of human cancers. The inactivation of SPARC through CpG island methylation was studied in colon cancers using oligonucleotide microarray analysis and methylation specific PCR (MSP). Gene expression of 7 colon cancer cell lines was ev...

journal_title：International journal of cancer

authors： Yang E,Kang HJ,Koh KH,Rhee H,Kim NK,Kim H

更新日期：2007-08-01 00:00:00

abstract：:A previously published case-control study of agricultural risk factors involved male cases of non-Hodgkin's lymphoma registered under code 202 of the International Classification of Diseases (ICD). This study has been expanded with the inclusion of cases registered under ICD code 200, and additional controls. The expa...

journal_title：International journal of cancer

authors： Pearce NE,Sheppard RA,Smith AH,Teague CA

更新日期：1987-02-15 00:00:00

abstract：:Our previous study has suggested that the cell cycle-related kinase (CCRK) is a putative candidate oncogene in glioblastoma tumorigenesis. The potential oncogenic role of CCRK and its clinical/prognostic significance, however, in ovarian carcinoma are unclear. In this study, CCRK expression was examined by immunohisto...

journal_title：International journal of cancer

authors： Wu GQ,Xie D,Yang GF,Liao YJ,Mai SJ,Deng HX,Sze J,Guan XY,Zeng YX,Lin MC,Kung HF

更新日期：2009-12-01 00:00:00

abstract：:Effects of 12-O-tetradecanoyl phorbol 13-acetate (TPA) and the hepatic peroxisome proliferators (HPPs) clofibrate, methyl clofenapate (MCP), di(2-ethylhexyl)phthalate (DEHP) and mono(2-ethylhexyl)phthalate (MEHP) were studied in 2 gap junctional intercellular communication (GJIC) systems, metabolic cooperation in V79 ...

journal_title：International journal of cancer

authors： Cruciani V,Mikalsen SO,Vasseur P,Sanner T

更新日期：1997-10-09 00:00:00

abstract：:Regional lymph-node (LN) lymphocytes may constitute an important defence against the spread of human melanoma beyond regional LNs. The present study was directed to clonal analysis of lymphocytes cultured either directly from the LNs or after stimulation in cultures with autologous melanoma (MLTC). T-cell clones deriv...

journal_title：International journal of cancer

authors： Chen Q,Hersey P

更新日期：1992-05-08 00:00:00

abstract：:In previous studies we showed that human sarcoma and melanoma cell lines synthesize and secrete into culture medium a glycoprotein, migrating in urea sodium dodecyl sulfate-polyacrylamide gel electrophoresis at Mr 140,000. It is not detected in cultures of the corresponding normal cells. Conditioned medium of the mela...

journal_title：International journal of cancer

authors： Bízik J,Vaheri A,Saksela O,Kalkkinen N,Meri S,Grófóva M

更新日期：1986-01-15 00:00:00

abstract：:Cell lines established from T-cell leukemias have recently been reported to exhibit a chromosome translocation t(8;14) involving proto-oncogene c-myc and the gene of the T-cell receptor alpha-chain(TcR-alpha). In this work, we have studied a case of T-cell leukemia presenting a t(8;14)(q24;q11) translocation that was ...

journal_title：International journal of cancer

authors： Mathieu-Mahul D,Sigaux F,Zhu C,Bernheim A,Mauchauffe M,Daniel MT,Berger R,Larsen CJ

更新日期：1986-12-15 00:00:00

abstract：:The mRNA levels of the ras-related human rhoA, rhoB and rhoC genes were studied in human breast-cancer cell lines (HBCal), and in normal and immortalized mammary epithelial cells (HMEC) by Northern blot analysis and in situ hybridization. In contrast to the ubiquitous rhoA and rhoC gene expression, dramatic variations...

journal_title：International journal of cancer

authors： de Cremoux P,Gauville C,Closson V,Linares G,Calvo F,Tavitian A,Olofsson B

更新日期：1994-11-01 00:00:00

abstract：:Prospective cohort studies about cutaneous melanoma (CM) risk are still few. Host factor- and UVR exposure data were collected prospectively by questionnaire in this population-based cohort study including 40,000 Swedish born women, aged 25-64 years at enrolment (1990). Risk for CM (Cox regression and Stepwise Cox reg...

journal_title：International journal of cancer

authors： Nielsen K,Måsbäck A,Olsson H,Ingvar C

更新日期：2012-08-01 00:00:00

abstract：:The p53 tumor suppressor pathway is impaired in more than 90% of cervical cancers and cancer-derived cell lines as a result of infection by human papillomavirus (HPV). The HPV E6 oncoprotein forms complexes with p53 and promotes its degradation via ubiquitin-dependent mechanism. In our study, we attempted to improve t...

journal_title：International journal of cancer

authors： Wang H,Song X,Zhang H,Zhang J,Shen X,Zhou Y,Fan X,Dai L,Qian G,Hoffman AR,Hu JF,Ge S

更新日期：2012-01-15 00:00:00

abstract：:The serine protease urokinase-type plasminogen activator (uPA) plays a significant role in tumor cell invasion and metastasis when bound to its specific receptor, uPAR (also known as CD87). In addition to the uPA-uPAR system, matrix metalloproteinases (MMPs) are involved in tumor cell invasion and metastasis. In this ...

journal_title：International journal of cancer

authors： Kunigal S,Lakka SS,Gondi CS,Estes N,Rao JS

更新日期：2007-11-15 00:00:00

abstract：:During 1984-88 a population-based case-control study was carried out in The Netherlands in collaboration with the International Agency for Research on Cancer in order to further explore the possible relationship between diet and exocrine pancreatic carcinoma. Past habitual dietary intake was assessed in 164 cases and ...

journal_title：International journal of cancer

authors： Bueno de Mesquita HB,Moerman CJ,Runia S,Maisonneuve P

更新日期：1990-09-15 00:00:00