Abstract:
:Angiogenesis is essential for tumor growth and metastasis. In the process of angiogenesis, the interaction between adhesive proteins of endothelial cells and extracellular matrix components plays an important role by mediating cell attachment, which is indispensable for their motility, and by transmitting the regulatory signals for cell locomotion and proliferation. In this study, we examined the hypothesis that CD44 expressed on the endothelial cell surface is involved in the angiogenesis process. The experiments using calf pulmonary artery endothelial cells (CPAE) and a human microvascular endothelial cell line (HMEC-1) show that a monoclonal antibody against CD44 (clone J 173) inhibits endothelial cell proliferation by about 30% and migration by 25-50%, and abolishes the stimulating effect of hyaluronan polysaccharides on endothelial cell migration and proliferation. This antibody also suppresses the capillary formation of CPAE in an in vitro model of angiogenesis using fibrin matrix. These results provide evidence of the involvement of endothelial-cell-associated CD44 in angiogenesis.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Trochon V,Mabilat C,Bertrand P,Legrand Y,Smadja-Joffe F,Soria C,Delpech B,Lu Hdoi
10.1002/(SICI)1097-0215(19960529)66:5<664::AID-IJCsubject
Has Abstractpub_date
1996-05-29 00:00:00pages
664-8issue
5eissn
0020-7136issn
1097-0215pii
10.1002/(SICI)1097-0215(19960529)66:5<664::AID-IJCjournal_volume
66pub_type
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