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Natural resistance against tumors grafted into the brain in association with histocompatibility-class-I-antigen expression.

Abstract：

:The role of MHC-class-I-antigen expression in intracerebral anti-tumor natural resistance was examined using MHC-positive Lym+ and MHC-negative Lym- lymphoma cell lines. Lym+ was sensitive to MHC-class-I-restricted CTL-mediated lysis, while lym- was resistant. Both lines were susceptible to NK-cell-mediated lysis. There was no difference in in vitro growth rate of in vivo intraperitoneal tumorigenicity between them. Inoculation of Lym+ cells into the brain caused upregulation of the intracellular MHC mRNA to the same level as after treatment with interferon-gamma, resulting in an increase in cell-surface MHC expression. Although inoculated Lym- cells also underwent an increase in cytosolic MHC mRNA, the cell-surface MHC expression remained negative. Immunoprecipitation revealed that the terminal glycosylation did not occur normally in Lym-. An in vivo intracerebral tumorigenicity assay, using 2 groups of untreated and NK-cell-depleted syngeneic mice, showed that Lym+ was less tumorigenic than Lym-. In T-cell-depleted mice, however, no difference was detected between them. In addition, when Lym+ and Lym- cells were inoculated into the brain of allogeneic or syngeneic preimmunized mice (immunized with tumor cells), Lym+ was rejected, while Lym- was accepted. When allogeneic mice had received treatment for T-cell depletion before intracerebral inoculation, no rejection was observed in Lym+. On the other hand, Lym- cells, when injected i.p. into NK-depleted mice, had greater killing activity than Lym+ cells, while in T-cell-depleted mice Lym- was less tumorigenic than Lym+. These results suggest that MHC-positive tumor cells grafted into the brain may be rejected by CTL in an MHC-dependent manner, whereas MHC-negative tumor cells can escape from T-cell-mediated immunosurveillance and grow progressively in the brain, due to absence of intracerebral natural resistance mediated by NK cells.

journal_name

Int J Cancer

journal_title

International journal of cancer

authors

Yamasaki T,Akiyama Y,Fukuda M,Kimura Y,Moritake K,Kikuchi H,Ljunggren HG,Kärre K,Klein G

doi

10.1002/(SICI)1097-0215(19960729)67:3<365::AID-IJC

subject

Has Abstract

pub_date

1996-07-29 00:00:00

pages

365-71

issue

eissn

0020-7136

issn

1097-0215

pii

10.1002/(SICI)1097-0215(19960729)67:3<365::AID-IJC

journal_volume

pub_type

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Natural resistance against tumors grafted into the brain in association with histocompatibility-class-I-antigen expression.