Occupational sun exposure and risk of melanoma according to anatomical site.

abstract：:We quantified the expression of survivin, both as mRNA in real-time PCR and protein in immunohistochemistry, in tumor samples of 112 patients with esophageal cancer (56 squamous cell carcinomas and 56 adenocarcinomas). Overall survival of squamous cell carcinoma patients with high survivin mRNA levels was significantl...

journal_title：International journal of cancer

authors： Rosato A,Pivetta M,Parenti A,Iaderosa GA,Zoso A,Milan G,Mandruzzato S,Del Bianco P,Ruol A,Zaninotto G,Zanovello P

更新日期：2006-10-01 00:00:00

abstract：:The utility of EBV load as a tumor marker in nasopharyngeal carcinoma (NPC) patients suggests that it might also serve as a screening test for individuals who are at high risk for developing NPC. We previously demonstrated that unaffected individuals from high-risk families had elevated anti-EBV antibody levels compar...

journal_title：International journal of cancer

authors： Yang X,Goldstein AM,Chen CJ,Rabkin CS,Chen JY,Cheng YJ,Hsu WL,Sun B,Diehl SR,Liu MY,Walters M,Shao W,Ortiz-Conde BA,Whitby D,Elmore SH,Gulley ML,Hildesheim A

更新日期：2006-02-01 00:00:00

abstract：:A specific chromosomal aberration was observed in 14 of 15 avian lymphoblastoid cell lines transformed with Marek's disease herpesvirus. This aberration, designated dup(1p)(p22-p23), appeared as an extra G-positive band and interband on the short arm of one chromosome I homolog. Using fluorescent in situ hybridization...

journal_title：International journal of cancer

authors： Moore FR,Schat KA,Hutchison N,Leciel C,Bloom SE

更新日期：1993-06-19 00:00:00

abstract：:The mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) encodes a protein that plays a critical role in tumor suppression, in part by modulating bioavailability of a potent mitogen, insulin-like growth factor-2 (IGF2). We tested the hypothesis that the common nonsynonymous genetic variants in M6P/IGF...

journal_title：International journal of cancer

authors： Hoyo C,Schildkraut JM,Murphy SK,Chow WH,Vaughan TL,Risch H,Marks JR,Jirtle RL,Calingaert B,Mayne S,Fraumeni J Jr,Gammon MD

更新日期：2009-12-01 00:00:00

abstract：:Risk of Hodgkin's disease (HD) in young adults has frequently been associated with limited access to social contact in childhood and related correlates of childhood social class. In addition, case clustering has sometimes been associated with influxes of population into relatively isolated communities. To investigate ...

journal_title：International journal of cancer

authors： Alexander FE,Ricketts TJ,McKinney PA,Cartwright RA

更新日期：1991-04-22 00:00:00

abstract：:Previously, the induction of pancreatic carcinogenesis in the rat using azaserine has involved a multiple-dose treatment protocol. The objective of the present study was to determine the effect of multiple azaserine treatments on pancreatic DNA synthesis and to develop a protocol for a single-dose initiation of pancre...

journal_title：International journal of cancer

authors： Yager JD Jr,Roebuck BD,Zurlo J,Longnecker DS,Weselcouch EO,Wilpone SA

更新日期：1981-11-15 00:00:00

abstract：:In Greenland, the incidence of cervical cancer is 5.7 times higher than in Denmark among women aged 20-39. From Nuuk (Greenland) and Nykøbing Falster (Denmark) a sample of 800 women aged 20-39 years was drawn at random. A total of 586 and 661 women were investigated in Greenland and Denmark respectively. All women had...

journal_title：International journal of cancer

authors： Kjaer SK,de Villiers EM,Haugaard BJ,Christensen RB,Teisen C,Møller KA,Poll P,Jensen H,Vestergaard BF,Lynge E

更新日期：1988-04-15 00:00:00

abstract：:Monoclonal antibody 38.13 was raised against the Burkitt lymphoma cell line Daudi and has been previously shown to recognize a globotriaosylceramide (Pk) determinant expressed selectively on Burkitt and a few other B-cell lymphomas. We report here that 38.13 binds to a subset of normal B lymphocytes in germinal centre...

journal_title：International journal of cancer

authors： Murray LJ,Habeshaw JA,Wiels J,Greaves MF

更新日期：1985-11-15 00:00:00

abstract：:Thirty-one different long-term established human carcinoma culture cell lines were examined for the presence or absence of receptors for the Fc portion of immunoglobulin G (IgG) ("Fc receptors"), the third component of complement (C3 receptors), sheep erythrocytes and mouse erythrocytes. Included in the catalogue of l...

journal_title：International journal of cancer

authors： Kerbel RS,Pross HF,Leibovitz A

更新日期：1977-11-15 00:00:00

abstract：:Mouse and human lymphoid cells were cultivated in the presence of T-cell growth factor (TCGF) and evaluated for their in vivo anti-tumor effect in mice. Cultured spleen cells of normal BALB/c mice or of mice bearing the M109 tumor had a high level of cytotoxic activity in vitro against a variety of tumor target cells ...

journal_title：International journal of cancer

authors： Gorelik E,Kedar E,Sredni B,Herberman R

更新日期：1981-08-15 00:00:00

abstract：:MicroRNA-9-1(miR-9-1) plays an important role in the mechanism that regulates the lineage fate of differentiating hematopoietic cells. Recent studies have shown that miR-9-1 is downregulated in t (8; 21) AML. However, the pathogenic mechanisms underlying miR-9-1 downregulation and the RUNX1-RUNX1T1 fusion protein, gen...

journal_title：International journal of cancer

authors： Fu L,Shi J,Liu A,Zhou L,Jiang M,Fu H,Xu K,Li D,Deng A,Zhang Q,Pang Y,Guo Y,Hu K,Zhou J,Wang Y,Huang W,Jing Y,Dou L,Wang L,Xu K,Ke X,Nervi C,Li Y,Yu L

更新日期：2017-02-01 00:00:00

abstract：:Cancers occurring at the gastroesophageal junction (GEJ) are classified as predominantly esophageal or gastric, which is often difficult to decipher. We hypothesized that the transcriptomic profile might reveal molecular subgroups which could help to define the tumor origin and behavior beyond anatomical location. The...

journal_title：International journal of cancer

authors： Bornschein J,Wernisch L,Secrier M,Miremadi A,Perner J,MacRae S,O'Donovan M,Newton R,Menon S,Bower L,Eldridge MD,Devonshire G,Cheah C,Turkington R,Hardwick RH,Selgrad M,Venerito M,Malfertheiner P,OCCAMS Consortium.,F

更新日期：2019-12-15 00:00:00

abstract：:Immunochromatographical fecal occult blood tests were shown to have higher sensitivity for detecting colorectal neoplasms than the commonly used guaiac-based test. However, positivity rates, sensitivity and specificity vary widely. We aimed to assess the reasons for this heterogeneity. Six dichotomous (qualitative) im...

journal_title：International journal of cancer

authors： Brenner H,Haug U,Hundt S

更新日期：2010-10-01 00:00:00

abstract：:A marked increase in natural killer (NK) activity is observed with lymphoid cells prepared from SJL/J mouse spleen and lymph nodes, in which a transplantable reticulum-cell neoplasm (RCN) is growing. The killer cells are non-adherent, non-phagocytic, relatively resistant to X-ray, and scarcely or only partially inacti...

journal_title：International journal of cancer

authors： Chang KS,Log T

更新日期：1980-03-15 00:00:00

abstract：:Previous studies have reported that poorly differentiated adenocarcinoma and mucinous carcinoma of the colon and rectum (Por & Muc) show a low incidence and poor prognosis. However, genetic alterations and tumourigenesis of Por & Muc remain unclear. In our study, we analyzed the genetic and epigenetic alterations of P...

journal_title：International journal of cancer

authors： Kanazawa T,Watanabe T,Kazama S,Tada T,Koketsu S,Nagawa H

更新日期：2002-11-20 00:00:00

abstract：:Although treatment of Hodgkin's lymphoma (HL) with a multi-drug approach has been very successful, its toxicity becomes evident after several years as secondary malignancies and cardiovascular disease. Therefore, the current goal in HL treatment is to find new therapies that specifically target the deregulated signali...

journal_title：International journal of cancer

authors： Mackenzie GG,Queisser N,Wolfson ML,Fraga CG,Adamo AM,Oteiza PI

更新日期：2008-07-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Little is known about its molecular pathogenesis and the relevance of DNA methylation for disease initiation and progression. Nevertheless, promoter methylation of some genes has been implicated as potential marker for HCC. Thirty-four HCC, 34...

journal_title：International journal of cancer

authors： Harder J,Opitz OG,Brabender J,Olschewski M,Blum HE,Nomoto S,Usadel H

更新日期：2008-06-15 00:00:00

abstract：:Early detection, clinical management and disease recurrence monitoring are critical areas in cancer treatment in which specific biomarker panels are likely to be very important in each of these key areas. We have previously demonstrated that levels of alpha-2-heremans-schmid-glycoprotein (AHSG), complement component C...

journal_title：International journal of cancer

authors： Dowling P,Clarke C,Hennessy K,Torralbo-Lopez B,Ballot J,Crown J,Kiernan I,O'Byrne KJ,Kennedy MJ,Lynch V,Clynes M

更新日期：2012-08-15 00:00:00

abstract：:Embryonal tumors such as Wilms' tumor (WT), embryonal rhabdomyosarcoma (eRMS) and hepatoblastoma have been thought to have a common pathogenetic mechanism. H19 was found to be inactivated in WT and eRMS either by loss of heterozygosity or by hypermethylation of the maternal allele. We show here that the expression of ...

journal_title：International journal of cancer

authors： Fukuzawa R,Umezawa A,Ochi K,Urano F,Ikeda H,Hata J

更新日期：1999-08-12 00:00:00

abstract：:Evidence suggests that the majority of lung cancer patients have tumour-derived genetic alterations in circulating plasma DNA, and that this may be developed as a diagnostic tool. To this end, we have studied 60 individuals attending bronchoscopy clinic, with symptoms suspicious of lung cancer, for genetic alterations...

journal_title：International journal of cancer

authors： Allan JM,Hardie LJ,Briggs JA,Davidson LA,Watson JP,Pearson SB,Muers MF,Wild CP

更新日期：2001-02-01 00:00:00

abstract：:The antiproliferative effect of 2',5' A3 core and 2',5'-3'dA3 (cordycepin trimer) core was measured in 8 human tumor cell lines. Cells were treated in a dose-response manner for 72 hr and the concentration of drug necessary to inhibit cell growth 50% (GI50) was determined. A wide range of sensitivities to these drugs ...

journal_title：International journal of cancer

authors： Hubbell HR,Pequignot EC,Willis DH,Lee C,Suhadolnik RJ

更新日期：1985-09-15 00:00:00

abstract：:The expression of the recently described rap genes, closely related in the effector region to the ras proto-oncogenes, was examined by Northern blot analysis in 41 primary human tumors. The structural and in vitro biological properties of the rap gene products suggest their possible antagonistic action in the same eff...

journal_title：International journal of cancer

authors： Culine S,Olofsson B,Gosselin S,Honore N,Tavitian A

更新日期：1989-12-15 00:00:00

abstract：:An epithelioid cell line, started from a human pancreatic carcinoma of ductal cell origin, has been maintained in culture for over 2 years and has been subcultured more than 40 times. The PANC-1 cell line has a doubling time of 52 h and G6PD activity of the slow mobility of B type. Chromosome studies show a modal numb...

journal_title：International journal of cancer

authors： Lieber M,Mazzetta J,Nelson-Rees W,Kaplan M,Todaro G

更新日期：1975-05-15 00:00:00

abstract：:The mismatch repair (MMR) genes are involved in the maintenance of genomic integrity. Recently, we showed that common variants in these genes are unlikely to contribute significantly to colorectal cancer risk. The aim of this study was to investigate the role of common variants in the mismatch repair pathway as progno...

journal_title：International journal of cancer

authors： Koessler T,Azzato EM,Perkins B,Macinnis RJ,Greenberg D,Easton DF,Pharoah PD

更新日期：2009-04-15 00:00:00

abstract：:Epstein-Barr virus genome-positive Burkitt's lymphoma is endemic in Africa and Papua New Guinea and in both countries the tumour is restricted to regions with holoendemic malaria. The present work has compared groups of healthy indigenous individuals living in malarious and non-malarious regions of Papua New Guinea fo...

journal_title：International journal of cancer

authors： Moss DJ,Burrows SR,Castelino DJ,Kane RG,Pope JH,Rickinson AB,Alpers MP,Heywood PF

更新日期：1983-06-15 00:00:00

abstract：:A subline of the murine P815 mastocytoma passaged for a long period of time in histoincompatible hosts was found to be deficient in surface MHC class-I antigens by serological and biochemical methods. In agreement with the lack of restriction elements, this variant cell line was no longer susceptible to killing by cyt...

journal_title：International journal of cancer

authors： Bertschmann M,Käsermann D,Keller R

更新日期：1990-10-15 00:00:00

abstract：:Non-neoplastic mesenchymal cells, along with 33 benign and 87 malignant soft-tissue tumors (STT) were examined for expression of HLA-A,B,C, beta 2-microglobulin (beta 2m), HLA-DR, -DP, and -DQ molecules and the HLA-D associated invariant chain (Ii). Serial frozen sections were immunostained using monoclonal antibodies...

journal_title：International journal of cancer

authors： Mechtersheimer G,Staudter M,Majdic O,Dörken B,Moldenhauer G,Möller P

更新日期：1990-11-15 00:00:00

abstract：:A panel of monoclonal antibodies and other markers (e.g., terminal deoxynucleotidyl transferase, sheep erythrocyte rosettes, peanut agglutinin) have been used in conjunction with flow cytometry and biochemical analysis to monitor the induction of maturation in human thymic (T) leukaemic cell lines by phorbol ester (TP...

journal_title：International journal of cancer

authors： Delia D,Greaves MF,Newman RA,Sutherland DR,Minowada J,Kung P,Goldstein G

更新日期：1982-01-15 00:00:00

abstract：:ERK and RSK2 drive proliferation and invasion of many cancers. Phosphoprotein enriched in astrocytes 15 (PEA15) binds ERK and RSK2 and high PEA15 levels can impair ERK- and RSK2-dependent transcription. PEA15 expression also inversely correlates with cell motility and invasiveness. We therefore tested PEA15 effects on...

journal_title：International journal of cancer

authors： Gawecka JE,Geerts D,Koster J,Caliva MJ,Sulzmaier FJ,Opoku-Ansah J,Wada RK,Bachmann AS,Ramos JW

更新日期：2012-10-01 00:00:00

abstract：:Smoking is indisputably linked to lung cancer, yet only a small fraction of smokers develops this disease. Although previously tobacco-derived carcinogens and enzyme polymorphisms have been identified to increase the risk for smokers, recent epidemiological data suggest even sex-specificity as a new and additional fac...

journal_title：International journal of cancer

authors： Stapelfeld C,Dammann C,Maser E

更新日期：2020-05-01 00:00:00