Abstract：
:A marked increase in natural killer (NK) activity is observed with lymphoid cells prepared from SJL/J mouse spleen and lymph nodes, in which a transplantable reticulum-cell neoplasm (RCN) is growing. The killer cells are non-adherent, non-phagocytic, relatively resistant to X-ray, and scarcely or only partially inactivated by treatment with anti-Thy 1.2 serum and complement. The killer activity is directed against a wide variety of tumor target cells, not requiring homology in histocompatibility, but is selective and not indiscriminate. Kinetics of in vivo development on NK activity, competitive inhibition of in vitro cytotoxicity by target cells and their membrane extracts are described. The NK activity appears to increase in parallel with the infiltration and growth of RCN in these organs. No such augmented NK activity was observed with other types of tumors that grew in these organs of SJL/J mice. (C57BL/6 X SJL/J)F1 mice pretreated with silica to abrogate Hh restriction and subsequently injected with RCN of SJL/J (H-2s) origin supported the growth of transplanted RCN. The high NK activity associated with this RCN was markedly reduced by in vitro treatment with anti-H2b serum plus complement, indicating the host origin of NK cells. However, the close association of RCN growth with elevated NK activity may indicate a special function of RCN in promoting NK activity by an unknown mechanism(s) of cellular interactions.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Chang KS,Log Tdoi
10.1002/ijc.2910250316subject
Has Abstractpub_date
1980-03-15 00:00:00pages
405-16issue
3eissn
0020-7136issn
1097-0215journal_volume
25pub_type
杂志文章abstract：:Loss of heterozygosity on chromosome arm 16q frequently occurs in human breast carcinomas regardless of the histological grade or type. To reveal whether the status of chromosome 16 corresponds to the histology of breast carcinomas, we examined the signal number of 16cen, 16q breakpoints and 1;16 fusions in the interp...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19990820)84:4<381::aid-ijc
更新日期：1999-08-20 00:00:00
abstract：:The expression of oestrogen (ER), progesterone (PR) and androgen (AR) receptors in female breast cancer was investigated by immunohistochemistry on snap-frozen tissue specimens of a series of 100 breast cancers. For detection of the AR we used a recently developed mouse monoclonal antibody specific for the N-terminal ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910520415
更新日期：1992-10-21 00:00:00
abstract：:Mutant KRAS provides a driving force for enhancement of cancer stem cells (CSCs) characteristics contributing transformation of colorectal cancer (CRC) cells harboring adenomatous polyposis coli (APC) mutations. Here, we identified the factors mediating the promotion of CSCs properties induced by KRAS mutation through...
journal_title：International journal of cancer
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abstract：:We used a cross-sectional survey to examine short-term anxiety and distress in women receiving different results following routine human papillomavirus (HPV) primary testing at cervical screening. Participants were women aged 24-65 (n = 1,127) who had attended screening at one of five sites piloting HPV primary screen...
journal_title：International journal of cancer
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更新日期：2020-04-15 00:00:00
abstract：:The t(14;19)(q32;q13) is a recurrent chromosomal translocation reported in a variety of B-cell leukemias and lymphomas, including chronic lymphocytic leukemia (CLL). CLL cases associated with t(14;19) often have atypical morphologic and immunophenotypic features and unmutated immunoglobulin heavy chain (IGH) variable ...
journal_title：International journal of cancer
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更新日期：1978-01-15 00:00:00
abstract：:Nasopharyngeal carcinoma (NPC) is rare in most parts of the world, but prevalent in Southern China. Although this disease poses a serious health problem in our population, the genetic alterations that lead to the development of NPC have yet to be defined. In a comparative genomic hybridization (CGH) study on NPC by ou...
journal_title：International journal of cancer
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更新日期：1999-10-29 00:00:00
abstract：:Germline variation in the TP53 network genes PRKAG2, PPP2R2B, CCNG1, PIAS1 and YWHAQ was previously suggested to have an impact on drug response in vitro. Here, we investigated the effect on breast cancer survival of germline variation in these genes in 925 Finnish breast cancer patients and further analyzed five sing...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.27884
更新日期：2013-05-01 00:00:00
abstract：:Oral leukoplakia is a heterogeneous lesion with risk of cancer development; there are no biomarkers to predict its potential of malignant transformation. Tissue proteomic analysis of oral leukoplakia using iTRAQ labeling liquid chromatography-mass spectrometry showed overexpression of heterogeneous ribonucleoprotein K...
journal_title：International journal of cancer
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更新日期：2009-09-15 00:00:00
abstract：:We have previously demonstrated that the delta isoform of protein kinase C (PKCdelta) is importantly involved in cell growth inhibition and tumor suppression in colon cancer cells. To investigate further the activity and mechanism of action of PKCdelta, we have retrovirally transduced a PKCdelta cDNA in HCT116 human c...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.20535
更新日期：2005-01-01 00:00:00
abstract：:Variants of human papillomavirus (HPV) type 31 have been shown to be related both to risk of cervical lesions and racial composition of a population. It is largely undetermined whether variants differ in their likelihood of persistence. Study subjects were women who participated in the ASCUS-LSIL Triage Study and who ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.27689
更新日期：2013-02-01 00:00:00
abstract：:Three monoclonal antibodies (MAbs) against p53 protein (PAb 24o, DO-I and PAb1801) were used to define the immunophenotype of 13 melanoma cell lines. Immunoreactions could be detected in 12 out of 13 cell lines by using the indirect immunofluorescence technique. In 7 of these the majority of cells displayed cytoplasmi...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910540427
更新日期：1993-06-19 00:00:00
abstract：:An experimental rabbit model was used to determine host responses to infection by various human T-lymphotropic virus type-I (HTLV-I) strains. Seven groups of 4 to 5 rabbits each were inoculated with lethally-irradiated HTLV-I-infected cell lines derived from patients with adult T-cell leukemia/lymphoma or from patient...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910500125
更新日期：1992-01-02 00:00:00
abstract：:We conducted a longitudinal cohort study to determine the association of Helicobacter pylori infection and the progression of chronic atrophic gastritis (CAG) with gastric cancer. A cohort of 4655 healthy asymptomatic subjects was followed for a mean period of 7.7 years. H. pylori infection was established by serum sp...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.11680
更新日期：2004-03-01 00:00:00
abstract：:Since most intracellular proteins are expressed with their ligands, ligands of cancer-testis (CT) antigens may also be CT in their distribution. Applying Sperm protein 17 (Sp17) as the bait in a yeast 2-hybrid system of a testicular cDNA library, 17 interacting clones were isolated and all encoded Ropporin, a spermato...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.22842
更新日期：2007-10-01 00:00:00
abstract：:Our previous clinicopathologic study revealed an inverse association of liver metastasis of colorectal cancer and stromal expression of matrix metalloproteinase-9 (MMP-9) or urokinase receptor (uPAR). This suggests that host cells, particularly macrophages, expressing matrix-degrading enzymes/factors could be protecti...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(20000401)86:1<24::aid-ijc4
更新日期：2000-04-01 00:00:00
abstract：:Monoclonal antibodies (MAbs) reactive with the ganglioside fucosyl GM1 (Fuc-GM1), an antigen associated with small-cell carcinoma of the lung (SCLC), were tested for their ability to mediate tumor-cell killing in vitro in conjunction with humoral and cellular effectors and to inhibit tumor engraftment in nude mice in ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910490619
更新日期：1991-12-02 00:00:00
abstract：:Sprague-Dawley rats were given combinations of aminopyrine or oxytetracycline and sodium nitrite in drinking water. Of 30 animals receiving 0.1% (1,000 ppm) of aminopyrine and sodium nitrite for 30 weeks, 29 died with hemangioendothelial sarcomas of the liver. The same tumor caused death in 26 of 30 animals that recei...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910160203
更新日期：1975-08-15 00:00:00
abstract：:Using a recently developed autochthonous mouse model of squamous cell carcinoma (SCC), a combination therapy targeting polyamine metabolism was evaluated. The therapy combined 2-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase (ODC), and MQT 1426, a polyamine transport inhibitor. In 1 trial last...
journal_title：International journal of cancer
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更新日期：2006-05-01 00:00:00
abstract：:The expression of the nuclear SV40-induced T antigen was measured by microfluorimetry on individual, asynchronously growing SV40-transformed cells which had been stained with hamster T-antiserum by the indirect immunofluorescence method. The same individual cells were first measured for T antigen and then for DNA by F...
journal_title：International journal of cancer
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doi：10.1002/ijc.2910150403
更新日期：1975-04-15 00:00:00
abstract：:The modifying effects of a Kunitz trypsin inhibitor (KTI) and a Bowman-Birk trypsin inhibitor (BBI), purified from soybean trypsin inhibitor, as dietary supplements on experimental and spontaneous pulmonary metastasis of murine Lewis lung carcinoma 3LL cells as well as peritoneal disseminated metastasis model in human...
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更新日期：2004-11-10 00:00:00
abstract：:The Cancer Incidence in Five Continents (CI5) series comprises nine volumes that bring together peer-reviewed results from population-based cancer registries worldwide. The aim of each is to make available comparable data on cancer incidence from as wide a range of geographical locations as possible. In addition, the ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.25517
更新日期：2010-12-15 00:00:00
abstract：:This study reports the induction of interferon (IFN) in human mononuclear cells (MNC) by hematopoietic tumor cells. Only 3 out of 15 cell lines were capable of inducing IFN in the mixed leukocyte/tumor-cell reaction (MLTR). K562, a pluripotent stem cell line and DUTKO-I, a hybrid between K562 and Daudi (Burkitt lympho...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910340108
更新日期：1984-07-15 00:00:00
abstract：:Human epidermoid carcinoma A431 cells attach more rapidly to collagen type-I and -IV substrates than to surfaces coated with laminin or fibronectin. The diminished intercellular interaction and rounding up manifested when these cells are exposed to epidermal growth factor (EGF) in tissue culture plastic or collagen fi...
journal_title：International journal of cancer
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doi：10.1002/ijc.2910370313
更新日期：1986-03-15 00:00:00
abstract：:Nasopharyngeal carcinoma (NPC) is an aggressive tumour of multifactorial aetiology that, although rare in most parts of the world, poses a significant mortality problem in its high incidence area of Southern China. Improved therapies are an urgent requirement and, towards this end, immunotherapeutic methods are being ...
journal_title：International journal of cancer
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更新日期：2000-12-15 00:00:00
abstract：:Chen, B., Liu, X., Savell, V.H., Dilday, B.R., Johnson, M.W., Jenkins, J.J., and Parham, D.M., Increased DNA methyltransferase expression in rhabdomyosarcomas. Int. J. Cancer, 83, 10-14 (1999). Due to a printer's error, the bottom of Figure 3 was cut off after the proofs had been approved by the author. The correct fi...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19991210)83:6<874::aid-ijc
更新日期：1999-12-10 00:00:00
abstract：:Powerful analytical tools are vital for characterizing the complex molecular changes underlying oncogenesis and cancer treatment. This is particularly true, if information is to be collected in vivo by noninvasive approaches. In the recent past, hyperpolarized (13)C magnetic resonance (MR) spectroscopy has been employ...
journal_title：International journal of cancer
pub_type： 杂志文章
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更新日期：2010-08-01 00:00:00
abstract：:The influence of 4 murine monoclonal antibodies (MAbs) directed against surface determinants of a metastasizing rat adenocarcinoma (BSp73ASML) on metastatic spread was evaluated and compared to their in vivo binding as well as to the induction of a humoral anti-MAb response, especially with respect to the development ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910460528
更新日期：1990-11-15 00:00:00
abstract：:Immunization of mice with 10(6) irradiated LSTRA murine leukemia cells (LX) induced weak immunity to subsequent tumor-cell challenge. Admixture of low doses (1.4-14 micrograms of C. parvum with the LX usually augmented the immunity. Higher doses (1,400-7,000 micrograms) of admixed C. parvum not only failed to augment ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910290617
更新日期：1982-06-15 00:00:00
abstract：:In the context of opportunistic cervical cancer screening settings of low-and-middle-income countries, little is known about the benefits of high-risk human papillomavirus (hrHPV) testing on high-grade cervical abnormality detection among women with atypical squamous cells of undetermined significance (ASC-US) cytolog...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.33318
更新日期：2020-10-02 00:00:00
