Combination therapy with 2-difluoromethylornithine and a polyamine transport inhibitor against murine squamous cell carcinoma.

abstract：:Seminoma lesions are characterized by a brisk inflammatory infiltrate containing both CD4 and CD8 T cells, which is of prognostic significance. However, whether seminoma cells express the HLA molecules required for classical T-cell recognition remains controversial. In the present study, we conducted a molecular, phen...

journal_title：International journal of cancer

authors： Hadrup SR,Braendstrup O,Jacobsen GK,Mortensen S,Pedersen LØ,Seremet T,Andersen MH,Becker JC,Straten PT

更新日期：2006-08-15 00:00:00

abstract：:The sensitivity of human tissues and tumors to infection with type C adenoviruses correlates with the expression of the human coxsackie B- and adenovirus receptor, hCAR. HCAR is heterogeneously expressed in various tissues and types of human cancer cells, which has implications for the use of adenoviruses as vectors i...

journal_title：International journal of cancer

authors： Fuxe J,Liu L,Malin S,Philipson L,Collins VP,Pettersson RF

更新日期：2003-03-01 00:00:00

abstract：:A population-based case-control study of esophageal cancer was conducted in urban Shanghai involving interviews with 902 cases and 1,552 controls. Risk of esophageal cancer was increased among tobacco smokers and alcohol drinkers. Odds ratios (OR) for smoking were 2.1 and 1.6 for men and women, respectively, and incre...

journal_title：International journal of cancer

authors： Gao YT,McLaughlin JK,Blot WJ,Ji BT,Benichou J,Dai Q,Fraumeni JF Jr

更新日期：1994-07-15 00:00:00

abstract：:In 1979, a hypothesis-generating, population-based case-control study was undertaken in Montreal, Canada, to explore the association between occupational exposure to 294 substances, 130 occupations and industries, and various cancers. Interviews were carried out with 3, 630 histologically confirmed cancer cases, of wh...

journal_title：International journal of cancer

authors： Dumas S,Parent ME,Siemiatycki J,Brisson J

更新日期：2000-09-15 00:00:00

abstract：:We report here side population (SP) cells, a cancer stem cell enriched fraction from pancreatic cancer cell line, have enormous superior potential of the epithelial to mesenchymal transition (EMT), invasion, and metastasis. In an isolated SP cell culture, the cells rapidly expressed and up-regulated E-cadherin, an epi...

journal_title：International journal of cancer

authors： Kabashima A,Higuchi H,Takaishi H,Matsuzaki Y,Suzuki S,Izumiya M,Iizuka H,Sakai G,Hozawa S,Azuma T,Hibi T

更新日期：2009-06-15 00:00:00

abstract：:Hormonal regulation of mouse mammary tumor virus (MMTV) synthesis was studied in the CCL-51-SF cell subline derived from the Sykes' mammary tumor cell line CCL-51 and adapted to grow in semi-synthetic in vitro conditions. The virus was quantitated by measuring the supernatant reverse transcriptase activity in exogenou...

journal_title：International journal of cancer

authors： Svec J,Links J

更新日期：1977-02-15 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a common neoplasm in Southeastern Asia, and cisplatin-containing regimens for combinational chemotherapy are widely used for treating locally recurrent or metastatic diseases. However, resistance to cisplatin is not infrequently seen and its associated side effects may be life-threate...

journal_title：International journal of cancer

authors： To YF,Sun RW,Chen Y,Chan VS,Yu WY,Tam PK,Che CM,Lin CL

更新日期：2009-04-15 00:00:00

abstract：:Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Tumor recurrence occurs in ∼20% of PTCs and some reach advanced stages. Promoter mutation in the telomerase reverse transcriptase (TERT) gene is identified to be a prognostic marker in PTC. However, the contribution of TERT promoter mutation ...

journal_title：International journal of cancer

authors： Bu R,Siraj AK,Divya SP,Kong Y,Parvathareddy SK,Al-Rasheed M,Al-Obaisi KAS,Victoria IG,Al-Sobhi SS,Al-Dawish M,Al-Dayel F,Al-Kuraya KS

更新日期：2018-05-15 00:00:00

abstract：:Cancer chemotherapy with platinum-based antineoplastic agents including oxaliplatin frequently results in a debilitating and painful peripheral neuropathy. We evaluated the antinociceptive effects of the alpha-2 adrenoceptor agonist, clonidine on oxaliplatin-induced neuropathic pain. Specifically, we determined if (i)...

journal_title：International journal of cancer

authors： Yeo JH,Yoon SY,Kim SJ,Oh SB,Lee JH,Beitz AJ,Roh DH

更新日期：2016-05-15 00:00:00

abstract：:Natural killer (NK) cells exhibit strong cytotoxic activity against tumor cells without prior sensitization, and have the potential to exert antibody-dependent cellular cytotoxicity (ADCC). In this clinical trial, we examined the safety and efficacy of the use of NK cells, generated using a novel expansion system, in ...

journal_title：International journal of cancer

authors： Ishikawa T,Okayama T,Sakamoto N,Ideno M,Oka K,Enoki T,Mineno J,Yoshida N,Katada K,Kamada K,Uchiyama K,Handa O,Takagi T,Konishi H,Kokura S,Uno K,Naito Y,Itoh Y

更新日期：2018-06-15 00:00:00

abstract：:Stage 4 neuroblastoma (NB) is a devastating childhood cancer whose poor outcome has remained essentially unchanged in the last 20 years. Receptor tyrosine kinases have important roles in the control of proliferation, differentiation and apoptosis of NB cells. Thus, we tested the activity of second-generation tyrosine ...

journal_title：International journal of cancer

authors： Vitali R,Mancini C,Cesi V,Tanno B,Piscitelli M,Mancuso M,Sesti F,Pasquali E,Calabretta B,Dominici C,Raschellà G

更新日期：2009-12-01 00:00:00

abstract：:Farnesyl transferase inhibitors (FTIs) were shown to be effective in modulating tumor growth in Ras-transformed tumor cells. Recent studies have focused on Rho GTPases as putative targets of FTI action. Previously, we demonstrated that FTIs were effective in inhibiting the growth and invasiveness of RhoC GTPase-overex...

journal_title：International journal of cancer

authors： Chatterjee M,van Golen KL

更新日期：2011-07-01 00:00:00

abstract：:Polyunsaturated fatty acids (PUFAs) have been suggested, on the basis of animal-model studies, to be related not only to cancer development but also to chemotherapeutic effects. Controversy persists, however, as to which types of PUFAs are beneficial in terms of chemosensitivity. In this study, we used the NIH3T3 cell...

journal_title：International journal of cancer

authors： Tsai WS,Nagawa H,Muto T

更新日期：1997-01-27 00:00:00

abstract：:The EBV-encoded membrane protein (LMP) and the nuclear antigen EBNA-1 were compared for their capacity to induce rejection of transfected murine mammary carcinoma cells in syngeneic hosts. The tumorigenic potential of stable LMP and EBNA-1 expressing sublines of the ACA (H-2f)-derived mammary carcinoma line S6C was te...

journal_title：International journal of cancer

authors： Trivedi P,Masucci MG,Winberg G,Klein G

更新日期：1991-07-09 00:00:00

abstract：:The radiosensitivity of three forms of response to injection of C. parvum in mice has been investigated. The increase in phagocytin index evoked by IP or IV injection of 0.7 mg C. parvum (but not that evoked by 1.4 mg) was reduced but not abolished in mice given 350-500 rad whole-body irradiation 4 days before C. parv...

journal_title：International journal of cancer

authors： Woodruff MF,Ghaffar A,Whitehead VL

更新日期：1976-05-15 00:00:00

abstract：:The role of transcript variants of cyclin D1 in cancer biology is unclear. Most tumors with high levels of cyclin D1 express 2 transcripts due to alternative splicing: one full-length transcript of 4.4 kb and one short transcript of approximately 1.7 kb. The short transcript lacks part of the 3'UTR region regulating m...

journal_title：International journal of cancer

authors： Sander B,Flygare J,Porwit-Macdonald A,Smith CI,Emanuelsson E,Kimby E,Liden J,Christensson B

更新日期：2005-11-10 00:00:00

abstract：:The association between Lichen planus (LP) and cancer has been under debate for decades. We studied the connection via population-based Finnish register data. All women with the diagnosis of LP (n = 13,100) were identified from the Finnish Hospital Discharge Registry from 1969-2012. These patients were linked with sub...

journal_title：International journal of cancer

authors： Halonen P,Jakobsson M,Heikinheimo O,Riska A,Gissler M,Pukkala E

更新日期：2018-01-01 00:00:00

abstract：:Marfe, G., Pucci, B., De Martino, L., Fiorito, F., Di Stefano, C., Indelicato, M., Aventaggiato, M., Russo, M. A. and Tafani, M. (2009), Heat-shock pretreatment inhibits sorbitol-induced apoptosis in K562, U937 and HeLa cells. Int. J. Cancer, 125: 2077-2085. doi: 10.1002/ijc.24572 The above article, published online o...

journal_title：International journal of cancer

authors：

更新日期：2019-08-15 00:00:00

abstract：:Sister chromatid exchange (SCE) is a genetic indicator of DNA damage in mammalian cells and may afford a sensitive monitor to follow genomic instability of some individuals with fragile chromosomal diseases or malignancies. In studies on the effect of dinitrosopiperazine (DNP), aflatoxin B1 (AFB1), methyl-nitro-nitros...

journal_title：International journal of cancer

authors： Li GY,Yao KT,Glaser R

更新日期：1989-04-15 00:00:00

abstract：:Fatty acids play a key role in cellular bioenergetics, membrane biosynthesis and intracellular signaling processes and thus may be involved in cancer development and progression. In the present study, we comprehensively assessed associations of 14,522 common single-nucleotide polymorphisms (SNPs) in 149 genes of the f...

journal_title：International journal of cancer

authors： Dai W,Liu H,Xu X,Ge J,Luo S,Zhu D,Amos CI,Fang S,Lee JE,Li X,Nan H,Li C,Wei Q

更新日期：2019-11-15 00:00:00

abstract：:Homeobox-containing genes are a network of genes encoding DNA-binding proteins highly conserved throughout evolution. They are involved in the control of normal development as well as in the regulation of gene expression in adult differentiating systems, including hematopoiesis. Aberrant expression of homeobox-contain...

journal_title：International journal of cancer

authors： Celetti A,Barba P,Cillo C,Rotoli B,Boncinelli E,Magli MC

更新日期：1993-01-21 00:00:00

abstract：:Radiotherapy and chemotherapy are known risk factors for second cancers after lymphoma. The role of genetic influences, however, remains largely unknown. We assessed risk of second cancers associated with family history of any cancer in 41,181 patients with Hodgkin lymphoma (HL) (n = 7,476), non-Hodgkin lymphoma (NHL)...

journal_title：International journal of cancer

authors： Landgren O,Pfeiffer RM,Stewart L,Gridley G,Mellemkjaer L,Hemminki K,Goldin LR,Travis LB

更新日期：2007-03-01 00:00:00

abstract：:A postal survey addressed to 2,083 general practitioners of childhood cancer survivors of reproductive age has revealed that females having undergone direct abdominal irradiation (exposed), particularly for Wilms' tumour, have an increased risk of several adverse pregnancy outcomes as compared with female survivors of...

journal_title：International journal of cancer

authors： Hawkins MM,Smith RA

更新日期：1989-03-15 00:00:00

abstract：:Angiogenesis and inflammation are the 2 major stroma reactions in colorectal carcinoma (CRC). Guanylate binding protein-1 (GBP-1) is a key mediator of angiostatic effects of inflammation. Therefore, we hypothesized that GBP-1 may be a biomarker of intrinsic angiostasis associated with an improved outcome in CRC patien...

journal_title：International journal of cancer

authors： Naschberger E,Croner RS,Merkel S,Dimmler A,Tripal P,Amann KU,Kremmer E,Brueckl WM,Papadopoulos T,Hohenadl C,Hohenberger W,Stürzl M

更新日期：2008-11-01 00:00:00

abstract：:Prolonged culture of hepatocytes isolated from mouse liver results in the spontaneous development of colonies of liver epithelial cells that can proliferate indefinitely in vitro. We established 5 such cell lines from C3H/HeJ mice (C3H) and 22 cell lines from C3H/HeJ x C57BL/6J F1 mice (C3B6F1) to investigate whether ...

journal_title：International journal of cancer

authors： Nishimori H,Ogawa K,Tateno H

更新日期：1994-10-01 00:00:00

abstract：:The evolution of precancerous cervical lesions is poorly understood. A widely held model of cervical intraepithelial neoplasia grade 3 (CIN3) development is sequential progression from normal through CIN1 and CIN2 to CIN3. Another hypothesis, the "molecular switch" model, postulates that CIN3 can evolve directly from ...

journal_title：International journal of cancer

authors： Nedjai B,Reuter C,Ahmad A,Banwait R,Warman R,Carton J,Boer S,Cuzick J,Lorincz AT

更新日期：2018-10-01 00:00:00

abstract：:Murine mammary aplastic carcinoma, when it is passed from one alloxan-diabetic animal to another, after several passages becomes conditioned to hypoinsulinemia by secreting its own substance(s) immunologically cross-reactive with insulin (SICRI). Although not cytotoxic, the total daily dose of 2.5 mg of synthetic line...

journal_title：International journal of cancer

authors： Vuk-Pavlović S,Bozikov V,Pavelić K

更新日期：1982-06-15 00:00:00

abstract：:We have studied the relationship between tumor necrosis factor (TNF)-sensitivity and doxorubicin-resistance in our doxorubicin-resistant cell line panel consisting of the parental cell line GLC4 plus GLC4-Adr2x and GLC4-Adr350x with respective resistance factors of 2 and 350 compared with GLC4. At the highest dose of ...

journal_title：International journal of cancer

authors： Sleijfer S,Asschert JG,Timmer-Bosscha H,Mulder NH

更新日期：1998-07-03 00:00:00

abstract：:Bladder cancer-associated protein (BLCAP) is a highly conserved protein among species, and it is considered a novel candidate tumor suppressor gene originally identified from human bladder carcinoma. However, little is known about the regulation or the function of this protein. Here, we show that the human BLCAP trans...

journal_title：International journal of cancer

authors： Galeano F,Leroy A,Rossetti C,Gromova I,Gautier P,Keegan LP,Massimi L,Di Rocco C,O'Connell MA,Gallo A

更新日期：2010-07-01 00:00:00

abstract：:Nanoparticle-based phototherapies, such as photothermal therapy (PTT) and photodynamic therapy (PDT), exhibit strong efficacy, minimal invasion and negligible side effects in tumor treatment. These phototherapies have received considerable attention and been extensively studied in recent years. In addition to directly...

journal_title：International journal of cancer

authors： Hou X,Tao Y,Pang Y,Li X,Jiang G,Liu Y

更新日期：2018-12-15 00:00:00