Telomerase reverse transcriptase mutations are independent predictor of disease-free survival in Middle Eastern papillary thyroid cancer.


:Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Tumor recurrence occurs in ∼20% of PTCs and some reach advanced stages. Promoter mutation in the telomerase reverse transcriptase (TERT) gene is identified to be a prognostic marker in PTC. However, the contribution of TERT promoter mutation to cancer progression in PTC patients is still not fully understood. In this study, we investigated the incidence of TERT promoter mutations and TERT protein expression and their association with clinicopathological outcomes in a large cohort of PTC samples using direct sequencing technology and immunohistochemistry. Furthermore, two PTC cell lines were utilized to investigate role of TERT mutations in mediating metastasis. Two promoter hotspot mutations C228T and C250T were identified in 18.0% (167/927) of our cohort and were significantly associated with poor 5 years disease-free survival and distant metastasis of PTC. TERT protein overexpression was noted in 20.1% of our PTC cohort and was significantly associated with poor prognostic markers such as older age, extrathyroidal extension and Stage IV tumors. A significant association was also found between TERT overexpression and epithelial-mesenchymal transition (EMT) markers. Functional analysis showed that TERT inhibition reduced cell growth, invasion, migration and angiogenesis in PTC via suppression of EMT in PTC cells. Our results suggest that TERT promoter mutation is an independent predictor of disease-free survival and might drive the metastasis, and downregulation of TERT could potentiate antitumor and antimetastatic activities in PTC.


Int J Cancer


Bu R,Siraj AK,Divya SP,Kong Y,Parvathareddy SK,Al-Rasheed M,Al-Obaisi KAS,Victoria IG,Al-Sobhi SS,Al-Dawish M,Al-Dayel F,Al-Kuraya KS




Has Abstract


2018-05-15 00:00:00












  • Risk factors for prostate cancer incidence and progression in the health professionals follow-up study.

    abstract::Risk factors for prostate cancer could differ for various sub-groups, such as for "aggressive" and "non-aggressive" cancers or by grade or stage. Determinants of mortality could differ from those for incidence. Using data from the Health Professionals Follow-Up Study, we re-examined 10 factors (cigarette smoking histo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Giovannucci E,Liu Y,Platz EA,Stampfer MJ,Willett WC

    更新日期:2007-10-01 00:00:00

  • Elevated stromelysin-1 and reduced collagenase-IV expression in invasive rat embryo fibroblasts expressing E1A deletion mutants + T24-H-ras.

    abstract::We have studied the in vitro invasive properties of 3 cell lines derived from the co-transfection of rat embryo fibroblasts (REF) with EIA genes deficient in exon 2 and T24-ras. All 3 cell lines showed invasive properties at passage 10 after isolation. Invasive cells expressed elevated levels of stromelysin-1 and redu...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Engel G,Popowicz P,Marshall H,Norling G,Svensson C,Auer G,Akusjärvi G,Linder S

    更新日期:1992-07-09 00:00:00

  • miR-135b- and miR-146b-dependent silencing of calcium-sensing receptor expression in colorectal tumors.

    abstract::Studies have shown that the calcium-sensing receptor (CaSR) mediates the antitumorigenic effects of calcium against colorectal cancer (CRC). Expression of the CaSR in colorectal tumors is often reduced. We have reported previously that silencing of CaSR in CRC is caused in part by methylation of CaSR promoter 2 and lo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fetahu IS,Tennakoon S,Lines KE,Gröschel C,Aggarwal A,Mesteri I,Baumgartner-Parzer S,Mader RM,Thakker RV,Kállay E

    更新日期:2016-01-01 00:00:00

  • A tumor-associated antigen expressed in melanoma cells with lower malignant potential.

    abstract::The antigen K-1-2, detectable by a MAb is found in nevi and melanomas. It is associated with melanoma cells of low invasive and metastatic potential as shown by immunoperoxidase studies with cell lines, biopsies and autopsies: K-1-2 occurs in melanoma cell line SK-Mel 25, but not in cell line A-375. A-375 has a higher...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Suter L,Brüggen J,Bröcker EB,Sorg C

    更新日期:1985-06-15 00:00:00

  • Nerve invasion distance is dependent on laminin gamma2 in tumors of pancreatic cancer.

    abstract::The distance of nerve invasion is an important prognostic factor in pancreatic cancer. The extracellular matrix (ECM) of nerve, mainly composed of laminin, collagen IV and anchoring fibrils, might affect nerve invasion. However, this relationship has not been demonstrated. Our study aimed at discovering the promoting ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mitsunaga S,Fujii S,Ishii G,Kinoshita T,Hasebe T,Aoyagi K,Sasaki H,Ochiai A

    更新日期:2010-08-15 00:00:00

  • DNA methylation age as a biomarker for cancer.

    abstract::Cancer is well established as an age-associated disease, and there is substantial overlap in the molecular, cellular and physiological changes observed with both ageing and the progression of cancer. Age-specific declines in resilience mechanisms such as DNA repair or epigenetic maintenance may contribute to the devel...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Lau CE,Robinson O

    更新日期:2021-01-04 00:00:00

  • Plasma microRNAs as biomarkers of pancreatic cancer risk in a prospective cohort study.

    abstract::Noninvasive biomarkers for early pancreatic ductal adenocarcinoma (PDAC) diagnosis and disease risk stratification are greatly needed. We conducted a nested case-control study within the Prospective Investigation into Cancer and Nutrition (EPIC) cohort to evaluate prediagnostic microRNAs (miRs) as biomarkers of subseq...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Duell EJ,Lujan-Barroso L,Sala N,Deitz McElyea S,Overvad K,Tjonneland A,Olsen A,Weiderpass E,Busund LT,Moi L,Muller D,Vineis P,Aune D,Matullo G,Naccarati A,Panico S,Tagliabue G,Tumino R,Palli D,Kaaks R,Katzke VA,

    更新日期:2017-09-01 00:00:00

  • Non-Hodgkin's lymphoma and skin malignancies--shared etiology?

    abstract::The Stockholm-Gotland Cancer Register was used to evaluate the clinical observation that patients with non-Hodgkin's lymphoma (NHL) had an increased risk of malignant melanoma or squamous-cell carcinoma of the skin (SCCS) and vice versa. During 1958-1992, NHL was diagnosed in a total of 6,176 patients. Of these patien...

    journal_title:International journal of cancer

    pub_type: 杂志文章


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    更新日期:1995-09-04 00:00:00

  • Genetic variations of DNA repair genes and their prognostic significance in patients with acute myeloid leukemia.

    abstract::Common genetic variations in genes involved in DNA repair or response to genotoxic stress may influence both cancer susceptibility and treatment response individually or interactively. However, in acute myeloid leukemia (AML), the relevance of these genetic variations remains to be fully established. In this study, we...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Shi JY,Ren ZH,Jiao B,Xiao R,Yun HY,Chen B,Zhao WL,Zhu Q,Chen Z,Chen SJ

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  • Patterns of gastro-intestinal cancer in European migrants to Australia: the role of dietary change.

    abstract::Cancers of the stomach, pancreas, colon and rectum are increasingly regarded as being diet-influenced. Migrants to Australia from England, Scotland, Ireland, Poland, Yugoslavia, Greece, and Italy have come from countries with varied dietary backgrounds and gastrointestinal cancer risks. Age-standardized cancer death r...

    journal_title:International journal of cancer

    pub_type: 杂志文章


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  • Altered expression of CD44 isoforms in squamous-cell carcinomas and cell lines derived from them.

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    journal_title:International journal of cancer

    pub_type: 杂志文章


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  • Redundancy of autocrine loops in human osteosarcoma cells.

    abstract::With the aim of identifying innovative therapeutic strategies for osteosarcoma patients who are refractory to conventional chemotherapy, we analyzed the in vitro effects of the blockage of autocrine circuits. Since the insulin-like growth factor-I receptor (IGF-IR)-mediated loop is relevant to the growth of osteosarco...

    journal_title:International journal of cancer

    pub_type: 杂志文章


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  • A monoclonal antibody detects heterogeneity in vascular endothelium of tumours and normal tissues.

    abstract::A new murine monoclonal antibody (MAb), E-9, has been raised using tissue-cultured human umbilical vein endothelial cells. The antigen recognized by this MAb is a peptide of 170 kDa under non-reducing conditions and 96 kDa under reducing conditions. MAb E-9 showed marked heterogeneity in its distribution in various ti...

    journal_title:International journal of cancer

    pub_type: 杂志文章


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    更新日期:1993-05-28 00:00:00

  • Persistent infection of rabbits with HTLV-I: patterns of anti-viral antibody reactivity and detection of virus by gene amplification.

    abstract::Two groups of rabbits were inoculated on the day of birth or at 4 weeks of age with a human T-cell leukemia virus type-I (HTLV-I)-infected and transformed rabbit cell line (Ra-I). Rabbits seroconverted to HTLV-I, as determined by indirect immunofluorescence, by 3 weeks after inoculation and remained persistently serop...

    journal_title:International journal of cancer

    pub_type: 杂志文章


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    更新日期:1990-01-15 00:00:00

  • Fibronectin isoforms are differentially expressed in normal and adenomatous human anterior pituitaries.

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Farnoud MR,Farhadian F,Samuel JL,Derome P,Peillon F,Li JY

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  • Sequence variation and physical state of human papillomavirus type 16 cervical cancer isolates from Australia and New Caledonia.

    abstract::Sequence diversity over 2600 nucleotides of the upstream regulatory region (URR) and the E6 and E2/E4 genes of 34 human papillomavirus (HPV)16 cervical cancer isolates from Australia and New Caledonia was investigated. One 81 base duplication, 41 single base substitutions and 1 single base insertion were identified in...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Watts KJ,Thompson CH,Cossart YE,Rose BR

    更新日期:2002-02-20 00:00:00

  • A portion of the feline leukaemia virus genome is not endogenous in cat cells.

    abstract::Although viral sequences closely related to feline leukaemia virus are represented in multiple copies in cellular DNA of all domestic cats, a specific fraction was present only in the virus-infected cells. This fraction was detected by viral cDNA enriched by a prior absorption of a total complementary DNA (cDNA) trans...

    journal_title:International journal of cancer

    pub_type: 杂志文章


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  • Expression of tissue inhibitor of matrix metalloproteinase-2 correlates with activation of matrix metalloproteinase-2 and predicts poor prognosis in tongue squamous cell carcinoma.

    abstract::Matrix metalloproteinase 2 (MMP-2) plays a crucial role in invasion and metastasis of malignant tumors. Membrane type 1-MMP (MT1-MMP) was originally identified as an activator of MMP-2. Tissue inhibitor of MMP-2 (TIMP-2) was identified as an inhibitor of MMP-2 and MT1-MMP. However, TIMP-2 was reported to be essential ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yoshizaki T,Maruyama Y,Sato H,Furukawa M

    更新日期:2001-01-20 00:00:00

  • Asthma and risk of lethal prostate cancer in the Health Professionals Follow-Up Study.

    abstract::Inflammation, and more generally, the immune response are thought to influence the development of prostate cancer. To determine the components of the immune response that are potentially contributory, we prospectively evaluated the association of immune-mediated conditions, asthma and hayfever, with lethal prostate ca...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Platz EA,Drake CG,Wilson KM,Sutcliffe S,Kenfield SA,Mucci LA,Stampfer MJ,Willett WC,Camargo CA Jr,Giovannucci E

    更新日期:2015-08-15 00:00:00

  • Increased cytotoxic effects of photodynamic therapy in IL-6 gene transfected cells via enhanced apoptosis.

    abstract::PDT has been reported to induce cancer cell expression of cytokines, such as IL-6 and TNF-alpha, but it has been unclear whether cytokine expression by cancer cells is directly related to the antitumor effect of PDT. We treated Lewis lung carcinoma (LLC) cells with a new photosensitizer, mono-L-aspartyl chlorin e6 (NP...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Usuda J,Okunaka T,Furukawa K,Tsuchida T,Kuroiwa Y,Ohe Y,Saijo N,Nishio K,Konaka C,Kato H

    更新日期:2001-08-15 00:00:00

  • Antitumor effects of a recombinant fowlpox virus expressing Apoptin in vivo and in vitro.

    abstract::Apoptin is a chicken anemia virus-derived, p53-independent, bcl-2-insensitive apoptotic protein with the ability to specifically induce apoptosis in tumor cells. To explore the use of the Apoptin gene in cancer gene therapy, we constructed a recombinant fowlpox virus expressing the Apoptin protein (vFV-Apoptin) and co...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Li X,Jin N,Mi Z,Lian H,Sun L,Li X,Zheng H

    更新日期:2006-12-15 00:00:00

  • Possible significance of VLA-4 (alpha 4 beta 1) for hematogenous metastasis of renal-cell cancer.

    abstract::Very late antigen-4 (VLA-4) composed of alpha 4 and beta 1, a member of the beta 1-integrin subfamily, facilitates cell-to-cell interaction with vascular cell-adhesion molecule-1 (VCAM-1) on endothelial cells (EC). Attachment of blood-borne tumor cells to EC is a crucial step for hematogenous metastasis, and VLA-4-pos...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tomita Y,Saito T,Saito K,Oite T,Shimizu F,Sato S

    更新日期:1995-03-16 00:00:00

  • MicroRNA-125b suppresses the development of bladder cancer by targeting E2F3.

    abstract::Increasing evidence has suggested that dysregulation of certain microRNAs (miRNAs) may contribute to tumorigenesis. microRNA-125b (miR-125b) was implicated to have close relationship with cell proliferation and differentiation, and downregulation of miR-125b was observed in various types of cancers. However, the biolo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Huang L,Luo J,Cai Q,Pan Q,Zeng H,Guo Z,Dong W,Huang J,Lin T

    更新日期:2011-04-15 00:00:00

  • Anti-idiotype vaccine against Hodgkin's lymphoma: induction of B- and T-cell immunity across species barriers against CD30 antigen by murine monoclonal internal image antibodies.

    abstract::Murine monoclonal antibody HRS-4 (Ab1), which defines the cell-bound and soluble CD30 antigen associated with Hodgkin's lymphoma, was used to generate monoclonal anti-idiotypic antibodies (Ab2) in syngeneic BALB/c mice. Murine monoclonal Ab2 14G9 and Ab2 9G10 directed against HRS-4 were shown to be anti-idiotypic Ab2 ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Pohl C,Renner C,Schwonzen M,Sieber M,Lorenz P,Pfreundschuh M,Diehl V

    更新日期:1992-04-01 00:00:00

  • Generalizability of established prostate cancer risk variants in men of African ancestry.

    abstract::Genome-wide association studies have identified more than 80 risk variants for prostate cancer, mainly in European or Asian populations. The generalizability of these variants in other racial/ethnic populations needs to be understood before the loci can be used widely in risk modeling. In our study, we examined 82 pre...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Han Y,Signorello LB,Strom SS,Kittles RA,Rybicki BA,Stanford JL,Goodman PJ,Berndt SI,Carpten J,Casey G,Chu L,Conti DV,Rand KA,Diver WR,Hennis AJ,John EM,Kibel AS,Klein EA,Kolb S,Le Marchand L,Leske MC,Murphy AB,

    更新日期:2015-03-01 00:00:00

  • Somatostatin receptor-positive primary breast tumors: genetic, patient and tumor characteristics.

    abstract::In a series of 87 primary breast tumors, somatostatin receptor (SSR) expression was detected by in vitro autoradiography in 58 tumors. In 41 tumors the SSR expression was homogeneous and in 17 it was heterogeneous. Although the tumors were not selected by the investigators upon entry in the study, examination of the t...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bootsma AH,van Eijck C,Schouten KK,Reubi JC,Waser B,Foekens JA,van Pel R,Zwarthoff EC,Lamberts SW,de Klein A

    更新日期:1993-05-28 00:00:00

  • Expression of cholecystokinin forms by medullary thyroid cancer.

    abstract::We have studied the production and release of cholecystokinin (CCK) forms by rat medullary thyroid cancer (MTC) in vivo. MTC cells were inoculated s.c. into 8 Wag-Rij rats. One month later, after i.v. injection of calcium plasma levels of CCK, calcitonin and tissue contents of gastrin and calcitonin were determined by...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Poston GJ,Draviam EJ,Seitz PK,Rajaraman S,Alexander RW,Cooper CW,Townsend CM Jr,Thompson JC

    更新日期:1991-07-09 00:00:00

  • Protein kinase B modulates the sensitivity of human neuroblastoma cells to insulin-like growth factor receptor inhibition.

    abstract::The potential of the novel insulin-like growth factor receptor (IGF-IR) inhibitor NVP-AEW541 as an antiproliferative agent in human neuroblastoma was investigated. Proliferation of a panel of neuroblastoma cell lines was inhibited by NVP-AEW541 with IC(50) values ranging from 0.15 to 5 microM. Experiments using an IGF...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Guerreiro AS,Boller D,Shalaby T,Grotzer MA,Arcaro A

    更新日期:2006-12-01 00:00:00

  • Human leukocyte antigen G polymorphism is associated with an increased risk of invasive cancer of the uterine cervix.

    abstract::Human leukocyte antigen (HLA)-G acts as negative regulator of the immune responses and its expression in tumor cells may enable them to escape immunosurveillance. The purpose of this study was to investigate the influence of HLA-G polymorphism on risk of high-grade cervical intraepithelial neoplasia (HG-CIN) and cervi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ferguson R,Ramanakumar AV,Koushik A,Coutlée F,Franco E,Roger M,Biomarkers of Cervical Cancer Risk Study Team.

    更新日期:2012-08-01 00:00:00

  • DHPLC is superior to SSCP in screening p53 mutations in esophageal cancer tissues.

    abstract::Mutations of the p53 tumor-suppressor gene universally occur on exons 5-8 in human cancer. We analyzed these mutations in esophageal cancer tissue from 207 patients in China using 2 methods, single-strand conformation polymorphism (SSCP), one of the most frequently used methods, and the recently developed denaturing h...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yamanoshita O,Kubota T,Hou J,Ping YM,Zhang XL,Li XP,Li SS,Li XX,Zhu DC,Fukushima Y,Nakajima T

    更新日期:2005-03-10 00:00:00