Serum DNA and urine DNA alterations of urinary transitional cell bladder carcinoma detected by fluorescent microsatellite analysis.

abstract：:V-ATPases are proton-translocating enzymes, which are found not only in numerous intracellular organelles but also in the plasma membranes of many eukaryotic cells. Using differential display, we have identified one of the proton pump subunit genes, ATP6C, as a cisplatin-inducible gene. Northern blot analysis demonstr...

journal_title：International journal of cancer

authors： Murakami T,Shibuya I,Ise T,Chen ZS,Akiyama S,Nakagawa M,Izumi H,Nakamura T,Matsuo K,Yamada Y,Kohno K

更新日期：2001-09-01 00:00:00

abstract：:Sex steroid hormones influence prostate development and maintenance through their roles in prostate cellular proliferation, differentiation and apoptosis. Although suspected to be involved in prostate carcinogenesis, an association between circulating androgens and prostate cancer has not been clearly established in e...

journal_title：International journal of cancer

authors： Weiss JM,Huang WY,Rinaldi S,Fears TR,Chatterjee N,Hsing AW,Crawford ED,Andriole GL,Kaaks R,Hayes RB

更新日期：2008-05-15 00:00:00

abstract：:The prognostic role of inflammation index like neutrophil-to-lymphocyte ratio (NLR) in colorectal cancer (CRC) remains controversial. We conduct a meta-analysis to determine the predictable value of NLR in the clinical outcome of CRC patients. The analysis was carried out based on the data from 16 studies (19 cohorts)...

journal_title：International journal of cancer

authors： Li MX,Liu XM,Zhang XF,Zhang JF,Wang WL,Zhu Y,Dong J,Cheng JW,Liu ZW,Ma L,Lv Y

更新日期：2014-05-15 00:00:00

abstract：:Diabetes has been consistently associated with an increased risk of liver, pancreas and endometrial cancer and has been implicated as a risk factor for esophageal and gastric cancers, although this association has been less well studied. We sought to determine the role of diabetes in the etiology of esophageal, gastri...

journal_title：International journal of cancer

authors： Jiang X,Bernstein L,Tseng CC,Wu AH

更新日期：2012-09-15 00:00:00

abstract：:Coffee has been proposed to decrease the circulating insulin and estrogen levels, which are related to the development of endometrial cancer. However, few studies have prospectively assessed the association between coffee consumption and endometrial cancer. We conducted a population-based prospective cohort study in 5...

journal_title：International journal of cancer

authors： Shimazu T,Inoue M,Sasazuki S,Iwasaki M,Kurahashi N,Yamaji T,Tsugane S,JPHC Study Group Members of the Japan Public Health Center-based Prospective Study.

更新日期：2008-11-15 00:00:00

abstract：:The MLN64 gene, which is localized in q12-q21 of the human chromosome 17, encodes a novel protein containing 2 distinct domains. At the N-terminal, MLN64 exhibits a potential trans-membrane region, while at the C-terminal, it shares homology with the F26F4.4 protein of Coenorhabditis elegans and the steroidogenic acut...

journal_title：International journal of cancer

authors： Moog-Lutz C,Tomasetto C,Régnier CH,Wendling C,Lutz Y,Muller D,Chenard MP,Basset P,Rio MC

更新日期：1997-04-10 00:00:00

abstract：:A persistent increase in incidence of thyroid carcinoma (TC) has been reported worldwide. The aim of our study was to assess trends in incidence and mortality of TC in The Netherlands between 1989 and 2003 and to examine whether these trends correlate with changes in diagnostic practices such as changes in the number ...

journal_title：International journal of cancer

authors： Netea-Maier RT,Aben KK,Casparie MK,den Heijer M,Grefte JM,Slootweg P,Hermus A

更新日期：2008-10-01 00:00:00

abstract：:gamma-L-glutaminyl-4-hydroxy-3-iodobenzene (I-GHB), a novel iodinated analog of gamma-L-glutaminyl-4-hydroxybenzene (GHB), demonstrates greater anti-tumor activity in human and in murine melanoma cell lines. These phenolic amides are substrates for gamma-glutamyltranspeptidase (GGTP; E.C. 2.3.2.2), a cell-membrane-ass...

journal_title：International journal of cancer

authors： Prezioso JA,Hughey RP,Wang N,Damodaran KM,Bloomer WD

更新日期：1994-03-15 00:00:00

abstract：:HNPCC is an autosomal dominantly inherited cancer-susceptibility syndrome that confers an increased risk for colorectal cancer and endometrial cancer at a young age. It also entails an increased risk of a variety of other tumors, such as ovarian, gastric, uroepithelial and biliary tract cancers. The underlying pathoge...

journal_title：International journal of cancer

authors： Caldes T,Godino J,de la Hoya M,Garcia Carbonero I,Perez Segura P,Eng C,Benito M,Diaz-Rubio E

更新日期：2002-04-10 00:00:00

abstract：:The relative expression of estrogen receptor (ER) and progesterone receptor (PR) mRNA transcripts was measured in 71 primary breast-cancer biopsies. ER and PR binding activity were estimated in parallel by the dextran-coated-charcoal method. There was a close correlation between the amount of ER mRNA and estradiol bin...

journal_title：International journal of cancer

authors： Nagai MA,Marques LA,Yamamoto L,Fujiyama CT,Brentani MM

更新日期：1994-11-01 00:00:00

abstract：:Thrombin is now recognized as an important factor in many cancers. Here, we examined the expression and role of the recently discovered thrombin receptor PAR4, in human colon cancer cells. PAR4 mRNA was found in 10 out of 14 (71%) human colon cancer cell lines tested but not in epithelial cells isolated from normal hu...

journal_title：International journal of cancer

authors： Gratio V,Walker F,Lehy T,Laburthe M,Darmoul D

更新日期：2009-04-01 00:00:00

abstract：:Although the net benefits of tamoxifen in adjuvant breast cancer therapy have been proven, the recurrence of the cancer in an aggressive and hormone independent form has been highly problematic. We previously demonstrated the important role mitochondrial DNA (mtDNA) plays in hormone-independence in prostate cancer. He...

journal_title：International journal of cancer

authors： Naito A,Carcel-Trullols J,Xie CH,Evans TT,Mizumachi T,Higuchi M

更新日期：2008-04-01 00:00:00

abstract：:Fecal occult blood test (FOBT) screening for colorectal cancer (CRC) is implemented in several countries. Approximately half of all FOBT-positive persons have screen-detected adenomas. Despite removal of these, patients with large/multiple adenomas have increased risk of later developing new advanced adenomas and CRC....

journal_title：International journal of cancer

authors： Bjerrum A,Lindebjerg J,Andersen O,Fischer A,Lynge E

更新日期：2020-08-15 00:00:00

abstract：:Oral leukoplakia is a heterogeneous lesion with risk of cancer development; there are no biomarkers to predict its potential of malignant transformation. Tissue proteomic analysis of oral leukoplakia using iTRAQ labeling liquid chromatography-mass spectrometry showed overexpression of heterogeneous ribonucleoprotein K...

journal_title：International journal of cancer

authors： Matta A,Tripathi SC,DeSouza LV,Grigull J,Kaur J,Chauhan SS,Srivastava A,Thakar A,Shukla NK,Duggal R,DattaGupta S,Ralhan R,Michael Siu KW

更新日期：2009-09-15 00:00:00

abstract：:Gastric cancer is the second most common cause of cancer deaths worldwide. The identification of molecular genetic parameters that are associated with response to chemotherapy and prognosis is of utmost interest. We examined methylation of the apoptosis-related genes, TMS1 and DAPK, in 81 primary gastric cancers using...

journal_title：International journal of cancer

authors： Kato K,Iida S,Uetake H,Takagi Y,Yamashita T,Inokuchi M,Yamada H,Kojima K,Sugihara K

更新日期：2008-02-01 00:00:00

abstract：:Progression from an androgen-dependent to an androgen-independent state often occurs in patients with prostate cancer (PCa) who undergo hormonal therapy. We have investigated whether inhibition of the epidermal growth factor receptor (EGFR) signaling pathway affects the antitumor effect of a nonsteroidal antiandrogen....

journal_title：International journal of cancer

authors： Festuccia C,Gravina GL,Angelucci A,Millimaggi D,Muzi P,Vicentini C,Bologna M

更新日期：2005-07-01 00:00:00

abstract：:Organochlorine insecticides have been studied extensively in relation to breast cancer incidence, and results from two meta-analyses have been null for late-life residues, possibly due to measurement error. Whether these compounds influence survival remains to be fully explored. We examined associations between organo...

journal_title：International journal of cancer

authors： Parada H Jr,Wolff MS,Engel LS,White AJ,Eng SM,Cleveland RJ,Khankari NK,Teitelbaum SL,Neugut AI,Gammon MD

更新日期：2016-02-01 00:00:00

abstract：:Epithelial ovarian cancer (EOC) is a complex disease comprising discrete histological and molecular subtypes, for which survival rates remain unacceptably low. Tailored approaches for this deadly heterogeneous disease are urgently needed. Efflux pumps belonging to the ATP-binding cassette (ABC) family of transporters ...

journal_title：International journal of cancer

authors： Jung M,Gao J,Cheung L,Bongers A,Somers K,Clifton M,Ramsay EE,Russell AJ,Valli E,Gifford AJ,George J,Kennedy CJ,Wakefield MJ,Topp M,Ho GY,Australian Ovarian Cancer Study.,Scott CL,Bowtell DD,deFazio A,Norris MD,Hab

更新日期：2020-10-15 00:00:00

abstract：:In the setting of breast cancer screening, 5-9% of needle core biopsies are diagnosed as lesions of uncertain malignant potential (B3). The management of these lesions is potentially problematic as the data on their outcome remains limited. In our study, we aim to assess the outcome of screen-detected lesions diagnose...

journal_title：International journal of cancer

authors： Rakha EA,Lee AH,Jenkins JA,Murphy AE,Hamilton LJ,Ellis IO

更新日期：2011-09-15 00:00:00

abstract：:The majority of small-cell lung cancers (SCLCs) express p16 but not pRb. Given our previous study showing loss of pRb in Merkel cell carcinoma (MCC)/neuroendocrine carcinoma of the skin and the clinicopathological similarities between SCLC and MCC, we wished to determine if this was also the case in MCC. Twenty-nine M...

journal_title：International journal of cancer

authors： Cook AL,Pollock PM,Welch J,Walsh MD,Bowman RV,Baumann KC,Hayward NK,Leonard JH

更新日期：2001-08-01 00:00:00

abstract：:Previously, we have identified aloe-emodin (AE) as a new type of anticancer agent, with activity that is based on apoptotic cell death promoted by a neuroectodermal tumor-specific drug uptake. We attempt to clarify the intracellular target of AE and the apoptosis-signaling pathway activated by AE in neuroblastoma cell...

journal_title：International journal of cancer

authors： Pecere T,Sarinella F,Salata C,Gatto B,Bet A,Dalla Vecchia F,Diaspro A,Carli M,Palumbo M,Palù G

更新日期：2003-10-10 00:00:00

abstract：:Cholangiocarcinoma is the second most common primary hepatic cancer, with a rising incidence worldwide. Owing to late diagnosis and limited treatment options, the prognosis for cholangiocarcinoma remains dismal, compelling a search for new treatments. As aspirin exhibits a well-supported chemopreventive effect on comm...

journal_title：International journal of cancer

authors： Shen X,Shen X

更新日期：2021-03-15 00:00:00

abstract：:To evaluate renal pelvis and ureter (RPU) cancer risk in relation to lifetime use of analgesics, a population-based case-control study was carried out in 3 areas of the United States. Among 502 cases and 496 controls diagnosed and interviewed during 1983-1986, no significant increases in risk were found for any of the...

journal_title：International journal of cancer

authors： Linet MS,Chow WH,McLaughlin JK,Wacholder S,Yu MC,Schoenberg JB,Lynch C,Fraumeni JF Jr

更新日期：1995-07-04 00:00:00

abstract：:The majority of lung cancer patients have tumor-derived genetic alterations in circulating plasma DNA that could be exploited as a diagnostic tool. We used fluorescent microsatellite analysis to detect alterations in plasma and tumor DNA in 34 patients who underwent bronchoscopy for lung cancer, including 11 small cel...

journal_title：International journal of cancer

authors： Beau-Faller M,Gaub MP,Schneider A,Ducrocq X,Massard G,Gasser B,Chenard MP,Kessler R,Anker P,Stroun M,Weitzenblum E,Pauli G,Wihlm JM,Quoix E,Oudet P

更新日期：2003-06-20 00:00:00

abstract：:The incidence of breast cancer among women in Shanghai, a traditionally low-risk population, has increased substantially over the past 20 years. To evaluate the association of menstrual and reproductive factors with breast cancer risk and the influence of these factors on the temporal trend of breast cancer incidence,...

journal_title：International journal of cancer

authors： Gao YT,Shu XO,Dai Q,Potter JD,Brinton LA,Wen W,Sellers TA,Kushi LH,Ruan Z,Bostick RM,Jin F,Zheng W

更新日期：2000-07-15 00:00:00

abstract：:The c-met oncogene encodes the receptor for hepatocyte growth factor/scatter factor (HGF/SF), a multifunctional cytokine able to mediate morphogenesis as well as mitogenesis, motogenesis and invasiveness of epithelial cells. HGF/SF has been implicated in branching tubulogenesis of the developing kidney and in regenera...

journal_title：International journal of cancer

authors： Natali PG,Prat M,Nicotra MR,Bigotti A,Olivero M,Comoglio PM,Di Renzo MF

更新日期：1996-06-21 00:00:00

abstract：:The mortality and incidence from stomach cancer were compared in Japan (a country with a high incidence where there was full application of mass screening during this period) and 2 countries with no screening policy: the USA (with a very low incidence) and Slovenia (with an intermediate rate). The registered cases of ...

journal_title：International journal of cancer

authors： Lambert R,Guilloux A,Oshima A,Pompe-Kirn V,Bray F,Parkin M,Ajiki W,Tsukuma H

更新日期：2002-02-20 00:00:00

abstract：:JNK activity has been implicated in the malignant proliferation, invasion and drug-resistance of glioma cells (GCs), but the molecular mechanisms underlying JNK activation are currently unknown. Here, we reported that MKK7, not MKK4, directly activates JNK in GCs and exerts oncogenic effects on tumor formation. Notabl...

journal_title：International journal of cancer

authors： Wang Y,Xia Y,Hu K,Zeng M,Zhi C,Lai M,Wu L,Liu S,Zeng S,Huang Z,Ma S,Yuan Z

更新日期：2019-11-01 00:00:00

abstract：:We have established human oral-squamous-cancer cell lines, BHY and HN, derived from non-metastatic cancer and metastatic cancer respectively. We examined the expression of matrix-degrading enzymes and their inhibitors in these cell lines. Both cell lines expressed pro-matrix metalloproteinase (MMP)1, proMMP2, proMMP9,...

journal_title：International journal of cancer

authors： Kawamata H,Nakashiro K,Uchida D,Harada K,Yoshida H,Sato M

更新日期：1997-01-06 00:00:00

abstract：:Histone deacetylase inhibitors (HDACi) represent a promising new class of anticancer agents. In the current investigation, we examined the activity of the HDACi belinostat in preclinical models of prostate cancer. In vitro proliferation assays demonstrated that belinostat potently inhibited the growth of prostate canc...

journal_title：International journal of cancer

authors： Qian X,Ara G,Mills E,LaRochelle WJ,Lichenstein HS,Jeffers M

更新日期：2008-03-15 00:00:00