Abstract:
:To evaluate renal pelvis and ureter (RPU) cancer risk in relation to lifetime use of analgesics, a population-based case-control study was carried out in 3 areas of the United States. Among 502 cases and 496 controls diagnosed and interviewed during 1983-1986, no significant increases in risk were found for any of the non-prescription and prescription analgesics evaluated or among regular users of phenacetin, acetaminophen or aspirin. Neither cumulative lifetime ingestion nor duration of regular use of these 3 drugs, whether alone or in combination, was associated with significantly increased risk of RPU cancer, although a slight excess was observed among long-term users of acetaminophen. Risk was not increased among persons reporting highest cumulative dose and/or longest duration of phenacetin use. Although our study of RPU cancer is the largest to date, it was nonetheless limited by the small number of regular analgesic users and the relatively low response rates. Because of the relatively recent onset of widespread use of acetaminophen, its pharmacologic similarity to phenacetin, a known urothelial carcinogen, and the elevation in risk seen in long-term users, further surveillance of this analgesic is warranted.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Linet MS,Chow WH,McLaughlin JK,Wacholder S,Yu MC,Schoenberg JB,Lynch C,Fraumeni JF Jrdoi
10.1002/ijc.2910620105subject
Has Abstractpub_date
1995-07-04 00:00:00pages
15-8issue
1eissn
0020-7136issn
1097-0215journal_volume
62pub_type
杂志文章,多中心研究abstract::The pharmacokinetics of methotrexate (MX) and 7-OH methotrexate (MXOH) was studied in 18 cancer patients treated with 6-hr intravenous (i.v.) infusion of 100 mg/kg (A), 80 mg/kg preceded by 20 mg/kg i.v. loading dose (B), and 70 mg/kg preceded by 30 mg/kg i.v. loading dose (C). Simultaneous analysis of MX and MXOH was...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910380603
更新日期:1986-12-15 00:00:00
abstract::Several tumour-derived factors have recently been identified which induce tissue factor (TF) expression in endothelial cells in vitro. However, there is only limited evidence that endothelial cells lining tumour blood vessels express elevated procoagulant activity (PCA) in vivo. We have investigated the effects of hum...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960611)66:6<784::AID-IJC
更新日期:1996-06-11 00:00:00
abstract::Resistance to anticancer drugs is the major problem in the treatment of many advanced cancers, including androgen-independent prostate cancer. Recently, increased expression of Id-1, a basic helix-loop-helix protein, is reported in several types of advanced cancer. It is suggested that high expression of Id-1 may prov...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21592
更新日期:2006-04-15 00:00:00
abstract::Signal transducer and activator of transcription 3 (STAT3) is activated in a variety of human cancers, including ovarian cancer. The molecular mechanism by which the STAT3 is activated in cancer cells is poorly understood. We observed that human ovarian xenograft tumors (A2780) in mice were severely hypoxic (pO(2) app...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24601
更新日期:2009-11-01 00:00:00
abstract::The deleted in liver cancer 1 (DLC1) tumor suppressor is an important RhoGTP activating protein (RhoGAP) that plays a crucial role in many types of human cancers. Small GTPases regulate normal cellular processes but aberrant expression and activation of GTPases contribute to tumorigenesis. RhoGAP suppresses Rho activi...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.28505
更新日期:2014-07-15 00:00:00
abstract::Emerging reports now implicate alterations of arachidonic acid (AA) metabolism with prostate carcinogenesis. To test this hypothesis, androgen-primed benign hyperplastic (BHC) and malignant tumorigenic (MTC) cells derived from the Lobund-Wistar rat model of autochthonous prostate adenocarcinoma were incubated with (14...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20245
更新日期:2004-08-20 00:00:00
abstract::The levels of tumour-specific antigen, antibody and specific immune complexes in the sera of rats bearing lung nodules of a chemically induced rat hepatoma, produced by intravenous inoculation of viable tumour cells, have been examined and compared with the levels of serum factors in animals actively immunized by intr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910170214
更新日期:1976-02-15 00:00:00
abstract::Oxidative stress may be involved in carcinogenesis and biomarkers of oxidative stress like derivatives of reactive oxygen metabolites (d-ROM) may be useful for cancer prediction. However, no previous study assessed the association of pre-diagnostic d-ROM measurements with cancer incidence. We measured serum d-ROM leve...
journal_title:International journal of cancer
pub_type: 杂志文章,meta分析
doi:10.1002/ijc.32073
更新日期:2019-07-01 00:00:00
abstract::Up to 30% of stage II patients with curatively resected colorectal cancer (CRC) will develop disease recurrence. We evaluated whether examination of lymph nodes by multilevel sectioning and immunohistochemical staining can improve prognostication. Lymph nodes (n = 780) from 36 CRC patients who had developed disease re...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24817
更新日期:2010-06-01 00:00:00
abstract::As with cyclooxygenase (COX)-2, genetic disruption of COX-1 gene or pharmacologic inhibition of its activity has been shown to decrease the number of intestinal polyps in Apc gene-deficient mice. The present study was designed to investigate the combined effects of COX-1 and COX-2 selective inhibitors on spontaneous p...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20012
更新日期:2004-04-20 00:00:00
abstract::The sialosyl Lewis a antigen was identified in a ganglioside extract from a malignant human urothelial cell line (Hu 1703He) by fast atom bombardment mass spectrometry. The presence of this antigen in urothelial cell lines with varying tumorigenic properties was further studied using the 19-9 monoclonal antibody (MAb)...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910450635
更新日期:1990-06-15 00:00:00
abstract::HPP1 is a recently discovered gene that is epigenetically silenced in a number of tumor types, suggesting a potential role as a tumor suppressor. However, whether HPP1 has tumor suppressor activity is not clearly known. We have sought to investigate the effects of HPP1 on tumor growth and survival and to identify sign...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23202
更新日期:2008-04-01 00:00:00
abstract::Oncostatin M is a leukocyte product that has been reported to have anti-proliferative effects directly on melanoma and other cancer cell lines in vitro. However, its function(s) in cancers in vivo appears complex and its roles in cancer growth in lungs are unknown. Here, we show that OSM promotes marked growth of tumo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29055
更新日期:2015-02-15 00:00:00
abstract::Two genome-wide association studies (GWAS) have identified 5p15.33 (TERT-CLPTM1L) as one of the susceptible regions for glioma in European background. A replication research of our group highlighted the association signals in the TERT gene of this region in a Chinese Han population. To comprehensively explore the regi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27417
更新日期:2012-10-01 00:00:00
abstract::The therapeutic potential of the somatostatin analogue RC-160 radiolabeled with 188Re was evaluated in nude mice bearing xenografts of human prostate adenocarcinoma. 188Re-RC-160 was selectively retained in both DU-145 and PC-3 tumors following direct intra-tumor injection at all time points examined (2, 6 and 24 hr p...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960117)65:2<214::AID-IJC
更新日期:1996-01-17 00:00:00
abstract::APC10.1 is a new intestinal cell line derived from ApcMin/+ mice that retains both the heterozygous Apc genotype and a nonactivated Wnt signaling pathway and displays an early neoplastic phenotype. Although tumorigenic both in immunodepressed and in immunocompetent syngeneic mice, it requires a high cell dose and a lo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11690
更新日期:2004-03-20 00:00:00
abstract::BALB/cfC3H female mice which develop mammary tumor virus (MTV)-induced mammary tumors possess not only serun antibodies directed against virus-associated antigens which are expressed on mammary tumor cells but also antibodies directed against antigenic specificities which are unique to each tumor. The possible range o...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910210413
更新日期:1978-04-15 00:00:00
abstract::Ten patients with bulky brain glioblastoma, recurring after surgery, radiotherapy or chemotherapy, underwent direct intralesional radioimmunotherapy (RIT) using a monoclonal antibody (MAb), BC-2, raised against tenascin and labelled with 131I. Tenascin, the BC-2-recognized glycoprotein, is an antigen expressed by the ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910510103
更新日期:1992-04-22 00:00:00
abstract::We have separated subpopulations of macrophages from an immunogenic fibrosarcoma by the technique of unit gravity velocity sedimentation. The activation state of these subpopulations was determined by measurement of the Fc receptor avidity of adherent cells, and by their 5' nucleotidase and acid phosphatase activity. ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910260513
更新日期:1980-11-15 00:00:00
abstract::The presence of TGF alpha mRNA has been reported previously to occur in primary colon cancers. We report the expression of the normal 4.5 kb TGF alpha transcript in the mucosa of the normal human gastro-intestinal tract from oesophagus through to colon. The highest levels of human TGF alpha mRNA occurred in the duoden...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910430305
更新日期:1989-03-15 00:00:00
abstract::Using a direct binding liquid competition radioimmunoassay, the amount of the ras oncogene protein product, p21, was quantitated in a variety of human tumors and adjacent apparently normal tissues. In 48 of 50 matched tumor and normal tissue biopsy specimens from 50 patients, more ras p21 was detected in the tumor tha...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910430315
更新日期:1989-03-15 00:00:00
abstract::In order to clarify the frequency of p16 gene inactivation and its relationship with Rb expression, immunohistochemical analysis of p16 and Rb proteins was carried out on 82 paraffin-embedded sections of primary non-small cell lung cancers (NSCLCs). From immunohistochemical results, abnormal p16 expression was observe...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980619)79:3<215::aid-ijc
更新日期:1998-06-19 00:00:00
abstract::Peripheral blood T cells from a patient with T-cell chronic lymphocytic leukemia (T-CLL) failed to respond to mitogenic lectins or alloantigens but could be induced to proliferate by the addition of exogenous interleukin-2 (IL-2). The T-CLL cells also proliferated in response to 12-O-tetradecanoyl phorbol-13-acetate (...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910320109
更新日期:1983-07-15 00:00:00
abstract::We examined the effects of acivicin, a specific inhibitor of the ectoenzyme gamma-glutamyltransferase (gamma-GT), on gamma-GT activity and apoptosis in 2 human T-lymphoblastoid CEM cell lines, CCRF and VBL-100. In both cell lines, acivicin was found to cause morphological and biochemical changes of apoptosis in a dose...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910620414
更新日期:1995-08-09 00:00:00
abstract::Analysis of the length of circulating DNA in plasma has been reported as a marker for solid tumor detection. We assessed the sensitivity and specificity of increased plasma DNA length to identify patients with head and neck squamous cell carcinoma (HNSCC) and monitor posttreatment disease status. Fifty-eight HNSCC pat...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22250
更新日期:2006-12-01 00:00:00
abstract::Human T-cell leukemia virus type I (HTLV-I) is etiologically associated with adult T-cell leukemia/lymphoma (ATL). We cloned and sequenced host DNA adjacent to the long terminal repeats of HTLV-I from uncultured leukemic cells of 4 ATL patients. The region flanking the provirus was generally A/T-rich (60-64% A/T), and...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960103)65:1<20::AID-IJC4
更新日期:1996-01-03 00:00:00
abstract::The Ontario Cancer Registry (OCR) and the Surveillance, Epidemiology and End Results (SEER) databases were used to describe temporal trends in the incidence and survival of squamous cancers of the upper aerodigestive tract (UADT) in Ontario and the US between 1984 and 2001. Between the 1984-86 and 1999-01 periods, the...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24533
更新日期:2009-11-01 00:00:00
abstract::Over 10% of children with Wilms tumor (WT) have an underlying cancer predisposition syndrome (CPS). Cognizant of increasing demand for genetic evaluation and limited resources across health care settings, there is an urgent need to rationalize genetic referrals for this population. The McGill Interactive Pediatric Onc...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.32561
更新日期:2020-02-15 00:00:00
abstract::We have established human oral-squamous-cancer cell lines, BHY and HN, derived from non-metastatic cancer and metastatic cancer respectively. We examined the expression of matrix-degrading enzymes and their inhibitors in these cell lines. Both cell lines expressed pro-matrix metalloproteinase (MMP)1, proMMP2, proMMP9,...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970106)70:1<120::aid-ijc
更新日期:1997-01-06 00:00:00
abstract::The expression of the nuclear SV40-induced T antigen was measured by microfluorimetry on individual, asynchronously growing SV40-transformed cells which had been stained with hamster T-antiserum by the indirect immunofluorescence method. The same individual cells were first measured for T antigen and then for DNA by F...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910150403
更新日期:1975-04-15 00:00:00