Analgesics and cancers of the renal pelvis and ureter.


:To evaluate renal pelvis and ureter (RPU) cancer risk in relation to lifetime use of analgesics, a population-based case-control study was carried out in 3 areas of the United States. Among 502 cases and 496 controls diagnosed and interviewed during 1983-1986, no significant increases in risk were found for any of the non-prescription and prescription analgesics evaluated or among regular users of phenacetin, acetaminophen or aspirin. Neither cumulative lifetime ingestion nor duration of regular use of these 3 drugs, whether alone or in combination, was associated with significantly increased risk of RPU cancer, although a slight excess was observed among long-term users of acetaminophen. Risk was not increased among persons reporting highest cumulative dose and/or longest duration of phenacetin use. Although our study of RPU cancer is the largest to date, it was nonetheless limited by the small number of regular analgesic users and the relatively low response rates. Because of the relatively recent onset of widespread use of acetaminophen, its pharmacologic similarity to phenacetin, a known urothelial carcinogen, and the elevation in risk seen in long-term users, further surveillance of this analgesic is warranted.


Int J Cancer


Linet MS,Chow WH,McLaughlin JK,Wacholder S,Yu MC,Schoenberg JB,Lynch C,Fraumeni JF Jr




Has Abstract


1995-07-04 00:00:00












  • Unique microRNA-profiles in EGFR-mutated lung adenocarcinomas.

    abstract::The findings of mutations and the development of targeted therapies have improved lung cancer management. Still, the prognosis remains poor, and we need to know more about the genetic and epigenetic alterations in lung cancer. MicroRNAs are involved in crucial biological processes like carcinogenesis by regulating gen...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bjaanaes MM,Halvorsen AR,Solberg S,Jørgensen L,Dragani TA,Galvan A,Colombo F,Anderlini M,Pastorino U,Kure E,Børresen-Dale AL,Brustugun OT,Helland A

    更新日期:2014-10-15 00:00:00

  • miRNA-124-3p/neuropilin-1(NRP-1) axis plays an important role in mediating glioblastoma growth and angiogenesis.

    abstract::Glioblastoma multiforme (GBM) is the most lethal brain malignancy which involves multi-gene abnormality. Unfortunately, effective therapy against GBM remains lacking. Previously, we found that NRP-1 and its downstream NRP-1/GIPC1 pathway played an important role in GBM. In our study, we further investigated the upstre...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zhang G,Chen L,Khan AA,Li B,Gu B,Lin F,Su X,Yan J

    更新日期:2018-08-01 00:00:00

  • Prognostic role of neutrophil-to-lymphocyte ratio in colorectal cancer: a systematic review and meta-analysis.

    abstract::The prognostic role of inflammation index like neutrophil-to-lymphocyte ratio (NLR) in colorectal cancer (CRC) remains controversial. We conduct a meta-analysis to determine the predictable value of NLR in the clinical outcome of CRC patients. The analysis was carried out based on the data from 16 studies (19 cohorts)...

    journal_title:International journal of cancer

    pub_type: 杂志文章,meta分析,评审


    authors: Li MX,Liu XM,Zhang XF,Zhang JF,Wang WL,Zhu Y,Dong J,Cheng JW,Liu ZW,Ma L,Lv Y

    更新日期:2014-05-15 00:00:00

  • Inhibition of a complement regulator in vivo enhances antibody therapy in a model of mammary adenocarcinoma.

    abstract::Membrane-bound complement regulatory proteins provide tumor cells with protection from antibody and complement in vitro. However, complement regulators are widely expressed on normal tissue, and inhibiting the function of complement regulatory proteins on tumor cells in vivo has not been investigated due to the absenc...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Imai M,Ohta R,Okada N,Tomlinson S

    更新日期:2004-07-20 00:00:00

  • ETV5 transcription factor is overexpressed in ovarian cancer and regulates cell adhesion in ovarian cancer cells.

    abstract::Epithelial ovarian cancer is the most lethal gynecological malignancy and the fifth leading cause of cancer deaths in women in the Western world. ETS transcription factors are known to act as positive or negative regulators of the expression of genes that are involved in various biological processes, including those t...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Llauradó M,Abal M,Castellví J,Cabrera S,Gil-Moreno A,Pérez-Benavente A,Colás E,Doll A,Dolcet X,Matias-Guiu X,Vazquez-Levin M,Reventós J,Ruiz A

    更新日期:2012-04-01 00:00:00

  • MHC-restricted responses of CD8+ and CD4+ T-cell clones from regional lymph nodes of melanoma patients.

    abstract::Regional lymph-node (LN) lymphocytes may constitute an important defence against the spread of human melanoma beyond regional LNs. The present study was directed to clonal analysis of lymphocytes cultured either directly from the LNs or after stimulation in cultures with autologous melanoma (MLTC). T-cell clones deriv...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chen Q,Hersey P

    更新日期:1992-05-08 00:00:00

  • Melanoma progression-associated glycoprotein MUC18/MCAM mediates homotypic cell adhesion through interaction with a heterophilic ligand.

    abstract::MUC18/MCAM is a cell-surface glycoprotein that is strongly expressed on advanced human melanomas. Transfection of 3 MCAM-negative melanoma cell lines with MCAM cDNA led to cell-surface expression and to a MCAM-dependent homotypic adhesion. This adhesion was independent of divalent cations and was inhibited at 4 degree...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Johnson JP,Bar-Eli M,Jansen B,Markhof E

    更新日期:1997-11-27 00:00:00

  • Phosphoglycerate kinase 1-overexpressing lung cancer cells reduce cyclooxygenase 2 expression and promote anti-tumor immunity in vivo.

    abstract::In addition to the known function in the glycolytic pathway, phosphoglycerate kinase 1 (PGK-1) promotes reduction of plasmin disulfide bonds leading to angiostatin formation and inhibition of tumor angiogenesis. In this study, the effects of PGK-1 on anti- tumor immunity against lung cancer were evaluated using the Te...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tang SJ,Ho MY,Cho HC,Lin YC,Sun GH,Chi KH,Wang YS,Jhou RS,Yang W,Sun KH

    更新日期:2008-12-15 00:00:00

  • Tube leukocyte adherence inhibition assay for the detection of anti-tumour immunity. II. Monocyte reacts with tumour antigen via cytophilic anti-tumour antibody.

    abstract::The peripheral blood monocyte is the reactive cell in the tube LAI assay. The monocyte loses its properties of adherence to glass upon exposure to specific antigen. Two different experiments to determine if lymphocytes, when they reacted with tumour, released mediators that were responsible for inhibiting monocyte gla...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Marti JH,Grosser N,Thomson DM

    更新日期:1976-07-15 00:00:00

  • Genetic control of oncogenesis by murine sarcoma virus Moloney pseudotype. II. A dominant epistatic susceptibility gene.

    abstract::We have shown in the preceding paper that AKR mice are highly resistant to M-MSV tumor development, and that resistance is transmitted as a dominant character. In the present studies the tumor-response pattern of F1 hybrids between resistant AKR and susceptible strains (C57Bl/6, BALB/c and B10BR) following injection w...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Colombatti A,Collavo D,Biasi G,Chieco-Bianchi L

    更新日期:1975-09-15 00:00:00

  • Serial transplantation of an HTLV-I-transformed hamster lymphoid cell line into hamsters.

    abstract::A hamster lymphoid cell line, HCT-2, transformed by human T-cell leukemia virus type I (HTLV-I) was serially transplanted for 9 passages in newborn hamsters. A total of 34 newborn hamsters inoculated intraperitoneally (i.p.) with 0.2-2 X 10(7) HCT-2 cells developed fatal lymphomas with dissemination to various organs ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Eguchi T,Kubonishi I,Daibata M,Yano S,Imamura J,Ohtsuki Y,Miyoshi I

    更新日期:1988-06-15 00:00:00

  • An immunohistochemical study of laminin, type-IV collagen and type-III pN-collagen with relation to reticular fibres in Hodgkin's disease.

    abstract::The distribution of aminoterminal propeptides of type-III procollagen (indicating the presence of type-III pN-collagen, i.e., type-III collagen molecule with a non-cleaved aminoterminal propeptide), laminin and type-IV collagen was studied by immunohistochemical methods. The results were compared with the distribution...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Karttunen T,Alavaikko M,Apaja-Sarkkinen M,Autio-Harmainen H

    更新日期:1988-01-15 00:00:00

  • CDKN2a mutation-negative melanoma families have increased risk exclusively for skin cancers but not for other malignancies.

    abstract::Germline CDKN2A mutations are found in 5-20% of melanoma families. Numerous studies have shown that carriers of CDKN2A mutations have increased risks of non-melanoma cancers, but so far there have been no studies investigating cancer risks in CDKN2A wild type (wt) melanoma families. In this prospective cohort study, i...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Helgadottir H,Höiom V,Tuominen R,Jönsson G,Månsson-Brahme E,Olsson H,Hansson J

    更新日期:2015-11-01 00:00:00

  • Total dietary antioxidant capacity, individual antioxidant intake and breast cancer risk: the Rotterdam Study.

    abstract::Some studies suggest a favorable role of antioxidants on breast cancer risk but this is still inconclusive. The aim of this study was to assess whether overall dietary antioxidant capacity, as assessed by dietary ferric reducing antioxidant potential (FRAP), and individual dietary antioxidant intake were associated wi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Pantavos A,Ruiter R,Feskens EF,de Keyser CE,Hofman A,Stricker BH,Franco OH,Kiefte-de Jong JC

    更新日期:2015-05-01 00:00:00

  • Chemical transformation of human revertant cells induced by murine sarcoma virus.

    abstract::A human revertant cell line, derived from non-producer human osteosarcoma cells (NP/KHOS) induced by Kirsten murine sarcoma virus, was treated in vitro with various levels of polycyclic aromatic hydrocarbons (3-methylcholanthrene, 7,12-dimethylbenz(alpha)anthracene, and benzo(alpha)pyrene [BP] or dimethyl sulfoxide (c...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Cho HY,Arnstein P,Rhim JS

    更新日期:1978-01-15 00:00:00

  • Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation.

    abstract::Withaferin A (WFA) is purified from the plant Withania somnifera and inhibits the vimentin cytoskeleton. Vimentin overexpression in cancer correlates with metastatic disease, induction of epithelial to mesenchymal transition and reduced patient survival. As vimentin functions in cell motility, we wanted to test the hy...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Thaiparambil JT,Bender L,Ganesh T,Kline E,Patel P,Liu Y,Tighiouart M,Vertino PM,Harvey RD,Garcia A,Marcus AI

    更新日期:2011-12-01 00:00:00

  • Toward a real liquid biopsy in metastatic breast and prostate cancer: Diagnostic LeukApheresis increases CTC yields in a European prospective multicenter study (CTCTrap).

    abstract::Frequently, the number of circulating tumor cells (CTC) isolated in 7.5 mL of blood is too small to reliably determine tumor heterogeneity and to be representative as a "liquid biopsy". In the EU FP7 program CTCTrap, we aimed to validate and optimize the recently introduced Diagnostic LeukApheresis (DLA) to screen lit...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Andree KC,Mentink A,Zeune LL,Terstappen LWMM,Stoecklein NH,Neves RP,Driemel C,Lampignano R,Yang L,Neubauer H,Fehm T,Fischer JC,Rossi E,Manicone M,Basso U,Marson P,Zamarchi R,Loriot Y,Lapierre V,Faugeroux V,Oulhen

    更新日期:2018-11-15 00:00:00

  • The ROR1 pseudokinase diversifies signaling outputs in MET-addicted cancer cells.

    abstract::MET is a master gene controlling a genetic program driving proliferation, apoptosis protection and invasion. The ROR1 pseudokinase acts as a MET substrate. However, its contribution to MET signaling and MET-dependent biological outcomes remains to be elucidated. By structure-function analysis of ROR1 mutants, we show ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Gentile A,Lazzari L,Benvenuti S,Trusolino L,Comoglio PM

    更新日期:2014-11-15 00:00:00

  • Risk of developing pancreatic cancer in families with familial atypical multiple mole melanoma associated with a specific 19 deletion of p16 (p16-Leiden).

    abstract::Familial atypical multiple mole melanoma (FAMMM) is an autosomal dominant disease characterized by the familial occurrence of malignant melanoma of the skin and multiple atypical precursor lesions. Germline mutations in the p16 (CDKN2A) gene have been reported in at least a quarter of such families. An association has...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Vasen HF,Gruis NA,Frants RR,van Der Velden PA,Hille ET,Bergman W

    更新日期:2000-09-15 00:00:00

  • Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype.

    abstract::A challenging task of the immune system is to fight cancer cells. However, a variety of human cancers educate immune cells to become tumor supportive. This is exemplified for tumor-associated macrophages (TAMs), which are polarized towards an anti-inflammatory and cancer promoting phenotype. Mechanistic explanations, ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Weigert A,Schiffmann S,Sekar D,Ley S,Menrad H,Werno C,Grosch S,Geisslinger G,Brüne B

    更新日期:2009-11-01 00:00:00

  • Human melanoma cells can be killed in vitro by an immunotoxin specific for melanoma-associated antigen p97.

    abstract::Conjugates (immunotoxins) comprising ricin A-chain and monoclonal antibody 96.5, which is specific for human melanoma-associated antigen p97, inhibited protein synthesis and colony formation of cultured human melanoma cells that expressed more than 80,000 molecules of p97 per cell. Cells expressing fewer than 5,000 mo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Casellas P,Brown JP,Gros O,Gros P,Hellström I,Jansen FK,Poncelet P,Roncucci R,Vidal H,Hellström KE

    更新日期:1982-10-15 00:00:00

  • In vivo generation and selection of variants with altered sensitivity to natural resistance (NR): a model of tumor progression.

    abstract::The stability of a cloned murine tumor for sensitivity to NR was examined following growth in vivo in order to test the hypothesis that tumor progression proceeds through the generation and selection of variants. Clonal sensitivity to the [131I]-dUrd elimination assay of NR was assessed for the L5178Y-F9 tumor grown i...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chow DA,Ray M,Greenberg AH

    更新日期:1983-01-15 00:00:00

  • Cytogenetic abnormalities in benign lymphoid hyperplasia: a dual-parameter study using chromosome analysis and flow cytometry.

    abstract::This is a prospective study of lymphoid tissue showing benign reactive hyperplasia (18 lymph nodes and 2 tonsils), using cytogenetic analysis of cells stimulated with T- or B-cell mitogens. The reason for this study was the detection of an abnormal chromosomal population in cells from an enlarged lymph node excised fr...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Grace J,Hall BE,Lew M,Singh S,Pittman S,Palmer AA,Zbroja R,Wass J,Vincent PC

    更新日期:1989-12-15 00:00:00

  • Increasing risk of uterine cervical cancer among young Japanese women: Comparison of incidence trends in Japan, South Korea and Japanese-Americans between 1985 and 2012.

    abstract::In Japan, cervical cancer incidence has increased since the late 1990s especially among young women, despite a decreasing trend in most developed countries. Here, we examined age, period and birth cohort trends in cervical cancer incidence rates from 1985 to 2012. Incidence rates were ascertained using three populatio...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Utada M,Chernyavskiy P,Lee WJ,Franceschi S,Sauvaget C,de Gonzalez AB,Withrow DR

    更新日期:2019-05-01 00:00:00

  • Signal processing in migrating T24 human bladder carcinoma cells: role of the autocrine interleukin-8 loop.

    abstract::T24 human bladder carcinoma cells reveal a high locomotor activity (70% locomoting cells) within a 3-dimensional collagen matrix. This high migratory activity is induced by an autocrine engagement of the interleukin-8 receptor A, as was shown by antibodies neutralizing the secreted interleukin-8. Treatment of the cell...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lang K,Niggemann B,Zanker KS,Entschladen F

    更新日期:2002-06-10 00:00:00

  • Recognition by a natural cytotoxic antibody of lactoneotetraglycosyl ceramide as an antigenic molecule in a syngeneic rat fibrosarcoma.

    abstract::Conventionally bred rats possess in their sera an NA which has a cytotoxic effect on a tumor cell line (KMT-17) derived from a fibrosarcoma induced by 3-methylcholanthrene and which can be absorbed by normal rat tissues. We have succeeded in purifying a glycosphingolipid as an antigen reactive to NA. GSLs isolated fro...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Takimoto M,Suzuki E,Naiki M,Itaya T,Takeichi N,Hosokawa M,Kobayashi H

    更新日期:1985-12-15 00:00:00

  • Telomerase reverse transcriptase mutations are independent predictor of disease-free survival in Middle Eastern papillary thyroid cancer.

    abstract::Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Tumor recurrence occurs in ∼20% of PTCs and some reach advanced stages. Promoter mutation in the telomerase reverse transcriptase (TERT) gene is identified to be a prognostic marker in PTC. However, the contribution of TERT promoter mutation ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bu R,Siraj AK,Divya SP,Kong Y,Parvathareddy SK,Al-Rasheed M,Al-Obaisi KAS,Victoria IG,Al-Sobhi SS,Al-Dawish M,Al-Dayel F,Al-Kuraya KS

    更新日期:2018-05-15 00:00:00

  • A universal anti-cancer vaccine: Chimeric invariant chain potentiates the inhibition of melanoma progression and the improvement of survival.

    abstract::For many years, clinicians and scientists attempt to develop methods to stimulate the immune system to target malignant cells. Recent data suggest that effective cancer vaccination requires combination immunotherapies to overcome tumor immune evasion. Through presentation of both MHC-I and II molecules, DCs-based vacc...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sharbi-Yunger A,Grees M,Cafri G,Bassan D,Eichmüller SB,Tzehoval E,Utikal J,Umansky V,Eisenbach L

    更新日期:2019-02-15 00:00:00

  • Cellular effects of combined adriamycin and x-irradiation in human tumor cells.

    abstract::The effects on cell survival in tissue culture of Adriamycin, of various Adriamycin derivatives and of the parent compound, daunomycin, have been studied. Adriamycin and three of its C-14 derivatives show similar toxicities towards cells chronically exposed in culture. Acute (30 min) exposures are significantly less t...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Byfield JE,Lynch M,Kulhanian F,Chan PY

    更新日期:1977-02-15 00:00:00

  • Herceptest: HER2 expression and gene amplification in non-small cell lung cancer.

    abstract::HER2 is an erbB/HER type 1 tyrosine kinase receptor that is frequently over-expressed in malignant epithelial tumours. Herceptin, a humanised mouse monoclonal antibody to HER2, is proven therapeutically in the management of metastatic breast cancer, significantly prolonging survival when combined with cytotoxic chemot...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Cox G,Vyberg M,Melgaard B,Askaa J,Oster A,O'Byrne KJ

    更新日期:2001-05-15 00:00:00