Abstract:
:We have separated subpopulations of macrophages from an immunogenic fibrosarcoma by the technique of unit gravity velocity sedimentation. The activation state of these subpopulations was determined by measurement of the Fc receptor avidity of adherent cells, and by their 5' nucleotidase and acid phosphatase activity. The subpopulations were compared to resident peritoneal macrophages and the peritoneal macrophage subpopulations elicited by injection of proteose peptone or C. parvum. The results show that two macrophage subpopulations exist within the tumour. The smaller, peroxidase-positive population, with a sedimentation velocity of 1-5 mm/h, is similar to proteose peptone stimulated macrophages with respect to Fc receptor expression, while the other, rapidly sedimenting population (5-9 mm/h) is partially activated. However, neither population achieved the level of activation demonstrated by rapidly sedimenting, C. parvum-activated macrophages. Analysis of the enzyme activity of rapidly adherent macrophages indicated that tumour, proteose peptone or C. parvum macrophages were all activated when compared to resident peritoneal macrophages. No significant differences were found with respect to the elevated levels of acid phosphatase in the three activated macrophage populations, but the 5' nucleotidase activity of C, parvum-elicited macrophages was significantly lower than either the proteose peptone or tumour macrophages. This again demonstrated that the tumour macrophages were less activated than C. parvum macrophages. These data show that tumour-infiltrating macrophages are a heterogeneous population composed of at least two subpopulations existing in different activation states and that within the tumour microenvironment they are not capable of differentiating to the higher activation state, demonstrated by C. parvum macrophages.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Moore K,McBride WHdoi
10.1002/ijc.2910260513subject
Has Abstractpub_date
1980-11-15 00:00:00pages
609-15issue
5eissn
0020-7136issn
1097-0215journal_volume
26pub_type
杂志文章abstract::Screening for cancer has to be carefully organized for maximum effectiveness, and introduced in full understanding of the natural history of the disease. There are major potential harms as well as benefits from screening. The current state of art for breast, cervix and prostate cancer screening is reviewed, only for b...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.25081
更新日期:2010-03-01 00:00:00
abstract::The aim of this study was to compare the seasonal variation in performance of a faecal immunochemical test for haemoglobin (FIT) and a guaiac test (gFOBT) for colorectal cancer screening. From June 2009 to May 2011, 18,290 screening participants (50-74 years old) performed OC-SENSOR quantitative FIT (1 sample) and Hem...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29187
更新日期:2015-04-15 00:00:00
abstract::Interleukin-11(rhIL-11) is a cytokine that has been shown to enhance the recovery of bone marrow and intestinal crypt cells after cytotoxic insult with radiation or anticancer drugs. The current study examined the effects of rhIL-11 on the response of CEM human lymphoblastic leukemia cells and on the EMT-6 murine mamm...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960917)67:6<864::AID-IJC
更新日期:1996-09-17 00:00:00
abstract::Apurinic/apyrimidinic (AP) sites are common mutagenic and cytotoxic DNA lesions that arise from the loss of normal bases. APE1, the major AP endonuclease of human cells, plays a central role in the repair of AP sites through both its endonuclease and phosphodiesterase activities. A common APE1 polymorphism, a T-->G tr...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.21768
更新日期:2006-06-15 00:00:00
abstract::The association between the consumption of preserved foods in infancy, childhood and adulthood and the risk of nasopharyngeal carcinoma was investigated in a case-control study among Singapore Chinese: 200 cases (73% male) were compared with 406 hospital controls (71% male). Significantly increased risks were observed...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910590502
更新日期:1994-12-01 00:00:00
abstract::Anti-idiotypic antibodies that mimic tumour-associated antigens can stimulate anti-tumour T-cell responses. In this article, we have studied the role of Fc in the presentation of T-cell epitopes by 2 anti-idiotypic antibodies, 105AD7 and 708. The human monoclonal antibody 105AD7, which mimics CD55, stimulated strong i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1194
更新日期:2001-05-01 00:00:00
abstract::Cancer-related cachexia is a metabolic syndrome characterized by a wasting disorder of adipose and skeletal muscle and is accompanied by body weight loss and systemic inflammation. The treatment options for cancer cachexia are limited, and the molecular mechanism remains poorly understood. Circular RNAs (circRNAs) are...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31977
更新日期:2019-05-15 00:00:00
abstract::The tumor microenvironment consists of an immunosuppressive niche created by the complex interactions between cancer cells and surrounding stromal cells. A critical component of this environment are myeloid-derived suppressor cells (MDSCs), a heterogeneous group of immature myeloid cells arrested at different stages o...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.30232
更新日期:2016-11-01 00:00:00
abstract::A population-based case-control study of esophageal cancer was conducted in urban Shanghai involving interviews with 902 cases and 1,552 controls. Risk of esophageal cancer was increased among tobacco smokers and alcohol drinkers. Odds ratios (OR) for smoking were 2.1 and 1.6 for men and women, respectively, and incre...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910580208
更新日期:1994-07-15 00:00:00
abstract::We have recently shown that an adenovirus carrying REIC/Dkk-3 (Ad-REIC) exhibits a potent tumor-specific cell-killing function for various human cancers. It has also become evident that some human cancers are resistant to Ad-REIC-induced apoptosis. The aim of the present study was to determine the molecular mechanisms...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24764
更新日期:2010-04-01 00:00:00
abstract::Innate lymphoid cells (ILCs) promptly initiate cytokine responses to pathogen exposure in the mucosa and mucosal-associated lymphoid tissues. ILCs were recently categorized as being of the lymphoid lineage and have been classified into three groups. ILCs play important roles in immunity against pathogens, and an anti-...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.29443
更新日期:2016-01-01 00:00:00
abstract::After a steady increase between the 1950s and the 1970s, laryngeal cancer mortality has been levelling off since the early 1980s in men from most western and southern European countries and since the early 1990s in central and eastern Europe. To update trends in laryngeal cancer mortality, we analyzed data provided by...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29833
更新日期:2016-02-15 00:00:00
abstract::The effect on tumor progression produced by the injection of VCN-treated tumor cells in dogs with spontaneous mammary tumors was investigated. Untreated dogs of different races and different ages with at least two palpable spontaneous mammary tumors were selected. One of the tumors was left in the animal for further c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910150307
更新日期:1975-03-15 00:00:00
abstract::The aim of our study was to analyze the alterations of some candidate tumor suppressor genes (TSGs) viz. LIMD1, LTF, CDC25A, SCOTIN, RASSF1A and CACNA2D2 located in the chromosomal region 3p21.31 associated with the development of early dysplastic lesions of head and neck. In analysis of 72 dysplastic lesions and 116 ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23834
更新日期:2008-12-01 00:00:00
abstract::Chloroethylene oxide and 2-chloroacetaldehyde, two possibly carcinogenic metabolities of vinyl chloride in mammals, caused a dose-dependent induction of 8-azaguanine- and ouabain-resistant mutants in Chinese hamster V79 cells in vitro. Up to one-hundred-fold higher concentrations of 2-chloroethanol or monochloroacetic...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910160414
更新日期:1975-10-15 00:00:00
abstract::Invasive pituitary adenomas (PAs) are generally refractory to conventional therapy and salvage treatment with temozolomide (TMZ). In addition to antiprotozoan effects, pyrimethamine (PYR) has recently shown its strong antitumor activity as an antineoplastic agent or in combination with TMZ in metastatic melanoma cells...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28199
更新日期:2013-10-15 00:00:00
abstract::BPV-1 induces focus formation in murine C127 cells and fibropapillomas in bovine fetal skin xenografts. In this study, we compared the specificity of neutralization of BPV-1 in both assay systems, using sera and monoclonal antibodies (MAbs) selected to define neutralizing epitopes. Sera from rabbits and cattle, inocul...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910490224
更新日期:1991-09-09 00:00:00
abstract::Previously, we have identified aloe-emodin (AE) as a new type of anticancer agent, with activity that is based on apoptotic cell death promoted by a neuroectodermal tumor-specific drug uptake. We attempt to clarify the intracellular target of AE and the apoptosis-signaling pathway activated by AE in neuroblastoma cell...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11312
更新日期:2003-10-10 00:00:00
abstract::Interaction between CD40 and its ligand, CD154, has a key function in immune regulation. Recent experimental data support a role of deregulated CD40 signalling in lymphomagenesis. Data from earlier studies that are part of this pooling study implicate a functional polymorphism (-1C>T, rs1883832) in the TNFRSF5 gene en...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/ijc.25420
更新日期:2011-03-15 00:00:00
abstract::The major obstacle for the treatment of gastric cancer is recurrence and metastasis; yet, its molecular mechanism is largely unknown. 2-methoxyestradiol (2-ME), a metabolite of the estradiol-17beta, has recently been demonstrated to have multifactorial effects against tumor proliferation and angiogenesis; how these ef...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22963
更新日期:2007-12-01 00:00:00
abstract::We studied the effect of retinoids on the growth and differentiation of a cell line (U 343 MG-A) derived from a human malignant astrocytoma. Cultures treated with all-trans or 13-cis retinoic acid showed a dose-dependent inhibition of proliferation and a marked reduction in the mean cell number at the plateau phase of...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910420319
更新日期:1988-09-15 00:00:00
abstract::The p53 tumor suppressor pathway is impaired in more than 90% of cervical cancers and cancer-derived cell lines as a result of infection by human papillomavirus (HPV). The HPV E6 oncoprotein forms complexes with p53 and promotes its degradation via ubiquitin-dependent mechanism. In our study, we attempted to improve t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26013
更新日期:2012-01-15 00:00:00
abstract::Interleukin-12 (IL-12) has potent antitumor activities via natural killer cells and cytotoxic T lymphocytes. However, the molecular mechanisms whereby IL-12 induces tumoricidal activities are poorly understood. Here, we report the genome-wide analysis of gene expression in a primary murine mammary carcinoma model that...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20145
更新日期:2004-07-01 00:00:00
abstract::In 1927 Otto Warburg established that tumours derive energy primarily from the conversion of glucose to lactic acid and only partially through cellular respiration involving oxygen. In the 1950s he proposed that all causes of cancer reflected different mechanisms of disabling cellular respiration in favour of fermenta...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.29012
更新日期:2015-10-01 00:00:00
abstract::Diabetes is a risk factor for many cancers; chronic hyperglycemia is hypothesized to be, in part, explanatory. We evaluated the association between glycated hemoglobin, a time-integrated glycemia measure, and cancer incidence and mortality in nondiabetic and diabetic men and women. We conducted a prospective study of ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27394
更新日期:2012-10-01 00:00:00
abstract::The Eph receptor A2 (EphA2) is overexpressed in a range of human epithelial cancers, a phenotype that is associated with cancer cell proliferation, progression and angiogenesis. Mouse models of mammary neoplasia have confirmed the role of EphA2 as mice carrying a knockout allele of EphA2 were resistant to breast cance...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24083
更新日期:2009-03-15 00:00:00
abstract::In the 7th edition of the AJCC staging system, the mitotic rate criterion replaced Clark level to increase correct classification of high-risk thin melanoma patients (pT1B). Additionally, sentinel node biopsy (SNB) was recommended for nodal staging of pT1B melanomas. The aim of this article was to evaluate the effects...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30607
更新日期:2017-04-15 00:00:00
abstract::Osteosacarcoma (OS) lung metastases are often resistant to chemotherapy. Most anticancer drugs are administered systemically. In many cases this is followed by dose-dependent toxicity, which may not allow the achievement of therapeutic levels in lungs to eradicate metastases. We determined the efficacy of gemcitabine ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21011
更新日期:2005-09-01 00:00:00
abstract::Nuclear factor-κB (NF-κB) is constitutively activated in many cancers, including oral squamous cell carcinoma (OSCC), and is involved in the invasive characteristics of OSCC, such as growth, antiapoptotic activity and protease production. However, the cellular mechanism underlying NF-κB's promotion of bone invasion by...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27435
更新日期:2012-09-01 00:00:00
abstract::Residential proximity to electrical power lines of different voltage in relation to childhood leukemia was investigated through a case-control study undertaken in Greece during 1993-1994. The study comprised 117 incident cases of childhood leukemia and 202 age-, gender- and place-of-residence-matched controls. Four me...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19971104)73:3<345::aid-ijc
更新日期:1997-11-04 00:00:00