Abstract:
:Peripheral blood T cells from a patient with T-cell chronic lymphocytic leukemia (T-CLL) failed to respond to mitogenic lectins or alloantigens but could be induced to proliferate by the addition of exogenous interleukin-2 (IL-2). The T-CLL cells also proliferated in response to 12-O-tetradecanoyl phorbol-13-acetate (TPA), or to TPA in combination with phytohemagglutinin (PHA). These TPA-mediated proliferative responses were transient, and only small but significant amounts of IL-2 activity were generated. In contrast, no IL-2 activity was produced after the T-CLL cells had been stimulated with PHA only. The T-CLL cells that were induced to proliferate with PHA and exogenous IL-2 could be maintained in continuous culture by the addition of exogenous IL-2 at regular intervals. These continuously proliferating T-CLL cells failed to produce IL-2 constitutively. However, they could be induced to produce IL-2 activity by stimulation with TPA or TPA plus PHA. Irradiation of the proliferating T-CLL cells prior to incubation with TPA or TPA plus PHA resulted in a 9-fold increase in IL-2 activity, suggesting that the proliferating T-CLL cells were able to consume the IL-2 they produced. Studies on the presence of human T-cell leukemia/lymphoma virus (HTLV) in the fresh and proliferating T-CLL cells revealed that 12% of the fresh cells expressed the HTLV p19 structural core protein. HTLV p19 expression was strongly enhanced in the T-CLL cells induced to proliferate by TPA (66%) and in the continuously growing IL-2-dependent T-CLL cells (82%). In the latter culture, but not in the fresh T-CLL cells, type-C virus particles were observed. These results indicate that HTLV expression correlates with T-CLL cell proliferation but not with IL-2 production by these cells.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Vyth-Dreese FA,de Vries JEdoi
10.1002/ijc.2910320109subject
Has Abstractpub_date
1983-07-15 00:00:00pages
53-9issue
1eissn
0020-7136issn
1097-0215journal_volume
32pub_type
杂志文章abstract::Since the investigation, at an individual level, of lifetime sun exposure remains difficult the site distribution of different types of skin cancer can be an important source of aetiological clues. The present report deals with 1,149 cases of cutaneous malignant melanoma (CMM), 7,685 of basal-cell carcinoma (BCC) and ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960703)67:1<24::AID-IJC6
更新日期:1996-07-03 00:00:00
abstract::A case-control study of prostate cancer (PC) was undertaken in Athens, Greece. Cases were 320 patients with histologically confirmed incident disease, whereas controls were 246 patients without history or symptomatology of benign prostatic hyperplasia, treated in the same hospitals as the cases for minor diseases or c...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/(sici)1097-0215(19990301)80:5<699::aid-ijc
更新日期:1999-03-01 00:00:00
abstract::Despite the steadily increasing number of patients suffering from squamous-cell carcinomas of the oropharyngeal region, little is known about the molecular steps involved in the induction of these neoplasms. We investigated oropharyngeal cancers from 38 patients for mutations in the p53 tumour-suppressor gene. The maj...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910560608
更新日期:1994-03-15 00:00:00
abstract::Primary cultures of hepatocytes isolated from normal F-344 rats or from F-344 rats with hepatocellular carcinomas generated by a 2-step model of chemical carcinogenesis were used to determine if dexamethasone (DEX) or alpha 2-macroglobulin (alpha 2M) modify the ability of transforming growth factors-beta type I (TGF-b...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910470223
更新日期:1991-01-21 00:00:00
abstract::Data on human T-cell lymphotropic-virus-type-I (HTLV-I) status and hematology from 528 individuals were analyzed for associations with low reactivity to the purified protein derivative (PPD) of Mycobacterium tuberculosis recall antigen. Subjects were classified as HTLV-I carriers with abnormal lymphocytes (Ably), carr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910560307
更新日期:1994-02-01 00:00:00
abstract::We undertook a study to determine the role and regulation of expression of urokinase-type plasminogen activator in squamous-cell carcinoma of the oral cavity. The contribution of urokinase to the invasive process was clearly demonstrated in experiments in which in vitro invasion by a cultured squamous-cell carcinoma c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910540113
更新日期:1993-04-22 00:00:00
abstract::As part of a collaborative study of risk factors for childhood brain tumours, the effects of the mother's smoking and her potential for passive smoking exposure during the pregnancy were assessed in a case-control study. Parents of 91 cases and 321 population controls from Northern Italy, matched for age, sex and resi...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.2910570602
更新日期:1994-06-15 00:00:00
abstract::Benzene is considered a carcinogen, mostly based on evidence of causality for myeloid leukemia from high levels of exposure in occupational studies. We used United States Environmental Protection Agency National Ambient Toxics Assessment (NATA) estimates of low-level ambient benzene to examine potential associations f...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32202
更新日期:2019-11-15 00:00:00
abstract::The UBE1L gene isolated from the chromosome 3p21 region has an extremely reduced level of mRNA in lung cancer. Sequence analysis showed a 45% homology to the human ubiquitin-activating enzyme E1 at the amino acid level. To further characterize the protein product, we generated UBE1L protein-specific antibodies. Immuno...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(20000315)85:6<871::aid-ijc
更新日期:2000-03-15 00:00:00
abstract::Diabetes refers to a group of metabolic diseases characterized by impaired insulin signalling and high blood glucose. A growing body of epidemiological evidence links diabetes to several types of cancer but the underlying molecular mechanisms are poorly understood. The signalling cascade connecting insulin and FOXO pr...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.30840
更新日期:2017-12-15 00:00:00
abstract::Cancers occurring at the gastroesophageal junction (GEJ) are classified as predominantly esophageal or gastric, which is often difficult to decipher. We hypothesized that the transcriptomic profile might reveal molecular subgroups which could help to define the tumor origin and behavior beyond anatomical location. The...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32384
更新日期:2019-12-15 00:00:00
abstract::Inbred rats were treated with extranuclear tumour membrane fractions or 3 M KCl-solubilized extracts of two antigenically distinct 3-methylcholanthrene-induced sarcomas, Mc7 and Mc57. The rats developed tumour-specific humoral antibody responses, but were not immune to tumour challenge. Moreover, they were unresponsiv...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910180511
更新日期:1976-11-15 00:00:00
abstract::The Swedish Family-Cancer Database was used to analyze concordant (same site) and discordant (different site) second primary neoplasms in 633,964 cancer patients diagnosed from 1958 to 1996. Cases of second malignant neoplasms were extracted from the Database if the diagnosis date of the first and second cancer differ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1317
更新日期:2001-07-15 00:00:00
abstract::Growing evidence suggests that people with autoimmune conditions may be at increased risk of hepatobiliary tumors. In the present study, we evaluated associations between autoimmune conditions and hepatobiliary cancers among adults aged ≥66 in the United States. We used Surveillance, Epidemiology, and End Results (SEE...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31835
更新日期:2019-02-15 00:00:00
abstract::Sperm protein 17 (Sp17) is an antigenic protein highly expressed in spermatozoa. Sp17 expression was demonstrated recently in multiple myeloma, suggesting that it may be a novel cancer-testis antigen. Expression of Sp17 mRNA and protein was examined in human ovarian tumors. Sp17 mRNA was evaluated by reverse transcrip...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11617
更新日期:2004-03-01 00:00:00
abstract::In both the rat kidney and lung, inhalation of cigarette smoke diluted with air (1/15) for a limited period of time (15 min) specifically induces aryl hydrocarbon hydroxylase (AHH)2 in less than 4 h. Up to four successive inhalations administered at 2-h intervals activities. The maximal effect corresponds to about 10 ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910190415
更新日期:1977-04-15 00:00:00
abstract::The effects of long-term treatment with mouse interferon on the phenotype of untransformed C3H/10T1/2 cells and cloned derivatives transformed by methylcholanthrene (MCA) and Simian virus 40 (SV40) were investigated. Continuous presence of interferon induced morphologic reversion, with the development of thick, submem...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910340119
更新日期:1984-07-15 00:00:00
abstract::The WHO Classification of Tumours provides the international standards for the classification and diagnosis of tumours. It enables direct comparisons to be made between different countries. In the new fifth edition, the series has gone digital with the launch of a website as well as a series of books, known widely as ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33210
更新日期:2021-03-01 00:00:00
abstract::The topic of this review is the role of stromal-epithelial interactions in normal and malignant prostatic growth. Because cell-cell interactions and androgens play such key roles in the prostate, the goal of this review will be to apply endocrinologic and developmental concepts to the understanding of normal and malig...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.11335
更新日期:2003-10-20 00:00:00
abstract::The c-KIT protooncogene encodes a tyrosine kinase receptor, KIT, that is expressed in many normal and cancerous tissues. In this study, we have examined the expression of c-KIT and its ligand, stem cell factor (SCF), in human epithelial ovarian tumors, in normal ovaries and in cultured ovarian surface epithelium (OSE)...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20000520)89:3<242::aid-ijc6>3.0.
更新日期:2000-05-20 00:00:00
abstract::The impact of the organised cervical cancer (CC) screening programmes implemented in Europe since the 1990s has been insufficiently evaluated. We investigated the changes in CC incidence following the introduction of a screening programme in the Emilia-Romagna Region (northern Italy). The study period was 1988-2013. T...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31806
更新日期:2019-03-01 00:00:00
abstract::Mutant KRAS provides a driving force for enhancement of cancer stem cells (CSCs) characteristics contributing transformation of colorectal cancer (CRC) cells harboring adenomatous polyposis coli (APC) mutations. Here, we identified the factors mediating the promotion of CSCs properties induced by KRAS mutation through...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32728
更新日期:2020-05-15 00:00:00
abstract::Few studies have examined cancer-related risk factors in relation to SES across the lifecourse in low to middle income countries. This analysis focuses on adult women in India, China, Mexico, Russia and South Africa, and examines the association between individual, parental and lifecourse SES with smoking, alcohol, BM...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30499
更新日期:2017-02-15 00:00:00
abstract::Matrix metalloproteinase 2 (MMP-2) plays a crucial role in invasion and metastasis of malignant tumors. Membrane type 1-MMP (MT1-MMP) was originally identified as an activator of MMP-2. Tissue inhibitor of MMP-2 (TIMP-2) was identified as an inhibitor of MMP-2 and MT1-MMP. However, TIMP-2 was reported to be essential ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20010120)95:1<44::aid-ijc1008>3.
更新日期:2001-01-20 00:00:00
abstract::Genome-wide association studies (GWAS) have identified several loci contributing to lung cancer and COPD risk independently; however, inflammation-related pathways likely harbor additional lung cancer risk-associated variants in biologically relevant immune genes that differ dependent on COPD. We selected single nucle...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32780
更新日期:2020-08-01 00:00:00
abstract::Langerhans' cells (LCs) are thought to play an important role in presentation of tumour antigens for the induction of anti-tumour immunity. Epidermis overlying some transplanted murine skin tumours contains increased numbers of LCs; however, alterations in LC numbers are not related to tumour antigenicity or host immu...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980119)75:2<210::aid-ijc
更新日期:1998-01-19 00:00:00
abstract::Ionizing radiation remains a major therapeutic tool against human cancers, especially epithelial tumors, which account for the majority of human malignancies. Although Fas and Fas-L are essential determinants of apoptosis, few data support their role in the cytotoxic effect of ionizing radiation. Epstein-Barr-virus (E...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(20000415)86:2<229::aid-ijc
更新日期:2000-04-15 00:00:00
abstract::Aberrant activation of wingless (Wnt) signaling is involved in the pathogenesis of various cancers. Recent studies suggested a role of Wnt signaling in gliomas, the most common primary brain tumors. We investigated 70 gliomas of different malignancy grades for promoter hypermethylation in 8 genes encoding members of t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24981
更新日期:2010-06-01 00:00:00
abstract::Germline CDKN2A mutations are found in 5-20% of melanoma families. Numerous studies have shown that carriers of CDKN2A mutations have increased risks of non-melanoma cancers, but so far there have been no studies investigating cancer risks in CDKN2A wild type (wt) melanoma families. In this prospective cohort study, i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29595
更新日期:2015-11-01 00:00:00
abstract::The sister chromatid exchange (SCE) rates of cell lines derived from patients with different malignant and premalignant disease were studied before and after intracerebral inoculation into nude mice and were compared to the SCE frequencies of cell lines from healthy controls. Lymphoma lines characterized by chromosoma...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280408
更新日期:1981-10-15 00:00:00