Lifecourse socioeconomic status and cancer-related risk factors: Analysis of the WHO study on global ageing and adult health (SAGE).

Abstract:

:Few studies have examined cancer-related risk factors in relation to SES across the lifecourse in low to middle income countries. This analysis focuses on adult women in India, China, Mexico, Russia and South Africa, and examines the association between individual, parental and lifecourse SES with smoking, alcohol, BMI, nutrition and physical activity. Data on 22,283 women aged 18 years and older were obtained from the 2007 WHO Study on Global Aging and Adult Health (SAGE). Overall, 34% of women had no formal education, 73% had mothers with no formal education and 73% of women had low lifecourse SES. Low SES women were almost four times more likely to exceed alcohol use guidelines (OR: 3.86, 95% CI: 1.23-12.10), and 68% more likely to smoke (OR: 1.68, 95% CI: 1.01-2.80) compared with higher SES. Women with low SES mothers and fathers were more likely to have poor nutrition (Mothers OR: 1.59, 95% CI: 1.17-2.16; Fathers OR: 1.33, 95% CI: 1.11-1.59) and more likely to smoke (Mothers OR: 1.46, 95% CI: 1.15-1.87; Fathers OR: 2.17, 95% CI: 1.80-2.63) compared with those with high SES parents. Women with stable low lifecourse SES were more likely to smoke (OR: 2.55, 95% CI: 1.47-4.43), while those with declining lifecourse SES were more likely to exceed alcohol use guidelines (OR: 3.63, 95% CI: 1.07-12.34). Cancer-related risk factors varied significantly by lifecourse SES, suggesting that cancer prevention strategies will need to be tailored to specific sub-groups in order to be most effective.

journal_name

Int J Cancer

authors

Akinyemiju T,Ogunsina K,Okwali M,Sakhuja S,Braithwaite D

doi

10.1002/ijc.30499

subject

Has Abstract

pub_date

2017-02-15 00:00:00

pages

777-787

issue

4

eissn

0020-7136

issn

1097-0215

journal_volume

140

pub_type

杂志文章
  • APE1 genotype and risk of bladder cancer: evidence for effect modification by smoking.

    abstract::Apurinic/apyrimidinic (AP) sites are common mutagenic and cytotoxic DNA lesions that arise from the loss of normal bases. APE1, the major AP endonuclease of human cells, plays a central role in the repair of AP sites through both its endonuclease and phosphodiesterase activities. A common APE1 polymorphism, a T-->G tr...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ijc.21768

    authors: Terry PD,Umbach DM,Taylor JA

    更新日期:2006-06-15 00:00:00

  • SET domain containing 1B gene is mutated in primary hepatic neuroendocrine tumors.

    abstract::Primary hepatic neuroendocrine tumors (PHNETs) are extremely rare NETs originating from the liver. These tumors are associated with heterogeneous prognosis, and few treatment targets for PHNETs have been identified. Because the major genetic alterations in PHNET are still largely unknown, we performed whole-exome sequ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.32334

    authors: Yang P,Huang X,Lai C,Li L,Li T,Huang P,Ouyang S,Yan J,Cheng S,Lei G,Wang Z,Yu L,Hong Z,Li R,Dong H,Wang C,Yu Y,Wang X,Li X,Wang L,Lv F,Yin Y,Yang H,Song J,Gao Q,Wang X,Zhang S

    更新日期:2019-12-01 00:00:00

  • A randomized, placebo-controlled, phase 1/2 study of tivantinib (ARQ 197) in combination with irinotecan and cetuximab in patients with metastatic colorectal cancer with wild-type KRAS who have received first-line systemic therapy.

    abstract::Cetuximab in combination with an irinotecan-containing regimen is a standard treatment in patients with KRAS wild-type (KRAS WT), metastatic colorectal cancer (mCRC). We investigated the addition of the oral MET inhibitor tivantinib to cetuximab + irinotecan (CETIRI) based on preclinical evidence that activation of th...

    journal_title:International journal of cancer

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/ijc.30049

    authors: Eng C,Bessudo A,Hart LL,Severtsev A,Gladkov O,Müller L,Kopp MV,Vladimirov V,Langdon R,Kotiv B,Barni S,Hsu C,Bolotin E,von Roemeling R,Schwartz B,Bendell JC

    更新日期:2016-07-01 00:00:00

  • Postsurgical chemotherapy in stage IB nonsmall cell lung cancer: Long-term survival in a randomized study.

    abstract::Although surgical resection is considered the adequate treatment in early stages of nonsmall cell lung cancer, long-term survival is not satisfactory and recurrence rate is high. We previously showed that postoperative chemotherapy at stage IB reduces recurrences and prolongs overall survival. We extended size and obs...

    journal_title:International journal of cancer

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/ijc.21933

    authors: Roselli M,Mariotti S,Ferroni P,Laudisi A,Mineo D,Pompeo E,Ambrogi V,Mineo TC

    更新日期:2006-08-15 00:00:00

  • Duplication of chromosome segment 12q15-24 is associated with atypical lipomatous tumors: a report of the CHAMP collaborative study group. CHromosomes And MorPhology.

    abstract::Ordinary lipomas are cytogenetically characterized by a variety of balanced rearrangements involving chromosome segment 12ql3-15, and atypical lipomatous tumors (ALT) by supernumerary ring chromosomes or giant markers known to contain amplified 12q sequences. In a series of 228 cytogenetically analyzed and histopathol...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0215(19960904)67:5<632::AID-IJC

    authors: Mandahl N,Akerman M,Aman P,Dal Cin P,De Wever I,Fletcher CD,Mertens F,Mitelman F,Rosai J,Rydholm A,Sciot R,Tallini G,Van den Berghe H,Van de Ven W,Vanni R,Willén H

    更新日期:1996-09-04 00:00:00

  • Non-Hodgkin's lymphoma and skin malignancies--shared etiology?

    abstract::The Stockholm-Gotland Cancer Register was used to evaluate the clinical observation that patients with non-Hodgkin's lymphoma (NHL) had an increased risk of malignant melanoma or squamous-cell carcinoma of the skin (SCCS) and vice versa. During 1958-1992, NHL was diagnosed in a total of 6,176 patients. Of these patien...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910620505

    authors: Hall P,Rosendahl I,Mattsson A,Einhorn S

    更新日期:1995-09-04 00:00:00

  • Tumor-reactive CD8+ T-cell clones in patients after NY-ESO-1 peptide vaccination.

    abstract::A major objective of peptide vaccination is the induction of tumor-reactive CD8+ T-cells. We have shown that HLA-A2 positive cancer patients frequently develop an antigen-specific CD8+ T-cell response after vaccination with NY-ESO-1 peptides p157-165/p157-167. These T-cells are highly reactive with the peptides used f...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.22957

    authors: Karbach J,Gnjatic S,Pauligk C,Bender A,Maeurer M,Schultze JL,Nadler K,Wahle C,Knuth A,Old LJ,Jäger E

    更新日期:2007-11-01 00:00:00

  • A minicircuitry of microRNA-9-1 and RUNX1-RUNX1T1 contributes to leukemogenesis in t(8;21) acute myeloid leukemia.

    abstract::MicroRNA-9-1(miR-9-1) plays an important role in the mechanism that regulates the lineage fate of differentiating hematopoietic cells. Recent studies have shown that miR-9-1 is downregulated in t (8; 21) AML. However, the pathogenic mechanisms underlying miR-9-1 downregulation and the RUNX1-RUNX1T1 fusion protein, gen...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.30481

    authors: Fu L,Shi J,Liu A,Zhou L,Jiang M,Fu H,Xu K,Li D,Deng A,Zhang Q,Pang Y,Guo Y,Hu K,Zhou J,Wang Y,Huang W,Jing Y,Dou L,Wang L,Xu K,Ke X,Nervi C,Li Y,Yu L

    更新日期:2017-02-01 00:00:00

  • Cetuximab ± chemotherapy enhances dendritic cell-mediated phagocytosis of colon cancer cells and ignites a highly efficient colon cancer antigen-specific cytotoxic T-cell response in vitro.

    abstract::Cetuximab is a human/mouse chimeric IgG1 monoclonal antibody (mAb) to epidermal growth factor receptor, approved for colorectal carcinoma treatment in combination with chemotherapy. The immune-mediated effects elicited by its human fraction of crystallization moiety might critically contribute to the overall anti-tumo...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.26181

    authors: Correale P,Botta C,Cusi MG,Del Vecchio MT,De Santi MM,Gori Savellini G,Bestoso E,Apollinari S,Mannucci S,Marra M,Abbruzzese A,Aquino A,Turriziani M,Bonmassar L,Caraglia M,Tagliaferri P

    更新日期:2012-04-01 00:00:00

  • Characteristics and prognostic significance of profiling the peripheral blood T-cell receptor repertoire in patients with advanced lung cancer.

    abstract::Lung cancer is one of the greatest threats to human health, and is initially detected and attacked by the immune system through tumor-reactive T cells. The aim of this study was to determine the basic characteristics and clinical significance of the peripheral blood T-cell receptor (TCR) repertoire in patients with ad...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.32145

    authors: Liu YY,Yang QF,Yang JS,Cao RB,Liang JY,Liu YT,Zeng YL,Chen S,Xia XF,Zhang K,Liu L

    更新日期:2019-09-01 00:00:00

  • Redundancy of autocrine loops in human osteosarcoma cells.

    abstract::With the aim of identifying innovative therapeutic strategies for osteosarcoma patients who are refractory to conventional chemotherapy, we analyzed the in vitro effects of the blockage of autocrine circuits. Since the insulin-like growth factor-I receptor (IGF-IR)-mediated loop is relevant to the growth of osteosarco...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0215(19990209)80:4<581::aid-ijc

    authors: Benini S,Baldini N,Manara MC,Chano T,Serra M,Rizzi S,Lollini PL,Picci P,Scotlandi K

    更新日期:1999-02-09 00:00:00

  • Enhancement of thermal killing by polyamines. I. Survival of Chinese hamster cells.

    abstract::Exposure of Chinese hamster cells to polyamines at an elevated temperature (42 degrees C) results in synergistic cell killing. The effectiveness of polyamines in potentiating thermal killing decreases in the following order: spermine greater than spermidine greater than cadaverine greater than putrescine. The magnitud...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910220515

    authors: Ben-Hur E,Prager A,Riklis E

    更新日期:1978-11-15 00:00:00

  • The ubiquitin-activating enzyme E1-like protein in lung cancer cell lines.

    abstract::The UBE1L gene isolated from the chromosome 3p21 region has an extremely reduced level of mRNA in lung cancer. Sequence analysis showed a 45% homology to the human ubiquitin-activating enzyme E1 at the amino acid level. To further characterize the protein product, we generated UBE1L protein-specific antibodies. Immuno...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0215(20000315)85:6<871::aid-ijc

    authors: McLaughlin PM,Helfrich W,Kok K,Mulder M,Hu SW,Brinker MG,Ruiters MH,de Leij LF,Buys CH

    更新日期:2000-03-15 00:00:00

  • Possible role of certain antioxidant enzymes in dimethylnitrosamine-induced liver carcinogenesis.

    abstract::An investigation was carried out to establish whether the reduction in catalase, glutathione peroxidase and superoxide dismutase activity, normally observed in liver tumours, is an early event and therefore of pathogenetic importance, or whether it is a late occurrence. Experiments performed on dimethylnitrosamine-tre...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910420529

    authors: Liotti FS,Menghini AR,Guerrieri P,Mariucci G,Locci P,Bruschelli G

    更新日期:1988-11-15 00:00:00

  • Pharmacological and small interference RNA-mediated inhibition of breast cancer-associated fatty acid synthase (oncogenic antigen-519) synergistically enhances Taxol (paclitaxel)-induced cytotoxicity.

    abstract::The relationship between breast cancer-associated fatty acid synthase (FAS; oncogenic antigen-519) and chemotherapy-induced cell damage has not been studied. We examined the ability of C75, a synthetic slow-binding inhibitor of FAS activity, to modulate the cytotoxic activity of the microtubule-interfering agent Taxol...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.20754

    authors: Menendez JA,Vellon L,Colomer R,Lupu R

    更新日期:2005-05-20 00:00:00

  • Inhibitory effect of 4-methylesculetin on hyaluronan synthesis slows the development of human pancreatic cancer in vitro and in nude mice.

    abstract::We report the inhibitory effect of 4-methylesculetin (ME), a 4-methylumbelliferone derivative, on hyaluronan (HA) synthesis by pancreatic cancer cells, and its resulting anticancer action. First, HA in cell culture was analyzed using competitive inhibition with hyaluronic acid-binding protein (HABP) to study HA synthe...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.22349

    authors: Hajime M,Shuichi Y,Makoto N,Masanori Y,Ikuko K,Atsushi K,Mutsuo S,Keiichi T

    更新日期:2007-06-15 00:00:00

  • The cannabinoid delta(9)-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells.

    abstract::Deregulation of cell survival pathways and resistance to apoptosis are widely accepted to be fundamental aspects of tumorigenesis. As in many tumours, the aberrant growth and survival of colorectal tumour cells is dependent upon a small number of highly activated signalling pathways, the inhibition of which elicits po...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.22917

    authors: Greenhough A,Patsos HA,Williams AC,Paraskeva C

    更新日期:2007-11-15 00:00:00

  • A recombinant vaccinia virus expressing human prostate-specific antigen (PSA): safety and immunogenicity in a non-human primate.

    abstract::Prostate-specific antigen (PSA) is a serine protease secreted by prostatic epithelial cells and is widely used as a marker for prostate cancer. The tissue specificity of PSA makes it a potential target for active specific immunotherapy, especially in prostate cancer patients who have undergone prostatectomy and in who...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910630215

    authors: Hodge JW,Schlom J,Donohue SJ,Tomaszewski JE,Wheeler CW,Levine BS,Gritz L,Panicali D,Kantor JA

    更新日期:1995-10-09 00:00:00

  • Cerebrovascular inflammation promotes the formation of brain metastases.

    abstract::Brain metastases are the most prevalent intracranial malignancy. Patient outcome is poor and treatment options are limited. Hence, new avenues must be explored to identify potential therapeutic targets. Inflammation is a known critical component of cancer progression. Intratumoral inflammation drives progression and l...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.32902

    authors: Sikpa D,Whittingstall L,Fouquet JP,Radulska A,Tremblay L,Lebel R,Paquette B,Lepage M

    更新日期:2020-07-01 00:00:00

  • Roles of lytic viral infection and IL-6 in early versus late passage lymphoblastoid cell lines and EBV-associated lymphoproliferative disease.

    abstract::Lytically infected EBV-positive lymphoblastoid cells enhance the growth of early-passage, but not late-passage, EBV-immortalized lymphoblastoid cell lines (LCLs) in SCID mice and have enhanced IL-6 secretion. Here, we have examined the importance of IL-6 for the growth of early-passage LCLs (EPL) in SCID mice, identif...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.22839

    authors: Jones RJ,Seaman WT,Feng WH,Barlow E,Dickerson S,Delecluse HJ,Kenney SC

    更新日期:2007-09-15 00:00:00

  • Sunlight, hormone replacement status and colorectal cancer risk in postmenopausal women.

    abstract::A reanalysis of the Women's Health Initiative (WHI) randomized clinical trial found a significant interaction between supplementation with vitamin D/calcium and estrogen therapy and the risk of colorectal cancer risk, with reduced risks from supplementation limited to the placebo arms of the estrogen trials. To explor...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.24903

    authors: Freedman DM,Rajaraman P,Fuhrman B,Hoffbeck R,Alexander BH

    更新日期:2010-04-15 00:00:00

  • Migration and death from malignant melanoma.

    abstract::The age-standardized mortality rates for malignant melanoma of the skin in immigrants to New Zealand were compared with those of New Zealand-born non-Maoris. Immigrants from European countries had mortality rates that were generally similar to those prevailing in their countries of origin, although, among immigrants f...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910360208

    authors: Cooke KR,Fraser J

    更新日期:1985-08-15 00:00:00

  • Colposcopy is not necessary to assess the risk to the cervix in HIV-positive women: an international cohort study of cervical pathology in HIV-1 positive women.

    abstract::The objectives of this prospective multicentre international cohort study are to describe the characteristics of a cohort of HIV-1 positive women and determine the best management system by comparing cervical pathology according to results of cytology, colposcopy and human papillomavirus (HPV) testing at baseline and ...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ijc.22947

    authors: Kitchener H,Nelson L,Adams J,Mesher D,Sasieni P,Cubie H,Moore C,Heard I,Agarossi A,Casolati E,Denny L,Bradbeer C,Lyons F,Beattie G,Niemiec T

    更新日期:2007-12-01 00:00:00

  • Antitumor effect of sunitinib against skeletal metastatic renal cell carcinoma through inhibition of osteoclast function.

    abstract::We investigated the inhibitory effect of sunitinib, a newly approved multitargeted tyrosine kinase inhibitor, against the progression of renal cell cancer (RCC) bone metastases in vivo. In vitro cell proliferation was determined using the MTS assay. To investigate the inhibitory effects of sunitinib in vivo, we establ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.26034

    authors: Maita S,Yuasa T,Tsuchiya N,Mitobe Y,Narita S,Horikawa Y,Hatake K,Fukui I,Kimura S,Maekawa T,Habuchi T

    更新日期:2012-02-01 00:00:00

  • Mutation induction in Chinese hamster V79 cells by two vinyl chloride metabolites, chloroethylene oxide and 2-chloroacetaldehyde.

    abstract::Chloroethylene oxide and 2-chloroacetaldehyde, two possibly carcinogenic metabolities of vinyl chloride in mammals, caused a dose-dependent induction of 8-azaguanine- and ouabain-resistant mutants in Chinese hamster V79 cells in vitro. Up to one-hundred-fold higher concentrations of 2-chloroethanol or monochloroacetic...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910160414

    authors: Huberman E,Bartsch H,Sachs L

    更新日期:1975-10-15 00:00:00

  • Isoenzyme pattern and subcellular localization of hexokinases in human breast cancer and nonpathological breast tissue.

    abstract::Subcellular distribution of hexokinase (HK) isoenzymes in 22 human breast cancers (21 primary cancers and 1 axillary metastatic growth) and 7 non-pathological human mammary gland tissue samples was studied with starch gel electrophoresis on isolated cell fractions obtained by differential centrifugation. Fractions use...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910340111

    authors: Gudnason V,Ingvarsson S,Jonasdottir A,Andresdottir V,Egilsson V

    更新日期:1984-07-15 00:00:00

  • Circulating lncRNA SNHG11 as a novel biomarker for early diagnosis and prognosis of colorectal cancer.

    abstract::Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer mortality worldwide. Emerging evidence indicates that tumour cells release substantial amounts of RNA into the bloodstream, in which RNA strongly resists RNases and is present at sufficient levels for quantitative analyses. ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.32747

    authors: Xu W,Zhou G,Wang H,Liu Y,Chen B,Chen W,Lin C,Wu S,Gong A,Xu M

    更新日期:2020-05-15 00:00:00

  • Childhood cancer incidence in Queensland, 1979-88.

    abstract::Data on the incidence of childhood cancer in Queensland during the 10-year period 1979-88 are presented. During this period, 786 cases were registered. The average annual crude and age-standardized (to the world population) incidence rates for both sexes were 12.63 and 13.30 per 100,000 respectively. The incidence of ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910450603

    authors: McWhirter WR,Petroeschevsky AL

    更新日期:1990-06-15 00:00:00

  • Genetic variants in ELOVL2 and HSD17B12 predict melanoma-specific survival.

    abstract::Fatty acids play a key role in cellular bioenergetics, membrane biosynthesis and intracellular signaling processes and thus may be involved in cancer development and progression. In the present study, we comprehensively assessed associations of 14,522 common single-nucleotide polymorphisms (SNPs) in 149 genes of the f...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.32194

    authors: Dai W,Liu H,Xu X,Ge J,Luo S,Zhu D,Amos CI,Fang S,Lee JE,Li X,Nan H,Li C,Wei Q

    更新日期:2019-11-15 00:00:00

  • Germline mutations in E-cadherin do not explain association of hereditary prostate cancer, gastric cancer and breast cancer.

    abstract::Somatic mutations in the E-cadherin (CDH1) gene have frequently been reported in cases with diffuse gastric and lobular breast cancers. Recently, germline mutations have been identified in families with diffuse gastric cancers. In families with hereditary prostate cancer (HPC), a significant association of prostate ca...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.10258

    authors: Jonsson BA,Bergh A,Stattin P,Emmanuelsson M,Grönberg H

    更新日期:2002-04-20 00:00:00