Residential ambient benzene exposure in the United States and subsequent risk of hematologic malignancies.

abstract：:We present a pilot study that aims to examine the possibility to easily and noninvasively detect and discriminate females with ovarian cancer (OC) from females that have no tumor(s) and from females that have benign genital tract neoplasia, using exhaled breath samples. The study is based on clinical samples and data ...

journal_title：International journal of cancer

authors： Amal H,Shi DY,Ionescu R,Zhang W,Hua QL,Pan YY,Tao L,Liu H,Haick H

更新日期：2015-03-15 00:00:00

abstract：:The cis-2a,3-diol and the trans-4,5-, trans-7,8-, trans-9,10- and trans-11,12-dihydrodiols of 3-methylcholanthrene and the trans-3,4, trans-5,6-, trans-8,9. and trans-10,11- dihydrodiols of 7,12-dimethylbenz[a]anthrancene have been tested, in comparison with the parent hydrocarbons, for their abilities to initiate sk...

journal_title：International journal of cancer

authors： Chouroulinkov I,Gentil A,Tierney B,Grover PL,Sims P

更新日期：1979-10-15 00:00:00

abstract：:Thymuses of 14-day-old AKR mouse embryos were infected with Gross murine leukemia virus (MuLV) and then maintained in organ culture for 3 weeks. When they were transplanted to 3-week-old (AKR X C3H)F1 mice, approximately 50% of these developed T lymphomas within 3-4 months. Most (22/23) tumors were of host, F1-hybrid,...

journal_title：International journal of cancer

authors： Riesenfeld I,Tufveson G,Alm GV

更新日期：1980-04-15 00:00:00

abstract：:Lytically infected EBV-positive lymphoblastoid cells enhance the growth of early-passage, but not late-passage, EBV-immortalized lymphoblastoid cell lines (LCLs) in SCID mice and have enhanced IL-6 secretion. Here, we have examined the importance of IL-6 for the growth of early-passage LCLs (EPL) in SCID mice, identif...

journal_title：International journal of cancer

authors： Jones RJ,Seaman WT,Feng WH,Barlow E,Dickerson S,Delecluse HJ,Kenney SC

更新日期：2007-09-15 00:00:00

abstract：:It has been demonstrated that the chemopreventive agent N-(4-hydroxyphenyl)retinamide (4-HPR) induces apoptotic cell death, but recent data has suggested that late stage/recurrent tumours lose their response to 4-HPR-induced cell death by mechanisms that are unknown. Our study investigated the ability of 4-HPR to indu...

journal_title：International journal of cancer

authors： Davies M,Paterson IC,Ganapathy A,Prime SS

更新日期：2006-12-15 00:00:00

abstract：:MAGE-1 and MAGE-3 or -6 are genes encoding melanoma-rejection antigens recognized by cytotoxic T lymphocytes in an HLA-A1 restriction manner. MAGE-1 and MAGE-3 or -6 were expressed in 5/14 (36%) and 6/14 (43%) neuroblastoma (NB) cell lines, and in 20/41 (49%) and 24/41 (59%) clinical NB-related tumors, respectively. A...

journal_title：International journal of cancer

authors： Ishida H,Matsumura T,Salgaller ML,Ohmizono Y,Kadono Y,Sawada T

更新日期：1996-10-21 00:00:00

abstract：:Paracrine motogenic cytokines secreted by normal cells can stimulate metastatic cell invasion. For example, human fibroblasts secrete hepatocyte growth factor/scatter factor (HGF/SF), which stimulates paracrine migration of epithelial and certain carcinoma cells, and migration-stimulating factor (MSF), which stimulate...

journal_title：International journal of cancer

authors： Hu M,Pollock RE,Nakamura T,Nicolson GL

更新日期：1995-09-04 00:00:00

abstract：:In order to examine whether or not the expression of the apoptosis-related receptor Fas (CD-95/APO-1) and its ligand (FasL) has relevance for patient survival, immunohistochemistry was used to analyze the proteins of both factors in 164 non-small cell lung carcinomas. Patients with Fas-positive tumors exhibited signif...

journal_title：International journal of cancer

authors： Koomägi R,Volm M

更新日期：1999-06-21 00:00:00

abstract：:The CpG island methylator phenotype (CIMP) is a distinct form of epigenomic instability. Many CIMP-high colorectal cancers (CRCs) with BRAF mutation are considered to arise from serrated pathway. We recently reported that microRNA-31 (miR-31) is associated with BRAF mutation in colorectal tumors. Emerging new approach...

journal_title：International journal of cancer

authors： Ito M,Mitsuhashi K,Igarashi H,Nosho K,Naito T,Yoshii S,Takahashi H,Fujita M,Sukawa Y,Yamamoto E,Takahashi T,Adachi Y,Nojima M,Sasaki Y,Tokino T,Baba Y,Maruyama R,Suzuki H,Imai K,Yamamoto H,Shinomura Y

更新日期：2014-12-01 00:00:00

abstract：:Androgen receptor (AR) mutations that modify both the ligand binding and the transactivation capacities of the AR represent one of the mechanisms involved in the transition of prostate cancer (PCa) from androgen-dependent to androgen-independent growth. We use a yeast-based functional assay to detect and analyze mutan...

journal_title：International journal of cancer

authors： Céraline J,Cruchant MD,Erdmann E,Erbs P,Kurtz JE,Duclos B,Jacqmin D,Chopin D,Bergerat JP

更新日期：2004-01-01 00:00:00

abstract：:The aim of our study was to investigate the protection afforded to the bone marrow by Goralatide (AcSDKP), an inhibitor of hemopoietic stem cell proliferation, when administered alone or in combination with a growth factor (granulocyte/macrophage colony-stimulating factor [GM-CSF]) during iterative cycles of Ara-C (cy...

journal_title：International journal of cancer

authors： Bogden AE,Moreau JP,Gamba-Vitalo C,Deschamps de Paillette E,Tubiana M,Frindel E,Carde P

更新日期：1998-03-30 00:00:00

abstract：:Sex steroid hormones influence prostate development and maintenance through their roles in prostate cellular proliferation, differentiation and apoptosis. Although suspected to be involved in prostate carcinogenesis, an association between circulating androgens and prostate cancer has not been clearly established in e...

journal_title：International journal of cancer

authors： Weiss JM,Huang WY,Rinaldi S,Fears TR,Chatterjee N,Hsing AW,Crawford ED,Andriole GL,Kaaks R,Hayes RB

更新日期：2008-05-15 00:00:00

abstract：:Liposarcomas are separated into clinicopathological entities with a characteristic morphological spectrum and mutually exclusive genetic alterations. Therefore, the rare occurrence of cases with combined patterns of well-differentiated liposarcoma and myxoid liposarcoma designated as mixed-type liposarcoma pose a conc...

journal_title：International journal of cancer

authors： de Vreeze RS,de Jong D,Koops W,Nederlof PM,Ariaens A,Haas RL,van Coevorden F

更新日期：2011-02-15 00:00:00

abstract：:Inhibition of programmed cell death (apoptosis) is associated with increased tumor aggressiveness. We hypothesized that a novel sensitive to apoptosis gene, SAG, may be expressed in tumors of patients with nonsmall cell lung cancer (NSCLC) and may affect their clinical outcome. Expression of SAG messenger RNA was eval...

journal_title：International journal of cancer

authors： Sasaki H,Yukiue H,Kobayashi Y,Moriyama S,Nakashima Y,Kaji M,Fukai I,Kiriyama M,Yamakawa Y,Fujii Y

更新日期：2001-11-20 00:00:00

abstract：:Variants of human papillomavirus (HPV) type 31 have been shown to be related both to risk of cervical lesions and racial composition of a population. It is largely undetermined whether variants differ in their likelihood of persistence. Study subjects were women who participated in the ASCUS-LSIL Triage Study and who ...

journal_title：International journal of cancer

authors： Xi LF,Schiffman M,Koutsky LA,He Z,Winer RL,Hulbert A,Lee SK,Ke Y,Kiviat NB

更新日期：2013-02-01 00:00:00

abstract：:The recently identified cell adhesion regulator (CAR) modulates the process of integrin-mediated cell adhesion. The CAR gene is located on 16q, a locus at which high levels of allelic losses have been demonstrated in advanced human hepatocellular carcinoma (HCC). We studied the possible involvement of the CAR gene in ...

journal_title：International journal of cancer

authors： Yamamoto H,Itoh F,Sakamoto H,Nakajima Y,Une Y,Hinoda Y,Imai K

更新日期：1997-06-20 00:00:00

abstract：:Dichlorodiphenyltrichloroethane (p,p'-DDT), an organochlorine pesticide known to have deleterious health effects in humans, has been linked to hepatocellular carcinoma (HCC) in rodents. A recent study has reported that p,p'-DDT and its most persistent metabolite, dichlorodiphenyldichloroethylene (p,p'-DDE), may also b...

journal_title：International journal of cancer

authors： Persson EC,Graubard BI,Evans AA,London WT,Weber JP,LeBlanc A,Chen G,Lin W,McGlynn KA

更新日期：2012-11-01 00:00:00

abstract：:The anti-tumor effects of actinomycin D (Act D) and recombinant human tumor necrosis factor (TNF)-alpha have been studied on 4 established murine tumor cell lines: MmB16 melanoma, Lewis lung (LL/2) carcinoma, L1 sarcoma and L1210 leukemia. During short-term incubation (24 hr) Act D produced dose-dependent cytostatic/c...

journal_title：International journal of cancer

authors： Lasek W,Giermasz A,Kuc K,Wańkowicz A,Feleszko W,Gołab J,Zagozdzon R,Stokłosa T,Jakóbisiak M

更新日期：1996-05-03 00:00:00

abstract：:Ionizing radiation remains a major therapeutic tool against human cancers, especially epithelial tumors, which account for the majority of human malignancies. Although Fas and Fas-L are essential determinants of apoptosis, few data support their role in the cytotoxic effect of ionizing radiation. Epstein-Barr-virus (E...

journal_title：International journal of cancer

authors： Abdulkarim B,Sabri S,Deutsch E,Vaganay S,Marangoni E,Vainchenker W,Bongrand P,Busson P,Bourhis J

更新日期：2000-04-15 00:00:00

abstract：:Proliferating cell nuclear antigen (PCNA) expression was studied by immunohistochemistry on paraffin-embedded sections of 293 primary colorectal adenocarcinomas and 56 corresponding lymph node metastases. PCNA-positive expression was detected in <25% of tumour cells in 172 (59%) cases and in > 25% in 121 (41%) cases. ...

journal_title：International journal of cancer

authors： Sun XF,Carstensen JM,Stål O,Zhang H,Nordenskjöld B

更新日期：1996-02-20 00:00:00

abstract：:Artemisia asiatica Nakai has been used in traditional Asian medicine for the treatment of inflammatory and other disorders. Previous studies have revealed that the formulated ethanol extract (DA-9601) of A. asiatica has pronounced antioxidative and antiinflammatory activities and exhibits cytoprotective effects agains...

journal_title：International journal of cancer

authors： Seo HJ,Park KK,Han SS,Chung WY,Son MW,Kim WB,Surh YJ

更新日期：2002-08-01 00:00:00

abstract：:Promoter hypermethylation of various tumor-related genes is extremely frequent in gastric carcinoma (GC) associated with Epstein-Barr virus (EBV). To investigate the significance of the promoter methylation in this type of GC, we examined the methylation densities of the promoter regions of p14ARF and p16INK4A in EBV-...

journal_title：International journal of cancer

authors： Sakuma K,Chong JM,Sudo M,Ushiku T,Inoue Y,Shibahara J,Uozaki H,Nagai H,Fukayama M

更新日期：2004-11-01 00:00:00

abstract：:We recently reported that hormone therapy induces antigen-specific autoantibody responses in prostate cancer patients. However, the contribution of autoantibody responses to clinical outcomes is unknown. We used an animal model to test the hypothesis that hormone therapy-induced immune responses may be associated with...

journal_title：International journal of cancer

authors： Hahn S,Nesslinger NJ,Drapala RJ,Bowden M,Rennie PS,Pai HH,Ludgate C,Nelson BH

更新日期：2009-12-15 00:00:00

abstract：:The SIL gene expression is increased in multiple cancers and correlates with the expression of mitotic spindle checkpoint genes and with increased metastatic potential. SIL regulates mitotic entry, organization of the mitotic spindle and cell survival. The E2F transcription factors regulate cell cycle progression by c...

journal_title：International journal of cancer

authors： Erez A,Chaussepied M,Castiel A,Colaizzo-Anas T,Aplan PD,Ginsberg D,Izraeli S

更新日期：2008-10-01 00:00:00

abstract：:AKT/PKB is a central signaling molecule related to stimulation of cell proliferation and inhibition of apoptosis. Perturbations of AKT expression and function play an important role in tumor development and progression. We wanted to determine (a) whether AKT is overexpressed in human prostatic tumors, (b) whether AKT ...

journal_title：International journal of cancer

authors： Liao Y,Grobholz R,Abel U,Trojan L,Michel MS,Angel P,Mayer D

更新日期：2003-11-20 00:00:00

abstract：:Mouse IFN gamma preparations purified 30-fold were found to have direct cytolytic activity against a number of tumor and normal cells. Cell killing was determined using a sensitive, rapid and accurate assay which employed very low numbers of cells and very small quantities of interferon. The cytolytic activity of IFN ...

journal_title：International journal of cancer

authors： Tyring S,Klimpel GR,Fleischmann WR Jr,Baron S

更新日期：1982-07-15 00:00:00

abstract：:Paclitaxel exerts its cytotoxic effect by kinetic suppression of microtubules that block cells in the G2/M phase of the cell cycle and trigger apoptosis. To investigate apoptosis induced by paclitaxel in nasopharyngeal carcinoma (NPC), and its possible molecular mechanism of action, the human NPC cell lines HNE-1 (bea...

journal_title：International journal of cancer

authors： Tan G,Heqing L,Jiangbo C,Ming J,Yanhong M,Xianghe L,Hong S,Li G

更新日期：2002-01-10 00:00:00

abstract：:The assessment of tumor molecular features in combination with the detection of occult malignant cells may provide important clinical information, beyond the standard staging of breast cancer. Using a nested RT-PCR technique, we assessed prospectively the presence of cytokeratin-19 (CK19) mRNA positive cells in the bl...

journal_title：International journal of cancer

authors： Giatromanolaki A,Koukourakis MI,Kakolyris S,Mavroudis D,Kouroussis C,Mavroudi C,Perraki M,Sivridis E,Georgoulias V

更新日期：2004-02-10 00:00:00

abstract：:Some studies suggest a favorable role of antioxidants on breast cancer risk but this is still inconclusive. The aim of this study was to assess whether overall dietary antioxidant capacity, as assessed by dietary ferric reducing antioxidant potential (FRAP), and individual dietary antioxidant intake were associated wi...

journal_title：International journal of cancer

authors： Pantavos A,Ruiter R,Feskens EF,de Keyser CE,Hofman A,Stricker BH,Franco OH,Kiefte-de Jong JC

更新日期：2015-05-01 00:00:00

abstract：:RAGE is a central driver of tumorigenesis by sustaining an inflammatory tumor microenvironment. This study links the soluble forms of RAGE (sRAGE and esRAGE) with clinical outcome of melanoma patients. Moreover, tissue expression of RAGE was analyzed using immunohistochemistry on two independent tissue microarrays (TM...

journal_title：International journal of cancer

authors： Wagner NB,Weide B,Reith M,Tarnanidis K,Kehrel C,Lichtenberger R,Pflugfelder A,Herpel E,Eubel J,Ikenberg K,Busch C,Holland-Letz T,Naeher H,Garbe C,Umansky V,Enk A,Utikal J,Gebhardt C

更新日期：2015-12-01 00:00:00