Abstract:
:BALB/cfC3H female mice which develop mammary tumor virus (MTV)-induced mammary tumors possess not only serun antibodies directed against virus-associated antigens which are expressed on mammary tumor cells but also antibodies directed against antigenic specificities which are unique to each tumor. The possible range of unique specificities is considerable; a survey of serum samples from 18 tumor-bearing females revealed only two which reacted with a tumor-unique specificity of another isologous MTV-induced mammary tumor. A retrospective study revealed that in multiparous females, the serum activity against tumor-unique antigenicity could be detected 1 to 4 months before the tumor was grossly visible. On the other hand, in virgin females, the serum activity was detectable only when the tumor was visible. On the basis of this difference in time of origin of reactivity, we speculate that the mechanism of tumor formation in parous females may involve a longer preneoplastic or latent neoplastic period than in virgin females; in the latter the change from normal to overtly neoplastic appears to be more abrupt.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Blair PB,Lane MLdoi
10.1002/ijc.2910210413subject
Has Abstractpub_date
1978-04-15 00:00:00pages
476-81issue
4eissn
0020-7136issn
1097-0215journal_volume
21pub_type
杂志文章abstract::Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. To improve existing therapies and broaden the spectrum of cytotoxic agents that can be used in RMS treatment, we performed a phage-display-based screening for peptides that bind specifically to RMS cells. Two peptides binding to RMS and to othe...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24170
更新日期:2009-05-01 00:00:00
abstract::Data from a hospital-based matched case-control study with 531 male pairs were analyzed for risks of cancer of the lower urinary tract associated with previous employment and particular occupational exposures. Statistically significant odds ratios were obtained for ever-employment as mining workers (2.0), turners (2.3...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910410309
更新日期:1988-03-15 00:00:00
abstract::Infection with a simian retrovirus (STLV-I) closely related to human T-lymphotropic virus type I (HTLV-I) was investigated in non-human primates living in their native countries in Africa and Asia. Serum antibodies cross-reacting with HTLV-I antigens were detected in 85 of 567 non-human primates of 30 species. Seropos...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910400219
更新日期:1987-08-15 00:00:00
abstract::We aimed to identify risk factors for Kaposi's sarcoma (KS) among HIV-positive patients and behaviors associated with human Herpesvirus 8 (HHV-8) infection, as well as to assess KS incidence and mortality rates longitudinally. To fulfill the first objective, a European case-control study was designed in the early 1990...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.22281
更新日期:2007-03-01 00:00:00
abstract::Premature chromosome condensation (PCC) was studied in direct preparations of tissues from patients with haematological diseases and carcinomas of various histological types. PCC was found in 6 out of 166 malignancies (128 haematological cases, 35 carcinomas and 3 malignant effusions) analysed with the GTG-technique. ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910360602
更新日期:1985-12-15 00:00:00
abstract::Extranodal, nasal NK/T-cell lymphomas are regularly Epstein-Barr virus (EBV)-positive, with a type II latency pattern, expressing thus EBNA-1 and LMP1. The contribution of EBV to the tumor development is not known. Similarly to normal natural killer (NK) cells, cell lines derived from malignancies with a NK phenotype ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22139
更新日期:2006-12-15 00:00:00
abstract::The detection of CTCs prior to and during therapy is an independent and strong prognostic marker, and it is predictive of poor treatment outcome. A major challenge is that different technologies are available for isolation and characterization of CTCs in peripheral blood (PB). We compare the CellSearch system and Adna...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1002/ijc.26111
更新日期:2012-04-01 00:00:00
abstract::The effects of concomitant administration of bombesin and of the diuretic drug amiloride on the development of large and small intestinal tumors induced by azoxymethane (AOM), the incidence of their metastasis to the peritoneum and the labeling index of intestinal adenocarcinomas were investigated in inbred Wistar rat...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910630518
更新日期:1995-11-27 00:00:00
abstract::An antigen, protein X (Px), was purified from immune complexes isolated from malignant pleural effusions from patients with adenocarcinoma of the lung by EDTA treatment, PEG 8000 precipitation, protein A affinity chromatography, and Sephadex G-200 separation in the presence of 3 M NaCl. The purified antigen had a M(r)...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910520404
更新日期:1992-10-21 00:00:00
abstract::Epithelial-mesenchymal transition (EMT) is a cell plasticity process required for metastasis and chemoresistance of carcinoma cells. We report a crucial role of the signal adaptor proteins CRK and CRKL in promoting EMT and tumor aggressiveness, as well as resistance against chemotherapy in colorectal and pancreatic ca...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32955
更新日期:2020-09-15 00:00:00
abstract::A new antigan has been revealed by means of antisera against Rauscher virus in mice with Rauscher virus-induced leukemia. This antigen appears to be different from both Rauscher type-specific antigen and MULV-gs-1 (p-30), as shown by studies of electrophoretic mobility and immunochemical specificity. Except in leukemi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910170617
更新日期:1976-06-15 00:00:00
abstract::In order to identify regulatory genes involved in the development of an apoptosis-resistant phenotype in patients with chemotherapy refractory B-cell chronic lymphocytic leukemia (B-CLL) expression of apoptosis-regulating genes in B-CLL cells was quantified using cDNA arrays and RT-PCR. Data were obtained from and com...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20614
更新日期:2005-02-20 00:00:00
abstract::Aberrant promoter methylation of normally unmethylated CpG-islands offers a promising tool for the development of molecular biomarkers. We investigated bronchial aspirates of patients admitted for suspected lung cancer with regard to the prevalence of aberrant methylation of potential marker genes. Applying quantitati...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21090
更新日期:2005-09-20 00:00:00
abstract::Dichlorodiphenyltrichloroethane (p,p'-DDT), an organochlorine pesticide known to have deleterious health effects in humans, has been linked to hepatocellular carcinoma (HCC) in rodents. A recent study has reported that p,p'-DDT and its most persistent metabolite, dichlorodiphenyldichloroethylene (p,p'-DDE), may also b...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27459
更新日期:2012-11-01 00:00:00
abstract::Innate lymphoid cells (ILCs) promptly initiate cytokine responses to pathogen exposure in the mucosa and mucosal-associated lymphoid tissues. ILCs were recently categorized as being of the lymphoid lineage and have been classified into three groups. ILCs play important roles in immunity against pathogens, and an anti-...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.29443
更新日期:2016-01-01 00:00:00
abstract::Suppression of apoptosis may favor the onset and progression of cancer. Survivin is an inhibitor of apoptosis that has been suggested as a novel diagnostic/prognostic marker of bladder cancer. In this study, survivin mRNA expression was measured by a sensitive real-time PCR assay in tumor tissue and urine from bladder...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21000
更新日期:2005-08-10 00:00:00
abstract::In EBV-immortalized lymphoblastoid cell lines (LCLs) a small number of "latent" proteins are expressed. These are the EBV nuclear antigens, EBNAs 1-6, and a latent membrane protein, LMP. We have investigated the expression of these proteins in a variety of EBV-associated tumours and cell lines. Whereas transplant and ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910450623
更新日期:1990-06-15 00:00:00
abstract::Mucinous colorectal cancer often presents at an advanced stage. We have previously observed that mucin production by human colon-cancer cells correlates with their ability to colonize the liver in experimental animal models. The present study was undertaken in order to further elucidate the mechanisms by which product...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910520113
更新日期:1992-08-19 00:00:00
abstract::Kidney cancer often diagnosed at late stages when treatment options are severely limited. Thus, greater understanding of tumor metabolism leading ultimately to novel approaches to diagnosis is needed. Our laboratory has been utilizing metabolomics to evaluate compounds appearing in kidney cancer patients' biofluids at...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26274
更新日期:2012-06-15 00:00:00
abstract::The present study was undertaken to define the gene(s) of importance on the long arm of chromosome 18 (chromosome 18q) in endometrial carcinomas. We analyzed loss of heterozygosity (LOH) at 3 loci on chromosome 18q and DCC gene expression by the reverse-transcriptase/polymerase chain reaction (RT-PCR) method. Among 61...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910570407
更新日期:1994-05-15 00:00:00
abstract::A cyclin-dependent kinase inhibitor CDKN2A (p16/Ink4a) is a tumor suppressor and upregulated in cellular senescence. CDKN2A promoter methylation and gene silencing are associated with the CpG island methylator phenotype (CIMP) in colon cancer. However, prognostic significance of CDKN2A methylation or loss of CDKN2A (p...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.25432
更新日期:2011-03-01 00:00:00
abstract::Prostate-specific antigen (PSA) is a serine protease secreted by prostatic epithelial cells and is widely used as a marker for prostate cancer. The tissue specificity of PSA makes it a potential target for active specific immunotherapy, especially in prostate cancer patients who have undergone prostatectomy and in who...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910630215
更新日期:1995-10-09 00:00:00
abstract::E-cadherin mutations are found in 50% of diffuse-type gastric carcinoma, but not in intestinal gastric carcinoma. Because cell-cell adhesion mediated by E-cadherin plays an important role in epithelial cell survival, E-cadherin mutations could alter the apoptotic behavior of tumor cells. p53 and Bcl-2 family members a...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10879
更新日期:2003-03-10 00:00:00
abstract::Human papillomavirus (HPV) is an important factor for the development of tonsillar squamous cell carcinoma (TSCC). In addition, patients with HPV-positive TSCC have a better clinical outcome than patients with HPV-negative TSCC. Although, HPV is an important prognostic marker, additional biomarkers are needed to bette...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27635
更新日期:2013-01-01 00:00:00
abstract::Although viral sequences closely related to feline leukaemia virus are represented in multiple copies in cellular DNA of all domestic cats, a specific fraction was present only in the virus-infected cells. This fraction was detected by viral cDNA enriched by a prior absorption of a total complementary DNA (cDNA) trans...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910220114
更新日期:1978-07-15 00:00:00
abstract::Extensive study of Bcl-2 protein expression in prostate cancer (CaP) tissues by means of immunocytochemistry (IC) has provided evidence that it positively correlates with high grade and stage of CaP and is associated with resistance to anti-androgen hormone therapy. In the present study, we investigated the expression...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19981218)79:6<614::aid-ijc
更新日期:1998-12-18 00:00:00
abstract::A subline of the murine P815 mastocytoma passaged for a long period of time in histoincompatible hosts was found to be deficient in surface MHC class-I antigens by serological and biochemical methods. In agreement with the lack of restriction elements, this variant cell line was no longer susceptible to killing by cyt...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910460431
更新日期:1990-10-15 00:00:00
abstract::O6-alkylguanine-DNA alkyltransferase (MGMT) represents the first line of defense against the toxic, mutagenic and carcinogenic effects of O6-alkylguanine adducts in DNA. These adducts mediate the biological activity from a series of alkylating agents, such as the tobacco-specific nitrosamines, believed to contribute t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21790
更新日期:2006-07-15 00:00:00
abstract::Oncogene-transformed fibroblasts which expressed IL-1, spontaneously or after activation with conditioned medium (CM) and lipopolysaccharide (LPS), regressed in the syngeneic host. Since regression was significantly influenced by the immune competence of the host (see companion report), we speculated that regression w...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910500321
更新日期:1992-02-01 00:00:00
abstract::Epithelial ovarian cancer is the most lethal gynecological malignancy and the fifth leading cause of cancer deaths in women in the Western world. ETS transcription factors are known to act as positive or negative regulators of the expression of genes that are involved in various biological processes, including those t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26148
更新日期:2012-04-01 00:00:00