CpG methylation of viral DNA in EBV-associated tumours.


:In EBV-immortalized lymphoblastoid cell lines (LCLs) a small number of "latent" proteins are expressed. These are the EBV nuclear antigens, EBNAs 1-6, and a latent membrane protein, LMP. We have investigated the expression of these proteins in a variety of EBV-associated tumours and cell lines. Whereas transplant and B-cell lymphomas from cotton-top tamarins appear to express the full range of antigens found in LCLs, we and others have found that in Burkitt's lymphomas (BL) and a nasopharyngeal carcinoma (NPC) isolate, EBNA expression is restricted to EBNA-I. (In NPC, but not in BL, LMP may also be expressed). In order to ask what restricts the expression of EBNA 2-6 in NPC and BL cells it seemed reasonable to consider the possibility that the DNA sequences normally regulating expression of these antigens could be chemically modified. In this analysis, a tight inverse correlation between methylation of CpG dinucleotides in the 5' flanking region of the EBNA-2 gene and the expression of EBNAs 2-6 has been revealed. In the NPC tumour, CpG methylation within the gene is also observed, as is specific methylation over the EBNA-I region I and II binding sites (in oriP). The significance of these observations is considered.


Int J Cancer


Allday MJ,Kundu D,Finerty S,Griffin BE




Has Abstract


1990-06-15 00:00:00












  • Glypican-3, overexpressed in hepatocellular carcinoma, modulates FGF2 and BMP-7 signaling.

    abstract::The Glypican (GPC) family is a prototypical member of the cell-surface heparan sulfate proteoglycans (HSPGs). The HSPGs have been demonstrated to interact with growth factors, act as coreceptors and modulate growth factor activity. Here we show that based on oligonucleotide array analysis, GPC3 was upregulated in hepa...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Midorikawa Y,Ishikawa S,Iwanari H,Imamura T,Sakamoto H,Miyazono K,Kodama T,Makuuchi M,Aburatani H

    更新日期:2003-02-10 00:00:00

  • Aerosol gemcitabine inhibits the growth of primary osteosarcoma and osteosarcoma lung metastases.

    abstract::Osteosacarcoma (OS) lung metastases are often resistant to chemotherapy. Most anticancer drugs are administered systemically. In many cases this is followed by dose-dependent toxicity, which may not allow the achievement of therapeutic levels in lungs to eradicate metastases. We determined the efficacy of gemcitabine ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Koshkina NV,Kleinerman ES

    更新日期:2005-09-01 00:00:00

  • Reversal of doxorubicin resistance in breast cancer cells by photochemical internalization.

    abstract::Multiple drug resistance (MDR) is a problem that seriously reduces the efficacy of many chemotherapy agents. One mechanism for MDR is increased acidification of endocytic vesicles and increased cytosol pH, so weak base chemotherapeutic agents, including doxorubicin, are trapped in endocytic vesicles and exhibit a drug...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lou PJ,Lai PS,Shieh MJ,Macrobert AJ,Berg K,Bown SG

    更新日期:2006-12-01 00:00:00

  • Pre-diagnostic plasma concentrations of Fibrinogen, sGPIIb/IIIa, sP-selectin, sThrombomodulin, Thrombopoietin in relation to cancer risk: Findings from a large prospective study.

    abstract::While enhanced platelet activation may drive cancer progression and metastases, less is known about its role in early cancer development. Thus, we evaluated whether pre-diagnostic biomarkers of platelet activation and coagulation are related to the risks of common cancers in the prospective EPIC-Heidelberg Study using...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Graf ME,Sookthai D,Johnson T,Schübel R,Maldonado SG,Pletsch-Borba L,Katzke V,Bugert P,Hoffmeister M,Kaaks R,Kühn T

    更新日期:2018-12-01 00:00:00

  • Morphological, immunohistochemical and biochemical characterization of 6 newly established human ovarian carcinoma cell lines.

    abstract::Six permanent human tumor cell lines (OV-MZ-1 to 6) were established from 6 patients with serous adenocarcinomas of the ovary. These cell lines were derived from both solid tumors and ascites, from pre-treated and untreated patients, and are available over a range of in vitro passage numbers. The tumor cells grow as m...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Möbus V,Gerharz CD,Press U,Moll R,Beck T,Mellin W,Pollow K,Knapstein PG,Kreienberg R

    更新日期:1992-08-19 00:00:00

  • Detailed examination of lymph nodes improves prognostication in colorectal cancer.

    abstract::Up to 30% of stage II patients with curatively resected colorectal cancer (CRC) will develop disease recurrence. We evaluated whether examination of lymph nodes by multilevel sectioning and immunohistochemical staining can improve prognostication. Lymph nodes (n = 780) from 36 CRC patients who had developed disease re...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Doekhie FS,Mesker WE,Kuppen PJ,van Leeuwen GA,Morreau H,de Bock GH,Putter H,Tanke HJ,van de Velde CJ,Tollenaar RA

    更新日期:2010-06-01 00:00:00

  • Familial risks in cervical cancer: is there a hereditary component?

    abstract::The Swedish Family-Cancer Database was used to analyze familial relationships in mothers and daughters in invasive and in situ cervical cancers from years 1958-1994, including a total of 125,000 in situ and 14,000 invasive cancers. In situ cancers were diagnosed on average 10 years earlier than invasive cancers. Famil...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hemminki K,Dong C,Vaittinen P

    更新日期:1999-09-09 00:00:00

  • Marker profile of mesothelial cells versus ovarian carcinoma cells.

    abstract::We investigated the marker profile of human ascitic and cultured mesothelial cells, and compared it to that of ovarian carcinoma cells which are related in terms of their histogenesis, unrelated colon carcinomas being used as reference. Mesothelial and ovarian carcinoma cells could not be distinguished by (intermediat...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: van Niekerk CC,Jap PH,Thomas CM,Smeets DF,Ramaekers FC,Poels LG

    更新日期:1989-06-15 00:00:00

  • Expression of the metastasis-associated MTA1 protein and its relationship to deacetylation of the histone H4 in esophageal squamous cell carcinomas.

    abstract::Metastasis-associated protein MTA1 and histone deacetylase form a protein complex with histone deacetylase activity that plays an important role in histone deacetylation, alteration of chromatin structure and transcriptional control. The precise role of the MTA1 protein in the malignant progression of human cancers re...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Toh Y,Ohga T,Endo K,Adachi E,Kusumoto H,Haraguchi M,Okamura T,Nicolson GL

    更新日期:2004-06-20 00:00:00

  • Family history of urogenital cancers in patients with bladder, renal cell and prostate cancers.

    abstract::Family history of urogenital cancers has been associated with an increased risk of cancer at the same sites. To evaluate the risks of bladder, prostate and renal cell neoplasms for family history of urogenital cancers in first-degree relatives, we analysed data from a case-control study conducted in northern Italy bet...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Randi G,Pelucchi C,Negri E,Talamini R,Galeone C,Franceschi S,La Vecchia C

    更新日期:2007-12-15 00:00:00

  • Migration and death from malignant melanoma.

    abstract::The age-standardized mortality rates for malignant melanoma of the skin in immigrants to New Zealand were compared with those of New Zealand-born non-Maoris. Immigrants from European countries had mortality rates that were generally similar to those prevailing in their countries of origin, although, among immigrants f...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Cooke KR,Fraser J

    更新日期:1985-08-15 00:00:00

  • Changing role of 3 screening modalities in the European randomized study of screening for prostate cancer (Rotterdam).

    abstract::A randomized screening trial was started in Europe to show the effect of early detection and treatment of prostate cancer on mortality (European Study on Screening of Prostate Cancer). In one centre (Rotterdam), the screening protocol initially consisted of 3 screening tests for all men: prostate-specific antigen (PSA...

    journal_title:International journal of cancer

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Beemsterboer PM,Kranse R,de Koning HJ,Habbema JD,Schröder FH

    更新日期:1999-08-20 00:00:00

  • Study of chromatin remodeling genes implicates SMARCA4 as a putative player in oncogenesis in neuroblastoma.

    abstract::In neuroblastoma (NB), genetic alterations in chromatin remodeling (CRGs) and epigenetic modifier genes (EMGs) have been described. We sought to determine their frequency and clinical impact. Whole exome (WES)/whole genome sequencing (WGS) data and targeted sequencing (TSCA®) of exonic regions of 33 CRGs/EMGs were ana...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bellini A,Bessoltane-Bentahar N,Bhalshankar J,Clement N,Raynal V,Baulande S,Bernard V,Danzon A,Chicard M,Colmet-Daage L,Pierron G,Le Roux L,Planchon JM,Combaret V,Lapouble E,Corradini N,Thebaud E,Gambart M,Valteau-Cou

    更新日期:2019-11-15 00:00:00

  • Chromosome 15 trisomy in spontaneous and carcinogen-induced murine lymphomas of B-cell origin.

    abstract::G-banding analyses of 14 independently derived B-cell lymphomas showed the frequent occurrence of chromosome 15 trisomy. It was present in seven of nine spontaneous B-cell lymphomas, but in company with other trisomies, monosomies and marker chromosomes. In five carcinogen-induced primary B-cell leukemias, trisomy 15 ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wiener F,Babonits M,Spira J,Bregula U,Klein G,Merwin RM,Asofsky R,Lynes M,Haughton G

    更新日期:1981-01-15 00:00:00

  • International renal-cell cancer study. IV. Occupation.

    abstract::The relationship between renal-cell cancer (RCC) and occupation was investigated in an international multicenter population-based case-control study. Study centers in Australia, Denmark, Germany, Sweden and the United States interviewed 1732 incident RCC cases and 2309 controls. Significant associations were found wit...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Mandel JS,McLaughlin JK,Schlehofer B,Mellemgaard A,Helmert U,Lindblad P,McCredie M,Adami HO

    更新日期:1995-05-29 00:00:00

  • Expression of the pS2 gene in normal, benign and neoplastic human stomach.

    abstract::The expression of the estrogen-regulated breast-cancer-associated pS2 gene was examined in 75 stomach resections taken from 45 patients. The 600-base pS2 mRNA was found in all of the 47 non-neoplastic samples at varying levels: in the histologically normal group we observed a Poisson-type distribution, whereas 79% of ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Luqmani Y,Bennett C,Paterson I,Corbishley CM,Rio MC,Chambon P,Ryall G

    更新日期:1989-11-15 00:00:00

  • Tumor targeting with radiolabeled antibodies in a human carcinoembryonic antigen transgenic mouse model.

    abstract::Mice transgenic for the carcinoembryonic (CEA) gene were used to study the biodistribution and tumor targeting of a radioiodinated monoclonal antibody (MAb), T84.66. The specificity of antibody uptake in tumors was assessed in mice bearing a CEA-transfected syngeneic tumor as well as the antigen-negative parental tumo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Szalai G,Williams LE,Primus FJ

    更新日期:2000-03-15 00:00:00

  • Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop.

    abstract::Established cell lines derived from human malignant astrocytomas typically express a combination of platelet-derived growth factor (PDGF) and PDGF receptor which could form an autocrine loop. In this study, we screened for the essential components of a PDGF autocrine loop in fresh surgical isolates of human astrocytom...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Guha A,Dashner K,Black PM,Wagner JA,Stiles CD

    更新日期:1995-01-17 00:00:00

  • ALDH1A1 in patient-derived bladder cancer spheroids activates retinoic acid signaling leading to TUBB3 overexpression and tumor progression.

    abstract::Acquired chemoresistance is a critical issue for advanced bladder cancer patients during long-term treatment. Recent studies reveal that a fraction of tumor cells with enhanced tumor-initiating potential, or cancer stem-like cells (CSCs), may particularly contribute to acquired chemoresistance and recurrence. Thus, CS...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Namekawa T,Ikeda K,Horie-Inoue K,Suzuki T,Okamoto K,Ichikawa T,Yano A,Kawakami S,Inoue S

    更新日期:2020-02-15 00:00:00

  • Synthesis and antitumor properties of selenocoxib-1 against rat prostate adenocarcinoma cells.

    abstract::Hormone refractory prostate cancer poses a huge problem and standard of care chemotherapy has not been very successful. We used a novel strategy to combine properties of 2 well-studied class of compounds (selenium and COX-2 inhibitor) and examined the resulting effectiveness against prostate cancer. Bearing in mind th...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Desai D,Sinha I,Null K,Wolter W,Suckow MA,King T,Amin S,Sinha R

    更新日期:2010-07-01 00:00:00

  • Association of DNA base excision repair genes (OGG1, APE1 and XRCC1) polymorphisms with outcome to platinum-based chemotherapy in advanced nonsmall-cell lung cancer patients.

    abstract::Polymorphism of DNA base excision repair (BER) genes affects DNA repair capacity and may alter sensitivity to platinum-based chemotherapy regimens. This study investigated polymorphisms of OGG1 Ser326Cys, APE1 Asp148Glu APE1-141T/G and XRCC1 Arg399Gln for association with clinical outcome in 235 advanced inoperable no...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Peng Y,Li Z,Zhang S,Xiong Y,Cun Y,Qian C,Li M,Ren T,Xia L,Cheng Y,Wang D

    更新日期:2014-12-01 00:00:00

  • Novel targets for sensitizing breast cancer cells to TRAIL-induced apoptosis with siRNA delivery.

    abstract::Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in variety of cancer cells without affecting most normal cells, which makes it a promising agent for cancer therapy. However, TRAIL therapy is clinically not effective due to resistance induction. To identify novel regulators of TRAIL th...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Thapa B,Bahadur Kc R,Uludağ H

    更新日期:2018-02-01 00:00:00

  • Site-specific risk of cutaneous malignant melanoma and pattern of sun exposure in New Zealand.

    abstract::The site-specific relationship between melanoma and sun exposure was investigated in the high-risk region of New Zealand. Age and latitude of residence were used as biological and geographical proxy measures of exposure for the 16,117 newly incident cases and 3,150 death records reported between 1968 and 1993. Age-sta...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bulliard JL

    更新日期:2000-03-01 00:00:00

  • Prenatal diethylstilbestrol exposure and mammographic density.

    abstract::In a prospective cohort study of the health effects associated with prenatal Diethylstilbestrol (DES) exposure, DES was associated with an increased breast cancer risk after 40 years of age. It is unknown whether it is associated with greater mammographic density, which strongly predicts breast cancer risk. A cohort o...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Strohsnitter WC,Bertrand KA,Troisi R,Scott CG,Cheville AL,Hoover RN,Palmer JR,Vachon CM

    更新日期:2018-09-15 00:00:00

  • Two survivin polymorphisms are cooperatively associated with bladder cancer susceptibility.

    abstract::Abnormal survivin expression has been reported to be involved in many types of cancer. A single-nucleotide polymorphism (SNP), C-31G, located in the promoter region of survivin reportedly may alter the mRNA level, while the significance of the nonsynonymous SNP A9194G in exon 4 has not yet been clarified. Here, the as...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kawata N,Tsuchiya N,Horikawa Y,Inoue T,Tsuruta H,Maita S,Satoh S,Mitobe Y,Narita S,Habuchi T

    更新日期:2011-10-15 00:00:00

  • Treatment of melanoma of unknown primary in the era of immunotherapy and targeted therapy: A Dutch population-based study.

    abstract::Melanoma of unknown primary (MUP) may have a different biology to melanoma of known primary, but clinical trials of novel therapies (e.g., immune checkpoint or BRAF/MEK inhibitors) have not reported the outcomes in this population. We therefore evaluated the overall survival (OS) among patients with MUP in the era of ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Verver D,van der Veldt A,van Akkooi A,Verhoef C,Grünhagen DJ,Louwman WJ

    更新日期:2020-01-01 00:00:00

  • Clonality of multifocal urothelial carcinomas: 10 years of molecular genetic studies.

    abstract::Multifocal occurrence and frequent recurrence are characteristic features of urothelial carcinomas of both the urinary bladder and the upper urinary tract. To describe the clonal nature of these tumors, 2 theories have been proposed. The monoclonality hypothesis describes the multiple tumors as descendants of a single...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Hafner C,Knuechel R,Stoehr R,Hartmann A

    更新日期:2002-09-01 00:00:00

  • Melphalan availability in hypoxia-inducible factor-1alpha+/+ and factor-1alpha-/- tumors is independent of tumor vessel density and correlates with melphalan erythrocyte transport.

    abstract::Many tumors are impervious to anticancer agents. Resistance due to lack of cytotoxic penetration into the tumor is often overlooked but can play a significant role in undermining therapy. Insufficient and irregular vascularization of tumors is a possible barrier to drug delivery, but there are others, e.g., impaired v...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wildiers H,Guetens G,de Boeck G,Landuyt W,Verbeken E,Highley M,de Bruijn EA,van Oosterom AT

    更新日期:2002-06-01 00:00:00

  • Thyroid and androgen receptor signaling are antagonized by μ-Crystallin in prostate cancer.

    abstract::Androgen deprivation therapy (ADT) remains a key approach in the treatment of prostate cancer (PCa). However, PCa inevitably relapses and becomes ADT resistant. Besides androgens, there is evidence that thyroid hormone thyroxine (T4) and its active form 3,5,3'-triiodo-L-thyronine (T3) are involved in the progression o...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Aksoy O,Pencik J,Hartenbach M,Moazzami AA,Schlederer M,Balber T,Varady A,Philippe C,Baltzer PA,Mazumder B,Whitchurch JB,Roberts CJ,Haitel A,Herac M,Susani M,Mitterhauser M,Marculescu R,Stangl-Kremser J,Hassler MR,Kr

    更新日期:2021-02-01 00:00:00

  • The bisphosphonate zoledronic acid has antimyeloma activity in vivo by inhibition of protein prenylation.

    abstract::Nitrogen-containing bisphosphonates (N-BPs) are effective antiosteolytic agents in patients with multiple myeloma. Preclinical studies have also demonstrated that these agents have direct antitumor effects in vitro and can reduce tumor burden in a variety of animal models, although it is not clear whether such effects...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Guenther A,Gordon S,Tiemann M,Burger R,Bakker F,Green JR,Baum W,Roelofs AJ,Rogers MJ,Gramatzki M

    更新日期:2010-01-01 00:00:00