Non-Hodgkin's lymphoma and skin malignancies--shared etiology?

abstract：:Cell populations resistant to high doses (30 microM) of 6-thioguanine (6-TG, 6-TG(r) cells) were selected from a human colon carcinoma cell line, LoVo. This cell line, which lacks hMSH2, a component of the human mismatch binding heterodimer hMutSalpha, is resistant to low doses of 6-TG. The level of activity of hypoxa...

journal_title：International journal of cancer

authors： Bemi V,Turchi G,Margotti E,Giorgelli F,Pesi R,Sgarrella F,Tozzi MG,Camici M

更新日期：1999-08-12 00:00:00

abstract：:The influence of 4 murine monoclonal antibodies (MAbs) directed against surface determinants of a metastasizing rat adenocarcinoma (BSp73ASML) on metastatic spread was evaluated and compared to their in vivo binding as well as to the induction of a humoral anti-MAb response, especially with respect to the development ...

journal_title：International journal of cancer

authors： Reber S,Matzku S,Günthert U,Ponta H,Herrlich P,Zöller M

更新日期：1990-11-15 00:00:00

abstract：:Some herds of miniature swine are genetically predisposed to cutaneous melanoma. To test if swine melanoma susceptibility could be linked to the CDKN2A gene, which is involved in a proportion of 9p21-linked human familial melanoma, we performed a genetic analysis of miniature pigs of the MeLiM strain. F(1) and backcro...

journal_title：International journal of cancer

authors： Le Chalony C,Renard C,Vincent-Naulleau S,Crechet F,Leplat JJ,Tricaud Y,Horak V,Gruand J,Le Roy P,Frelat G,Geffrotin C

更新日期：2003-02-20 00:00:00

abstract：:The MDM2 gene encodes a 90-kDa oncoprotein that is overexpressed in several human carcinomas, osteosarcomas, gliomas and soft tissue sarcomas (STSs). This overexpression is the result of several mechanisms, for example, enhanced transcription or translation, gene amplification and alternative splicing. We found that 1...

journal_title：International journal of cancer

authors： Bartel F,Meye A,Würl P,Kappler M,Bache M,Lautenschläger C,Grünbaum U,Schmidt H,Taubert H

更新日期：2001-05-20 00:00:00

abstract：:Cancer is associated with epigenetic (i.e., histone hypoacetylation) and metabolic (i.e., aerobic glycolysis) alterations. Levels of N-acetyl-L-aspartate (NAA), the primary storage form of acetate in the brain, and aspartoacylase (ASPA), the enzyme responsible for NAA catalysis to generate acetate, are reduced in glio...

journal_title：International journal of cancer

authors： Tsen AR,Long PM,Driscoll HE,Davies MT,Teasdale BA,Penar PL,Pendlebury WW,Spees JL,Lawler SE,Viapiano MS,Jaworski DM

更新日期：2014-03-15 00:00:00

abstract：:Classical Hodgkin lymphoma (HL) is characterized by the presence of Hodgkin and Reed-Sternberg cells (H&RS) and a prominent lymphocytic infiltration. We previously reported Hodgkin-like adult T-cell leukemia/lymphoma (HL-like ATLL) (new WHO classification). Various CXC and CC chemokines are expressed on H&RS cells and...

journal_title：International journal of cancer

authors： Ohshima K,Karube K,Hamasaki M,Suefuji H,Tutiya T,Yamaguchi T,Suzumiya J,Kikuchi M

更新日期：2003-09-20 00:00:00

abstract：:In vitro, tumor-selective Hsp70 plasma membrane localization correlates with increased sensitivity to lysis mediated by a subpopulation of human natural killer (NK) cells that adhere to plastic following cytokine stimulation. In the present study, we analyzed the capacity of adoptively transferred human NK cells in SC...

journal_title：International journal of cancer

authors： Multhoff G,Pfister K,Botzler C,Jordan A,Scholz R,Schmetzer H,Burgstahler R,Hiddemann W

更新日期：2000-12-01 00:00:00

abstract：:Treatment of lung cancer is often performed with cone-down oblique beams to spare spinal cord and normal structures. However, there is no optimum technique to determine oblique beam angles when a CT simulation is not available. Impact of oblique beam angle was investigated in this study. Fifteen patients with centrall...

journal_title：International journal of cancer

authors： Das IJ,Cheng EC,Anderson PR,Movsas B

更新日期：2000-12-20 00:00:00

abstract：:To understand the mechanisms underlying increased expression of Myc protein in human urinary bladder cancer, expression of c-myc mRNA and the copy number of the c-myc gene were determined. Expression of mRNA was measured by quantitative RT-PCR in 40 urothelial carcinomas and in 18 histologically normal mucosae. Mean e...

journal_title：International journal of cancer

authors： Christoph F,Schmidt B,Schmitz-Dräger BJ,Schulz WA

更新日期：1999-04-20 00:00:00

abstract：:We treated 72 patients with metastatic renal-cell cancer according to 2 protocols consisting of two 5-week induction cycles of continuous i.v. high-dose interleukin-2 (IL-2), i.m. interferon-alpha (IFN alpha) and ex vivo IL-2-activated lymphocytes, followed for patients with stable disease (SD), partial response (PR) ...

journal_title：International journal of cancer

authors： Gratama JW,Schmitz PI,Goey SH,Lamers CH,Stoter G,Bolhuis RL

更新日期：1996-01-17 00:00:00

abstract：:An orang-utan (Pongo pygmaeus) suspension line, CP81, was shown to lack myeloid markers of lysozyme activity an d phagocytosis but to be positive for lymphocytic N-alkaline phosphatase activity, and to release a B-cell-tropic herpesvirus. This herpesvirus, termed Herpesvirus pongo, had 30--40% DNA homology with EBV an...

journal_title：International journal of cancer

authors： Rabin H,Neubauer RH,Hopkins RF 3rd,Nonoyama M

更新日期：1978-06-15 00:00:00

abstract：:Cytokines play a crucial role in tumor initiation and progression. Here, we demonstrate that interleukin (IL)-6 is a key factor by driving tumor progression from benign to malignant, invasive tumors in the HaCaT-model of human skin carcinoma. IL-6 activates STAT3 and directly stimulates proliferation and migration of ...

journal_title：International journal of cancer

authors： Lederle W,Depner S,Schnur S,Obermueller E,Catone N,Just A,Fusenig NE,Mueller MM

更新日期：2011-06-15 00:00:00

abstract：:TDE2, a gene with sequence similarity to the mouse testicular tumor-differentially-expressed (Tde1/MUSTETU) gene, was identified by serial analysis of gene expression (SAGE) in nonsmall cell lung cancers (NSCLC). Here we characterized the TDE2 gene and determined its transcript levels in a panel of lung tumors, adjace...

journal_title：International journal of cancer

authors： Player A,Gillespie J,Fujii T,Fukuoka J,Dracheva T,Meerzaman D,Hong KM,Curran J,Attoh G,Travis W,Jen J

更新日期：2003-11-01 00:00:00

abstract：:The population of Leningrad suffered from severe starvation, cold and psychological stress during the siege in World War II in 1941-1944. We investigated the long-term effects of the siege on cancer mortality in 3,901 men and 1,429 women, born between 1910 and 1940. All study subjects were residents of St. Petersburg,...

journal_title：International journal of cancer

authors： Koupil I,Plavinskaja S,Parfenova N,Shestov DB,Danziger PD,Vågerö D

更新日期：2009-03-15 00:00:00

abstract：:Inflammation, and more generally, the immune response are thought to influence the development of prostate cancer. To determine the components of the immune response that are potentially contributory, we prospectively evaluated the association of immune-mediated conditions, asthma and hayfever, with lethal prostate ca...

journal_title：International journal of cancer

authors： Platz EA,Drake CG,Wilson KM,Sutcliffe S,Kenfield SA,Mucci LA,Stampfer MJ,Willett WC,Camargo CA Jr,Giovannucci E

更新日期：2015-08-15 00:00:00

abstract：:In our previous experiments in Syrian hamsters the in vivo semiquantitative method of determination of the natural resistance-depressing (NRD) activity of tumor cells was described. It was demonstrated that inactivated cells of different tissue culture cell lines derived from in vivo tumors in contrast to normal, or i...

journal_title：International journal of cancer

authors： Deichman GI,Kluchareva TE,Kashkina LM,Matveeva VA,Vendrov EL,Zemtsova VI

更新日期：1982-09-15 00:00:00

abstract：:We have established human oral-squamous-cancer cell lines, BHY and HN, derived from non-metastatic cancer and metastatic cancer respectively. We examined the expression of matrix-degrading enzymes and their inhibitors in these cell lines. Both cell lines expressed pro-matrix metalloproteinase (MMP)1, proMMP2, proMMP9,...

journal_title：International journal of cancer

authors： Kawamata H,Nakashiro K,Uchida D,Harada K,Yoshida H,Sato M

更新日期：1997-01-06 00:00:00

abstract：:Insulin-like growth factor binding protein-3 (IGFBP-3) inhibits the mitogenic and antiapoptotic activity of insulin-like growth factor (IGF) by blocking the binding of IGF to its receptor. However, under certain circumstances, IGFBP-3 can enhance the activity of IGF by protecting IGF from degradation. More than half o...

journal_title：International journal of cancer

authors： Moon JW,Chang YS,Ahn CW,Yoo KN,Shin JH,Kong JH,Kim YS,Chang J,Kim SK,Kim HJ,Kim SK

更新日期：2006-01-15 00:00:00

abstract：:The effect of interferon on the long-term clinical outcome of patients with chronic hepatitis C remains unclear. This study included 594 patients with chronic hepatitis C who received interferon-alpha therapy (Interferon group) and 144 patients with chronic hepatitis C who did not receive interferon (Control group). T...

journal_title：International journal of cancer

authors： Tanaka H,Tsukuma H,Kasahara A,Hayashi N,Yoshihara H,Masuzawa M,Kanda T,Kashiwagi T,Inoue A,Kato M,Oshima A,Kinoshita Y,Kamada T

更新日期：2000-09-01 00:00:00

abstract：:A randomized clinical trial designed to compare the effectiveness of cytoxan (CTX) alone versus a combination consisting of CTX, vincristine (Oncovin) and methotrexate (COM) in the treatment of Burkitt's lymphoma (BL) was carried out. Nineteen patients were selected at random to receive CTX alone while 21 received COM...

journal_title：International journal of cancer

authors： Olweny CL,Katongole-Mbidde E,Kaddu-Mukasa A,Atine I,Owor R,Lwanga S,Carswell W,Magrath IT

更新日期：1976-04-15 00:00:00

abstract：:Gain of chromosome 1q is a hallmark of breast cancer, and likely reflects oncogene amplification. We previously identified mitotic kinesin KIF14 (kinesin family member 14) as an overexpressed candidate oncogene in the 1q31.3-1q32.1 minimal region of genomic gain in breast cancer cell lines. KIF14 also showed high expr...

journal_title：International journal of cancer

authors： Corson TW,Gallie BL

更新日期：2006-09-01 00:00:00

abstract：:Metastasis is one of the most important and complex processes in human neoplastic disease. A large number of both positive and negative events must occur to permit a tumor cell to colonize a distant site successfully. To identify mouse strains that harbor dominant genetic modifiers of this process, a strain survey was...

journal_title：International journal of cancer

authors： Lifsted T,Le Voyer T,Williams M,Muller W,Klein-Szanto A,Buetow KH,Hunter KW

更新日期：1998-08-12 00:00:00

abstract：:In an attempt to obtain cell lines from the different components found in primary breast cancers, we used a low-calcium medium to culture epithelial cells of mixed phenotype and a recombinant T antigen containing retrovirus to immortalize cells found in these cultures. In each case, the histology of the sample used fo...

journal_title：International journal of cancer

authors： Shearer M,Bartkova J,Bartek J,Berdichevsky F,Barnes D,Millis R,Taylor-Papadimitriou J

更新日期：1992-06-19 00:00:00

abstract：:No data exist on the population prevalence of, or risk factors for, human papillomavirus (HPV) infection in Iran or the Middle East. Cervical specimens were obtained from 825 married women aged 18-59 years from the general population of Tehran, Iran and from 45 locally diagnosed invasive cervical cancers (ICC) accordi...

journal_title：International journal of cancer

authors： Khodakarami N,Clifford GM,Yavari P,Farzaneh F,Salehpour S,Broutet N,Bathija H,Heideman DA,van Kemenade FJ,Meijer CJ,Hosseini SJ,Franceschi S

更新日期：2012-07-15 00:00:00

abstract：:Oncogenic HPV types are the major cause of worldwide cervical cancer, but only a small proportion of infected women will develop high-grade cervical intraepithelial neoplasia or cancer (CIN2/3+). We performed a prospective study including 781 women with normal, atypical squamous cells of undetermined significance (ASC...

journal_title：International journal of cancer

authors： Dalstein V,Riethmuller D,Prétet JL,Le Bail Carval K,Sautière JL,Carbillet JP,Kantelip B,Schaal JP,Mougin C

更新日期：2003-09-01 00:00:00

abstract：:Signal transducer and activator of transcription 5b (STAT5b) is likely the relevant STAT5 isoform with respect to the process of malignant progression in gliomas. STAT5b is a latent cytoplasmic protein involved in cell signaling through the modulation of growth factors, apoptosis, and angiogenesis. Previous in vitro s...

journal_title：International journal of cancer

authors： Gressot LV,Doucette TA,Yang Y,Fuller GN,Heimberger AB,Bögler O,Rao A,Latha K,Rao G

更新日期：2015-05-01 00:00:00

abstract：:The effect of blockade of NF-kappaB activity on human pancreatic cancer angiogenesis was determined in an orthotopic xenograft model. Highly metastatic L3.3 human pancreatic cancer cells, which expressed an elevated level of constitutive NF-kappaB activity, were transfected with a mutated IkappaBalpha (IkappaBalphaM)....

journal_title：International journal of cancer

authors： Xiong HQ,Abbruzzese JL,Lin E,Wang L,Zheng L,Xie K

更新日期：2004-01-10 00:00:00

abstract：:Heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) is a member of the EGF family of polypeptide growth factors, which includes EGF, transforming growth factor alpha(TGF-alpha), amphiregulin (AR) and betacellulin (BTC). To assess the potential role of HB-EGF in human gastric carcinomas, the expre...

journal_title：International journal of cancer

authors： Naef M,Yokoyama M,Friess H,Büchler MW,Korc M

更新日期：1996-05-03 00:00:00

abstract：:MM is a B-cell malignancy mainly characterized by monoclonal expansion of plasma cells in the BM, presence of paraprotein in serum and occurrence of osteolytic bone lesions. MMPs are a family of proteolytic enzymes that can contribute to cancer growth, invasion, angiogenesis, bone degradation and other processes impor...

journal_title：International journal of cancer

authors： Van Valckenborgh E,Bakkus M,Munaut C,Noël A,St Pierre Y,Asosingh K,Van Riet I,Van Camp B,Vanderkerken K

更新日期：2002-10-20 00:00:00

abstract：:Tenascin-C (TN-C) and matrix metalloproteinases (MMPs) are highly expressed in cancer tissues and probably promote cell migration during cancer progression. TN-C and MMPs are often co-localized in areas of active tissue remodeling in pathologic conditions, suggesting reciprocal regulation. To investigate whether TN-C ...

journal_title：International journal of cancer

authors： Kalembeyi I,Inada H,Nishiura R,Imanaka-Yoshida K,Sakakura T,Yoshida T

更新日期：2003-05-20 00:00:00