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Over-expression and amplification of the c-myc gene in human urothelial carcinoma.

Abstract：

:To understand the mechanisms underlying increased expression of Myc protein in human urinary bladder cancer, expression of c-myc mRNA and the copy number of the c-myc gene were determined. Expression of mRNA was measured by quantitative RT-PCR in 40 urothelial carcinomas and in 18 histologically normal mucosae. Mean expression in tumors was significantly increased (3.23+/-2.63 AU vs. 1.90+/-0.95 AU, p < 0.023) and exceeded the highest level in normal mucosa in 15 (37.5%) tumors. The c-myc gene copy number was higher than in leukocytes and normal bladder mucosa in 14 of 40 tumors, but only 3 among these showed a more than 4-fold increase indicative of gene amplification. Most, but not all, tumors with elevated expression displayed an increased gene copy number (p < 0.0001). In line with other studies of the protein level, no significant association either of c-myc mRNA over-expression or of increased gene copy number with tumor stage or grade was observed. The data indicate that elevated mRNA expression as a consequence of increases in c-myc gene copy number often underlies Myc protein over-expression in bladder cancer. This increase may be a consequence of, most frequently, chromosome 8q gain and, occasionally, gene amplification, while in some tumors deregulation of mRNA expression occurs without evident changes in the c-myc gene copy number.

journal_name

Int J Cancer

journal_title

International journal of cancer

authors

Christoph F,Schmidt B,Schmitz-Dräger BJ,Schulz WA

doi

10.1002/(sici)1097-0215(19990420)84:2<169::aid-ijc

keywords:

subject

Has Abstract

pub_date

1999-04-20 00:00:00

pages

169-73

issue

2

eissn

0020-7136

issn

1097-0215

pii

10.1002/(SICI)1097-0215(19990420)84:2<169::AID-IJC

journal_volume

84

pub_type

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