Abstract:
:Leukocyte functions (superoxide production and phagocytosis) were evaluated in patients with testicular cancer who had undergone super-high-dose chemotherapy (SHDT) with peripheral blood stem cell transplantation (PBSCT). In 5 patients with advanced or relapsed testicular cancer who received 8 cycles of SHDT with PBSCT, we measured superoxide production activity by phorbol myristate acetate (PMA) stimulation, as well as phagocytic activity using latex particles before and after PBSCT. The median time to reach a leukocyte count of > or = 1,000/microl was 9 days after PBSCT. Superoxide production activity was significantly decreased on day 7 compared with the pre-chemotherapy level. However, it recovered by day 12 and sustained such a level thereafter. Phagocytic activity was within the normal range on day 7 but declined slightly on days 12 and 21 compared with the pre-chemotherapy level. Our results indicate that leukocyte function and leukocyte count recover promptly following PBSCT and that PBSCT is a safe and convenient adjunctive therapy after SHDT for patients with advanced testicular cancer.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Yamada Y,Hara I,Gohji K,Okada H,Arakawa S,Kamidono Sdoi
10.1002/(sici)1097-0215(19970703)72:1<39::aid-ijc5subject
Has Abstractpub_date
1997-07-03 00:00:00pages
39-42issue
1eissn
0020-7136issn
1097-0215pii
10.1002/(SICI)1097-0215(19970703)72:1<39::AID-IJC5journal_volume
72pub_type
杂志文章abstract::Stage 4 neuroblastoma (NB) is a devastating childhood cancer whose poor outcome has remained essentially unchanged in the last 20 years. Receptor tyrosine kinases have important roles in the control of proliferation, differentiation and apoptosis of NB cells. Thus, we tested the activity of second-generation tyrosine ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24606
更新日期:2009-12-01 00:00:00
abstract::It is generally assumed that inflammation influences carcinogenesis. We previously reported that dextran sodium sulfate (DSS) strongly enhances colon carcinogenesis in the Apc(Min/+) mice and the over-expression of inducible nitric oxide synthase (iNOS) contributes to this enhancement. In the current study, we investi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22736
更新日期:2007-08-01 00:00:00
abstract::Imbalance in the Kb and Db region encoded molecules is observed in Lewis lung carcinoma clones. The uncloned metastatic population and the D122 high-metastatic clone show no expression of H-2Kb products, while the nonmetastatic A9 clone expresses Kb products. Twenty-nine new subclones of 3LL and A9 were analyzed for D...
journal_title:International journal of cancer
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doi:10.1002/ijc.2910320118
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990209)80:4<516::aid-ijc
更新日期:1999-02-09 00:00:00
abstract::The application of dendritic cells (DC) to the active immunotherapy of cancer currently relies on the generation of potent DC capable of presenting tumor antigens such as carcinoembryonic antigen (CEA). It is unknown whether the T cells of patients with advanced malignancies can be reliably stimulated against tumor an...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990702)82:1<121::aid-ijc
更新日期:1999-07-02 00:00:00
abstract::Two hundred and twelve archival bladder-cancer biopsy specimens were analyzed immunohistochemically analysis were correlated to established histological and quantitative prognostic factors and survival of patients during a mean follow-up period of more than 10 years. Twenty-nine percent of tumours were positive for p5...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910530304
更新日期:1993-02-01 00:00:00
abstract::The incidence of non-Hodgkin's lymphoma (NHL) has markedly increased in the US and other westernized countries in recent years and presents a considerable clinical challenge. NHL is divided into subtypes that follow an aggressive or indolent course. Follicular lymphoma (FL), the most common indolent subtype, and mantl...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
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更新日期:2006-09-01 00:00:00
abstract::Pediatric high-grade gliomas (HGGs) are highly malignant tumors that remain incurable and relatively understudied. The crucial role of noncoding RNAs (ncRNAs) has been reported in various cancers. However, the study on miRNAs in pediatric HGGs is scant and there is no report till date on the status of other small ncRN...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29610
更新日期:2015-11-15 00:00:00
abstract::In advanced prostate cancer, cellular changes occur leading to a transition from androgen-dependent to androgen-independent growth. During this transition, proliferation of androgen-dependent prostate cancer cells becomes more and more dependent on growth factors, like the epidermal growth factor (EGF). Endocytosis of...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20612
更新日期:2005-02-10 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:
更新日期:2000-10-20 00:00:00
abstract::The mass screening (MS) of neuroblastoma has been undertaken in Japan by measuring urinary catecholamine metabolites in infants at the age of 6 months. To clarify the biological characteristics of MS-positive (MS+) tumors in infants and MS-negative (MS-)/late-presenting tumors in young children, metaphase cytogenetic ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990105)80:1<54::aid-ijc1
更新日期:1999-01-05 00:00:00
abstract::Our aim was to determine the long-term outcome and the possible role of neoadjuvant (preoperative) radiation therapy for breast cancers unsuitable for primary conservative surgery. From 1977 to 1992, 75 unifocal non-inflammatory and non-metastatic T2 and T3 breast cancers were treated in our department. All these pati...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1024
更新日期:2001-08-20 00:00:00
abstract::The human surface antigen CD24 is over-expressed in small-cell lung cancer. Here we describe the isolation, sequencing and functional characterization of the 5'-flanking region of the human CD24 gene. A sequence (accession number: Y14692) of 3.4 kb regulates the activity of a luciferase reporter gene in CD24-expressin...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19981109)78:4<496::aid-ijc
更新日期:1998-11-09 00:00:00
abstract::Although the incidence of testis cancer has risen markedly in many Western populations over the past half-century, it is not clear whether rates in other populations also have increased. To clarify this issue, we examined testis cancer incidence rates over the 25-year time period of 1973-1997 for selected populations ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20931
更新日期:2005-07-10 00:00:00
abstract::Secreted frizzled-related proteins (SFRPs) are antagonists of the Wnt signaling pathway whose epigenetic downregulation have been shown to be involved in hepatocarcinogenesis. However, dysregulation of SFRPs induced by hepatitis B virus (HBV) X protein (HBx) has never been studied in HBV-related hepatocellular carcino...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28697
更新日期:2014-08-01 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910530211
更新日期:1993-01-21 00:00:00
abstract::Human B- or T-cell lymphoma lines and primary murine lymphomas were treated with DNA oligonucleotides homologous to the telomere (TTAGGG repeat; "T-oligo"), either alone or in combination with standard, widely-used anticancer chemotherapeutic agents. T-oligo induces cell cycle arrest and apoptosis in cultured human or...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23946
更新日期:2009-01-15 00:00:00
abstract::Sera from 450 individuals between the age of 1 and 80 years, representing the general population of the Czech Republic, were tested for the presence of antibodies to human-papillomavirus(HPV)-derived antigens. The following antigens were used: (i) HPV1 virions; (ii) HPV16, -18 and -33-virus-like particles (VLP); (iii)...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980831)77:5<689::aid-ijc
更新日期:1998-08-31 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2019-04-15 00:00:00
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journal_title:International journal of cancer
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更新日期:1988-09-15 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2006-08-01 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910330305
更新日期:1984-03-15 00:00:00
abstract::We obtained Thy-I-positive cells directly from growing methylcholanthrene-induced (MCA-1510) sarcomas using fluorescence-activated cell sorting, then cultured these lymphocytes in medium containing Interleukin-2 and tested their activity in vivo against various MCA-sarcoma lines with the Winn assay. We found that cult...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280513
更新日期:1981-11-15 00:00:00
abstract::IL-15 is an immunostimulatory cytokine with IL-2-like activities. To exploit the potential role of IL-15 in cancer immuno-/gene therapy, we engineered murine TS/A cells with different IL-15 cDNA constructs. Significant IL-15 secretion was achieved only by the use of a modified cDNA encoding for an IL-15 pre-protein be...
journal_title:International journal of cancer
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doi:
更新日期:2000-08-15 00:00:00
abstract::Studies have shown that the calcium-sensing receptor (CaSR) mediates the antitumorigenic effects of calcium against colorectal cancer (CRC). Expression of the CaSR in colorectal tumors is often reduced. We have reported previously that silencing of CaSR in CRC is caused in part by methylation of CaSR promoter 2 and lo...
journal_title:International journal of cancer
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更新日期:2016-01-01 00:00:00
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journal_title:International journal of cancer
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更新日期:2001-10-15 00:00:00
abstract::140.240, an IgG2a mouse monoclonal antibody raised against a cultured human melanoma cell line, was highly specific for melanoma cells as determined by direct and absorption analyses in a mixed hemadsorption assay. Supernatants of doubly cloned hybridomas producing antibody 140.240 reacted with all cultured and fresh ...
journal_title:International journal of cancer
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更新日期:1982-11-15 00:00:00
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journal_title:International journal of cancer
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abstract::Established cell lines derived from human malignant astrocytomas typically express a combination of platelet-derived growth factor (PDGF) and PDGF receptor which could form an autocrine loop. In this study, we screened for the essential components of a PDGF autocrine loop in fresh surgical isolates of human astrocytom...
journal_title:International journal of cancer
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更新日期:1995-01-17 00:00:00
abstract::The mechanism of tumor cell killing by OXI4503 was investigated by studying vascular functional and morphological changes post drug administration. SCID mice bearing MHEC5-T hemangioendothelioma were given a single dose of OXI4503 at 100 mg/kg. Tumor blood flow, measured by microsphere fluorescence, was reduced by 50%...
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