Long-term results of neoadjuvant radiation therapy for breast cancer.

abstract：:To elucidate the mechanisms responsible for the development of anti-estrogen resistance, we have cloned and established 3 stable ICI-182,780-resistant sub-lines, MCF-7/182R-1, MCF-7/182R-6 and MCF-7/182R-7 from the estrogen-receptor(ER)-positive and estrogen-responsive human breast-cancer MCF-7 cell line by long-term ...

journal_title：International journal of cancer

authors： Larsen SS,Madsen MW,Jensen BL,Lykkesfeldt AE

更新日期：1997-09-17 00:00:00

abstract：:The stroma of ductal infiltrating carcinoma of the human breast shows characteristic and localized areas of collagen rarefaction and fragmentation. This finding has been correlated with a peculiar type of fibrillar damage, observed in a small percentage of collagen fibrils isolated in the native state from the tumour ...

journal_title：International journal of cancer

authors： Pucci-Minafra I,Luparello C,Schillaci R,Sciarrino S

更新日期：1987-05-15 00:00:00

abstract：:The physiological stress response to surgery promotes wound healing and functional recovery and includes the activation of neural, inflammatory and proangiogenic signaling pathways. Paradoxically, the same pathways also promote metastatic spread and growth of residual cancer. Human and animal studies show that cancer ...

journal_title：International journal of cancer

authors： Raskov H,Orhan A,Salanti A,Gögenur I

更新日期：2020-06-15 00:00:00

abstract：:The effects of a new metalloproteinase inhibitor, BE16627B [L-N-(N-hydroxy-2-isobutylsuccinynamoyl)-seryl-L-valine, MW: 375.2] isolated from microbial cultures, on human tumor cell growth in nude mice were investigated. BE16627B inhibited metalloproteinases in enzyme assays, as well as gelatinolysis and collagenolysis...

journal_title：International journal of cancer

authors： Naito K,Kanbayashi N,Nakajima S,Murai T,Arakawa K,Nishimura S,Okuyama A

更新日期：1994-09-01 00:00:00

abstract：:Dimethylbenzanthracene (DMBA)-induced rat mammary tumors were analyzed for the structure and expression of the oncogenes c-Ha-ras and neu and the effects of anti-estrogen treatment. Tumor samples were divided into 3 groups, the first consisting of untreated tumors, the second of anti-estrogen (toremifene)-treated unre...

journal_title：International journal of cancer

authors： Vuorio T,Wärri A,Sandberg M,Alitalo K,Vuorio E

更新日期：1988-11-15 00:00:00

abstract：:Cetuximab is a human/mouse chimeric IgG1 monoclonal antibody (mAb) to epidermal growth factor receptor, approved for colorectal carcinoma treatment in combination with chemotherapy. The immune-mediated effects elicited by its human fraction of crystallization moiety might critically contribute to the overall anti-tumo...

journal_title：International journal of cancer

authors： Correale P,Botta C,Cusi MG,Del Vecchio MT,De Santi MM,Gori Savellini G,Bestoso E,Apollinari S,Mannucci S,Marra M,Abbruzzese A,Aquino A,Turriziani M,Bonmassar L,Caraglia M,Tagliaferri P

更新日期：2012-04-01 00:00:00

abstract：:CXCR1 and CXCR2 are receptors for CXCL-8 and are differentially expressed on melanoma and endothelial cells. In this study, we determined the functional role of these receptors in melanoma progression. We stably knock-down the expression of CXCR1 and/or CXCR2 in A375-SM (SM; high metastatic) human melanoma cells by sh...

journal_title：International journal of cancer

authors： Singh S,Sadanandam A,Varney ML,Nannuru KC,Singh RK

更新日期：2010-01-15 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract. These tumors span a wide clinical spectrum from benign to malignant and have long been recognized for their nearly absolute resistance to chemotherapy and radiation treatment. We reviewed the worldwide experience on ...

journal_title：International journal of cancer

authors： Rossi CR,Mocellin S,Mencarelli R,Foletto M,Pilati P,Nitti D,Lise M

更新日期：2003-11-01 00:00:00

abstract：:A pilot case-control study on bladder cancer, with population-based controls matched for each of 74 cases, has been conducted in two industrial areas of Southern Belgium in order to analyze the influence of tobacco use and occupation. Observed bladder cancer risk for smokers is more than 5 times higher than that for n...

journal_title：International journal of cancer

authors： Schifflers E,Jamart J,Renard V

更新日期：1987-03-15 00:00:00

abstract：:The ability of endogenously synthesized protoporphyrin IX (PpIX) to damage Chinese hamster lung fibroblasts of the line V79 by exposure to light was examined. This treatment induced reduction of cellular ATP, GTP, of the NADH/NAD+ ratio and of oxygen consumption. The present results indicate a close relationship betwe...

journal_title：International journal of cancer

authors： Shevchuk I,Chekulayev V,Moan J,Berg K

更新日期：1996-09-17 00:00:00

abstract：:Imbalance in the Kb and Db region encoded molecules is observed in Lewis lung carcinoma clones. The uncloned metastatic population and the D122 high-metastatic clone show no expression of H-2Kb products, while the nonmetastatic A9 clone expresses Kb products. Twenty-nine new subclones of 3LL and A9 were analyzed for D...

journal_title：International journal of cancer

authors： Eisenbach L,Segal S,Feldman M

更新日期：1983-07-15 00:00:00

abstract：:Epidemiologic evidence on the association of antioxidant intake and prostate cancer incidence is inconsistent. Total antioxidant intake and prostate cancer incidence have not previously been examined. Using the ferric-reducing antioxidant potential (FRAP) assay, the total antioxidant content (TAC) of diet and suppleme...

journal_title：International journal of cancer

authors： Russnes KM,Wilson KM,Epstein MM,Kasperzyk JL,Stampfer MJ,Kenfield SA,Smeland S,Blomhoff R,Giovannucci EL,Willett WC,Mucci LA

更新日期：2014-03-01 00:00:00

abstract：:Endometrial cancer (EC) shares some environmental or genetic risk factors with colorectal cancer (CRC). It represents a risk factor for CRC. Furthermore, EC is the most frequent extracolonic neoplasm in HNPCC (hereditary nonpolyposis colorectal cancer) and, in this syndrome, it has the same inheritance pattern as CRC....

journal_title：International journal of cancer

authors： Fornasarig M,Campagnutta E,Talamini R,Franceschi S,Boz G,Scarabelli C,Andreaus CM,Scozzari G,Valentini M

更新日期：1998-07-03 00:00:00

abstract：:Acquired chemoresistance is a critical issue for advanced bladder cancer patients during long-term treatment. Recent studies reveal that a fraction of tumor cells with enhanced tumor-initiating potential, or cancer stem-like cells (CSCs), may particularly contribute to acquired chemoresistance and recurrence. Thus, CS...

journal_title：International journal of cancer

authors： Namekawa T,Ikeda K,Horie-Inoue K,Suzuki T,Okamoto K,Ichikawa T,Yano A,Kawakami S,Inoue S

更新日期：2020-02-15 00:00:00

abstract：:We have developed novel 3-dimensional in vitro and in vivo tissue models that mimic premalignant disease of human stratified epithelium in order to analyze the stromal contribution of extracellular matrix and basement membrane proteins to the progression of intraepithelial neoplasia. Three-dimensional, organotypic cul...

journal_title：International journal of cancer

authors： Andriani F,Garfield J,Fusenig NE,Garlick JA

更新日期：2004-01-20 00:00:00

abstract：:Diabetes is a risk factor for many cancers; chronic hyperglycemia is hypothesized to be, in part, explanatory. We evaluated the association between glycated hemoglobin, a time-integrated glycemia measure, and cancer incidence and mortality in nondiabetic and diabetic men and women. We conducted a prospective study of ...

journal_title：International journal of cancer

authors： Joshu CE,Prizment AE,Dluzniewski PJ,Menke A,Folsom AR,Coresh J,Yeh HC,Brancati FL,Platz EA,Selvin E

更新日期：2012-10-01 00:00:00

abstract：:The LIM 1863 colon carcinoma cell line grows in the form of morphologically and functionally organized organoids. Cells are arranged around a central lumen with a brush border and nuclei are polarized to the periphery. The organoids contain 3 morphological cell types (columnar, goblet and caveolated cells). By agar cl...

journal_title：International journal of cancer

authors： Hayward IP,Whitehead RH

更新日期：1992-03-12 00:00:00

abstract：:Aberrant DNA methylation, microsatellite instability (MSI) and chromosomal instability (CIN) are well-characterised molecular features of sporadic colorectal cancers (CRCs). In addition to CpG island methylator phenotype (CIMP) associated with MSI, an intermediate methylation subgroup is also a feature of non-MSI canc...

journal_title：International journal of cancer

authors： Silver A,Sengupta N,Propper D,Wilson P,Hagemann T,Patel A,Parker A,Ghosh A,Feakins R,Dorudi S,Suraweera N

更新日期：2012-03-01 00:00:00

abstract：:Previous literature, although not consistent, suggests that moderate alcohol consumption might be associated with decreased risk of renal cell carcinoma (RCC) in women. Thus, we examined the association between alcohol intake and the incidence of RCC by analyzing data from the Swedish Mammography Cohort, a population-...

journal_title：International journal of cancer

authors： Rashidkhani B,Akesson A,Lindblad P,Wolk A

更新日期：2005-12-10 00:00:00

abstract：:Complement-dependent cytotoxic antibodies to three cervical carcinoma cell lines (Me-180, SW-732 and HeLa) and to Herpes simplex virus type 2 (HSV-2)-infected cells were determined in a long-term study of women with cervical carcinoma. Cytolysis of surface antigens differed significantly between the cervical carcinoma...

journal_title：International journal of cancer

authors： Christenson B

更新日期：1977-11-15 00:00:00

abstract：:The E5 oncoprotein of human papillomavirus type 16 downregulates surface MHC Class I and interacts with the heavy chain of the MHC complex via the first hydrophobic domain, believed to form the first helical transmembrane region (TM1) of E5. TM1 contains 4 equally spaced di-leucine (LL1-LL4) motifs. Di-leucine motifs ...

journal_title：International journal of cancer

authors： Cortese MS,Ashrafi GH,Campo MS

更新日期：2010-04-01 00:00:00

abstract：:We evaluated cell survival, DNA double strand breaks (dsbs), and DNA synthesis following camptothecin (CPT) alone or concurrent CPT and X-radiation treatments in exponential-phase cultures of a radioresistant human melanoma cell line. Cell survival was measured by a clonogenic assay. DNA dsbs were measured by pulsed-f...

journal_title：International journal of cancer

authors： Ng CE,Mazaheri K,Payant C,Raaphorst GP

更新日期：2001-10-20 00:00:00

abstract：:We recently reported that standardized quantitative immunohistochemical (IHC) assays allowed prediction of an adverse outcome among 572 node negative (N-) patients with breast carcinoma (BrCa). To further validate our prior findings, we repeated the IHC stains including a second series of BrCa diagnosed at Yale Univer...

journal_title：International journal of cancer

authors： Charpin C,Tavassoli F,Secq V,Giusiano S,Villeret J,Garcia S,Birnbaum D,Bonnier P,Lavaut MN,Boubli L,Carcopino X,Iovanna J

更新日期：2012-08-01 00:00:00

abstract：:The SIL gene expression is increased in multiple cancers and correlates with the expression of mitotic spindle checkpoint genes and with increased metastatic potential. SIL regulates mitotic entry, organization of the mitotic spindle and cell survival. The E2F transcription factors regulate cell cycle progression by c...

journal_title：International journal of cancer

authors： Erez A,Chaussepied M,Castiel A,Colaizzo-Anas T,Aplan PD,Ginsberg D,Izraeli S

更新日期：2008-10-01 00:00:00

abstract：:MaTu is a novel agent which may be of relevance in human oncogenesis, and has 2 components. One of them, the exogenous MX (coding for protein p58X), is transmissible to human fibroblasts, to HeLa and to HeLa x fibroblast (H/F) hybrids. The other component, MN, is a cellular gene. Its product, the protein p54/58N, is i...

journal_title：International journal of cancer

authors： Závada J,Závadová Z,Pastoreková S,Ciampor F,Pastorek J,Zelník V

更新日期：1993-05-08 00:00:00

abstract：:The ability of verapamil to overcome resistance to adriamycin in a multidrug-resistant derivative of the V79 cell line (LZ), grown as multicellular spheroids or as monolayers, was examined. Verapamil was much less effective in overcoming resistance to adriamycin in spheroids than in monolayers. Verapamil increased the...

journal_title：International journal of cancer

authors： Sakata K,Kwok TT,Gordon GR,Waleh NS,Sutherland RM

更新日期：1994-10-15 00:00:00

abstract：:Oncogenic HPV types are the major cause of worldwide cervical cancer, but only a small proportion of infected women will develop high-grade cervical intraepithelial neoplasia or cancer (CIN2/3+). We performed a prospective study including 781 women with normal, atypical squamous cells of undetermined significance (ASC...

journal_title：International journal of cancer

authors： Dalstein V,Riethmuller D,Prétet JL,Le Bail Carval K,Sautière JL,Carbillet JP,Kantelip B,Schaal JP,Mougin C

更新日期：2003-09-01 00:00:00

abstract：:As many patients with mammary carcinoma are now treated by conservative forms of surgery, there is a need for prognostic information obtainable from the primary tumour alone. One possible source is the antigenic profile of tumour cells. Using an indirect immunoperoxidase technique, we stained histological sections of ...

journal_title：International journal of cancer

authors： Wilkinson MJ,Howell A,Harris M,Taylor-Papadimitriou J,Swindell R,Sellwood RA

更新日期：1984-03-15 00:00:00

abstract：:Risk factors for pancreatic cancer, other than smoking and diabetes, are not well-established, especially for women. In a cohort of 1.3 million middle-aged women, followed for 9.2 million person-years for cancer incidence and 11.5 million person-years for mortality, there were 1,338 incident pancreatic cancer cases an...

journal_title：International journal of cancer

authors： Stevens RJ,Roddam AW,Spencer EA,Pirie KL,Reeves GK,Green J,Beral V,Million Women Study Collaborators.

更新日期：2009-05-15 00:00:00

abstract：:UDP-glucuronosyltransferase 1A1 (UGT1A1) is an enzyme which catalyses not only the glucuronidation of tobacco smoke carcinogens like benzopyrene, but also of the endogenous substrate bilirubin. Bilirubin for a long time was considered to be only a toxic waste product of hemoglobin degradation, but recent findings have...

journal_title：International journal of cancer

authors： Lacko M,Roelofs HM,Te Morsche RH,Voogd AC,Ophuis MB,Peters WH,Manni JJ

更新日期：2010-12-15 00:00:00