Tobacco and occupation as risk factors in bladder cancer: a case-control study in southern Belgium.


:A pilot case-control study on bladder cancer, with population-based controls matched for each of 74 cases, has been conducted in two industrial areas of Southern Belgium in order to analyze the influence of tobacco use and occupation. Observed bladder cancer risk for smokers is more than 5 times higher than that for non-smokers, and the risk for people having an a priori hazardous occupation is about 3.5 times higher than that of other subjects. A dose-response relationship was found for tobacco exposure and duration of employment. It seems that the risk is increased in a log-linear way by these variables. Population attributable risks show that in 20 cases of bladder cancer, 17 could be explained by the two factors combined. This study also reveals an increased risk for metal workers, truck and engine drivers, coal-miners, and rubber and coal-tar workers. The risk for metal workers is specially high in the case of turners, metal fitters, blacksmiths, stokers and workers exposed to hot metal.


Int J Cancer


Schifflers E,Jamart J,Renard V




Has Abstract


1987-03-15 00:00:00












  • Type of alcoholic beverage and cancer of the oral cavity, pharynx and oesophagus in an Italian area with high wine consumption.

    abstract::The role of different types of alcoholic beverage on cancer of the upper digestive tract was investigated in a case-control study conducted in the northern part of Italy on 305 male cases of cancer of the oral cavity and pharynx, 288 of oesophageal cancer and 1621 controls admitted to hospital for acute, non-neoplasti...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Barra S,Franceschi S,Negri E,Talamini R,La Vecchia C

    更新日期:1990-12-15 00:00:00

  • NAD(P)H:quinone oxidoreductase (DT-diaphorase) activity and mRNA content in normal and neoplastic mouse lung epithelia.

    abstract::DT-diaphorase (DTD) is a flavoprotein which catalyzes obligate two-electron reduction of a diverse group of substrates. We have reported previously that non-tumorigenic mouse lung alveolar type-II pneumocytes have high DTD activity, while cell lines derived from lung tumors do not. In contrast, other investigators, us...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Thaete LG,Siegel D,Malkinson AM,Forrest GL,Ross D

    更新日期:1991-08-19 00:00:00

  • Cell-cell and cell-collagen interactions influence gelatinase production by human breast-carcinoma cell line 8701-BC.

    abstract::We previously produced evidence that the human mammary-carcinoma cell line 8701-BC expresses several metalloproteinases (MMP-1, -2, -9, and -10) and their tissue inhibitors). In order to obtain a better understanding of the environmental control over gelatinolytic activities, we have tested the enzyme production of 87...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Minafra S,Giambelluca C,Andriolo M,Pucci-Minafra I

    更新日期:1995-09-15 00:00:00

  • Global trends in oral and pharyngeal cancer incidence and mortality.

    abstract::To provide an up-to-date overview of recent trends in mortality from oral and pharyngeal cancer, we analyzed death certification data for 61 countries worldwide provided by the World Health Organization in 2010-2015, and, for selected most populous countries, over the period 1970-2016. For 12 largest countries, we ana...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bosetti C,Carioli G,Santucci C,Bertuccio P,Gallus S,Garavello W,Negri E,La Vecchia C

    更新日期:2020-08-15 00:00:00

  • Prevalence and clinical impact of TP53 germline mutations in Chinese women with breast cancer.

    abstract::The prevalence and clinical relevance of TP53 germline mutations in a large unselected breast cancer series are largely unknown. Here, we determined TP53 germline mutations in a large cohort of 10,053 unselected breast cancer patients through multigene panel-based next-generation and/or Sanger sequencing assays. We fo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sheng S,Xu Y,Guo Y,Yao L,Hu L,Ouyang T,Li J,Wang T,Fan Z,Fan T,Lin B,Xie Y

    更新日期:2020-01-15 00:00:00

  • Genetic variants in one-carbon metabolism genes and breast cancer risk in European American and African American women.

    abstract::Folate-mediated one-carbon metabolism plays critical roles in DNA synthesis, repair and DNA methylation. The impact of single nucleotide polymorphisms (SNPs) in folate-metabolizing enzymes has been investigated in risk of breast cancer among European or Asian populations, but not among women of African ancestry. We co...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Gong Z,Yao S,Zirpoli G,David Cheng TY,Roberts M,Khoury T,Ciupak G,Davis W,Pawlish K,Jandorf L,Bovbjerg DH,Bandera EV,Ambrosone CB

    更新日期:2015-08-01 00:00:00

  • Familial and second primary pancreatic cancers: a nationwide epidemiologic study from Sweden.

    abstract::Familial risk of pancreatic cancer has been mainly assessed through case-control studies based on reported but not medically verified cancers in family members. We used the nationwide Swedish Family-Cancer Database on 10.2 million individuals and 21,000 pancreatic cancers to calculate standardized incidence ratios (SI...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hemminki K,Li X

    更新日期:2003-02-10 00:00:00

  • Mammographic screening after the age of 65 years: evidence for a reduction in breast cancer mortality.

    abstract::We evaluated whether regular mammographic screening of women aged 65 years or older affected breast cancer mortality. In Nijmegen, a population-based screening program for breast cancer was started in 1975, with biennial mammography for women aged 35-64 years. Since 1977, elderly women have also been participating. Fo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Van Dijck JA,Verbeek AL,Beex LV,Hendriks JH,Holland R,Mravunac M,Straatman H,Werre JM

    更新日期:1996-06-11 00:00:00

  • COPD-dependent effects of genetic variation in key inflammation pathway genes on lung cancer risk.

    abstract::Genome-wide association studies (GWAS) have identified several loci contributing to lung cancer and COPD risk independently; however, inflammation-related pathways likely harbor additional lung cancer risk-associated variants in biologically relevant immune genes that differ dependent on COPD. We selected single nucle...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Watza D,Lusk CM,Dyson G,Purrington KS,Wenzlaff AS,Neslund-Dudas C,Soubani AO,Gadgeel SM,Schwartz AG

    更新日期:2020-08-01 00:00:00

  • Nanoparticle-based photothermal and photodynamic immunotherapy for tumor treatment.

    abstract::Nanoparticle-based phototherapies, such as photothermal therapy (PTT) and photodynamic therapy (PDT), exhibit strong efficacy, minimal invasion and negligible side effects in tumor treatment. These phototherapies have received considerable attention and been extensively studied in recent years. In addition to directly...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Hou X,Tao Y,Pang Y,Li X,Jiang G,Liu Y

    更新日期:2018-12-15 00:00:00

  • Novel function of Oncostatin M as a potent tumour-promoting agent in lung.

    abstract::Oncostatin M is a leukocyte product that has been reported to have anti-proliferative effects directly on melanoma and other cancer cell lines in vitro. However, its function(s) in cancers in vivo appears complex and its roles in cancer growth in lungs are unknown. Here, we show that OSM promotes marked growth of tumo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lauber S,Wong S,Cutz JC,Tanaka M,Barra N,Lhoták S,Ashkar A,Richards CD

    更新日期:2015-02-15 00:00:00

  • Gamma-glutamyltranspeptidase expression regulates the growth-inhibitory activity of the anti-tumor prodrug gamma-L-glutaminyl-4-hydroxy-3-iodobenzene.

    abstract::gamma-L-glutaminyl-4-hydroxy-3-iodobenzene (I-GHB), a novel iodinated analog of gamma-L-glutaminyl-4-hydroxybenzene (GHB), demonstrates greater anti-tumor activity in human and in murine melanoma cell lines. These phenolic amides are substrates for gamma-glutamyltranspeptidase (GGTP; E.C., a cell-membrane-ass...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Prezioso JA,Hughey RP,Wang N,Damodaran KM,Bloomer WD

    更新日期:1994-03-15 00:00:00

  • Mammary tumor latency is increased in mice lacking the inducible nitric oxide synthase.

    abstract::Nitric oxide (NO) and its metabolites are implicated in carcinogenesis and metastasis. Both stimulatory and inhibitory effects of NO have been reported in relation to breast cancer and its role in the development of malignancies and metastasis remains uncertain. We have used the polyomavirus middle T antigen (PyV-mT) ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ellies LG,Fishman M,Hardison J,Kleeman J,Maglione JE,Manner CK,Cardiff RD,MacLeod CL

    更新日期:2003-08-10 00:00:00

  • Predictors of level of circulating abnormal lymphocytes among human T-lymphotropic virus type I carriers in Japan.

    abstract::Human T-lymphotropic virus type I (HTLV-I) carriers often have abnormal lymphocytes (Ably) that resemble malignant cells of adult T-cell leukemia (ATL). To identify predictors of the level of Ably in a longitudinal study of asymptomatic HTLV-I carriers, we analyzed data from 215 subjects (67 men and 148 women) with mu...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hisada M,Okayama A,Tachibana N,Stuver SO,Spiegelman DL,Tsubouchi H,Mueller NE

    更新日期:1998-07-17 00:00:00

  • Characterization of a lung-cancer-associated auto-antigen.

    abstract::An antigen, protein X (Px), was purified from immune complexes isolated from malignant pleural effusions from patients with adenocarcinoma of the lung by EDTA treatment, PEG 8000 precipitation, protein A affinity chromatography, and Sephadex G-200 separation in the presence of 3 M NaCl. The purified antigen had a M(r)...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zeng CQ,Alpert LC,Alpert E

    更新日期:1992-10-21 00:00:00

  • Plasmacytoma induction in radiochimeras.

    abstract::We have induced plasmacytomas (MPC) in BALB/c radiochimeras (RCh) repopulated with syngeneic hemopoietic cells carrying distinctive chromosomal markers. A group of 38 RCh that received 0.5 ml pristane, followed by Abelson virus infection 2-3 weeks later, developed 7 tumors (18.5%) of donor origin after a relatively sh...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Silva S,Babonits M,Wiener F,Klein G

    更新日期:1989-08-15 00:00:00

  • Polymorphisms and haplotype structures in genes for transforming growth factor beta1 and its receptors in familial and unselected breast cancers.

    abstract::Alterations in TGF-beta signaling appear to be associated with an altered risk of developing cancer, including breast cancer. We carried out a case-control study on 8 polymorphisms, including 5 in the TGF-beta1 gene (G-800A, C-509T, Leu10-->Pro, Arg25-->Pro and Thr263-->Ile), a polyalanine polymorphism (9A-->6A) in th...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Jin Q,Hemminki K,Grzybowska E,Klaes R,Söderberg M,Zientek H,Rogozinska-Szczepka J,Utracka-Hutka B,Pamula J,Pekala W,Försti A

    更新日期:2004-10-20 00:00:00

  • Chromosome-9 loss detected by fluorescence in situ hybridization in bladder cancer.

    abstract::A loss of chromosome-9 material is one of the most frequent genomic aberrations known in bladder cancer. In order to better understand the role of chromosome-9 losses in bladder cancer, 125 formalin-fixed and 37 unfixed bladder tumors were examined using fluorescence in situ hybridization (FISH). A repetitive probe fo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sauter G,Moch H,Carroll P,Kerschmann R,Mihatsch MJ,Waldman FM

    更新日期:1995-04-21 00:00:00

  • Brain-derived neurotrophic factor is a potential osteoclast stimulating factor in multiple myeloma.

    abstract::Multiple myeloma (MM) is characterized by accumulation of monoclonal plasma cells in the bone marrow and progression of lytic bone lesions. The mechanisms of enhanced bone resorption in patients with myeloma are not fully defined. We have previously identified the role of brain-derived neurotrophic factor (BDNF) in pr...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sun CY,Chu ZB,She XM,Zhang L,Chen L,Ai LS,Hu Y

    更新日期:2012-02-15 00:00:00

  • Anxiety and distress following receipt of results from routine HPV primary testing in cervical screening: The psychological impact of primary screening (PIPS) study.

    abstract::We used a cross-sectional survey to examine short-term anxiety and distress in women receiving different results following routine human papillomavirus (HPV) primary testing at cervical screening. Participants were women aged 24-65 (n = 1,127) who had attended screening at one of five sites piloting HPV primary screen...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: McBride E,Marlow LAV,Forster AS,Ridout D,Kitchener H,Patnick J,Waller J

    更新日期:2020-04-15 00:00:00

  • Trends in childhood acute lymphoblastic leukemia in Western Australia, 1960-2006.

    abstract::Increases in the incidence of childhood acute lymphoblastic leukemia (ALL) have been reported in some countries, while other reports from similar geographical regions have indicated stable rates. The reasons for the discrepancies have been debated in the literature, with the focus on whether the observed increases are...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Milne E,Laurvick CL,de Klerk N,Robertson L,Thompson JR,Bower C

    更新日期:2008-03-01 00:00:00

  • Treatment of oral leukoplakia with a low-dose of beta-carotene and vitamin C supplements: a randomized controlled trial.

    abstract::Management of oral leukoplakia-a potentially malignant disorder-is currently not evidence-based. Of the few randomized trials that have been reported, most have negative data. Therefore, a multi-centre, randomized, double-blind controlled trial (RCT) was undertaken to evaluate the use of low-dose beta-carotene combine...

    journal_title:International journal of cancer

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Nagao T,Warnakulasuriya S,Nakamura T,Kato S,Yamamoto K,Fukano H,Suzuki K,Shimozato K,Hashimoto S

    更新日期:2015-04-01 00:00:00

  • Adolescent and mid-life diet and subsequent risk of thyroid cancer in the NIH-AARP diet and health study.

    abstract::Although thyroid cancer is suspected to have a nutritional etiology, prospective studies examining the relationship between diet and thyroid cancer are lacking. During 1996-1997, NIH-AARP Diet and Health Study participants, ages 51-72 years, completed a 37-item food frequency questionnaire about diet at ages 12-13 yea...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Braganza MZ,Potischman N,Park Y,Thompson FE,Hollenbeck AR,Kitahara CM

    更新日期:2015-11-15 00:00:00

  • LAF-4 is aberrantly expressed in human breast cancer.

    abstract::LAF-4, which encodes a nuclear protein with transactivation potential, is fused to the MLL gene in acute lymphoblastic leukemia (ALL). We identified LAF-4 as a gene that is transcriptionally deregulated in breast tumors and thus may have a pathological role in mammary tumorigenesis. In line with the previous finding t...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: To MD,Faseruk SA,Gokgoz N,Pinnaduwage D,Done SJ,Andrulis IL

    更新日期:2005-07-01 00:00:00

  • Overcoming evasive resistance from vascular endothelial growth factor a inhibition in sarcomas by genetic or pharmacologic targeting of hypoxia-inducible factor 1α.

    abstract::Increased levels of hypoxia and hypoxia-inducible factor 1α (HIF-1α) in human sarcomas correlate with tumor progression and radiation resistance. Prolonged antiangiogenic therapy of tumors not only delays tumor growth but may also increase hypoxia and HIF-1α activity. In our recent clinical trial, treatment with the v...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kim YJ,Lee HJ,Kim TM,Eisinger-Mathason TS,Zhang AY,Schmidt B,Karl DL,Nakazawa MS,Park PJ,Simon MC,Yoon SS

    更新日期:2013-01-01 00:00:00

  • Nonsteroidal anti-inflammatory drugs and risk of lung cancer.

    abstract::Regular aspirin and non-aspirin nonsteroidal anti-inflammatory drug (NSAID) use is associated with a reduced risk of colorectal cancer. The effect of NSAIDs on the risk of other cancers remains unclear. To evaluate whether use of aspirin or other specific NSAIDs protects against lung cancer, we conducted a case-contro...

    journal_title:International journal of cancer

    pub_type: 杂志文章,随机对照试验


    authors: Hernández-Díaz S,García Rodríguez LA

    更新日期:2007-04-01 00:00:00

  • The advantage of residualizing radiolabels for targeting B-cell lymphomas with a radiolabeled anti-CD22 monoclonal antibody.

    abstract::CD22 antibodies (Abs) bound to B-cell lymphomas are known to be internalized and catabolized rapidly. Therefore, it would be expected that use of CD22 as a target for radioimmunotherapy should be enhanced by the use of "residualizing" radiolabels, which are trapped within the cell after catabolism of the Ab to which t...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mattes MJ,Shih LB,Govindan SV,Sharkey RM,Ong GL,Xuan H,Goldenberg DM

    更新日期:1997-05-02 00:00:00

  • Epstein-Barr virus antibody patterns preceding the diagnosis of non-Hodgkin's lymphoma.

    abstract::Immunosuppressed patients who develop non-Hodgkin's lymphoma (NHL) have abnormal antibody responses against the Epstein-Barr virus (EBV) prior to the diagnosis of malignancy. To see if this is also true of "spontaneous" cases in the general population, we undertook a collaborative serologic case-control study. From 4 ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mueller N,Mohar A,Evans A,Harris NL,Comstock GW,Jellum E,Magnus K,Orentreich N,Polk BF,Vogelman J

    更新日期:1991-09-30 00:00:00

  • Antigen shedding vs. development of natural suppressor cells as mechanism of tumor escape in mice bearing Ehrlich tumor.

    abstract::C57BL/6J mice immunized with devitalized Ehrlich tumor (ET) cells produce high serum levels of IgM antibodies to ET cell-surface carbohydrates that are critical in the observed resistance against this tumor. However, this response is not found in ET-bearing mice at any stage of tumor development. Since previous studie...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Viñuela JE,Rodriguez R,Gil J,Coll J,De la Concha EG,Subiza JL

    更新日期:1991-01-02 00:00:00

  • Transforming growth factor-beta1 enhances the invasiveness of human MDA-MB-231 breast cancer cells by up-regulating urokinase activity.

    abstract::Transforming growth factor-beta (TGFbeta1) enhances human MDA-MB-231 breast tumour cell invasion of reconstituted basement membrane in vitro but does not inhibit proliferation of this cell line. In contrast to basal invasion, which is plasmin-, urokinase (uPA)-, tissue-type plasminogen activator (t-PA)-, matrix metall...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Farina AR,Coppa A,Tiberio A,Tacconelli A,Turco A,Colletta G,Gulino A,Mackay AR

    更新日期:1998-03-02 00:00:00