Occupational exposure to polyvinyl chloride as a risk factor for testicular cancer evaluated in a case-control study.

abstract：:Cancer-germline genes (CGGs) code for immunogenic antigens that are present on various human tumors but not on normal tissues. The importance of CGGs in cancer immunotherapy has led to detailed studies of their expression in a range of human tumors. We measured the levels of expression of 12 CGGs in various pediatric ...

journal_title：International journal of cancer

authors： Jacobs JF,Brasseur F,Hulsbergen-van de Kaa CA,van de Rakt MW,Figdor CG,Adema GJ,Hoogerbrugge PM,Coulie PG,de Vries IJ

更新日期：2007-01-01 00:00:00

abstract：:The serine protease urokinase-type plasminogen activator (uPA) plays a significant role in tumor cell invasion and metastasis when bound to its specific receptor, uPAR (also known as CD87). In addition to the uPA-uPAR system, matrix metalloproteinases (MMPs) are involved in tumor cell invasion and metastasis. In this ...

journal_title：International journal of cancer

authors： Kunigal S,Lakka SS,Gondi CS,Estes N,Rao JS

更新日期：2007-11-15 00:00:00

abstract：:To investigate whether human melanoma cells intrinsically resistant to autologous LAKs do exist, and whether a relationship between the level of lysis of LAKs and spontaneous drug resistance can be identified at the clonal level, we studied 44 clones obtained from a metastatic melanoma lesion. The antigenic phenotype ...

journal_title：International journal of cancer

authors： Gambacorti-Passerini C,Rivoltini L,Supino R,Mariani M,Parmiani G

更新日期：1988-10-15 00:00:00

abstract：:Microspheres containing cisplatin (CDDP) embedded in poly-d,l-lactic acid (PLA) and polyethylene glycol acid (CDDP-PPMS) were developed to improve treatment of malignant effusions. In vitro studies demonstrated that CDDP was released continuously for more than 4 weeks from CDDP-PPMS without initial burst. CDDP-PPMS wa...

journal_title：International journal of cancer

authors： Tokuda K,Natsugoe S,Shimada M,Kumanohoso T,Baba M,Takao S,Nakamura K,Yamada K,Yoshizawa H,Hatate Y,Aikou T

更新日期：1998-05-29 00:00:00

abstract：:Extensive hypermethylation and consecutive transcriptional silencing of tumorsuppressor genes have been documented in multiple tumor entities including breast cancer. In a microarray based genome-wide methylation analysis of five sporadic breast carcinomas we identified a hypermethylated CpG island within the first in...

journal_title：International journal of cancer

authors： Versmold B,Felsberg J,Mikeska T,Ehrentraut D,Köhler J,Hampl JA,Röhn G,Niederacher D,Betz B,Hellmich M,Pietsch T,Schmutzler RK,Waha A

更新日期：2007-08-01 00:00:00

abstract：:Some ovarian cancer cells in vivo are in a reversible quiescent state where they can contribute to cancer spread under favorable growth conditions. The serine/threonine kinase Mirk/dyrk1B was expressed in each of seven ovarian cancer cell lines and in 21 of 28 resected human ovarian cancers, and upregulated in 60% of ...

journal_title：International journal of cancer

authors： Hu J,Nakhla H,Friedman E

更新日期：2011-07-15 00:00:00

abstract：:A hamster lymphoid cell line, HCT-2, transformed by human T-cell leukemia virus type I (HTLV-I) was serially transplanted for 9 passages in newborn hamsters. A total of 34 newborn hamsters inoculated intraperitoneally (i.p.) with 0.2-2 X 10(7) HCT-2 cells developed fatal lymphomas with dissemination to various organs ...

journal_title：International journal of cancer

authors： Eguchi T,Kubonishi I,Daibata M,Yano S,Imamura J,Ohtsuki Y,Miyoshi I

更新日期：1988-06-15 00:00:00

abstract：:Cancers of the stomach, pancreas, colon and rectum are increasingly regarded as being diet-influenced. Migrants to Australia from England, Scotland, Ireland, Poland, Yugoslavia, Greece, and Italy have come from countries with varied dietary backgrounds and gastrointestinal cancer risks. Age-standardized cancer death r...

journal_title：International journal of cancer

authors： McMichael AJ,McCall MG,Hartshorne JM,Woodings TL

更新日期：1980-04-15 00:00:00

abstract：:Cytological screening for cervical cancer is hampered by high false negative rates. Inter-observer reproducibility needs optimizing. The potential of p16(INK4a) as a biomarker for cervical lesions was examined in a study of liquid-based cytology (LBC), HPV DNA testing by MY09/MY11 consensus PCR and type-specific PCRs ...

journal_title：International journal of cancer

authors： Sahebali S,Depuydt CE,Segers K,Moeneclaey LM,Vereecken AJ,Van Marck E,Bogers JJ

更新日期：2004-03-01 00:00:00

abstract：:Cell kinetics is a predictive parameter of breast-cancer aggressiveness, and mutations occurring in mammary tumorigenesis may favor uncontrolled cell proliferation. In this study, cell kinetics, clinico-pathological characteristics and genetic alterations at the int-2, bcl-1, c-myc, c-erbB-2, and DF3 loci were analyze...

journal_title：International journal of cancer

authors： Contegiacomo A,Pizzi C,De Marchis L,Alimandi M,Delrio P,Di Palma E,Petrella G,Ottini L,French D,Frati L

更新日期：1995-03-29 00:00:00

abstract：:The enzyme alpha1,3galactosyltransferase synthesizes the alphaGal epitope, a carbohydrate structure (Galalpha1,3Galbeta1,4GlcNAc-R), on glycoconjugates in lower mammals. The enzyme is absent in humans but large amounts of natural antibodies that recognize alphaGal epitopes are present in human serum. It is likely that...

journal_title：International journal of cancer

authors： Aubert M,Crotte C,Bernard JP,Lombardo D,Sadoulet MO,Mas E

更新日期：2003-12-20 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is an epithelial tumor uniquely prevalent in southern Chinese. HLA-A2 is associated with NPC. In a previous study, we showed that the genes associated with susceptibility to NPC are primarily located within the HLA-A locus in Taiwanese NPC patients. However, the pathogenic genes causing ...

journal_title：International journal of cancer

authors： Lu CC,Chen JC,Tsai ST,Jin YT,Tsai JC,Chan SH,Su IJ

更新日期：2005-07-10 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) receptors constitute a family of transmembrane proteins that bind TGF-beta ligands. In this study we assessed the growth responsiveness to TGF-beta 1 in pancreatic cancer cell lines and characterized the levels of expression of TGF-beta receptors in these cell lines and in hu...

journal_title：International journal of cancer

authors： Baldwin RL,Friess H,Yokoyama M,Lopez ME,Kobrin MS,Büchler MW,Korc M

更新日期：1996-07-17 00:00:00

abstract：:We describe the anatomic and histologic presentation and prognosis of non-Hodgkin's lymphoma (NHL) among people with AIDS (PWA) and determine their contribution to the NHL burden. We linked AIDS and cancer registries in selected areas of the United States and compared NHL sites and histologies in PWA and non-PWA, afte...

journal_title：International journal of cancer

authors： Coté TR,Biggar RJ,Rosenberg PS,Devesa SS,Percy C,Yellin FJ,Lemp G,Hardy C,Geodert JJ,Blattner WA

更新日期：1997-11-27 00:00:00

abstract：:The diagnostic specificity of the detection of disseminated prostatic cells by reverse-transcriptase polymerase chain reaction (RT-PCR) of PSA mRNA was investigated. A sensitive nested PCR was developed. In blood samples from 10 healthy female and 10 healthy male persons examined by RT-PCR, mRNA of PSA was detected 3 ...

journal_title：International journal of cancer

authors： Henke W,Jung M,Jung K,Lein M,Schlechte H,Berndt C,Rudolph B,Schnorr D,Loening SA

更新日期：1997-01-06 00:00:00

abstract：:Although childhood exposure to ionizing radiation is a well-established risk factor for thyroid cancer, the risk associated with adulthood exposure remains unclear. We prospectively examined the association between cumulative, low-to-moderate dose occupational radiation exposure to the thyroid and thyroid cancer incid...

journal_title：International journal of cancer

authors： Kitahara CM,Preston DL,Neta G,Little MP,Doody MM,Simon SL,Sigurdson AJ,Alexander BH,Linet MS

更新日期：2018-11-01 00:00:00

abstract：:Twin studies suggest a familial aggregation of bladder cancer but elements of this increased familial risk of bladder cancer are not well understood. To characterize familial risk of bladder cancer, we examined the relationship between family history of bladder and other types of cancer among first-degree relatives an...

journal_title：International journal of cancer

authors： Koutros S,Decker KL,Baris D,Pardo LA,Johnson A,Hosain GMM,Rothman N,Karagas MR,Schwenn MR,Silverman DT

更新日期：2021-01-27 00:00:00

abstract：:The cystine/glutamate antiporter, system xc- , is essential for the efficient uptake of cystine into cells. Interest in the mechanisms of system xc- function soared with the recognition that system xc- presents the most upstream node of ferroptosis, a recently described form of regulated necrosis relevant for degenera...

journal_title：International journal of cancer

authors： Sato M,Onuma K,Domon M,Hasegawa S,Suzuki A,Kusumi R,Hino R,Kakihara N,Kanda Y,Osaki M,Hamada J,Bannai S,Feederle R,Buday K,Angeli JPF,Proneth B,Conrad M,Okada F,Sato H

更新日期：2020-12-01 00:00:00

abstract：:Subcellular distribution of hexokinase (HK) isoenzymes in 22 human breast cancers (21 primary cancers and 1 axillary metastatic growth) and 7 non-pathological human mammary gland tissue samples was studied with starch gel electrophoresis on isolated cell fractions obtained by differential centrifugation. Fractions use...

journal_title：International journal of cancer

authors： Gudnason V,Ingvarsson S,Jonasdottir A,Andresdottir V,Egilsson V

更新日期：1984-07-15 00:00:00

abstract：:It is well known that certain cancers have shown clustering in socioeconomic groups, but limited data are available on recent results and time trends in such clustering. We determined standardized incidence ratios (SIR) for cancer, adjusted for age, period, region, parity and age at first childbirth among men and wome...

journal_title：International journal of cancer

authors： Hemminki K,Zhang H,Czene K

更新日期：2003-07-10 00:00:00

abstract：:Telomerase activity is considered to be a diagnostic marker of malignancy since most malignant cells express this activity and most somatic cells do not. However, the detection of telomerase activity is rather complicated and is affected by many factors. Recently, human telomerase components were cloned and found to c...

journal_title：International journal of cancer

authors： Sumida T,Hamakawa H,Sogawa K,Sugita A,Tanioka H,Ueda N

更新日期：1999-01-05 00:00:00

abstract：:Increases in the incidence of childhood acute lymphoblastic leukemia (ALL) have been reported in some countries, while other reports from similar geographical regions have indicated stable rates. The reasons for the discrepancies have been debated in the literature, with the focus on whether the observed increases are...

journal_title：International journal of cancer

authors： Milne E,Laurvick CL,de Klerk N,Robertson L,Thompson JR,Bower C

更新日期：2008-03-01 00:00:00

abstract：:Ninety-eight cases of transitional-cell carcinoma (TCC) of the renal pelvis and ureter, including dysplastic lesions, were studied for tumor incorporation of human papillomavirus (HPV) type-16 and type-18 DNA by in situ hybridization (ISH) with DNA probes for each HPV viral type. Immunohistochemical analysis of p53 ex...

journal_title：International journal of cancer

authors： Furihata M,Yamasaki I,Ohtsuki Y,Sonobe H,Morioka M,Yamamoto A,Terao N,Kuwahara M,Fujisaki N

更新日期：1995-10-20 00:00:00

abstract：:Multiple drug resistance (MDR) is a problem that seriously reduces the efficacy of many chemotherapy agents. One mechanism for MDR is increased acidification of endocytic vesicles and increased cytosol pH, so weak base chemotherapeutic agents, including doxorubicin, are trapped in endocytic vesicles and exhibit a drug...

journal_title：International journal of cancer

authors： Lou PJ,Lai PS,Shieh MJ,Macrobert AJ,Berg K,Bown SG

更新日期：2006-12-01 00:00:00

abstract：:The mechanism of tumor cell killing by OXI4503 was investigated by studying vascular functional and morphological changes post drug administration. SCID mice bearing MHEC5-T hemangioendothelioma were given a single dose of OXI4503 at 100 mg/kg. Tumor blood flow, measured by microsphere fluorescence, was reduced by 50%...

journal_title：International journal of cancer

authors： Sheng Y,Hua J,Pinney KG,Garner CM,Kane RR,Prezioso JA,Chaplin DJ,Edvardsen K

更新日期：2004-09-10 00:00:00

abstract：:A population-based case-control study of gastric cancer was conducted in areas with contrasting incidence rates in Sweden. Face-to-face interviews were carried out with 338 (74.1%) of all eligible cases and 679 (77.3%) of the selected controls. Consumption of selected nutrients during adolescence and 20 years prior to...

journal_title：International journal of cancer

authors： Hansson LE,Nyrén O,Bergström R,Wolk A,Lindgren A,Baron J,Adami HO

更新日期：1994-06-01 00:00:00

abstract：:The murine B16 melanoma (H-2b) was transfected with a retroviral vector containing the mouse IFN-alpha 1 gene. IFN-alpha 1-transfected cells produced IFN-alpha in vitro and exhibited an altered phenotype characterized by a decreased rate of multiplication, enhanced expression of H-2 antigens, an antiviral state to VSV...

journal_title：International journal of cancer

authors： Kaido T,Bandu MT,Maury C,Ferrantini M,Belardelli F,Gresser I

更新日期：1995-01-17 00:00:00

abstract：:Our study directly compares the performance of liquid-based (LBC) and conventional cytology for detecting high-grade cervical intraepithelial neoplasia and cancer (CIN 2+) in high-risk, previously unscreened women. As part of a larger randomized clinical trial assessing the efficacy and safety of a "screen and treat" ...

journal_title：International journal of cancer

authors： Taylor S,Kuhn L,Dupree W,Denny L,De Souza M,Wright TC Jr

更新日期：2006-02-15 00:00:00

abstract：:NDRG3 belongs to the N-myc down-regulated gene (NDRG) family that contains 4 paralogs: NDRG1, -2, -3 and -4. The function of NDRG3 and its relationship to cancer has not been studied. We herein report our examination of the expression and biological roles of NDRG3 in prostate cancers. We showed that NDRG3 expression i...

journal_title：International journal of cancer

authors： Wang W,Li Y,Li Y,Hong A,Wang J,Lin B,Li R

更新日期：2009-02-01 00:00:00

abstract：:Myf-3 is the human homologue of the murine Myo-D1 gene involved in muscle-cell differentiation. Using Southern blot analysis, we examined methylation of Myf-3 in histologically normal colonic mucosae, adenomas and carcinomas from a large series of patients with primary colorectal cancer. Hypermethylation of this gene ...

journal_title：International journal of cancer

authors： Shannon B,Kay P,House A,Iacopetta B

更新日期：1999-04-20 00:00:00