Human melanoma cells can be killed in vitro by an immunotoxin specific for melanoma-associated antigen p97.

abstract：:Inflammation, and more generally, the immune response are thought to influence the development of prostate cancer. To determine the components of the immune response that are potentially contributory, we prospectively evaluated the association of immune-mediated conditions, asthma and hayfever, with lethal prostate ca...

journal_title：International journal of cancer

authors： Platz EA,Drake CG,Wilson KM,Sutcliffe S,Kenfield SA,Mucci LA,Stampfer MJ,Willett WC,Camargo CA Jr,Giovannucci E

更新日期：2015-08-15 00:00:00

abstract：:Hepatocellular carcinoma (HCC) development entails changes in liver metabolism. Current knowledge on metabolic perturbations in HCC is derived mostly from case-control designs, with sparse information from prospective cohorts. Our objective was to apply comprehensive metabolite profiling to detect metabolites whose se...

journal_title：International journal of cancer

authors： Stepien M,Keski-Rahkonen P,Kiss A,Robinot N,Duarte-Salles T,Murphy N,Perlemuter G,Viallon V,Tjønneland A,Rostgaard-Hansen AL,Dahm CC,Overvad K,Boutron-Ruault MC,Mancini FR,Mahamat-Saleh Y,Aleksandrova K,Kaaks R,Kühn T,

更新日期：2021-02-01 00:00:00

abstract：:Streptovaricins (Sv), ansa macrolide antibiotics, inhibited Rauscher leukemia virus (RLV) splenomegaly by 25-50%. All streptovaricins tested were effective when administered orally either by diet ad lib or by intubation from infection to time of killing. When delivered by intubation, Sv was measurable in plasma for up...

journal_title：International journal of cancer

authors： Borden EC,Carter WA,Sensenbrenner LL,Owens AH,Lichtenstein J,Gray GD,Neil GL,Nichol FR,Li LH

更新日期：1974-12-15 00:00:00

abstract：:Melanoma of unknown primary (MUP) may have a different biology to melanoma of known primary, but clinical trials of novel therapies (e.g., immune checkpoint or BRAF/MEK inhibitors) have not reported the outcomes in this population. We therefore evaluated the overall survival (OS) among patients with MUP in the era of ...

journal_title：International journal of cancer

authors： Verver D,van der Veldt A,van Akkooi A,Verhoef C,Grünhagen DJ,Louwman WJ

更新日期：2020-01-01 00:00:00

abstract：:To identify characteristics of gastric cancer associated with hereditary non-polyposis colorectal cancer (HNPCC), we gathered clinical data and tumor samples relating to patients recorded in the Finnish HNPCC registry. Our series included 51 families with a characterized mutation and/or that met the Amsterdam criteria...

journal_title：International journal of cancer

authors： Aarnio M,Salovaara R,Aaltonen LA,Mecklin JP,Järvinen HJ

更新日期：1997-10-21 00:00:00

abstract：:Hepatocellular carcinoma is the second leading cause of cancer deaths worldwide. It is characterized by unique features that can be utilized for selective and targeted therapy, which aids in preserving healthy tissues from deteriorating effects of traditional chemotherapeutics. In this minireview, a brief overview of ...

journal_title：International journal of cancer

authors： Mohamed NK,Hamad MA,Hafez MZ,Wooley KL,Elsabahy M

更新日期：2017-04-01 00:00:00

abstract：:This report describes maternal and perinatal risk factors for Wilms' tumor analyzed in a case-control study nested in a nationwide cohort in Sweden. The Swedish National Cancer Registry ascertained 110 cases from among successive birth cohorts from 1973 through 1984, identified by the Swedish Medical Birth Registry, t...

journal_title：International journal of cancer

authors： Lindblad P,Zack M,Adami HO,Ericson A

更新日期：1992-04-22 00:00:00

abstract：:A correlation analysis was performed on 125 cytogenetically characterized breast cancer cases to assess the relationship between the tumor karyotype and clinicopathologic features. The carcinomas of young women had a higher modal chromosome number than those of older women. The number of chromosomal aberrations and mo...

journal_title：International journal of cancer

authors： Pandis N,Idvall I,Bardi G,Jin Y,Gorunova L,Mertens F,Olsson H,Ingvar C,Beroukas K,Mitelman F,Heim S

更新日期：1996-04-10 00:00:00

abstract：:Heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) is a member of the EGF family of polypeptide growth factors, which includes EGF, transforming growth factor alpha(TGF-alpha), amphiregulin (AR) and betacellulin (BTC). To assess the potential role of HB-EGF in human gastric carcinomas, the expre...

journal_title：International journal of cancer

authors： Naef M,Yokoyama M,Friess H,Büchler MW,Korc M

更新日期：1996-05-03 00:00:00

abstract：:A family history of stomach cancer in first-degree relatives increases the risk of stomach cancer, but uncertainties remain as concerns the variation of the risk according to age, sex and type of relative, as well as on the role of family history of other cancers. We investigated the issue using data from a multicentr...

journal_title：International journal of cancer

authors： Foschi R,Lucenteforte E,Bosetti C,Bertuccio P,Tavani A,La Vecchia C,Negri E

更新日期：2008-09-15 00:00:00

abstract：:In sub-Saharan Africa, invasive cervical cancer (ICC) incidence and mortality are among the highest in the world. This cross-sectional epidemiological study assessed human papillomavirus (HPV) prevalence and type distribution in women with ICC in Ghana, Nigeria, and South Africa. Cervical biopsy specimens were obtaine...

journal_title：International journal of cancer

authors： Denny L,Adewole I,Anorlu R,Dreyer G,Moodley M,Smith T,Snyman L,Wiredu E,Molijn A,Quint W,Ramakrishnan G,Schmidt J

更新日期：2014-03-15 00:00:00

abstract：:Interleukin-12 (IL-12) has potent antitumor activities via natural killer cells and cytotoxic T lymphocytes. However, the molecular mechanisms whereby IL-12 induces tumoricidal activities are poorly understood. Here, we report the genome-wide analysis of gene expression in a primary murine mammary carcinoma model that...

journal_title：International journal of cancer

authors： Shi X,Liu J,Xiang Z,Mitsuhashi M,Wu RS,Ma X

更新日期：2004-07-01 00:00:00

abstract：:Recently, air pollution has been classified as a carcinogen largely on the evidence of epidemiological studies of lung cancer. However, there have been few prospective studies that have evaluated associations between fine particulate matter (PM2.5 ) and cancer at lower concentrations. We conducted a prospective analys...

journal_title：International journal of cancer

authors： Tomczak A,Miller AB,Weichenthal SA,To T,Wall C,van Donkelaar A,Martin RV,Crouse DL,Villeneuve PJ

更新日期：2016-11-01 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract. These tumors span a wide clinical spectrum from benign to malignant and have long been recognized for their nearly absolute resistance to chemotherapy and radiation treatment. We reviewed the worldwide experience on ...

journal_title：International journal of cancer

authors： Rossi CR,Mocellin S,Mencarelli R,Foletto M,Pilati P,Nitti D,Lise M

更新日期：2003-11-01 00:00:00

abstract：:Following exposure to feline leukemia virus (FeLV), cats that resist leukemia produce complement dependent antibodies (CDA) which lyse leukemia cells in the presence of cat complement. The CDA activity has been shown to be directed to feline oncornavirus-associated cell membrane antigen (FOCMA) found on the surface of...

journal_title：International journal of cancer

authors： Grant CK,Michalek MT

更新日期：1981-08-15 00:00:00

abstract：:The specific aim of three-dimensional conformal radiotherapy is to deliver adequate therapeutic radiation dose to the target volume while concomitantly keeping the dose to surrounding and intervening normal tissues to a minimum. The objective of this study is to examine dose distributions produced by various radiother...

journal_title：International journal of cancer

authors： Ahmad M,Nath R

更新日期：2001-02-20 00:00:00

abstract：:The antiproliferative effect of 2',5' A3 core and 2',5'-3'dA3 (cordycepin trimer) core was measured in 8 human tumor cell lines. Cells were treated in a dose-response manner for 72 hr and the concentration of drug necessary to inhibit cell growth 50% (GI50) was determined. A wide range of sensitivities to these drugs ...

journal_title：International journal of cancer

authors： Hubbell HR,Pequignot EC,Willis DH,Lee C,Suhadolnik RJ

更新日期：1985-09-15 00:00:00

abstract：:We present data on test positivity, relative sensitivity, rates of detection and relative specificity for primary human papillomavirus (HPV) testing with different cutoff levels for test positivity, in comparison to conventional cytology. In 2003-2004, 18,438 women were screened primarily with Hybrid Capture 2 (HC 2) ...

journal_title：International journal of cancer

authors： Kotaniemi-Talonen L,Malila N,Nieminen P,Anttila A,Tarkkanen J,Laurila P,Hakama M

更新日期：2008-12-15 00:00:00

abstract：:Serum alkaline DNase activity (SADA) was investigated in rats receiving s.c. transplants of tumor cells sensitive or resistant to chemotherapy. Serum samples from each animal were collected before transplantation, during the development of tumors and after therapy. Within a few days after transplantation of both tumor...

journal_title：International journal of cancer

authors： Economidou-Karaoglou A,Brasseur F,Lans M,Taper HS,Roberfroid MB

更新日期：1989-05-15 00:00:00

abstract：:Obesity is considered a chronic inflammatory state characterized by continued secretion of adipokines and cytokines. Experimental and epidemiological evidence indicates that circulating adipokines may be associated with the development of obesity-related cancers, but it is unclear if these associations are causal or c...

journal_title：International journal of cancer

authors： Dimou NL,Papadimitriou N,Mariosa D,Johansson M,Brennan P,Peters U,Chanock SJ,Purdue M,Bishop DT,Gago-Dominquez M,Giles GG,Moreno V,Platz EA,Tangen CM,Wolk A,Zheng W,Wu X,Campbell PT,Giovannucci E,Lin Y,CCFR, Endom

更新日期：2020-10-10 00:00:00

abstract：:Cholangiocarcinoma is the second most common primary hepatic cancer, with a rising incidence worldwide. Owing to late diagnosis and limited treatment options, the prognosis for cholangiocarcinoma remains dismal, compelling a search for new treatments. As aspirin exhibits a well-supported chemopreventive effect on comm...

journal_title：International journal of cancer

authors： Shen X,Shen X

更新日期：2021-03-15 00:00:00

abstract：:Using a method optimized in hepatocellular carcinoma (HCC), we established patient-derived xenograft (PDX) models with an increased take rate (42.2%) and demonstrated that FBS +10% dimethyl sulfoxide exhibited the highest tumor take rate efficacy. Among 254 HCC patients, 103 stably transplantable xenograft lines that ...

journal_title：International journal of cancer

authors： Hu B,Li H,Guo W,Sun YF,Zhang X,Tang WG,Yang LX,Xu Y,Tang XY,Ding GH,Qiu SJ,Zhou J,Li YX,Fan J,Yang XR

更新日期：2020-03-15 00:00:00

abstract：:Malignant activation of oncogenes ras or trk is implicated in a number of solid tumors and leukemias. We determined the chemosensitivity profile of wild-type mouse NIH-3T3 fibroblasts, and that of NIH-3T3 lines transformed by the H-ras (S2-721) and trk (106-632) oncogenes, against 11 different drugs from various class...

journal_title：International journal of cancer

authors： Peters GJ,Wets M,Keepers YP,Oskam R,van Ark-Otte J,Noordhuis P,Smid K,Pinedo HM

更新日期：1993-05-28 00:00:00

abstract：:Ninety-eight cases of transitional-cell carcinoma (TCC) of the renal pelvis and ureter, including dysplastic lesions, were studied for tumor incorporation of human papillomavirus (HPV) type-16 and type-18 DNA by in situ hybridization (ISH) with DNA probes for each HPV viral type. Immunohistochemical analysis of p53 ex...

journal_title：International journal of cancer

authors： Furihata M,Yamasaki I,Ohtsuki Y,Sonobe H,Morioka M,Yamamoto A,Terao N,Kuwahara M,Fujisaki N

更新日期：1995-10-20 00:00:00

abstract：:Little research has been conducted on the long-term value of human papillomavirus (HPV) testing after conization. We investigated whether cytology adds to the value of a negative HPV test for long-term prediction of cervical intraepithelial neoplasia grade 2 or worse (CIN2+). In addition, we compared risk of CIN2+ fol...

journal_title：International journal of cancer

authors： Gosvig CF,Huusom LD,Andersen KK,Duun-Henriksen AK,Frederiksen K,Iftner A,Svare E,Iftner T,Kjaer SK

更新日期：2015-12-15 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in variety of cancer cells without affecting most normal cells, which makes it a promising agent for cancer therapy. However, TRAIL therapy is clinically not effective due to resistance induction. To identify novel regulators of TRAIL th...

journal_title：International journal of cancer

authors： Thapa B,Bahadur Kc R,Uludağ H

更新日期：2018-02-01 00:00:00

abstract：:There is a well-established link between inflammation and cancer of various organs, but little data are available on inflammation-associated markers of diagnostic and prognostic clinical utility in pulmonary malignancy. Blood samples were prospectively collected from 75 resectable lung cancer patients before surgery a...

journal_title：International journal of cancer

authors： Infante M,Allavena P,Garlanda C,Nebuloni M,Morenghi E,Rahal D,Roncalli M,Cavuto S,Pesce S,Monari M,Valaperta S,Montanelli A,Solomon D,Bottoni E,Errico V,Voulaz E,Bossi M,Chiesa G,Passera E,Mantovani A,Alloisio M

更新日期：2016-02-15 00:00:00

abstract：:Chemotherapy-induced gastrointestinal toxicity (CIGT) occurs in up to 80% of all patients undergoing cancer treatment, and leads to symptoms such as diarrhoea, abdominal bleeding and pain. There is currently limited understanding of how to predict an individual patient's risk of CIGT. It is believed the gut microbiome...

journal_title：International journal of cancer

authors： Secombe KR,Coller JK,Gibson RJ,Wardill HR,Bowen JM

更新日期：2019-05-15 00:00:00

abstract：:Using radioiodinated Staphylococcus aureus protein A [125I]SPA to measure syngeneic, allogeneic and heterogeneic IgG bound to murine tumor cells, we performed a serological analysis of surface antigens of 8 solid tumors and 2 leukemias of BALB/c mice (3 chemically-induced colon carcinomas, 3 chemically-induced sarcoma...

journal_title：International journal of cancer

authors： Cleveland PH,Belnap LP,Knotts FB,Nayak SK,Baird SM,Pilch YH

更新日期：1979-03-15 00:00:00

abstract：:Nitric oxide (NO) and its metabolites are implicated in carcinogenesis and metastasis. Both stimulatory and inhibitory effects of NO have been reported in relation to breast cancer and its role in the development of malignancies and metastasis remains uncertain. We have used the polyomavirus middle T antigen (PyV-mT) ...

journal_title：International journal of cancer

authors： Ellies LG,Fishman M,Hardison J,Kleeman J,Maglione JE,Manner CK,Cardiff RD,MacLeod CL

更新日期：2003-08-10 00:00:00