Novel targets for sensitizing breast cancer cells to TRAIL-induced apoptosis with siRNA delivery.

abstract：:Cloned lines from 4 different families of B-16 melanoma cells were heated repeatedly in tissue culture at 45 degrees C with step-up time intervals. These lines included the partially heat-resistant lines previously selected at 43 degrees C(HR 43 degrees) from wheat-germ-agglutinin-resistant mutant (WGAR, HR43 degrees)...

journal_title：International journal of cancer

authors： Tao Tw

更新日期：1985-09-15 00:00:00

abstract：:The EMS1 gene encodes an 80/85 kDa c-src substrate and localises with the CCND1 gene to chromosome 11q13. This locus is amplified in approximately 13% of human breast cancers. EMS1 gene amplification and expression were characterised in a panel of human breast cancer cell lines to determine at what levels expression i...

journal_title：International journal of cancer

authors： Campbell DH,deFazio A,Sutherland RL,Daly RJ

更新日期：1996-11-15 00:00:00

abstract：:Herein, we show that γδT, CD8(+) αβT lymphocytes and natural killer (NK) cells display a different sensitivity to survival signals delivered via NKG2D surface receptor. All the three effector cell populations activate Akt1/PKBalpha through the engagement of this molecule. Upon binding to leukemic cells expressing NKG2...

journal_title：International journal of cancer

authors： Poggi A,Zancolli M,Boero S,Catellani S,Musso A,Zocchi MR

更新日期：2011-07-15 00:00:00

abstract：:The translation-initiation factor eIF4E is rate-limiting for protein synthesis, and its over-expression results in oncogenic transformation of mammalian cells. eIF4E facilitates the synthesis of several powerful tumor angiogenic factors (FGF-2 and VEGF) by selectively enhancing their translation. In breast carcinomas,...

journal_title：International journal of cancer

authors： DeFatta RJ,Turbat-Herrera EA,Li BD,Anderson W,De Benedetti A

更新日期：1999-02-09 00:00:00

abstract：:We investigated the ability of endogenous and recombinant interleukin-2 (IL-2)-stimulated NK cells from normal donors and ovarian cancer patients to mediate lysis of ovarian tumors, and found that peripheral blood (PB) mononuclear cells of normal donors or cancer patients did not display tumoricidal activity against o...

journal_title：International journal of cancer

authors： Lotzová E,Savary CA,Freedman RS,Edwards CL,Wharton JT

更新日期：1988-08-15 00:00:00

abstract：:The association of fruit and vegetable consumption and lung cancer incidence was evaluated using the most recent data from the European Prospective Investigation into Cancer and Nutrition (EPIC), applying a refined statistical approach (calibration) to account for measurement error potentially introduced by using food...

journal_title：International journal of cancer

authors： Linseisen J,Rohrmann S,Miller AB,Bueno-de-Mesquita HB,Büchner FL,Vineis P,Agudo A,Gram IT,Janson L,Krogh V,Overvad K,Rasmuson T,Schulz M,Pischon T,Kaaks R,Nieters A,Allen NE,Key TJ,Bingham S,Khaw KT,Amiano P,Bar

更新日期：2007-09-01 00:00:00

abstract：:The MYH gene has recently been shown to be associated with a recessive form of colorectal adenomatous polyposis. Two common mutations in the MYH gene have been identified that lend themselves to rapid screening. We have examined a series of 302 individuals comprising 120 control subjects, 120 patients diagnosed with a...

journal_title：International journal of cancer

authors： Kairupan CF,Meldrum CJ,Crooks R,Milward EA,Spigelman AD,Burgess B,Groombridge C,Kirk J,Tucker K,Ward R,Williams R,Scott RJ

更新日期：2005-08-10 00:00:00

abstract：:Promoter hypermethylation of various tumor-related genes is extremely frequent in gastric carcinoma (GC) associated with Epstein-Barr virus (EBV). To investigate the significance of the promoter methylation in this type of GC, we examined the methylation densities of the promoter regions of p14ARF and p16INK4A in EBV-...

journal_title：International journal of cancer

authors： Sakuma K,Chong JM,Sudo M,Ushiku T,Inoue Y,Shibahara J,Uozaki H,Nagai H,Fukayama M

更新日期：2004-11-01 00:00:00

abstract：:The colo-rectum and stomach are the 2 sites for which the role of diet in the etiology of cancer is most heavily implicated. Quantitative estimates as to the proportion of cancer deaths attributable to diet vary considerably. This may be partially due to the application of the concept of population attributable risk w...

journal_title：International journal of cancer

authors： Wahrendorf J

更新日期：1987-11-15 00:00:00

abstract：:The association between certain human papillomaviruses (HPV) and cervical intraepithelial neoplasia (CIN) is well documented, but there is uncertainty about the strength of association and the role of co-factors is unclear. This population-based case-control study in Norwegian women 20-44 years of age included 103 cas...

journal_title：International journal of cancer

authors： Olsen AO,Gjøen K,Sauer T,Orstavik I,Naess O,Kierulf K,Sponland G,Magnus P

更新日期：1995-05-04 00:00:00

abstract：:Serum levels of IL-6 were evaluated in a large group of patients with benign or malignant gynecological tumors. The results obtained were correlated with the patients' clinicopathological features and follow-up data. Using a highly sensitive immunoenzymatic method for the evaluation of serum IL-6 levels, we observed t...

journal_title：International journal of cancer

authors： Scambia G,Testa U,Panici PB,Martucci R,Foti E,Petrini M,Amoroso M,Masciullo V,Peschle C,Mancuso S

更新日期：1994-05-01 00:00:00

abstract：:There are approximately 100 genes which when mutated are known to predispose to one or more forms of cancer. Currently, genetic testing is offered for many of these, either as single genes or as multi-gene panels. Features of hereditary cancer include a positive family history of cancer, early age of onset and the app...

journal_title：International journal of cancer

authors： Cybulski C,Nazarali S,Narod SA

更新日期：2014-10-15 00:00:00

abstract：:The relationship between breast cancer and radiation treatment for cervical cancer was evaluated in an international study of 953 women who subsequently developed breast cancer and 1,806 matched controls. Radiation doses to the breast (average 0.31 Gy) and ovaries (average 32 Gy) were reconstructed for exposed subject...

journal_title：International journal of cancer

authors： Boice JD Jr,Blettner M,Kleinerman RA,Engholm G,Stovall M,Lisco H,Austin DF,Bosch A,Harlan L,Krementz ET,Latouret HB,Merril JA,Petters LJ,Schulz MD,Wactawski J,Storm HH,Björkholm E,Pettersson F,Bell CM,Coleman MP,F

更新日期：1989-07-15 00:00:00

abstract：:High dietary intakes of calcium and dairy products have been hypothesized to enhance prostate cancer risk, but available prospective data regarding these associations are inconsistent. We examined dietary intakes of calcium and dairy products in relation to risk of prostate cancer in the Alpha-Tocopherol, Beta-Caroten...

journal_title：International journal of cancer

authors： Mitrou PN,Albanes D,Weinstein SJ,Pietinen P,Taylor PR,Virtamo J,Leitzmann MF

更新日期：2007-06-01 00:00:00

abstract：:We previously produced evidence that the human mammary-carcinoma cell line 8701-BC expresses several metalloproteinases (MMP-1, -2, -9, and -10) and their tissue inhibitors). In order to obtain a better understanding of the environmental control over gelatinolytic activities, we have tested the enzyme production of 87...

journal_title：International journal of cancer

authors： Minafra S,Giambelluca C,Andriolo M,Pucci-Minafra I

更新日期：1995-09-15 00:00:00

abstract：:The anatomic site-dependent expression of hematopoietic progenitor cell antigen CD34 is a feature of gastrointestinal stromal tumours (GISTs). The basis for the differential CD34 expression is only incompletely understood. This study aimed at understanding the regulation of CD34 in GISTs and clarification of its site-...

journal_title：International journal of cancer

authors： Bure I,Braun A,Kayser C,Geddert H,Schaefer IM,Cameron S,Ghadimi MB,Ströbel P,Werner M,Hartmann A,Wiemann S,Agaimy A,Haller F,Moskalev EA

更新日期：2017-12-01 00:00:00

abstract：:Kaposi sarcoma (KS) is among the most common childhood malignancies in central, eastern, and southern Africa. Although its unique clinical features have been established, biological mechanisms related to the causative agent, KS-associated herpes-virus (KSHV), have yet to be explored in children. We performed a prospec...

journal_title：International journal of cancer

authors： El-Mallawany NK,Mehta PS,Kamiyango W,Villiera J,Peckham-Gregory EC,Kampani C,Krysiak R,Sanders MK,Caro-Vegas C,Eason AB,Ahmed S,Schutze GE,Martin SC,Kazembe PN,Scheurer ME,Dittmer DP

更新日期：2019-01-01 00:00:00

abstract：:In normal somatic cells, the methylation pattern of DNA is stably maintained by DNA (cytosine-5-)-methyltransferase (DNA methyltransferase). Increased expression of DNA methyltransferase has been detected in many types of human cancer and has been thought to play an important role in tumorigenesis. In our study, we de...

journal_title：International journal of cancer

authors： Chen B,Liu X,Savell VH,Dilday BR,Johnson MW,Jenkins JJ,Parham DM

更新日期：1999-09-24 00:00:00

abstract：:Although heparin can regulate angiogenesis, tumor growth and metastasis, its clinical application, as well as that of low-molecular heparin (LMWH), for treating cancer are limited because of heparin's anticoagulant activity and risk of hemorrhages. LMWH-taurocholate conjugates (LHT7), which have low anticoagulant acti...

journal_title：International journal of cancer

authors： Lee E,Kim YS,Bae SM,Kim SK,Jin S,Chung SW,Lee M,Moon HT,Jeon OC,Park RW,Kim IS,Byun Y,Kim SY

更新日期：2009-06-15 00:00:00

abstract：:Radiotherapy and chemotherapy are known risk factors for second cancers after lymphoma. The role of genetic influences, however, remains largely unknown. We assessed risk of second cancers associated with family history of any cancer in 41,181 patients with Hodgkin lymphoma (HL) (n = 7,476), non-Hodgkin lymphoma (NHL)...

journal_title：International journal of cancer

authors： Landgren O,Pfeiffer RM,Stewart L,Gridley G,Mellemkjaer L,Hemminki K,Goldin LR,Travis LB

更新日期：2007-03-01 00:00:00

abstract：:Vitamin D has anticarcinogenic properties and might influence colorectal cancer (CRC) risk, but the epidemiological evidence is inconsistent. Many mechanisms of action for vitamin D have been proposed, with some of them initiating via its binding to the vitamin D receptor (VDR). Using a large Scottish case-control stu...

journal_title：International journal of cancer

authors： Theodoratou E,Farrington SM,Tenesa A,McNeill G,Cetnarskyj R,Barnetson RA,Porteous ME,Dunlop MG,Campbell H

更新日期：2008-11-01 00:00:00

abstract：:Matrix metalloproteinase 2 (MMP-2) plays a crucial role in invasion and metastasis of malignant tumors. Membrane type 1-MMP (MT1-MMP) was originally identified as an activator of MMP-2. Tissue inhibitor of MMP-2 (TIMP-2) was identified as an inhibitor of MMP-2 and MT1-MMP. However, TIMP-2 was reported to be essential ...

journal_title：International journal of cancer

authors： Yoshizaki T,Maruyama Y,Sato H,Furukawa M

更新日期：2001-01-20 00:00:00

abstract：:The purpose of this analysis was to correlate isotope selection with the urinary symptoms of patients who received a combination of external beam radiotherapy (EBRT) and a transperineal interstitial permanent prostate brachytherapy (TIPPB) boost with either a (103)palladium ((103)Pd) or a (125)iodine ((125)I) radioiso...

journal_title：International journal of cancer

authors： Chen CT,Waterman FM,Valicenti RK,Gomella LG,Strup SE,Dicker AP

更新日期：2001-01-01 00:00:00

abstract：:Metastasis of colorectal cancer (CRC) is the leading cause of CRC-associated mortality. Angiogenin (ANG), a member of the ribonuclease A superfamily, not only activates endothelial cells to induce tumor angiogenesis, but also targets tumor cells to promote cell survival, proliferation and/or migration. However, its cl...

journal_title：International journal of cancer

authors： Li S,Shi X,Chen M,Xu N,Sun D,Bai R,Chen H,Ding K,Sheng J,Xu Z

更新日期：2019-09-01 00:00:00

abstract：:Previous studies have shown that macrophage cell lines retained the ability to phagocytize, to secrete lysosomal enzymes, and to function as effector cells in antibody-dependent cellular cytoxicity. In this paper, the cytolytic activity of murine macrophage cell lines against tumor target cells was assessed using an 1...

journal_title：International journal of cancer

authors： Taniyama T,Holden HT

更新日期：1980-07-15 00:00:00

abstract：:Immunogenicity of a long 20-mer NY-ESO-1f peptide vaccine was evaluated in a lung cancer patient TK-f01, immunized with the peptide with Picibanil OK-432 and Montanide ISA-51. We showed that internalization of the peptide was necessary to present CD8 T-cell epitopes on APC, contrasting with the direct presentation of ...

journal_title：International journal of cancer

authors： Eikawa S,Kakimi K,Isobe M,Kuzushima K,Luescher I,Ohue Y,Ikeuchi K,Uenaka A,Nishikawa H,Udono H,Oka M,Nakayama E

更新日期：2013-01-15 00:00:00

abstract：:We have investigated the effect of pre-treatment with the anti-cancer drugs cisplatin and etoposide on the susceptibility of P815 murine mastocytoma cells to lysis by murine spleen-derived anti-CD3-activated killer-T (AK-T) cells. A 20 hr pre-treatment with cisplatin (0.2-2 microg/ml) or etoposide (0.01-1 microg/ml) r...

journal_title：International journal of cancer

authors： Williams BA,Makrigiannis AP,Blay J,Hoskin DW

更新日期：1997-11-04 00:00:00

abstract：:Human papillomavirus (HPV) infections and HPV-associated penile lesions are frequently found in male sexual partners of women with cervical intraepithelial neoplasia (CIN). To determine the significance of these findings, we studied the prevalence of HPV and HPV associated penile lesions in a male hospital population ...

journal_title：International journal of cancer

authors： Bleeker MC,Hogewoning CJ,Voorhorst FJ,van den Brule AJ,Berkhof J,Hesselink AT,Lettink M,Starink TM,Stoof TJ,Snijders PJ,Meijer CJ

更新日期：2005-01-01 00:00:00

abstract：:To understand the mechanisms underlying increased expression of Myc protein in human urinary bladder cancer, expression of c-myc mRNA and the copy number of the c-myc gene were determined. Expression of mRNA was measured by quantitative RT-PCR in 40 urothelial carcinomas and in 18 histologically normal mucosae. Mean e...

journal_title：International journal of cancer

authors： Christoph F,Schmidt B,Schmitz-Dräger BJ,Schulz WA

更新日期：1999-04-20 00:00:00

abstract：:The diagnostic specificity of the detection of disseminated prostatic cells by reverse-transcriptase polymerase chain reaction (RT-PCR) of PSA mRNA was investigated. A sensitive nested PCR was developed. In blood samples from 10 healthy female and 10 healthy male persons examined by RT-PCR, mRNA of PSA was detected 3 ...

journal_title：International journal of cancer

authors： Henke W,Jung M,Jung K,Lein M,Schlechte H,Berndt C,Rudolph B,Schnorr D,Loening SA

更新日期：1997-01-06 00:00:00