Increased analytical sensitivity of RT-PCR of PSA mRNA decreases diagnostic specificity of detection of prostatic cells in blood.

abstract：:Immune cells in tumor microenvironment play a prominent role in tumor progression and metastasis. MicroRNA-155 (miR-155) represents an important player in innate and adaptive immunity by regulating differentiation, maturation and activation of macrophages, dendritic cells, B cells and T cells. However, the role of miR...

journal_title：International journal of cancer

authors： Wang J,Yu F,Jia X,Iwanowycz S,Wang Y,Huang S,Ai W,Fan D

更新日期：2015-03-15 00:00:00

abstract：:Hypoxia-inducible factor-1 (HIF-1) plays an important role in stress-responsive gene expression. Although primarily sensitive to hypoxia, HIF-1 signaling can be regulated by a number of stress factors including metabolic stress, growth factors and molecules present in the extracellular matrix (ECM). Degradation of ECM...

journal_title：International journal of cancer

authors： Surazynski A,Donald SP,Cooper SK,Whiteside MA,Salnikow K,Liu Y,Phang JM

更新日期：2008-03-15 00:00:00

abstract：:Claudin7 (cld7) is a cancer-initiating cell (CIC) marker in gastrointestinal tumors, a cld7-knockdown (kd) being accompanied by loss of tumor progression. Tumor exosomes (TEX) restoring CIC activities, we explored the contribution of cld7. This became particularly interesting, as tight junction (TJ)- and glycolipid-en...

journal_title：International journal of cancer

authors： Kyuno D,Zhao K,Schnölzer M,Provaznik J,Hackert T,Zöller M

更新日期：2019-10-15 00:00:00

abstract：:The surface and intracellular expression of mdrI-P-glycoprotein in parental drug-sensitive human breast cancer cells (MCF-7) and their multidrug-resistant (MDR) variants has been studied by using the monoclonal antibodies (MAbs) MM4.17 and MRK-16, which recognize 2 different epitopes of the drug efflux pump molecule. ...

journal_title：International journal of cancer

authors： Molinari A,Cianfriglia M,Meschini S,Calcabrini A,Arancia G

更新日期：1994-12-15 00:00:00

abstract：:HER2 is an erbB/HER type 1 tyrosine kinase receptor that is frequently over-expressed in malignant epithelial tumours. Herceptin, a humanised mouse monoclonal antibody to HER2, is proven therapeutically in the management of metastatic breast cancer, significantly prolonging survival when combined with cytotoxic chemot...

journal_title：International journal of cancer

authors： Cox G,Vyberg M,Melgaard B,Askaa J,Oster A,O'Byrne KJ

更新日期：2001-05-15 00:00:00

abstract：:To investigate whether addition of local therapy to EGFR-TKIs could provide survival benefit than EGFR-TKIs alone in EGFR-mutant NSCLC patients with oligometastatic or oligoprogressive liver metastases (LM). Patients with EGFR-mutant NSCLC and oligometastatic or oligoprogressive LM who met inclusion criteria were retr...

journal_title：International journal of cancer

authors： Jiang T,Chu Q,Wang H,Zhou F,Gao G,Chen X,Li X,Zhao C,Xu Q,Li W,Wu F,Xiong A,Zhao J,Xu Y,Su C,Ren S,Zhou C,Hirsch FR

更新日期：2019-05-15 00:00:00

abstract：:The p53 tumor suppressor pathway is impaired in more than 90% of cervical cancers and cancer-derived cell lines as a result of infection by human papillomavirus (HPV). The HPV E6 oncoprotein forms complexes with p53 and promotes its degradation via ubiquitin-dependent mechanism. In our study, we attempted to improve t...

journal_title：International journal of cancer

authors： Wang H,Song X,Zhang H,Zhang J,Shen X,Zhou Y,Fan X,Dai L,Qian G,Hoffman AR,Hu JF,Ge S

更新日期：2012-01-15 00:00:00

abstract：:It has been suggested that smoking is associated with estrogen-negative breast cancer but not with estrogen-positive breast cancer. A population-based case-control study was conducted in Geneva, Switzerland, to determine the relation of passive and active smoking to breast cancer when the referent unexposed category c...

journal_title：International journal of cancer

authors： Morabia A,Bernstein M,Ruiz J,Héritier S,Diebold Berger S,Borisch B

更新日期：1998-01-30 00:00:00

abstract：:The evolution of precancerous cervical lesions is poorly understood. A widely held model of cervical intraepithelial neoplasia grade 3 (CIN3) development is sequential progression from normal through CIN1 and CIN2 to CIN3. Another hypothesis, the "molecular switch" model, postulates that CIN3 can evolve directly from ...

journal_title：International journal of cancer

authors： Nedjai B,Reuter C,Ahmad A,Banwait R,Warman R,Carton J,Boer S,Cuzick J,Lorincz AT

更新日期：2018-10-01 00:00:00

abstract：:Oral tongue squamous cell carcinoma (OTSCC) is associated with poor prognosis. To improve prognostication, we analyzed four gene probes (TERC, CCND1, EGFR and TP53) and the centromere probe CEP4 as a marker of chromosomal instability, using fluorescence in situ hybridization (FISH) in single cells from the tumors of s...

journal_title：International journal of cancer

authors： Wangsa D,Chowdhury SA,Ryott M,Gertz EM,Elmberger G,Auer G,Åvall Lundqvist E,Küffer S,Ströbel P,Schäffer AA,Schwartz R,Munck-Wikland E,Ried T,Heselmeyer-Haddad K

更新日期：2016-01-01 00:00:00

abstract：:Trilaciclib is an intravenous CDK4/6 inhibitor administered prior to chemotherapy to preserve haematopoietic stem and progenitor cells and immune system function from chemotherapy-induced damage (myelopreservation). The effects of administering trilaciclib prior to carboplatin, etoposide and atezolizumab (E/P/A) were ...

journal_title：International journal of cancer

authors： Daniel D,Kuchava V,Bondarenko I,Ivashchuk O,Reddy S,Jaal J,Kudaba I,Hart L,Matitashvili A,Pritchett Y,Morris SR,Sorrentino JA,Antal JM,Goldschmidt J

更新日期：2020-12-21 00:00:00

abstract：:DNA sequences coding for simian virus 40 (SV40) large T antigen have been detected at different frequencies in human non-Hodgkin's lymphomas (NHL) by PCR techniques as well as immunohistochemistry. A highly sensitive quantitative real-time PCR specific for a sequence of SV40 large T antigen was established to test whe...

journal_title：International journal of cancer

authors： Schüler F,Dölken SC,Hirt C,Dölken MT,Mentel R,Gürtler LG,Dölken G

更新日期：2006-01-15 00:00:00

abstract：:Limited success has been achieved in extending the survival of patients with metastatic and hormone-refractory prostate cancer (HRPC). There is a strong need for novel agents in the treatment and prevention of HRPC. We have shown that flavokawain B (FKB), a kava chalcone, is about 4- to 12-fold more effective in reduc...

journal_title：International journal of cancer

authors： Tang Y,Li X,Liu Z,Simoneau AR,Xie J,Zi X

更新日期：2010-10-15 00:00:00

abstract：:Powerful analytical tools are vital for characterizing the complex molecular changes underlying oncogenesis and cancer treatment. This is particularly true, if information is to be collected in vivo by noninvasive approaches. In the recent past, hyperpolarized (13)C magnetic resonance (MR) spectroscopy has been employ...

journal_title：International journal of cancer

authors： Karlsson M,Jensen PR,in 't Zandt R,Gisselsson A,Hansson G,Duus JØ,Meier S,Lerche MH

更新日期：2010-08-01 00:00:00

abstract：:We analyzed the role of reproductive factors on the risk of endometrial cancer using data from a case-control study conducted in Italy. Cases were 752 women with histologically confirmed endometrial cancer < 75 years of age. Controls were 2,606 patients < 75 years of age admitted for acute, non-gynecological non-hormo...

journal_title：International journal of cancer

authors： Parazzini F,Negri E,La Vecchia C,Benzi G,Chiaffarino F,Polatti A,Francheschi S

更新日期：1998-06-10 00:00:00

abstract：:Breast cancer is heterogeneous in clinical behavior by subtypes; however, it is unclear how this heterogeneity is related to epidemiological factors. To evaluate the differences in epidemiological factors by breast tumor subtypes, we investigated the associations of epidemiological factors between tumor subtypes in Ko...

journal_title：International journal of cancer

authors： Song N,Choi JY,Sung H,Chung S,Song M,Park SK,Han W,Lee JW,Kim MK,Yoo KY,Ahn SH,Noh DY,Kang D

更新日期：2014-08-01 00:00:00

abstract：:In STU mice bearing metastasizing SV40-transformed 51A-232B-M tumors, an immune response against a cellular 60kDa protein (p60) developed in about 50% of the tumor-bearing animals, in addition to the response against SV40 large T-antigen and cellular protein p53. The anti-p60 auto-immune response could be observed as ...

journal_title：International journal of cancer

authors： Manneck HE,Pfaff M,Anderer FA

更新日期：1988-12-15 00:00:00

abstract：:IL-21 is a member of the IL-2 cytokine family, produced by CD4+ T cells. We previously showed that immunotherapy (IT) with IL-21-transduced neuroblastoma cells (Neuro2a/IL-21) cured 33% of syngeneic mice bearing systemic NB. Here, we studied whether the removal of Treg cells could potentiate the therapeutic efficacy o...

journal_title：International journal of cancer

authors： Croce M,Corrias MV,Orengo AM,Brizzolara A,Carlini B,Borghi M,Rigo V,Pistoia V,Ferrini S

更新日期：2010-09-01 00:00:00

abstract：:We evaluated the therapeutic potential of the replication competent vector VA7-EGFP, which is based on the avirulent Semliki Forest virus (SFV) strain A7 (74) carrying the EGFP marker gene in an orthotopic lung cancer tumor model in nude mice. We have previously shown that this oncolytic vector destroys tumor cells ef...

journal_title：International journal of cancer

authors： Määttä AM,Mäkinen K,Ketola A,Liimatainen T,Yongabi FN,Vähä-Koskela M,Pirinen R,Rautsi O,Pellinen R,Hinkkanen A,Wahlfors J

更新日期：2008-10-01 00:00:00

abstract：:Although 45% of men and 39% of women will be diagnosed with cancer in their lifetime, it is difficult to predict which individuals will be affected. For some cancers, substantial progress in individual risk estimation has already been made. However, relatively few models have been developed to predict lung cancer risk...

journal_title：International journal of cancer

authors： Cassidy A,Duffy SW,Myles JP,Liloglou T,Field JK

更新日期：2007-01-01 00:00:00

abstract：:Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. To improve existing therapies and broaden the spectrum of cytotoxic agents that can be used in RMS treatment, we performed a phage-display-based screening for peptides that bind specifically to RMS cells. Two peptides binding to RMS and to othe...

journal_title：International journal of cancer

authors： Witt H,Hajdin K,Iljin K,Greiner O,Niggli FK,Schäfer BW,Bernasconi M

更新日期：2009-05-01 00:00:00

abstract：:I-compounds are bulky indigenous DNA adducts that can be detected by (32)P-postlabeling. A subgroup, termed type II I-compounds, represents DNA lesions induced by oxidative stress. Several major type II I-compounds have been identified as dinucleotides containing 3'-terminal 8,5'-cyclo-2'-deoxyadenosine (cA). Levels o...

journal_title：International journal of cancer

authors： Zhou GD,Randerath K,Donnelly KC,Jaiswal AK

更新日期：2004-12-10 00:00:00

abstract：:Tumorigenesis of head and neck squamous cell carcinomas (HNSCC) is associated with various genetic changes such as loss of heterozygosity (LOH) on human chromosome 18q21. This chromosomal region maps a gene cluster coding for a family of intracellular serine protease inhibitors (serpins), including SERPINB13. As SERPI...

journal_title：International journal of cancer

authors： de Koning PJ,Bovenschen N,Leusink FK,Broekhuizen R,Quadir R,van Gemert JT,Hordijk GJ,Chang WS,van der Tweel I,Tilanus MG,Kummer JA

更新日期：2009-10-01 00:00:00

abstract：:In the last decade, mitochondrial DNA (mtDNA) haplogroups have been associated with the occurrence of breast cancer. However, the underlying mechanism is not known. Combining a case-control study with a large cohort of women from Southern China with breast cancer and functional analyses with trans-mitochondrial techno...

journal_title：International journal of cancer

authors： Ma L,Fu Q,Xu B,Zhou H,Gao J,Shao X,Xiong J,Gu Q,Wen S,Li F,Shen L,Chen G,Fang H,Lyu J

更新日期：2018-05-01 00:00:00

abstract：:Heparan sulfate 3-O-sulfotransferase 2 (HS3ST2), an enzyme mediating 3-O-sulfation of heparan sulfate (HS), is silenced by hypermethylation in breast cancer. As HS has an important co-receptor function for numerous signal transduction pathways, the phenotypical changes due to HS3ST2 reexpression were investigated in v...

journal_title：International journal of cancer

authors： Vijaya Kumar A,Salem Gassar E,Spillmann D,Stock C,Sen YP,Zhang T,Van Kuppevelt TH,Hülsewig C,Koszlowski EO,Pavao MS,Ibrahim SA,Poeter M,Rescher U,Kiesel L,Koduru S,Yip GW,Götte M

更新日期：2014-12-01 00:00:00

abstract：:Children are especially sensitive to ionizing radiation and chemical carcinogens, and limiting their cancer risk is of great public concern. Calorie restriction (CR) is a potent intervention for suppressing cancer. However, CR is generally not appropriate for children. This study, therefore, examined to see if adult-o...

journal_title：International journal of cancer

authors： Shang Y,Kakinuma S,Yamauchi K,Morioka T,Kokubo T,Tani S,Takabatake T,Kataoka Y,Shimada Y

更新日期：2014-09-01 00:00:00

abstract：:Faecal occult blood test (FOBT) screening for colorectal cancer (CRC) is implemented in several countries. Approximately half of all screen positive persons have negative colonoscopy, but consensus is lacking on how these persons should be followed up. Health authorities in Denmark and The Netherlands recommend suspen...

journal_title：International journal of cancer

authors： Bjerrum A,Andersen O,Fischer A,Lindebjerg J,Lynge E

更新日期：2017-08-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a major inducer of angiogenesis in tumors. Basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) have both been shown to interact with VEGF. The involvement of VEGF, bFGF, and EGF in melanoma angiogenesis was investigated here. Four human melanoma cell lin...

journal_title：International journal of cancer

authors： Danielsen T,Rofstad EK

更新日期：1998-06-10 00:00:00

abstract：:The identification of high-risk patients with thyroid cancer and the preoperative differentiation between follicular adenoma and carcinoma remain clinically challenging. Our study was conducted to analyze whether the quantification of matrix metalloproteinases (MMPs) and urokinase-type plasminogen activator receptor (...

journal_title：International journal of cancer

authors： Buergy D,Weber T,Maurer GD,Mudduluru G,Medved F,Leupold JH,Brauckhoff M,Post S,Dralle H,Allgayer H

更新日期：2009-08-15 00:00:00

abstract：:Protein inhibitor of activated signal transducer and activator of transcription 3 (STAT3) (PIAS3) is an endogenous inhibitor of STAT3 that negatively regulates STAT3 transcriptional activity and cell growth and demonstrates limited expression in the majority of human squamous cell carcinomas of the lung. In this study...

journal_title：International journal of cancer

authors： Dabir S,Kluge A,McColl K,Liu Y,Lam M,Halmos B,Wildey G,Dowlati A

更新日期：2014-03-01 00:00:00