Long-term risk of colorectal cancer after negative colonoscopy in a Danish gFOBT screening cohort.


:Faecal occult blood test (FOBT) screening for colorectal cancer (CRC) is implemented in several countries. Approximately half of all screen positive persons have negative colonoscopy, but consensus is lacking on how these persons should be followed up. Health authorities in Denmark and The Netherlands recommend suspending screening for 8-10 years, while patients in UK are invited to screening after 2 years. In this cohort-study, we followed 166,277 individuals invited to FOBT-screening in 2005-2006 and a reference group comprising the remaining 1,240,348 Danes of the same age. We linked Danish population and health service registers to obtain information about colonoscopy outcome and incident CRC. We estimated CRC risk by colonoscopy outcome (adenoma, other colorectal pathology or negative colonoscopy) for the reference group, the screening group, and subgroups. Persons with positive screening FOBT followed by negative colonoscopy had the same long-term CRC risk as persons with adenoma detected due to a positive screening FOBT (aHR 1.33, 95% CI: 0.65-2.71). We found no difference in the long-term CRC risk between persons with negative colonoscopy after a positive FOBT screening test and the unscreened reference population (aHR 1.05, 95% CI: 0.62-1.78). Since FOBT screen positive persons in our study remained at average risk of CRC despite of a negative index colonoscopy, we question the safety of suspending FOBT screening for this group. It needs to be monitored whether recent efforts to improve colonoscopy quality have been successful in ensuring low CRC risk after negative colonoscopy also in FOBT positive persons.


Int J Cancer


Bjerrum A,Andersen O,Fischer A,Lindebjerg J,Lynge E




Has Abstract


2017-08-01 00:00:00












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    pub_type: 杂志文章


    authors: Landgren O,Pfeiffer RM,Stewart L,Gridley G,Mellemkjaer L,Hemminki K,Goldin LR,Travis LB

    更新日期:2007-03-01 00:00:00

  • Dissecting the journey to breast cancer diagnosis in sub-Saharan Africa: Findings from the multicountry ABC-DO cohort study.

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Foerster M,McKenzie F,Zietsman A,Galukande M,Anele A,Adisa C,Parham G,Pinder L,Schüz J,McCormack V,Dos-Santos-Silva I

    更新日期:2021-01-15 00:00:00

  • EGF signalling in prostate cancer cell lines is inhibited by a high expression level of the endocytosis protein REPS2.

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    pub_type: 杂志文章


    authors: Oosterhoff JK,Kühne LC,Grootegoed JA,Blok LJ

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    authors: Schavinsky-Khrapunsky Y,Priel E,Aboud M

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    更新日期:2019-01-01 00:00:00

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Pedersen MW,Tkach V,Pedersen N,Berezin V,Poulsen HS

    更新日期:2004-02-20 00:00:00

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    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Edamoto Y,Hara A,Biernat W,Terracciano L,Cathomas G,Riehle HM,Matsuda M,Fujii H,Scoazec JY,Ohgaki H

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    journal_title:International journal of cancer

    pub_type: 杂志文章,随机对照试验


    authors: Yu K,Fan J,Ding X,Li C,Wang J,Xiang Y,Wang QS

    更新日期:2014-10-01 00:00:00

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Shinozaki K,Ebert O,Woo SL

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    journal_title:International journal of cancer

    pub_type: 杂志文章


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    authors: Klinghammer K,Keller J,George J,Hoffmann J,Chan EL,Hayman MJ

    更新日期:2018-01-01 00:00:00

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    authors: Yano T,Yasumoto K,Togami M,Ishida T,Kimura G,Sugimachi K,Nomoto K

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    journal_title:International journal of cancer

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    authors: Levesque P,Ramchurren N,Saini K,Joyce A,Libertino J,Summerhayes IC

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    journal_title:International journal of cancer

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    更新日期:2001-06-01 00:00:00

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    journal_title:International journal of cancer

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    journal_title:International journal of cancer

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    journal_title:International journal of cancer

    pub_type: 杂志文章


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    journal_title:International journal of cancer

    pub_type: 杂志文章


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    更新日期:1996-07-29 00:00:00

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    journal_title:International journal of cancer

    pub_type: 杂志文章


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    更新日期:1998-06-19 00:00:00

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    journal_title:International journal of cancer

    pub_type: 杂志文章


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    更新日期:2018-08-01 00:00:00

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    journal_title:International journal of cancer

    pub_type: 杂志文章


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    更新日期:1976-04-15 00:00:00

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lorenzi T,Lorenzi M,Altobelli E,Marzioni D,Mensà E,Quaranta A,Paolinelli F,Morroni M,Mazzucchelli R,De Luca A,Procopio AD,Baldi A,Muzzonigro G,Montironi R,Castellucci M

    更新日期:2013-12-01 00:00:00

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Moore K,McBride WH

    更新日期:1980-11-15 00:00:00