Cancer prevention by adult-onset calorie restriction after infant exposure to ionizing radiation in B6C3F1 male mice.

abstract：:As many patients with mammary carcinoma are now treated by conservative forms of surgery, there is a need for prognostic information obtainable from the primary tumour alone. One possible source is the antigenic profile of tumour cells. Using an indirect immunoperoxidase technique, we stained histological sections of ...

journal_title：International journal of cancer

authors： Wilkinson MJ,Howell A,Harris M,Taylor-Papadimitriou J,Swindell R,Sellwood RA

更新日期：1984-03-15 00:00:00

abstract：:A-kinase anchoring protein 3 (AKAP3) is a sperm protein and its expression appears to be restricted to the testis in normal adult tissues. We investigated AKAP3 mRNA expression in 20 normal ovaries and 54 ovarian cancers of different histological types, grades and stages by reverse transcription-polymerase chain react...

journal_title：International journal of cancer

authors： Hasegawa K,Ono T,Matsushita H,Shimono M,Noguchi Y,Mizutani Y,Kodama J,Kudo T,Nakayama E

更新日期：2004-01-01 00:00:00

abstract：:Viruses that replicate selectively in cancer cells hold considerable promise as novel therapeutic agents for the treatment of malignancy. We report an orthotopic model of multi-focal colorectal cancer (CRC) metastases in the livers of syngeneic and immune-competent rats, which permitted rigorous testing of oncolytic v...

journal_title：International journal of cancer

authors： Shinozaki K,Ebert O,Woo SL

更新日期：2005-04-20 00:00:00

abstract：:Tissue recombinants (TRs) composed of mouse urogenital mesenchyme (mUGM) plus an immortalized nontumorigenic human prostatic epithelial cell line (BPH-1) were grown under the kidney capsule of male athymic nude mice under different hormonal conditions. The objectives were to determine temporal plasma concentrations of...

journal_title：International journal of cancer

authors： Ricke WA,Ishii K,Ricke EA,Simko J,Wang Y,Hayward SW,Cunha GR

更新日期：2006-05-01 00:00:00

abstract：:In biliary tract cancer (BTC), tissue biopsies to guide treatment are rarely feasible, thus implementing liquid biopsy approaches to improve patient management represents a priority. So far, studies on circulating tumor cells (CTCs) in BTC are insufficient to promote their use in patient clinical management and are li...

journal_title：International journal of cancer

authors： Reduzzi C,Vismara M,Silvestri M,Celio L,Niger M,Peverelli G,De Braud F,Daidone MG,Cappelletti V

更新日期：2020-06-15 00:00:00

abstract：:Etiological risk factors for proximal (right-sided) colon cancers may be different to those of distal colon and rectal (left-sided) cancers if these tumors develop along distinct pathways. The CpG Island Methylator Phenotype (CIMP+) occurs in approximately 15% of colorectal cancers (CRC) and predominantly in the proxi...

journal_title：International journal of cancer

authors： Iacopetta B,Heyworth J,Girschik J,Grieu F,Clayforth C,Fritschi L

更新日期：2009-07-01 00:00:00

abstract：:Murine monoclonal antibody HRS-4 (Ab1), which defines the cell-bound and soluble CD30 antigen associated with Hodgkin's lymphoma, was used to generate monoclonal anti-idiotypic antibodies (Ab2) in syngeneic BALB/c mice. Murine monoclonal Ab2 14G9 and Ab2 9G10 directed against HRS-4 were shown to be anti-idiotypic Ab2 ...

journal_title：International journal of cancer

authors： Pohl C,Renner C,Schwonzen M,Sieber M,Lorenz P,Pfreundschuh M,Diehl V

更新日期：1992-04-01 00:00:00

abstract：:Hyaluronan (HA) has been shown to play important roles in the growth, invasion and metastasis of malignant tumors. Our previous study showing that high HA expression in malignant peripheral nerve sheath tumors (MPNST) is predictive of poor patient prognosis, prompted us to speculate that inhibition of HA synthesis in ...

journal_title：International journal of cancer

authors： Ikuta K,Ota T,Zhuo L,Urakawa H,Kozawa E,Hamada S,Kimata K,Ishiguro N,Nishida Y

更新日期：2017-01-15 00:00:00

abstract：:MicroRNA (miRNA) expression is frequently altered in human cancers. To search for epigenetically silenced miRNAs in non-small-cell lung cancer (NSCLC), we mapped human miRNAs on autosomal chromosomes and selected 55 miRNAs in silico. We treated six NSCLC cell lines with the DNA methylation inhibitor 5-aza-2'-deoxycyti...

journal_title：International journal of cancer

authors： Watanabe K,Emoto N,Hamano E,Sunohara M,Kawakami M,Kage H,Kitano K,Nakajima J,Goto A,Fukayama M,Nagase T,Yatomi Y,Ohishi N,Takai D

更新日期：2012-06-01 00:00:00

abstract：:In 584 consecutive patients with no previous history of cancer or polypectomy, 769 adenomas were excised endoscopically and classified retrospectively according to the following parameters: macroscopic growth pattern, size, histological type, grade of dysplasia, anatomical site, presence of adenocarcinoma (ADK), numbe...

journal_title：International journal of cancer

authors： Gatteschi B,Costantini M,Bruzzi P,Merlo F,Torcoli R,Nicolo G

更新日期：1991-10-21 00:00:00

abstract：:Previously, we studied the surface expression of LFA-1 (CD11a/CD18) and ICAM-1 (CD54) in a panel of 16 human T-cell lines and found that those carrying HTLV-1 pro-viruses expressed high levels of ICAM-1. Enhanced expression of ICAM-1 was also seen in fresh leukemic cells from ATL patients. In the present study, we sys...

journal_title：International journal of cancer

authors： Imai T,Tanaka Y,Fukudome K,Takagi S,Araki K,Yoshie O

更新日期：1993-11-11 00:00:00

abstract：:Cancer vaccines directed against tumor associate antigen (TAA) have produced encouraging results in preclinical models but not in cancer patients. A major limitation of this strategy is the relative degree of tolerance to these antigens and the low and heterogeneous tumor cell expression of TAA and major histocompatib...

journal_title：International journal of cancer

authors： Correale P,Aquino A,Giuliani A,Pellegrini M,Micheli L,Cusi MG,Nencini C,Petrioli R,Prete SP,De Vecchis L,Turriziani M,Giorgi G,Bonmassar E,Francini G

更新日期：2003-04-20 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is a tumour classification that is defined by oestrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 receptor negativity. TNBCs share a similar gene expression profile to BRCA-mutated tumours, have been shown to carry a high proportion of BRCA mutati...

journal_title：International journal of cancer

authors： Wong-Brown MW,Avery-Kiejda KA,Bowden NA,Scott RJ

更新日期：2014-01-15 00:00:00

abstract：:Six oncogenic cell lines were established from primary sarcomas that had been induced in thymectomized, aged, BALB/cSt mice by the injection of 3-methylcholanthrene. Of these lines, three produced B-tropic murine leukemia virus (MuLV), i.e. MuLV that would patently infect fibroblasts of BALB/c origin but not those fro...

journal_title：International journal of cancer

authors： Gillespie GY,Jensen FC,Russell SW

更新日期：1978-02-15 00:00:00

abstract：:The effect that polymorphonuclear leukocytes (PMN) may have on the metastatic colonization of tumor cells is controversial: some laboratories have reported that PMN can inhibit metastasis whereas others have shown an augmentation effect. We have exploited our finding that a particular fibrosarcoma (BMT-11) transplante...

journal_title：International journal of cancer

authors： Ishikawa M,Koga Y,Hosokawa M,Kobayashi H

更新日期：1986-06-15 00:00:00

abstract：:The tumor microenvironment consists of an immunosuppressive niche created by the complex interactions between cancer cells and surrounding stromal cells. A critical component of this environment are myeloid-derived suppressor cells (MDSCs), a heterogeneous group of immature myeloid cells arrested at different stages o...

journal_title：International journal of cancer

authors： Pyzer AR,Cole L,Rosenblatt J,Avigan DE

更新日期：2016-11-01 00:00:00

abstract：:Because of the absence of data on smoking history for patients in cancer registries, large population-based studies have been unable to directly assess the role of smoking in the risk of multiple primary cancers. In a random sample of 618 adults diagnosed with invasive cancer in 2002 and reported to the population-bas...

journal_title：International journal of cancer

authors： Polednak AP

更新日期：2006-07-01 00:00:00

abstract：:Liquid-based cytology (LBC) has replaced conventional cytology (CC) for cervical cancer screening in some countries. However, it remains unclear whether LBC is superior to CC. A randomized controlled trial was conducted between August 2007 and March 2009 in Germany to compare LBC, alone and in combination with compute...

journal_title：International journal of cancer

authors： Klug SJ,Neis KJ,Harlfinger W,Malter A,König J,Spieth S,Brinkmann-Smetanay F,Kommoss F,Weyer V,Ikenberg H

更新日期：2013-06-15 00:00:00

abstract：:Recombinant human (rhu) macrophage colony-stimulating factor (M-CSF) was evaluated for efficacy, either alone or in combination with local X-irradiation (LR), in mice inoculated subcutaneously (s.c.) with Lewis lung carcinoma (LLC) cells. The size of the primary tumor and numbers of lung metastases, 21 days after tumo...

journal_title：International journal of cancer

authors： Lu L,Shen RN,Lin ZH,Aukerman SL,Ralph P,Broxmeyer HE

更新日期：1991-01-02 00:00:00

abstract：:Lung cancer is one of the greatest threats to human health, and is initially detected and attacked by the immune system through tumor-reactive T cells. The aim of this study was to determine the basic characteristics and clinical significance of the peripheral blood T-cell receptor (TCR) repertoire in patients with ad...

journal_title：International journal of cancer

authors： Liu YY,Yang QF,Yang JS,Cao RB,Liang JY,Liu YT,Zeng YL,Chen S,Xia XF,Zhang K,Liu L

更新日期：2019-09-01 00:00:00

abstract：:IL-10 mRNA expression and protein production in established melanoma cell lines and freshly cultured primary and metastatic melanoma cells was examined. The in situ distribution of IL-10 in native melanoma tissue was also investigated by immunohistochemistry in primary tumors, metastases, benign melanocytic nevi and n...

journal_title：International journal of cancer

authors： Dummer W,Bastian BC,Ernst N,Schänzle C,Schwaaf A,Bröcker EB

更新日期：1996-05-29 00:00:00

abstract：:Diabetes is a risk factor for many cancers; chronic hyperglycemia is hypothesized to be, in part, explanatory. We evaluated the association between glycated hemoglobin, a time-integrated glycemia measure, and cancer incidence and mortality in nondiabetic and diabetic men and women. We conducted a prospective study of ...

journal_title：International journal of cancer

authors： Joshu CE,Prizment AE,Dluzniewski PJ,Menke A,Folsom AR,Coresh J,Yeh HC,Brancati FL,Platz EA,Selvin E

更新日期：2012-10-01 00:00:00

abstract：:Annamycin (Ann) is a non-cross-resistant lipophilic anthracycline antiobiotic optimally suited for liposome delivery. We studied how vesicle size and presence of phospholipids with a high phase transition temperature and monosialoganglioside (GM I) in the liposome bilayers affect the pharmacokinetics, tumor selectivit...

journal_title：International journal of cancer

authors： Zou Y,Ling YH,Reddy S,Priebe W,Perez-Soler R

更新日期：1995-05-29 00:00:00

abstract：:XIAP directly inhibits executor caspases, making it the most downstream antiapoptotic molecule. Here, we examined the expression and function of XIAP in normal urothelium and TCC. We also examined the therapeutic effect of xiap AS PODN on the cell cycle and apoptosis of multidrug-resistant T24 bladder cancer cells. XI...

journal_title：International journal of cancer

authors： Bilim V,Kasahara T,Hara N,Takahashi K,Tomita Y

更新日期：2003-01-01 00:00:00

abstract：:Human germ cell tumors comprise a heterogeneous group of neoplasms. Those of the adult testis, known as TGCTs, originate from carcinoma in situ (CIS), which are initiated during intra-uterine development. We present here a molecular model for the development of TGCTs, including various parameters, such as apoptosis, c...

journal_title：International journal of cancer

authors： Looijenga LH,de Munnik H,Oosterhuis JW

更新日期：1999-12-10 00:00:00

abstract：:DCs hold promise for cancer immunotherapy due to their functional ambivalence: iDCs internalize antigens, then mDCs trigger naive T-cell activation. However, no consensus has been reached concerning the optimal mode of antigen acquisition for efficient cross-priming of TAA-specific CTLs, and this remains a field of in...

journal_title：International journal of cancer

authors： Labarrière N,Bretaudeau L,Gervois N,Bodinier M,Bougras G,Diez E,Lang F,Gregoire M,Jotereau F

更新日期：2002-09-20 00:00:00

abstract：:Chen, B., Liu, X., Savell, V.H., Dilday, B.R., Johnson, M.W., Jenkins, J.J., and Parham, D.M., Increased DNA methyltransferase expression in rhabdomyosarcomas. Int. J. Cancer, 83, 10-14 (1999). Due to a printer's error, the bottom of Figure 3 was cut off after the proofs had been approved by the author. The correct fi...

journal_title：International journal of cancer

authors： Chen B,Liu X,Savell VH,Dilday BR,Johnson MW,Jenkins JJ,Parham DM

更新日期：1999-12-10 00:00:00

abstract：:TK is a pyrimidine metabolic pathway enzyme involved in salvage DNA synthesis. What roles TK may play in epithelial ovarian cancer and the relationships between TK and the other pyrimidine pathway enzymes remain unclear. We examined TK1 gene expression by RT-PCR and related it to gene expression of TS, TP and DPD in 6...

journal_title：International journal of cancer

authors： Fujiwaki R,Hata K,Nakayama K,Moriyama M,Iwanari O,Katabuchi H,Okamura H,Sakai E,Miyazaki K

更新日期：2002-05-20 00:00:00

abstract：:It has become axiomatic that critical windows of susceptibility to genotoxins exist and that genetic damage in utero may be a trigger for later life cancers. Data supporting this critical window hypothesis are remarkably few. This study provides a quantitative bridge between DNA damage by the liver carcinogen aflatoxi...

journal_title：International journal of cancer

authors： Chawanthayatham S,Thiantanawat A,Egner PA,Groopman JD,Wogan GN,Croy RG,Essigmann JM

更新日期：2015-03-15 00:00:00

abstract：:The melanosomal protein TRP2 expressed by melanocytes and most melanoma cells is an attractive, clinically relevant model antigen for the experimental development of melanoma immunotherapy in mice. A peptide shared by murine and human TRP2 can be recognized by melanoma-reactive CTL in C57BL/6 mice, as well as in human...

journal_title：International journal of cancer

authors： Steitz J,Brück J,Steinbrink K,Enk A,Knop J,Tüting T

更新日期：2000-04-01 00:00:00