Human papillomavirus and cervical intraepithelial neoplasia grade II-III: a population-based case-control study.

abstract：:Invasiveness is one of the key features of aggressive prostate cancer; however, our understanding of the precise mechanisms effecting invasion remains limited. The ceramide hydrolyzing enzyme acid ceramidase (AC), overexpressed in most prostate tumors, causes an aggressive and invasive phenotype through downstream eff...

journal_title：International journal of cancer

authors： Beckham TH,Lu P,Cheng JC,Zhao D,Turner LS,Zhang X,Hoffman S,Armeson KE,Liu A,Marrison T,Hannun YA,Liu X

更新日期：2012-11-01 00:00:00

abstract：:In ovarian carcinomas, recurrence and acquired chemoresistance are the first leading causes of therapeutic failure and are responsible for the poor overall survival rate. Cisplatin exposure of sensitive cells has been previously associated with a down-regulation of Bcl-X(L) expression and apoptosis, whereas recurrence...

journal_title：International journal of cancer

authors： Brotin E,Meryet-Figuière M,Simonin K,Duval RE,Villedieu M,Leroy-Dudal J,Saison-Behmoaras E,Gauduchon P,Denoyelle C,Poulain L

更新日期：2010-02-15 00:00:00

abstract：:This study investigates the role of tumor nitric oxide (NO) and vascular regulation in tumor ulceration following high-dose tumor necrosis factor-alpha (TNF) treatment. Using TNF-responsive (MethA) and nonresponsive (LL2) mouse tumors, tumor NO concentration was measured with an electrochemical sensor and tumor blood ...

journal_title：International journal of cancer

authors： Menon C,Bauer TW,Kelley ST,Raz DJ,Bleier JI,Patel K,Steele K,Prabakaran I,Shifrin A,Buerk DG,Sehgal CM,Fraker DL

更新日期：2008-07-15 00:00:00

abstract：:A major objective of peptide vaccination is the induction of tumor-reactive CD8+ T-cells. We have shown that HLA-A2 positive cancer patients frequently develop an antigen-specific CD8+ T-cell response after vaccination with NY-ESO-1 peptides p157-165/p157-167. These T-cells are highly reactive with the peptides used f...

journal_title：International journal of cancer

authors： Karbach J,Gnjatic S,Pauligk C,Bender A,Maeurer M,Schultze JL,Nadler K,Wahle C,Knuth A,Old LJ,Jäger E

更新日期：2007-11-01 00:00:00

abstract：:Cervical cancer is a public health concern as it represents the second cause of cancer death in women worldwide. High-risk human papillomaviruses (HPV) are the etiologic agents, and HPV E6 and/or E7 oncogene-specific therapeutic vaccines are under development to treat HPV-related lesions in women. Whether the use of m...

journal_title：International journal of cancer

authors： Decrausaz L,Domingos-Pereira S,Duc M,Bobst M,Romero P,Schiller JT,Jichlinski P,Nardelli-Haefliger D

更新日期：2011-08-01 00:00:00

abstract：:We have previously described an inverse relationship between Cu-Zn superoxide dismutase (SOD) activity and invasiveness of a clone of human tongue cancer cells. In these cells, suppression of Cu-Zn SOD activity by transfection with anti-sense cDNA enhanced motility in vitro. The present studies were undertaken to dete...

journal_title：International journal of cancer

authors： Tanaka M,Kogawa K,Nishihori Y,Kuribayashi K,Nakamura K,Muramatsu H,Koike K,Sakamaki S,Niitsu Y

更新日期：1997-10-09 00:00:00

abstract：:BRCA1 and BRCA2 play essential roles in maintaining the genome stability. Pathogenic germline mutations in these two genes disrupt their function, lead to genome instability and increase the risk of developing breast and ovarian cancers. BRCA mutations have been extensively screened in Caucasian populations, and the r...

journal_title：International journal of cancer

authors： Bhaskaran SP,Chandratre K,Gupta H,Zhang L,Wang X,Cui J,Kim YC,Sinha S,Jiang L,Lu B,Wu X,Qin Z,Huang T,Wang SM

更新日期：2019-08-15 00:00:00

abstract：:The factors associated with risk of lung cancer among nonsmokers have not been fully elucidated, but dietary factors have consistently been shown to play a role. Chinese women are unique in having a high incidence of lung cancer despite a low smoking prevalence. This population is also known to have a high intake of s...

journal_title：International journal of cancer

authors： Seow A,Poh WT,Teh M,Eng P,Wang YT,Tan WC,Chia KS,Yu MC,Lee HP

更新日期：2002-01-20 00:00:00

abstract：:A recent 2-dimensional gel electrophoresis study revealed several polypeptide differences between a strongly metastatic and a weakly metastatic clone from a single chemically induced murine fibrosarcoma (Jellum et al., 1984). To exclude the possibility that this was merely coincidental, the study is extended here to 2...

journal_title：International journal of cancer

authors： Grimstad IA,Thorsrud AK,Varani J,Ward PA,Jellum E

更新日期：1988-04-15 00:00:00

abstract：:We have studied the clonal heterogeneity of 2 spontaneously metastasizing mammary carcinomas which recently arose spontaneously in C3H/He female retired breeders. Cells of early (2nd to 5th) transplant generations of these tumors were cloned by a combination of semi-solid agarose colony formation and limiting dilution...

journal_title：International journal of cancer

authors： Brodt P,Parhar R,Sankar P,Lala PK

更新日期：1985-02-15 00:00:00

abstract：:Socioeconomic status (SES) is a determinant of outcome in various types of cancer. The aim of this study is to analyze the impact of the SES in Hodgkin's lymphoma (HL). From 2001 to 2005, 194 consecutive patients were prospectively followed in 5 institutions. Patients answered a questionnaire with a set of items used ...

journal_title：International journal of cancer

authors： Soares A,Biasoli I,Scheliga A,Luiz RR,Costa MA,Land M,Romano S,Morais JC,Spector N

更新日期：2007-02-15 00:00:00

abstract：:Powerful analytical tools are vital for characterizing the complex molecular changes underlying oncogenesis and cancer treatment. This is particularly true, if information is to be collected in vivo by noninvasive approaches. In the recent past, hyperpolarized (13)C magnetic resonance (MR) spectroscopy has been employ...

journal_title：International journal of cancer

authors： Karlsson M,Jensen PR,in 't Zandt R,Gisselsson A,Hansson G,Duus JØ,Meier S,Lerche MH

更新日期：2010-08-01 00:00:00

abstract：:The effect of cyclic phosphatidic acid, a unique analogue of lysophosphatidic acid, on the induction of bombesin-enhanced peritoneal metastases from intestinal adenocarcinomas induced by azoxymethane was investigated in male Wistar rats. Rats were given 10 weekly injections of azoxymethane (7.4 mg/kg body weight, s.c....

journal_title：International journal of cancer

authors： Ishihara R,Tatsuta M,Iishi H,Baba M,Uedo N,Higashino K,Mukai M,Ishiguro S,Kobayashi S,Murakami-Murofushi K

更新日期：2004-06-10 00:00:00

abstract：:Many tumors are impervious to anticancer agents. Resistance due to lack of cytotoxic penetration into the tumor is often overlooked but can play a significant role in undermining therapy. Insufficient and irregular vascularization of tumors is a possible barrier to drug delivery, but there are others, e.g., impaired v...

journal_title：International journal of cancer

authors： Wildiers H,Guetens G,de Boeck G,Landuyt W,Verbeken E,Highley M,de Bruijn EA,van Oosterom AT

更新日期：2002-06-01 00:00:00

abstract：:Interleukin-11(rhIL-11) is a cytokine that has been shown to enhance the recovery of bone marrow and intestinal crypt cells after cytotoxic insult with radiation or anticancer drugs. The current study examined the effects of rhIL-11 on the response of CEM human lymphoblastic leukemia cells and on the EMT-6 murine mamm...

journal_title：International journal of cancer

authors： Teicher BA,Chen YN,Ara G,Emi Y,Kakeji Y,Maehara Y,Keyes S,Northey D

更新日期：1996-09-17 00:00:00

abstract：:The association between parity and hepatocellular carcinoma (HCC) was studied using a data-base generated by linking 2 Swedish nation-wide registries; the Cancer Registry and the Fertility Registry. Among women born between 1925 and 1960, 133 patients with HCC recorded in the Cancer Registry between 1958 and 1984 were...

journal_title：International journal of cancer

authors： Lambe M,Trichopoulos D,Hsieh CC,Ekbom A,Pavia M

更新日期：1993-11-11 00:00:00

abstract：:The INK4A gene, localized to human chromosome 9p21, encodes p16INK4A, a tumor suppressor that functions at least in part through the inhibition of CDK4, a cyclin-dependent kinase encoded by a gene at 12q13. To examine INK4A gene alterations in uncultured samples of osteosarcoma and the relationship between INK4A and C...

journal_title：International journal of cancer

authors： Wei G,Lonardo F,Ueda T,Kim T,Huvos AG,Healey JH,Ladanyi M

更新日期：1999-01-18 00:00:00

abstract：:Monoclonal antibody (MAb) K 112 was generated after a single intrasplenic immunization with a recurrent laryngeal squamous-cell carcinoma. The antibody detects a 43-kDa nuclear antigen, with a pI of 5.4, which is expressed only in cycling cells. Expression is typically seen in a granular pattern excluding the nucleoli...

journal_title：International journal of cancer

authors： Quak JJ,van Dongen G,Koken MA,Brakkee JG,Scheper RJ,Balm AJ,de Jong L,Snow GB,Meijer CJ

更新日期：1990-07-15 00:00:00

abstract：:Therapy-induced senescence (TIS) as a permanent growth arrest can be induced by various stimuli, including anticancer compounds. TIS emerged as a promising strategy to overcome resistance phenomena. However, senescent cancer cells might regain proliferation activity in vivo or even secrete tumor-promoting cytokines. T...

journal_title：International journal of cancer

authors： Weiland T,Lampe J,Essmann F,Venturelli S,Berger A,Bossow S,Berchtold S,Schulze-Osthoff K,Lauer UM,Bitzer M

更新日期：2014-01-01 00:00:00

abstract：:The 1100delC mutation of the cell cycle checkpoint kinase 2 (CHEK2) gene confers an increased risk for breast cancer, but the clinical impact of other CHEK2 gene variants remains unclear. We determined the frequency of two functionally relevant CHEK2 gene mutations, I157T and IVS2+1G > A, in two large series of breast...

journal_title：International journal of cancer

authors： Bogdanova N,Enssen-Dubrowinskaja N,Feshchenko S,Lazjuk GI,Rogov YI,Dammann O,Bremer M,Karstens JH,Sohn C,Dörk T

更新日期：2005-08-20 00:00:00

abstract：:A hospital-based case-control study of renal-cell carcinoma was conducted in France from 1987 to 1991. A total of 196 histologically confirmed cases (138 males and 58 females) and 347 controls (235 males and 112 females), matched for sex, age at interview, hospital and interviewer, were included. The risk of renal-cel...

journal_title：International journal of cancer

authors： Benhamou S,Lenfant MH,Ory-Paoletti C,Flamant R

更新日期：1993-08-19 00:00:00

abstract：:The glycoprotein 90K was originally described as a tumor-secreted antigen and subsequently found to have immunostimulatory activity as well as other possible functions. This protein interacts with an endogenous lectin, galectin-3, and may play a role in tumor metastasis through this interaction. Because 90K is heavily...

journal_title：International journal of cancer

authors： Tinari N,Kuwabara I,Huflejt ME,Shen PF,Iacobelli S,Liu FT

更新日期：2001-01-15 00:00:00

abstract：:Cancer survival varies by place of residence, but it remains uncertain whether this reflects differences in tumour, patient and treatment characteristics (including tumour stage, indicators of socioeconomic status (SES), comorbidity and information on received surgery and radiotherapy) or possibly regional differences...

journal_title：International journal of cancer

authors： Skyrud KD,Bray F,Eriksen MT,Nilssen Y,Møller B

更新日期：2016-05-01 00:00:00

abstract：:Carcinomatous meningitis is a devastating metastatic complication of systemic carcinoma, which may occur insidiously, accompanied by a confusing spectrum of clinical symptoms and signs. In the absence of reliable diagnostic tumour markers, the diagnosis is established by the demonstration of malignant cells within the...

journal_title：International journal of cancer

authors： Moseley RP,Oge K,Shafqat S,Moseley CM,Sullivan NM,Badley RA,Burchell J,Taylor-Papadimitriou J,Coakham HB

更新日期：1989-09-15 00:00:00

abstract：:Fine-needle aspiration cytology (FNAC) is currently used in evaluating the nature of breast nodules. In the present study we have examined whether monoclonal antibodies (MAbs) to breast-tumor-associated antigens (BTAA) can be employed in FNAC for the diagnosis of breast cancer. For this purpose we have used 2 murine M...

journal_title：International journal of cancer

authors： Nuti M,Mottolese M,Viora M,Donnorso RP,Schlom J,Natali PG

更新日期：1986-04-15 00:00:00

abstract：:Dietary carbohydrates have different glycemic and insulinemic potentials depending on type (glycemic index, GI) and amount (glycemic load, GL) of carbohydrate consumed or both. Insulin in turn has been implicated as a risk factor for several cancers, including that of the prostate. We assessed the relationship of GI a...

journal_title：International journal of cancer

authors： Augustin LS,Galeone C,Dal Maso L,Pelucchi C,Ramazzotti V,Jenkins DJ,Montella M,Talamini R,Negri E,Franceschi S,La Vecchia C

更新日期：2004-11-10 00:00:00

abstract：:Data on the incidence of 15 cancers in the Jewish population of Israel from the period 1961-1981 have been studied with emphasis on the risk of disease in relation to birthplace, calendar time, and duration of residence in Israel. The results show wide variations in incidence by birthplace, from less than 2-fold for p...

journal_title：International journal of cancer

authors： Parkin DM,Steinitz R,Khlat M,Kaldor J,Katz L,Young J

更新日期：1990-04-15 00:00:00

abstract：:In previous studies we showed that human sarcoma and melanoma cell lines synthesize and secrete into culture medium a glycoprotein, migrating in urea sodium dodecyl sulfate-polyacrylamide gel electrophoresis at Mr 140,000. It is not detected in cultures of the corresponding normal cells. Conditioned medium of the mela...

journal_title：International journal of cancer

authors： Bízik J,Vaheri A,Saksela O,Kalkkinen N,Meri S,Grófóva M

更新日期：1986-01-15 00:00:00

abstract：:The occurrence of metastasis severely affects prognosis and survival of breast cancer patients. In order to metastasize, breast cancer cells need to cross the basement membrane (BM) tissue boundaries. Matrix metalloproteases (MMPs) are enzymes with proteolytic activity towards extracellular matrix components (ECM) of ...

journal_title：International journal of cancer

authors： Giannelli G,Erriquez R,Fransvea E,Daniele A,Trerotoli P,Schittulli F,Grano M,Quaranta M,Antonaci S

更新日期：2004-05-01 00:00:00

abstract：:Prostate cancer is the most common malignancy in men, and patients with metastatic disease have poor outcome even with the most advanced therapeutic approaches. Most cancer therapies target the bulk tumor cells, but may leave intact a small population of tumor-initiating cells (TICs), which are believed to be responsi...

journal_title：International journal of cancer

authors： Marian CO,Wright WE,Shay JW

更新日期：2010-07-15 00:00:00