Abstract:
:Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer mortality worldwide. Emerging evidence indicates that tumour cells release substantial amounts of RNA into the bloodstream, in which RNA strongly resists RNases and is present at sufficient levels for quantitative analyses. Our study aimed to discover blood-based markers for the early detection of CRC and to ascertain their efficiency in discriminating healthy controls, patients with polyps and adenomas and cancer patients. We first analysed and screened ZFAS1, SNHG11, LINC00909 and LINC00654 in a bioinformatics database and then collected clinical plasma samples for preliminary small-scale analysis and further large-scale verification. We then explored the mechanism of dominant lncRNA SNHG11 expression in CRC by in vitro and in vivo assays. The combination of ZFAS1, SNHG11, LINC00909 and LINC00654 showed high diagnostic performance for CRC (AUC: 0.937), especially early-stage disease (AUC: 0.935). Plasma levels of the four candidate lncRNAs were significantly reduced in postoperative samples compared to preoperative samples. A panel including these four lncRNAs performed well in distinguishing patient groups with different stages of colon disease, and SNHG11 exhibited the greatest diagnostic ability to identify precancerous lesions and early-stage tumour formation. Mechanistically, high SNHG11 expression promotes proliferation and metastasis by targeting the Hippo pathway. Taken together, the data indicate that SNHG11 may be a novel therapeutic target for the treatment of CRC and a potential biomarker for the early detection of CRC.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Xu W,Zhou G,Wang H,Liu Y,Chen B,Chen W,Lin C,Wu S,Gong A,Xu Mdoi
10.1002/ijc.32747subject
Has Abstractpub_date
2020-05-15 00:00:00pages
2901-2912issue
10eissn
0020-7136issn
1097-0215journal_volume
146pub_type
杂志文章abstract::Uveal melanoma is associated with a high tumor-related mortality due to the propensity to develop metastases. The mechanisms that are responsible for malignant dissemination are largely unknown and need to be explored to facilitate diagnosis and treatment of metastases. To identify molecules involved in dissemination,...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11262
更新日期:2003-09-10 00:00:00
abstract::A human papillomavirus (HPV) was cloned from a patient with multiple squamous cell carcinomas (SCCs) and identified as HPV88, recently categorized into a new species within the genus Gamma. The HPV88 viral load in an SCC of the index patient exceeded 1 million copies/cell. By contrast, a survey of 447 skin lesions (79...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23115
更新日期:2008-01-15 00:00:00
abstract::The major obstacle for the treatment of gastric cancer is recurrence and metastasis; yet, its molecular mechanism is largely unknown. 2-methoxyestradiol (2-ME), a metabolite of the estradiol-17beta, has recently been demonstrated to have multifactorial effects against tumor proliferation and angiogenesis; how these ef...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22963
更新日期:2007-12-01 00:00:00
abstract::Rapid growth of residual tumor after partial hepatectomy has been observed during the period of liver regeneration in children with malignant embryonal hepatoblastoma. The aim of this study was to elucidate the role of hepatocyte growth-factor-scatter factor (HGF-SF) in this phenomenon. Markedly increased serum levels...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(20000115)85:2<151::AID-IJC
更新日期:2000-01-15 00:00:00
abstract::The Eph receptor A2 (EphA2) is overexpressed in a range of human epithelial cancers, a phenotype that is associated with cancer cell proliferation, progression and angiogenesis. Mouse models of mammary neoplasia have confirmed the role of EphA2 as mice carrying a knockout allele of EphA2 were resistant to breast cance...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24083
更新日期:2009-03-15 00:00:00
abstract::Pediatric high-grade gliomas (HGGs) are highly malignant tumors that remain incurable and relatively understudied. The crucial role of noncoding RNAs (ncRNAs) has been reported in various cancers. However, the study on miRNAs in pediatric HGGs is scant and there is no report till date on the status of other small ncRN...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29610
更新日期:2015-11-15 00:00:00
abstract::In order to identify regulatory genes involved in the development of an apoptosis-resistant phenotype in patients with chemotherapy refractory B-cell chronic lymphocytic leukemia (B-CLL) expression of apoptosis-regulating genes in B-CLL cells was quantified using cDNA arrays and RT-PCR. Data were obtained from and com...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20614
更新日期:2005-02-20 00:00:00
abstract::Trends in incidence rates of cutaneous malignant melanoma in Western Australia from 1975-76 to 1980-1981 have been examined with reference to age, sex, body site, presence or absence of dermal invasion, tumour thickness, histological type, socioeconomic status and occupation. The incidence rates of all melanomas incre...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910370207
更新日期:1986-02-15 00:00:00
abstract::Elevated platelet counts in patients diagnosed with malignant tumors were first described more than 100 years ago. Today it is well known that in many types of solid tumors, thrombocytosis at the time of diagnosis is associated with shorter survival. From this well-documented clinical correlation between platelet coun...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.27441
更新日期:2012-06-15 00:00:00
abstract::We have previously demonstrated that the delta isoform of protein kinase C (PKCdelta) is importantly involved in cell growth inhibition and tumor suppression in colon cancer cells. To investigate further the activity and mechanism of action of PKCdelta, we have retrovirally transduced a PKCdelta cDNA in HCT116 human c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20535
更新日期:2005-01-01 00:00:00
abstract::Inflammatory bowel disease (IBD) patients may bear an increased neuroendocrine tumor (NET) risk. These tumors are mostly reported as coincidental findings during surgery. We aimed to determine the prevalence of colonic NET in a Dutch nationwide IBD cohort and calculate the prevalence rate ratios (PRR) compared with th...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30096
更新日期:2016-08-01 00:00:00
abstract::The steady-state level of nucleophosmin/B23 mRNA decreased during berberine-induced (25 microg/ml, 24 to 96 hr) apoptosis of human leukemia HL-60 cells. A decline in telomerase activity was also observed in HL-60 cells treated with berberine. A stable clone of nucleophosmin/B23 overexpressed in HL-60 cells was selecte...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990611)81:6<923::aid-ijc
更新日期:1999-06-11 00:00:00
abstract::As Phase 0 studies have proven to be reasonably predictive of therapeutic dose pharmacokinetics, the application of microdosing has expanded into metabolism, drug-drug interactions and now diagnostics. One potentially serious issue with this application of microdosing that has not been previously discussed is the poss...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.28773
更新日期:2015-04-01 00:00:00
abstract::The antineoplastic effect of paclitaxel is mainly related to its ability to bind the beta subunit of tubulin, thus preventing tubulin chain depolarization and inducing apoptosis. The relevance of the Class I beta-tubulin characteristics have also been confirmed in the clinical setting where mutations of paclitaxel-bin...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22557
更新日期:2007-05-15 00:00:00
abstract::Somatic mutations in the E-cadherin (CDH1) gene have frequently been reported in cases with diffuse gastric and lobular breast cancers. Recently, germline mutations have been identified in families with diffuse gastric cancers. In families with hereditary prostate cancer (HPC), a significant association of prostate ca...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10258
更新日期:2002-04-20 00:00:00
abstract::Partial or total loss of chromosome 22 is often associated with tumors of the central nervous system and in particular with meningiomas. As in the case of other tumors, the ganglioside pattern is modified in transformed tissues. Cytogenetic analysis of 30 human meningiomas has been performed and the results compared t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910470303
更新日期:1991-02-01 00:00:00
abstract::We have developed novel 3-dimensional in vitro and in vivo tissue models that mimic premalignant disease of human stratified epithelium in order to analyze the stromal contribution of extracellular matrix and basement membrane proteins to the progression of intraepithelial neoplasia. Three-dimensional, organotypic cul...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11525
更新日期:2004-01-20 00:00:00
abstract::A randomized clinical trial designed to compare the effectiveness of cytoxan (CTX) alone versus a combination consisting of CTX, vincristine (Oncovin) and methotrexate (COM) in the treatment of Burkitt's lymphoma (BL) was carried out. Nineteen patients were selected at random to receive CTX alone while 21 received COM...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/ijc.2910170404
更新日期:1976-04-15 00:00:00
abstract::The International Classification of Childhood Cancer (ICCC) updates the widely used Birch and Marsden classification scheme. ICCC is based on the second edition of the International Classification of Diseases for Oncology (ICD-O-2). The purpose of the new classification is to accommodate important changes in recogniti...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/(SICI)1097-0215(19961211)68:6<759::AID-IJC
更新日期:1996-12-11 00:00:00
abstract::The early arrest patterns of a methylcholanthrene-induced fibrosarcoma were determined after injection of 125IUdR-labelled cells into the systemic circulation of mice bearing transplanted lymphosarcomas, and of normal animals. Similar experiments were performed using radiolabelled lymphosarcoma cells and normal or fib...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910180608
更新日期:1976-12-15 00:00:00
abstract::Inflammation, and more generally, the immune response are thought to influence the development of prostate cancer. To determine the components of the immune response that are potentially contributory, we prospectively evaluated the association of immune-mediated conditions, asthma and hayfever, with lethal prostate ca...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29463
更新日期:2015-08-15 00:00:00
abstract::The effects of combined administration of bombesin (40 micrograms/kg body weight) and the ornithine decarboxylase (ODC) inhibitor, 1,3-diaminopropane (DAP), on the development of large and small intestinal tumors and the incidence of their metastasis to the peritoneum induced by azoxymethane (AOM, 7.4 mg/kg body weigh...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910580414
更新日期:1994-08-15 00:00:00
abstract::No animal model exists for the in vivo growth of Hodgkin's-lymphoma-derived cells. Neither unmanipulated Hodgkin's-disease(HD)-derived cell lines nor primary biopsy tissue could be grown in nude mice. Since the severe combined immunodeficient (SCID) mouse has been reported to be a better recipient for transplanted hum...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910520610
更新日期:1992-12-02 00:00:00
abstract::The active form of vitamin D(3), 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), induces caspase-independent apoptosis in MCF-7 and T47D breast cancer cells. Before the appearance of apoptotic cells at Day 4 after the addition of 1,25(OH)(2)D(3), the MCF-7 cells are sensitized to the caspase-mediated apoptosis induced b...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1325
更新日期:2001-07-15 00:00:00
abstract::To identify prognostic factors in medulloblastoma, a common malignant brain tumor of childhood, expression of the oncogene c-myc was examined at the mRNA level by in situ hybridization. c-myc mRNA expression was observed in 30 of 72 tumors (42%). The c-myc gene copy number was determined by quantitative PCR from genom...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:
更新日期:2000-09-20 00:00:00
abstract::A new antigan has been revealed by means of antisera against Rauscher virus in mice with Rauscher virus-induced leukemia. This antigen appears to be different from both Rauscher type-specific antigen and MULV-gs-1 (p-30), as shown by studies of electrophoretic mobility and immunochemical specificity. Except in leukemi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910170617
更新日期:1976-06-15 00:00:00
abstract::Hybridomas producing syngeneic monoclonal antibodies (MAbs) were prepared by fusion of spleen cells of BALB/c mice, which were immunized with sublethal doses of RMB-I cells. This cell line originates from a Rauscher virus (R-MuLV)-induced myeloid leukemia and forms tumors when re-inoculated into mice. MAbs were charac...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910420121
更新日期:1988-07-15 00:00:00
abstract::Fatty acid ester surfactants, e.g., Cremophor EL and Solutol HS 15, that modulate multi-drug resistance (MDR) have been described; however, the drug potential of these preparations is unclear because of the molecular heterogeneity of these and other commercial surfactants. In previous experiments, an active but still ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960103)65:1<74::AID-IJC1
更新日期:1996-01-03 00:00:00
abstract::A large genotyping project within the Breast Cancer Association Consortium (BCAC) recently identified 41 associations between single nucleotide polymorphisms (SNPs) and overall breast cancer (BC) risk. We investigated whether the effects of these 41 SNPs, as well as six SNPs associated with estrogen receptor (ER) nega...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29188
更新日期:2015-03-15 00:00:00
abstract::Dietary information from a case-control study of pancreatic cancer conducted in Metropolitan Toronto between 1983 and 1986 is reported. A total of 249 cases and 505 population-based controls completed quantitative diet histories from which total caloric intake and the intake of a number of nutrients were estimated. A ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910450405
更新日期:1990-04-15 00:00:00