Variants at chromosome 20 (ASIP locus) and melanoma risk.


:Agouti signaling protein (ASIP) locus on chromosome 20q11 is implicated, as shown by genome-wide association studies, in phenotype variation and melanoma risk. We genotyped 837 melanoma cases and 1,154 controls for 21 single nucleotide polymorphisms (SNPs) informative for 495 polymorphisms at the locus. Our data showed an increased risk of melanoma (odds ratio [OR] 1.27, 95% confidence interval [95% CI] 1.03-1.57) in carriers of the rs4911414 variant, located 120 kb upstream of ASIP. The main effect of rs4911414, as reported previously, was in tandem with a 10 kb adjacent polymorphism rs1015362; two constituted risk-associated haplotype/diplotype. Except for rs1015363, none of the 12 tagging SNPs, genotyped to cover 239.9 kb region with polymorphisms linked to rs4911414 and rs1015362, were associated with melanoma. Our data confirmed a previous association of melanoma risk (OR 1.82, 95% CI 1.37-2.41) with rs4911442, located in intron 5 of the nuclear receptor coactivator 6 (NCOA6) gene. The rs910871, one of the six variants, genotyped to cover NCOA6, showed an association with melanoma risk (OR 1.33, 95% CI 1.04-1.70). Both, rs4911442 and rs910871 were in moderate linkage with a, previously reported, risk-associated rs910873 polymorphism. A haplotype from the variants within NCOA6 showed an association with risk of melanoma (OR 1.49, 95% CI 1.17-1.88). Interaction between risk-associated polymorphisms and previously genotyped melanocortin receptor 1 (MC1R) variants, in our study, was not statistically significant. Nevertheless, the carriers of the variant alleles over the background of MC1R variants were at a higher risk than the carriers not enriched for MC1R variants. Our data confirmed the association of different variants at chromosome 20q11 with melanoma risk.


Int J Cancer


Maccioni L,Rachakonda PS,Scherer D,Bermejo JL,Planelles D,Requena C,Hemminki K,Nagore E,Kumar R




Has Abstract


2013-01-01 00:00:00












  • Oncogenesis by interspecific interaction of malignant murine and non-malignant hamster cells in vitro.

    abstract::A clone of Cloudman S91 murine melanoma was fused in vitro with non-malignant hamster cheek pouch cells by means of lysolecithin, and the putative hybrid progeny cells, HCP-MM, were found to be highly malignant in hamster, but not in appropriate mice. A malignant clone of HCP-MM cells was shown to have hamster species...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Goldenberg DM,Pavia RA

    更新日期:1975-02-15 00:00:00

  • Human astrocytomas and glioblastomas express monocyte chemoattractant protein-1 (MCP-1) in vivo and in vitro.

    abstract::Expression of the monocyte chemoattractant protein-1 (MCP-1) was examined in human central nervous system tumours (glioblastomas and astrocytomas) and normal human brain. Northern blot analysis demonstrated constitutive expression of MCP-1 mRNA in 6 of 12 glioblastoma cell lines. Expression could be stimulated by inte...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Desbaillets I,Tada M,de Tribolet N,Diserens AC,Hamou MF,Van Meir EG

    更新日期:1994-07-15 00:00:00

  • A bispecific transmembrane antibody simultaneously targeting intra- and extracellular epitopes of the epidermal growth factor receptor inhibits receptor activation and tumor cell growth.

    abstract::Epidermal growth factor receptor (EGFR) plays an important role in essential cellular processes such as proliferation, survival and migration. Aberrant activation of EGFR is frequently found in human cancers of various origins and has been implicated in cancer pathogenesis. The therapeutic antibody cetuximab (Erbitux)...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Müller N,Hartmann C,Genssler S,Koch J,Kinner A,Grez M,Wels WS

    更新日期:2014-06-01 00:00:00

  • Tenascin-C upregulates matrix metalloproteinase-9 in breast cancer cells: direct and synergistic effects with transforming growth factor beta1.

    abstract::Tenascin-C (TN-C) and matrix metalloproteinases (MMPs) are highly expressed in cancer tissues and probably promote cell migration during cancer progression. TN-C and MMPs are often co-localized in areas of active tissue remodeling in pathologic conditions, suggesting reciprocal regulation. To investigate whether TN-C ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kalembeyi I,Inada H,Nishiura R,Imanaka-Yoshida K,Sakakura T,Yoshida T

    更新日期:2003-05-20 00:00:00

  • OCT-4, an embryonic stem cell marker, is highly expressed in bladder cancer.

    abstract::OCT-4 (also known as POU5F1) is a key regulator of self-renewal in embryonic stem cells. Regarding the new cancer stem cell concept, the expression of such genes is potentially correlated with tumorigenesis and can affect some aspects of tumor behavior, such as tumor recurrence or resistance to therapies. Although OCT...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Atlasi Y,Mowla SJ,Ziaee SA,Bahrami AR

    更新日期:2007-04-01 00:00:00

  • Gefitinib prevents cancer progression in mice expressing the activated rat HER2/neu.

    abstract::We tested the efficacy of gefitinib in the prevention of HER2/neu-mediated breast cancer development in BALB-NeuT transgenic mice. Oral administration of gefitinib to female transgenic mice from 5 to 14 weeks of age reduced tumor multiplicity from 9.6 +/- 0.82 to 0.58 +/- 1.1 (83%). We observed a decrease in the numbe...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Piechocki MP,Dibbley SK,Lonardo F,Yoo GH

    更新日期:2008-04-15 00:00:00

  • Evidence of heterogeneity within colorectal liver metastases for allelic losses, mRNA level expression and in vitro response to chemotherapeutic agents.

    abstract::A goal of oncology is to predict chemosensitivity of tumors. This approach assumes that in a patient all tumor deposits are homogeneous. We have tested the heterogeneity between several samples of the same liver metastasis (LM; intrametastatic heterogeneity) or between multiple LM (intermetastatic heterogeneity) from ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Goasguen N,de Chaisemartin C,Brouquet A,Julié C,Prevost GP,Laurent-Puig P,Penna C

    更新日期:2010-09-01 00:00:00

  • Resistance to etoposide-induced apoptosis in a Burkitt's lymphoma cell line.

    abstract::Burkitt's lymphoma cells that vary in their phenotypic characteristics show significantly different degrees of susceptibility to radiation-induced apoptosis. Propensity to undergo apoptosis is reflected in the degradation of substrates such as DNA-dependent protein kinase but the status of bcl-2, c-myc and p53 has bee...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zhao EG,Song Q,Cross S,Misko I,Lees-Miller SP,Lavin MF

    更新日期:1998-08-31 00:00:00

  • Epstein-Barr virus antibody patterns preceding the diagnosis of non-Hodgkin's lymphoma.

    abstract::Immunosuppressed patients who develop non-Hodgkin's lymphoma (NHL) have abnormal antibody responses against the Epstein-Barr virus (EBV) prior to the diagnosis of malignancy. To see if this is also true of "spontaneous" cases in the general population, we undertook a collaborative serologic case-control study. From 4 ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mueller N,Mohar A,Evans A,Harris NL,Comstock GW,Jellum E,Magnus K,Orentreich N,Polk BF,Vogelman J

    更新日期:1991-09-30 00:00:00

  • Gene expression changes during HPV-mediated carcinogenesis: a comparison between an in vitro cell model and cervical cancer.

    abstract::We used oligonucleotide microarrays to investigate gene expression changes associated with multi-step human papillomavirus type 16 (HPV16)-mediated carcinogenesis in vitro. Gene expression profiles in 4 early passage HPV16-immortalized human keratinocyte (HKc) lines derived from different donors were compared with the...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wan F,Miao X,Quraishi I,Kennedy V,Creek KE,Pirisi L

    更新日期:2008-07-01 00:00:00

  • High levels of nm23-H1 and nm23-H2 messenger RNA in human squamous-cell lung carcinoma are associated with poor differentiation and advanced tumor stages.

    abstract::Expression of the candidate metastasis-suppressor gene nm23-H1 has been shown to correlate inversely with metastatic potential in some human tumors, but not in all. Until now, few studies have been carried out on the activity of the homologous nm23-H2 gene in human cancer. No nm23 transcription studies exist for human...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Engel M,Theisinger B,Seib T,Seitz G,Huwer H,Zang KD,Welter C,Dooley S

    更新日期:1993-09-30 00:00:00

  • Expression patterns of mitotic and meiotic cell cycle regulators in testicular cancer and development.

    abstract::Mitotic and meiotic cell cycle regulation is essential for normal development and tumor prevention. The underlying molecular mechanisms are not completely characterized. The aim of our analysis was to derive a global expression map of cell cycle regulators in mitosis and meiosis. First, the expression of cyclins, CDKs...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Diederichs S,Bäumer N,Schultz N,Hamra FK,Schrader MG,Sandstede ML,Berdel WE,Serve H,Müller-Tidow C

    更新日期:2005-08-20 00:00:00

  • Ultrastructural evidence of collagenolytic activity in ductal infiltrating carcinoma of the human breast.

    abstract::The stroma of ductal infiltrating carcinoma of the human breast shows characteristic and localized areas of collagen rarefaction and fragmentation. This finding has been correlated with a peculiar type of fibrillar damage, observed in a small percentage of collagen fibrils isolated in the native state from the tumour ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Pucci-Minafra I,Luparello C,Schillaci R,Sciarrino S

    更新日期:1987-05-15 00:00:00

  • Combined karyotyping, CGH and M-FISH analysis allows detailed characterization of unidentified chromosomal rearrangements in Merkel cell carcinoma.

    abstract::Merkel cell carcinoma (MCC) is a rare aggressive neuroendocrine tumor of the skin. Cytogenetic studies have indicated that deletions and unbalanced translocations involving chromosome 1 short arm material occur in 40% of the investigated cases. Recurrent chromosomal imbalances detected by comparative genomic hybridiza...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Van Gele M,Leonard JH,Van Roy N,Van Limbergen H,Van Belle S,Cocquyt V,Salwen H,De Paepe A,Speleman F

    更新日期:2002-09-10 00:00:00

  • Uterine carcinosarcoma is derived from a single stem cell: an in vitro study.

    abstract::Expression of intermediate filaments (IFs) has been suggested to be a reliable marker for differentiating epithelial and non-epithelial tumors. Moreover, the c-erbB-2 and p53 genes are considered to be involved relatively early in the process of human carcinogenesis. In order to elucidate the origin of uterine carcino...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Gorai I,Yanagibashi T,Taki A,Udagawa K,Miyagi E,Nakazawa T,Hirahara F,Nagashima Y,Minaguchi H

    更新日期:1997-09-04 00:00:00

  • Expression of the ALK protein by anaplastic large-cell lymphomas correlates with high proliferative activity.

    abstract::A variable fraction of anaplastic large-cell lymphomas (ALCLs) exhibits a t(2;5)(p23;q35) translocation that results in expression of the chimeric hyperphosphorylated protein NPM-ALK (p80). Tumor cells expressing NPM-ALK exhibit markedly enhanced proliferative activity, but comparative cellular kinetic studies on ALK(...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Leoncini L,Lazzi S,Scano D,Mura A,Onida A,Massarelli G,Tosi P,Barbini P,Cevenini G,Massai MR,Pileri S,Falini B,Giordano A,Kraft R,Laissue JA,Cottier H

    更新日期:2000-06-15 00:00:00

  • Lack of expression of c-KIT in ovarian cancers is associated with poor prognosis.

    abstract::The c-KIT protooncogene encodes a tyrosine kinase receptor, KIT, that is expressed in many normal and cancerous tissues. In this study, we have examined the expression of c-KIT and its ligand, stem cell factor (SCF), in human epithelial ovarian tumors, in normal ovaries and in cultured ovarian surface epithelium (OSE)...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tonary AM,Macdonald EA,Faught W,Senterman MK,Vanderhyden BC

    更新日期:2000-05-20 00:00:00

  • Determination of the origin of oral squamous cell carcinoma by microarray analysis: Squamous epithelium or minor salivary gland?

    abstract::More than 90% of oral cancers are histopathologically squamous cell carcinomas (SCCs). According to clinical behavior and histopathological features, we hypothesize that oral SCC can originate from either oral squamous epithelium or minor salivary glands. Here, we examined whether some oral SCCs originate from minor s...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kinouchi M,Izumi S,Nakashiro KI,Haruyama Y,Kobashi G,Uchida D,Hasegawa T,Kawamata H

    更新日期:2018-11-15 00:00:00

  • Farnesyl transferase inhibitor treatment of breast cancer cells leads to altered RhoA and RhoC GTPase activity and induces a dormant phenotype.

    abstract::Farnesyl transferase inhibitors (FTIs) were shown to be effective in modulating tumor growth in Ras-transformed tumor cells. Recent studies have focused on Rho GTPases as putative targets of FTI action. Previously, we demonstrated that FTIs were effective in inhibiting the growth and invasiveness of RhoC GTPase-overex...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chatterjee M,van Golen KL

    更新日期:2011-07-01 00:00:00

  • Immortalization of oral keratinocytes by functional inactivation of the p53 and pRb pathways.

    abstract::A subgroup of head and neck squamous cell carcinomas (HNSCCs) contains high-risk human papillomavirus-type 16 (HPV16). The viral E6 and E7 oncoproteins inactivate the p53 and pRb proteins, respectively. We examined the causative effect of HPV16 E6 and E7 expression on the immortalization of normal oral keratinocytes (...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Smeets SJ,van der Plas M,Schaaij-Visser TB,van Veen EA,van Meerloo J,Braakhuis BJ,Steenbergen RD,Brakenhoff RH

    更新日期:2011-04-01 00:00:00

  • Diverse expression patterns of the EMT suppressor grainyhead-like 2 (GRHL2) in normal and tumour tissues.

    abstract::The transcription factor grainyhead-like 2 (GRHL2) plays a crucial role in various developmental processes. Although GRHL2 recently has attracted considerable interest in that it could be identified as a novel suppressor of the epithelial-to-mesenchymal transition, evidence is emerging that GRHL2 also exhibits tumour-...

    journal_title:International journal of cancer

    pub_type: 杂志文章,meta分析


    authors: Riethdorf S,Frey S,Santjer S,Stoupiec M,Otto B,Riethdorf L,Koop C,Wilczak W,Simon R,Sauter G,Pantel K,Assmann V

    更新日期:2016-02-15 00:00:00

  • Bcl-XL and MCL-1 constitute pertinent targets in ovarian carcinoma and their concomitant inhibition is sufficient to induce apoptosis.

    abstract::In ovarian carcinomas, recurrence and acquired chemoresistance are the first leading causes of therapeutic failure and are responsible for the poor overall survival rate. Cisplatin exposure of sensitive cells has been previously associated with a down-regulation of Bcl-X(L) expression and apoptosis, whereas recurrence...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Brotin E,Meryet-Figuière M,Simonin K,Duval RE,Villedieu M,Leroy-Dudal J,Saison-Behmoaras E,Gauduchon P,Denoyelle C,Poulain L

    更新日期:2010-02-15 00:00:00

  • Effectiveness of sorafenib dose modifications on treatment outcome of hepatocellular carcinoma: Analysis in real-life settings.

    abstract::Controlling adverse events (AEs) through dose reduction can enhance drug adherence and treatment response. Currently, there is no guide for sorafenib dosing. The aim of this study was to evaluate whether sorafenib dosing could affect treatment outcomes. A total of 782 hepatocellular carcinoma (HCC) patients treated wi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tak KY,Nam HC,Choi JY,Yoon SK,Kim CW,Kim HY,Lee SW,Lee HL,Chang UI,Song DS,Yang JM,Kwon JH,Yoo SH,Sung PS,Choi SW,Song MJ,Kim SH,Jang JW

    更新日期:2020-10-01 00:00:00

  • Prenatal diethylstilbestrol exposure and mammographic density.

    abstract::In a prospective cohort study of the health effects associated with prenatal Diethylstilbestrol (DES) exposure, DES was associated with an increased breast cancer risk after 40 years of age. It is unknown whether it is associated with greater mammographic density, which strongly predicts breast cancer risk. A cohort o...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Strohsnitter WC,Bertrand KA,Troisi R,Scott CG,Cheville AL,Hoover RN,Palmer JR,Vachon CM

    更新日期:2018-09-15 00:00:00

  • Correlation between cytogenetic data and ganglioside pattern in human meningiomas.

    abstract::Partial or total loss of chromosome 22 is often associated with tumors of the central nervous system and in particular with meningiomas. As in the case of other tumors, the ganglioside pattern is modified in transformed tissues. Cytogenetic analysis of 30 human meningiomas has been performed and the results compared t...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Berra B,Papi L,Bigozzi U,Serino D,Morichi R,Mennonna P,Rapelli S,Cogliati T,Montali E

    更新日期:1991-02-01 00:00:00

  • Risk factors for renal-cell carcinoma in Denmark. III. Role of weight, physical activity and reproductive factors.

    abstract::A population-based case-control study of risk factors for renal-cell carcinoma was conducted in Denmark from 1989 to 1992. A total of 368 histologically verified cases and 396 controls were included. Information on weight, height, physical activity and reproductive factors were collected in a structured interview, alo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mellemgaard A,Engholm G,McLaughlin JK,Olsen JH

    更新日期:1994-01-02 00:00:00

  • Metabolic obesity phenotypes and risk of colorectal cancer in postmenopausal women.

    abstract::Obesity has been postulated to increase the risk of colorectal cancer by mechanisms involving insulin resistance and the metabolic syndrome. We examined the associations of body mass index (BMI), waist circumference, the metabolic syndrome, metabolic obesity phenotypes and homeostasis model-insulin resistance (HOMA-IR...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Kabat GC,Kim MY,Stefanick M,Ho GYF,Lane DS,Odegaard AO,Simon MS,Bea JW,Luo J,Wassertheil-Smoller S,Rohan TE

    更新日期:2018-08-01 00:00:00

  • Treatment of intracranial human glioblastoma by direct intratumoral administration of 131I-labelled anti-tenascin monoclonal antibody BC-2.

    abstract::Ten patients with bulky brain glioblastoma, recurring after surgery, radiotherapy or chemotherapy, underwent direct intralesional radioimmunotherapy (RIT) using a monoclonal antibody (MAb), BC-2, raised against tenascin and labelled with 131I. Tenascin, the BC-2-recognized glycoprotein, is an antigen expressed by the ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Riva P,Arista A,Sturiale C,Moscatelli G,Tison V,Mariani M,Seccamani E,Lazzari S,Fagioli L,Franceschi G

    更新日期:1992-04-22 00:00:00

  • NK and CD8+ T cell-mediated eradication of poorly immunogenic B16-F10 melanoma by the combined action of IL-12 gene therapy and 4-1BB costimulation.

    abstract::In previous reports, systemic administration of a stimulatory monoclonal antibody directed against the 4-1BB receptor had no effect on survival or tumor burden in mice inoculated with the poorly immunogenic B16-F10 melanoma. We combined IL-12 gene transfer with 4-1BB costimulation to explore a previously noted coopera...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Xu D,Gu P,Pan PY,Li Q,Sato AI,Chen SH

    更新日期:2004-04-20 00:00:00

  • Changes in tumor-specific antigen expression during passage in vitro and in vivo of newly derived methylcholanthrene-induced sarcomas of BALB/C mice.

    abstract::The characteristics of tumor antigens of the transplantation type, TATA, were studied in a series of methylcholanthrene-induced sarcomas in pedigreed BALB/cAN mice. Each of the six sarcomas exhibited unique TATA when assayed for tumor rejection in syngeneic hosts. In three instances, however, in sarcomas CI-I, CII-5 a...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Law LW

    更新日期:1980-02-15 00:00:00