Abstract：
:Agouti signaling protein (ASIP) locus on chromosome 20q11 is implicated, as shown by genome-wide association studies, in phenotype variation and melanoma risk. We genotyped 837 melanoma cases and 1,154 controls for 21 single nucleotide polymorphisms (SNPs) informative for 495 polymorphisms at the locus. Our data showed an increased risk of melanoma (odds ratio [OR] 1.27, 95% confidence interval [95% CI] 1.03-1.57) in carriers of the rs4911414 variant, located 120 kb upstream of ASIP. The main effect of rs4911414, as reported previously, was in tandem with a 10 kb adjacent polymorphism rs1015362; two constituted risk-associated haplotype/diplotype. Except for rs1015363, none of the 12 tagging SNPs, genotyped to cover 239.9 kb region with polymorphisms linked to rs4911414 and rs1015362, were associated with melanoma. Our data confirmed a previous association of melanoma risk (OR 1.82, 95% CI 1.37-2.41) with rs4911442, located in intron 5 of the nuclear receptor coactivator 6 (NCOA6) gene. The rs910871, one of the six variants, genotyped to cover NCOA6, showed an association with melanoma risk (OR 1.33, 95% CI 1.04-1.70). Both, rs4911442 and rs910871 were in moderate linkage with a, previously reported, risk-associated rs910873 polymorphism. A haplotype from the variants within NCOA6 showed an association with risk of melanoma (OR 1.49, 95% CI 1.17-1.88). Interaction between risk-associated polymorphisms and previously genotyped melanocortin receptor 1 (MC1R) variants, in our study, was not statistically significant. Nevertheless, the carriers of the variant alleles over the background of MC1R variants were at a higher risk than the carriers not enriched for MC1R variants. Our data confirmed the association of different variants at chromosome 20q11 with melanoma risk.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Maccioni L,Rachakonda PS,Scherer D,Bermejo JL,Planelles D,Requena C,Hemminki K,Nagore E,Kumar Rdoi
10.1002/ijc.27648subject
Has Abstractpub_date
2013-01-01 00:00:00pages
42-54issue
1eissn
0020-7136issn
1097-0215journal_volume
132pub_type
杂志文章abstract：:Major etiologic factors associated with human hepatocellular carcinomas (HCCs) include infection with hepatitis C (HCV) and hepatitis B virus (HBV), excess alcohol intake and aflatoxin B(1) exposure. While the G-->T p53 mutation at codon 249 has been identified as a genetic hallmark of HCC caused by aflatoxin B(1), th...
journal_title：International journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1002/ijc.11254
更新日期：2003-09-01 00:00:00
abstract：:The role of spontaneous and induced abortion on breast cancer risk is examined among 267,361 women recruited into the European Prospective Investigation into Cancer and nutrition between 1992 and 2000. The data were collected from 20 centers, across 9 countries, and included information on a total of 4,805 women with ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.22001
更新日期：2006-10-01 00:00:00
abstract：:In a prospective study with a median follow-up of 13 months on a series of 71 breast cancer patients, 9 developed haematogenous metastases. The neu protein was found on the cell membranes in 27 of the 71 carcinomas (38%) by an immunohistochemical technique using a monoclonal antibody (MAb). Eight of the 9 patients wit...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910450112
更新日期：1990-01-15 00:00:00
abstract：:In a novel attempt to understand the variations in DNA sequences underlying HLA class I alleles associated with HPV16-related CaCx, we determined the alleles by reconstructing SNP-based haplotypes from resequencing of the most polymorphic exons 2 and 3 of HLA-A, HLA-B and HLA-C. We also determined the impact of SNPs a...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.30681
更新日期：2017-06-01 00:00:00
abstract：:The role of gender and genetic (strain-specific) factors in the regulation of teratocarcinogenesis was studied by monitoring the outgrowth of benign and malignant embryo-derived teratoid tumors, i.e., teratomas and teratocarconomas in several mouse strains. Teratocarcinomas were produced in all mouse strains tested, b...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910240612
更新日期：1979-12-15 00:00:00
abstract：:A case-control study involving interviews with 1,244 patients (758 males and 486 females) with cancer of the esophagus or gastric cardia and 1,314 population-based controls (789 males, 525 females) was carried out in Linxian, a rural county in North Central China with one of the world's highest mortality rates for the...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910430502
更新日期：1989-05-15 00:00:00
abstract：:Gliomas represents more than 80% of all malignant brain tumors. However, the etiology still remains largely unknown. Human WW domain-containing oxidoreductase (WWOX), which is located at 16q23.1-16q23.2, the common fragile site 16D (FRA16D), an area with a high frequency of gene deletions or chromosomal alterations, h...
journal_title：International journal of cancer
pub_type： 杂志文章,随机对照试验
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更新日期：2014-10-01 00:00:00
abstract：:Over-expression of the HER2/neu (HER2) proto-oncogene in breast carcinoma imparts an enhanced metastatic potential. Metastasis requires escape of the tumor cell from the vasculature into subjacent tissue, a transmigration event across an endothelial cell (EC) monolayer. EC retraction has been reported to precede trans...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/1097-0215(200002)9999:9999<::aid-ijc1061>3
更新日期：2001-02-01 00:00:00
abstract：:Pre-malignant and malignant human colorectal tumour epithelial cell lines both secreted precursor forms of the 2 cysteine proteinases, cathepsins B and L. The amount of proteinases secreted by these cell lines varied according to the cell density. Comparison at similar cell densities showed that the pre-malignant, ade...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910430323
更新日期：1989-03-15 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.25846
更新日期：2011-10-15 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1002/ijc.30127
更新日期：2016-08-15 00:00:00
abstract：:Histologic characteristics of bladder cancer in Boston, USA, Manchester, UK, and Nagoya, Japan, were evaluated. In each of these areas broadly-based series of cases were assembled during a collaborative case-control study. The present analysis was based on 589 cases in Boston, 484 cases in Manchester, and 241 cases in...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910300605
更新日期：1982-12-15 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.33303
更新日期：2021-03-15 00:00:00
abstract：:The recently described PGM-2 leukemia displays a hierarchical structure with bipotential stem cells, B-lymphocyte and macrophage progenitor cells, and post-mitotic end cells. Because the different cell types can easily be identified in vitro by clonal culture assays and simple staining procedures, this leukemia is a u...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910600515
更新日期：1995-03-03 00:00:00
abstract：:Complement-dependent cytotoxic antibodies to three cervical carcinoma cell lines (Me-180, SW-732 and HeLa) and to Herpes simplex virus type 2 (HSV-2)-infected cells were determined in a long-term study of women with cervical carcinoma. Cytolysis of surface antigens differed significantly between the cervical carcinoma...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910200508
更新日期：1977-11-15 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910250316
更新日期：1980-03-15 00:00:00
abstract：:Cytogenetic deletions of the short arm of chromosome 9, 9p, have been detected in cell lines of malignant mesothelioma as well as in tumor material. Many tumor types carry deletions of chromosome 9 or more specifically of 9p21. The tumor-suppressor genes, CDKN2A and CDKN2B, each of which encodes a structurally and fun...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19980209)75:4<649::aid-ijc
更新日期：1998-02-09 00:00:00
abstract：:Allelic losses on the chromosome arms 1p and 19q have been associated with favorable response to chemotherapy and good prognosis in anaplastic oligodendroglioma patients, but the molecular mechanisms responsible for this relationship are as yet unknown. The DNA repair enzyme O(6)-methylguanine DNA methyltransferase (M...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.20575
更新日期：2005-01-20 00:00:00
abstract：:Although viral sequences closely related to feline leukaemia virus are represented in multiple copies in cellular DNA of all domestic cats, a specific fraction was present only in the virus-infected cells. This fraction was detected by viral cDNA enriched by a prior absorption of a total complementary DNA (cDNA) trans...
journal_title：International journal of cancer
pub_type： 杂志文章
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更新日期：1978-07-15 00:00:00
abstract：:Natural killer (NK)6 cell activity of peripheral blood lymphocytes against human leukemia cell lines was measured in patients with chronic B-cell lymphocytic leukemia (CLL) and age- and sex-matched controls. In order to remove the leukemia cells that interfere with the in vitro assay we (1) isolated lymphocytes that f...
journal_title：International journal of cancer
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更新日期：1981-03-15 00:00:00
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更新日期：1987-11-15 00:00:00
abstract：:In light of recent, strong inverse findings between lifetime red wine consumption and prostate cancer among younger men, we revisited our previous cohort analysis to more thoroughly investigate red wine consumption and prostate cancer in the Health Professionals Follow-up Study (HPFS). In 1986, HPFS participants repor...
journal_title：International journal of cancer
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doi：10.1002/ijc.22498
更新日期：2007-04-01 00:00:00
abstract：:Vascular endothelial growth factor (VEGF) is an angiogenic factor that also functions as an autocrine growth factor for VEGF receptor (VEGFR)-2(+) melanomas. In multiple studies, VEGFR-2 was detected by immunostaining in 78-89% of human melanoma cells, suggesting that most patients with melanoma would benefit from an...
journal_title：International journal of cancer
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更新日期：2011-12-15 00:00:00
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journal_title：International journal of cancer
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更新日期：1985-06-15 00:00:00
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journal_title：International journal of cancer
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abstract：:During natural metastasis, cancer cells are released continuously into the bloodstream and arrested in target organs; the process is repetitive rather than a single event. In this communication, the effect of preceding on successive "pulses" of cancer cells is discussed in relation to the arrest, retention and tumor f...
journal_title：International journal of cancer
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abstract：:Metastasis-associated protein MTA1 and histone deacetylase form a protein complex with histone deacetylase activity that plays an important role in histone deacetylation, alteration of chromatin structure and transcriptional control. The precise role of the MTA1 protein in the malignant progression of human cancers re...
journal_title：International journal of cancer
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abstract：:Using a recently developed autochthonous mouse model of squamous cell carcinoma (SCC), a combination therapy targeting polyamine metabolism was evaluated. The therapy combined 2-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase (ODC), and MQT 1426, a polyamine transport inhibitor. In 1 trial last...
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abstract：:Clinical case reports have suggested that specific bacterial infections are associated with certain non-Hodgkin lymphoma (NHL) subtypes. Epidemiological case-control studies have been conducted using antibiotics as a proxy for bacterial infections, but with inconclusive results. The aim of this study was, in a cohort ...
journal_title：International journal of cancer
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更新日期：2012-10-01 00:00:00
abstract：:Serum alkaline DNase activity (SADA) was investigated in rats receiving s.c. transplants of tumor cells sensitive or resistant to chemotherapy. Serum samples from each animal were collected before transplantation, during the development of tumors and after therapy. Within a few days after transplantation of both tumor...
journal_title：International journal of cancer
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