Abstract:
:In vitro infection of EBV-negative lymphoma cell lines with immortalizing strains of Epstein-Barr virus induces the cell-surface expression of B-cell markers, such as the EBV receptor/CR2 (CD21) and the CD23 antigen. The non-immortalizing EBV variant, P3HRI, which carries a deletion encompassing the EBV nuclear antigen 2 (EBNA2) gene, fails to induce any such expression. We show here that the EBV-mediated up-regulation of cell-surface expression of these molecules is associated with an increased level of the specific steady-state RNA corresponding to these 2 genes. These results suggest that the role of EBNA2 in B-cell growth and immortalization may be related to its role in transactivation of cellular genes. In order to identify other cellular genes whose expression may be modulated by EBV, we analyzed the level of transcription of a set of genes possibly involved in Burkitt's lymphoma pathogenesis. The level of the c-myc oncogene transcript was not significantly affected by in vitro EBV infection. The c-fgr oncogene, thought to be specifically activated in EBV-infected cells, was found to be expressed in some EBV-negative lymphoma cells and also to be activated by both non-immortalizing and immortalizing strains of EBV. The expression of vimentin, the major 56-kDa polypeptide of mesenchymal cell intermediate filaments, was altered by all EBV isolates, in either a negative or a positive way, depending on the cell line. Expression of lymphocyte-function-associated antigens, LFA-1 alpha/beta (CD11 a/18) and LFA-3 (CD58), involved in intercellular adhesion and the T-cytotoxic pathway, were differentially regulated by EBV; a crucial observation was the activation by immortalizing EBV isolates of LFA-1 beta chain (CD18) and of LFA-3 (CD58). The EBV-and possibly EBNA2-associated modulation of cellular genes, such as CR2 (CD21), CD23 and LFAs, probably represents key events for EBV-induced B-cell proliferation, and also for in vivo immune control of EBV-infected B cells.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Calender A,Cordier M,Billaud M,Lenoir GMdoi
10.1002/ijc.2910460418subject
Has Abstractpub_date
1990-10-15 00:00:00pages
658-63issue
4eissn
0020-7136issn
1097-0215journal_volume
46pub_type
杂志文章abstract::Epigenetic alterations play an important role in carcinogenesis. Recent studies suggested that global histone modifications are predictors of cancer recurrence in various tumor entities. Our study was performed to evaluate histone H3 lysine 4 mono-methyl (H3K4me1), -di-methyl (H3K4me2) and -trimethyl (H3K4me3) pattern...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25250
更新日期:2010-11-15 00:00:00
abstract::Multidrug resistance, the phenomenon by which cells treated with a drug become resistant to the cytotoxic effect of a variety of other structurally and functionally unrelated drugs, is often associated with the expression of P-glycoprotein, an efflux membrane pump coded by the MDR1 (ABCB1) gene. Transcription from MDR...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23149
更新日期:2008-03-01 00:00:00
abstract::Acquired chemoresistance is a critical issue for advanced bladder cancer patients during long-term treatment. Recent studies reveal that a fraction of tumor cells with enhanced tumor-initiating potential, or cancer stem-like cells (CSCs), may particularly contribute to acquired chemoresistance and recurrence. Thus, CS...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32505
更新日期:2020-02-15 00:00:00
abstract::We evaluated promoter hypermethylation of a panel of tumor suppressor genes as a means to detect epigenetic alterations in oral squamous cell carcinomas (OSCC) of Indian-origin and compare with North-American head and neck squamous cell carcinomas (HNSCC). Quantitative-methylation-specific PCR was used to investigate ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25377
更新日期:2010-11-15 00:00:00
abstract::Mitotic and meiotic cell cycle regulation is essential for normal development and tumor prevention. The underlying molecular mechanisms are not completely characterized. The aim of our analysis was to derive a global expression map of cell cycle regulators in mitosis and meiosis. First, the expression of cyclins, CDKs...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21034
更新日期:2005-08-20 00:00:00
abstract::A group of 83 Spanish BC/OC families were analysed for BRCA1 germ-line mutations. Analysis of the entire coding sequence was carried out by SSCP and PTT. We identified 5 frameshift mutations: 185delAG (2 times), 189insTGTC, 1241delAC, and 5537delA and 3 missense mutations in BRCA1: 330A > G, 1240C > T, and 5263G > A. ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19991112)83:4<465::aid-ijc
更新日期:1999-11-12 00:00:00
abstract::By using a functional complementation approach, suppression of tumorigenicity was observed after transfer of intact or truncated copies of chromosome 3 into a nasopharyngeal carcinoma (NPC) HONE1 cell line. The extra exogenous chromosome 3 in the microcell hybrids (MCHs) significantly extended the lag period of tumor ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23528
更新日期:2008-07-15 00:00:00
abstract::Microtubule-targeted drugs are now indispensable for the therapy of various cancer types worldwide. In this article, we report MT119 [6-[2-(4-methoxyphenyl) -ethyl]-9-[(pyridine-3-ylmethyl)amino]pyrido[2',1':2,3]imida-zo[4,5-c]isoquinolin-5(6H)-one] as a new microtubule-targeted agent. MT119 inhibited tubulin polymeri...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25661
更新日期:2011-07-01 00:00:00
abstract::The granulin-epithelin precursor (GEP/PCDGF), a 68-88 kDa secreted glycoprotein, has been shown to be an important growth and survival factor for ovarian cancer cells. Furthermore, GEP expression is a predictor of patient survival in metastatic ovarian cancer cells. Up to this point, however, the molecular mechanisms ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22559
更新日期:2007-06-01 00:00:00
abstract::Exercise has been shown to reduce risk and improve prognosis of several types of cancers. Irisin is a myokine linked to exercise and lean body mass, which is thought to favorably alter metabolism systemically, potentially providing benefit for metabolic disease (including cancer). We evaluated the effects of various c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29142
更新日期:2015-02-15 00:00:00
abstract::Evidence indicates that acquired resistance of cancers to chemotherapeutic agents can occur via epigenetic mechanisms. Down-regulation of expression of argininosuccinate synthetase (ASS1), the rate-limiting enzyme in the biosynthesis of arginine, has been associated with the development of platinum resistance in ovari...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24546
更新日期:2009-09-15 00:00:00
abstract::The incidence of adult T-cell leukemia/lymphoma (ATL) and its impact on that of total non-Hodgkin lymphoma (NHL) were evaluated in Nagasaki, an area in southwestern Japan where human T-cell lymphotropic virus type I (HTLV-I) is endemic. The first study area comprised 4 towns located on the K Islands, which had a popul...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(20000201)85:3<319::aid-ijc
更新日期:2000-02-01 00:00:00
abstract::To identify characteristics of gastric cancer associated with hereditary non-polyposis colorectal cancer (HNPCC), we gathered clinical data and tumor samples relating to patients recorded in the Finnish HNPCC registry. Our series included 51 families with a characterized mutation and/or that met the Amsterdam criteria...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19971021)74:5<551::aid-ijc
更新日期:1997-10-21 00:00:00
abstract::Tobacco smoking and alcohol drinking histories were obtained from 194 patients with hepatocellular carcinoma (HCC) and 456 hospital controls, and the results were analysed in conjunction with the results of serological determinations of hepatitis B surface antigen (HBsAg), antibody to HBsAg (anti-HBs) and antibody to ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910390109
更新日期:1987-01-15 00:00:00
abstract::Undifferentiated nasopharyngeal carcinoma (NPC) is a remarkable entity among human tumors because of its constant association with the Epstein-Barr virus (EBV). Malignant epithelial cells harbor the EBV genome and often express at least 2 species of latent EBV protein (EBNA1 and LMP1). Despite the massive presence of ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910500605
更新日期:1992-04-01 00:00:00
abstract::It has been debated whether the reported increased risk of Hodgkin's lymphoma (HL) after tonsillectomy could be due to some underlying factor rather than the surgery itself. We studied whether not only tonsillectomy but also tonsillitis was associated with HL. This nationwide cohort study included all Danish residents...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24973
更新日期:2010-08-01 00:00:00
abstract::The effect on tumor progression produced by the injection of VCN-treated tumor cells in dogs with spontaneous mammary tumors was investigated. Untreated dogs of different races and different ages with at least two palpable spontaneous mammary tumors were selected. One of the tumors was left in the animal for further c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910150307
更新日期:1975-03-15 00:00:00
abstract::The surface and intracellular expression of mdrI-P-glycoprotein in parental drug-sensitive human breast cancer cells (MCF-7) and their multidrug-resistant (MDR) variants has been studied by using the monoclonal antibodies (MAbs) MM4.17 and MRK-16, which recognize 2 different epitopes of the drug efflux pump molecule. ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910590614
更新日期:1994-12-15 00:00:00
abstract::The large geographic variations in the incidence of gastric cancer (GC) are likely due to differential environmental exposures, in particular to Helicobacter pylori (H. pylori) infection. We aimed to investigate the impact of H. pylori on the epigenome in normal gastric mucosa and methylation changes associated with c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31381
更新日期:2018-08-01 00:00:00
abstract::Pseudomyxoma peritonei (PMP) is a rare disorder with unique pathological and genetic changes. Although several studies have reported the clinical features and mutational changes of PMP that originates from the appendix, few studies on PMP originating from the ovary have been reported due to its extreme rarity. In orde...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33460
更新日期:2021-01-05 00:00:00
abstract::Three human ovarian cancer xenografts of different origin and grown s.c. in nude mice as well-established tumors were studied for their sensitivity to cisplatin (CDDP), cyclophosphamide (CTX), 131I-labelled anti-episialin monoclonal antibody (MAb) 139H2, or external-beam radiotherapy. The maximum tolerated dose of CDD...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910510120
更新日期:1992-04-22 00:00:00
abstract::Gab2, a docking-type signaling protein with demonstrated oncogenic potential, is overexpressed in breast cancer, but its prognostic significance and role in disease evolution remain unclear. Immunohistochemical detection of Gab2 in a large cohort of primary human breast cancers of known outcome revealed that while Gab...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25172
更新日期:2010-09-01 00:00:00
abstract::The incidence of cutaneous melanoma in children aged 0-14 years was examined in Queensland, Australia. Details of notifications were collected from the population-based Australian Paediatric Cancer Registry. Between 1987 and 1994, the age-adjusted incidence rates of invasive cutaneous melanoma occurring in Queensland ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910630602
更新日期:1995-12-11 00:00:00
abstract::The prognostic impact of distinct KRAS mutations in colorectal carcinomas is not fully characterized. We hypothesized that the prognostic impact of KRAS mutations is modulated by KRAS mutant allele-specific imbalance (MASI). KRAS MASI was assessed by sequencing electropherograms in KRAS-mutated colorectal carcinomas (...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27461
更新日期:2012-10-15 00:00:00
abstract::The APTIMA HPV Assay (AHPV) allows detection of 14 high-risk human papillomavirus (HPV) RNA types in cervical specimens. Until present, the assay has been compared to HPV DNA tests only in triage settings. Herein, we compare AHPV with a DNA assay (Hybrid Capture 2; HC2) and liquid-based cytology (LBC; using PreservCyt...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25726
更新日期:2011-08-01 00:00:00
abstract::The effects of single-agent therapy with two clinically useful drugs, 5-fluorouracil (5-FU) and 1-3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) against nine human colorectal tumors (rectum T 157 and T 348, lung metastasis T 84, lymph-node metastasis T 245, colon, T 183, T 219, T 347, T 362 and T 380) transplanted and pas...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910270103
更新日期:1981-01-15 00:00:00
abstract::Oxidative stress plays a role in the regulation of cancer cell metastasis which involves cell invasion and adhesion that could be supported by ADAM proteins through the activities of their metalloprotease and disintegrin domains. We hypothesized that oxidative stress could act through the induction of ADAM9 protein in...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25746
更新日期:2011-08-15 00:00:00
abstract::The amplification of the q21 band of chromosome 8 (8q21) occurs in a large percentage of breast cancers. WWP1, an HECT domain-containing ubiquitin E3 ligase located in the 8q21 region, negatively regulates the TGF-beta tumor suppressor pathway. To characterize the role of WWP1 in breast cancer, we analyzed WWP1 gene d...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22653
更新日期:2007-07-01 00:00:00
abstract::Hybridoma CE7 produces a murine antibody (gamma 1/kappa) which binds to a 190-kDa cell-surface glycoprotein of human neuroblastoma. Because of its tumor specificity, it has been used routinely in clinical pathology to confirm diagnosis of neuroblastoma. We have isolated the gene segments coding for the variable region...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910530127
更新日期:1993-01-02 00:00:00
abstract::AKR-2B mouse fibroblasts were treated with 50 micrograms/ml of crude transforming growth factor (TGF) of human origin. Cell surface proteins of treated cells were radioiodinated and compared to untreated cells at various times after the addition of TGF. Treated cells showed a severalfold increase (approximately 6-fold...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910330121
更新日期:1984-01-15 00:00:00