Abstract：
:The incidence of cutaneous melanoma in children aged 0-14 years was examined in Queensland, Australia. Details of notifications were collected from the population-based Australian Paediatric Cancer Registry. Between 1987 and 1994, the age-adjusted incidence rates of invasive cutaneous melanoma occurring in Queensland children were estimated at 8.5/million for males and 7.1/million for females. Incidence rates rose steeply in both sexes with increasing age, from less than 1/million in the 0-4 age group, to nearly 30/million in the 10-14 age group. To assess the uniformity of the anatomical distribution of lesions, relative tumour densities (RTDs) were calculated compared with the body as a whole. In both sexes, melanomas were most common on the trunk (RTD > 3), while lower limb lesions were less common (RTD < 0.6) and no melanomas were reported on the buttocks or external genitalia. Although not statistically significant, there was a tendency for truncal lesions in males to occur on the back, while in females, truncal melanomas were more evenly distributed across the chest, back and shoulders. No consistent relationship between latitude and melanoma incidence was observed, with higher rates reported in the subtropical than the tropical regions of Queensland. These are the first reported incidence rates of cutaneous melanoma in Australian children and are the highest ever reported in the world in this age group. Our findings provide baseline data from which to monitor changes in the occurrence of cutaneous melanoma in children.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Whiteman D,Valery P,McWhirter W,Green Adoi
10.1002/ijc.2910630602subject
Has Abstractpub_date
1995-12-11 00:00:00pages
765-8issue
6eissn
0020-7136issn
1097-0215journal_volume
63pub_type
杂志文章abstract：:Recurrent deletions of chromosome fragments observed in neoplasms are thought to participate in tumor development through the inactivation of tumor-suppressor genes. In gliomas, the most frequent deletions involve chromosome arms 9p, 10q, 17p, 19q and 22q. We have analysed deletions of chromosome 22 in gliomas by stud...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910600409
更新日期：1995-02-08 00:00:00
abstract：:Exfoliated nasopharyngeal (NP) cells from 62 normal Cantonese Chinese having IgA/VCA antibodies for more than a year and from 39 similar persons without IgA/VCA antibodies, were tested for the presence of EBV/DNA sequences by spot followed by blot hybridization tests, using the cloned internal repeat of B95-8 viral DN...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910320504
更新日期：1983-11-15 00:00:00
abstract：:We have studied the relationship between tumor necrosis factor (TNF)-sensitivity and doxorubicin-resistance in our doxorubicin-resistant cell line panel consisting of the parental cell line GLC4 plus GLC4-Adr2x and GLC4-Adr350x with respective resistance factors of 2 and 350 compared with GLC4. At the highest dose of ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19980703)77:1<101::aid-ijc
更新日期：1998-07-03 00:00:00
abstract：:An experiment in which rats were injected intrapleurally with asbestos, the injection taking place at an age of either 2 or 10 months, is reported. In the former group 19 out of 48 rats developed a mesothelioma compared with 17 out of 90 in the latter group. However, by considering the two groups at equal times after ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910170410
更新日期：1976-04-15 00:00:00
abstract：:Epstein-Barr virus (EBV) can be detected in Hodgkin and Reed-Sternberg (HRS) cells in about one-half of cases of Hodgkin's disease (HD) in Western countries. To determine whether EBV is also associated with HD in a developing country such as China, we studied paraffin sections from 28 Chinese cases of HD for expressio...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910550303
更新日期：1993-09-30 00:00:00
abstract：:Prostate-specific antigen (PSA) is a serine protease secreted by prostatic epithelial cells and is widely used as a marker for prostate cancer. The tissue specificity of PSA makes it a potential target for active specific immunotherapy, especially in prostate cancer patients who have undergone prostatectomy and in who...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910630215
更新日期：1995-10-09 00:00:00
abstract：:Very late antigen-4 (VLA-4) composed of alpha 4 and beta 1, a member of the beta 1-integrin subfamily, facilitates cell-to-cell interaction with vascular cell-adhesion molecule-1 (VCAM-1) on endothelial cells (EC). Attachment of blood-borne tumor cells to EC is a crucial step for hematogenous metastasis, and VLA-4-pos...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910600604
更新日期：1995-03-16 00:00:00
abstract：:Diet is the primary source of cadmium-a proven Group 1 human carcinogen-for non-smokers. Observational studies investigating the effect of cadmium from food sources on breast cancer risk have produced inconsistent results. We examined the association between dietary cadmium and risk of breast cancer defined by estroge...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.32039
更新日期：2019-05-01 00:00:00
abstract：:Reverse-transcriptase polymerase chain reaction has been used to analyze the expression of 2 latent genes (EBNA-1 and LMP-1) and one replicative gene (BZLF-1) of Epstein-Barr virus in mononuclear cells from bone marrow and peripheral blood of healthy donors. EBV-gene transcription was detected in 8 out of 15 bone-marr...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19970304)70:5<524::aid-ijc
更新日期：1997-03-04 00:00:00
abstract：:Breast cancer incidence increases considerably in women who migrate from Japan to the United States. Based on the hypothesis that mammographic density in healthy mammograms reflects differences in breast cancer risk, we compared mammographic density in 3 groups of women at different levels of risk: Caucasian and Japan...
journal_title：International journal of cancer
pub_type： 历史文章,杂志文章
doi：10.1002/ijc.10673
更新日期：2002-11-01 00:00:00
abstract：:The impact of the ABC transporters breast cancer resistance protein/mitoxantrone resistance associated transporter (BCRP/MXR), multidrug resistance-associated protein 1 (MRP1) and multidrug resistance gene-1/P-glycoprotein (MDR1/PGP) on the multidrug resistance (MDR) phenotype in chemoresistance and thermoresistance w...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.10131
更新日期：2002-02-20 00:00:00
abstract：:In this study the antigenic profile of Hodgkin (H) and Sternberg-Reed (SR) cells from cases of Hodgkin's disease was analysed using a large panel of monoclonal and polyclonal antibodies reactive with cells of lymphoid and haemotopoietic origin. The aim of this investigation was, firstly, to throw light on the origin o...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910300411
更新日期：1982-10-15 00:00:00
abstract：:Gene expression levels of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), thymidine phosphorylase (TP) and orotate phosphoribosyl transferase (OPRT) have been shown to be associated with response to 5-fluorouracil-based therapies. Analyzing these gene expression levels in liver metastases is importan...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.21692
更新日期：2006-08-01 00:00:00
abstract：:In ovarian carcinomas, recurrence and acquired chemoresistance are the first leading causes of therapeutic failure and are responsible for the poor overall survival rate. Cisplatin exposure of sensitive cells has been previously associated with a down-regulation of Bcl-X(L) expression and apoptosis, whereas recurrence...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.24787
更新日期：2010-02-15 00:00:00
abstract：:Endometrial carcinoma (EC) is traditionally characterized as endometrioid and nonendometrioid based on histopathologic phenotypes. Molecular-based classifications have been proposed, but are not widely implemented. Herein we examine molecular profiles between EC histologic subtypes. 3133 ECs were submitted between Mar...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.30537
更新日期：2017-03-15 00:00:00
abstract：:Aberrant promoter methylation of normally unmethylated CpG-islands offers a promising tool for the development of molecular biomarkers. We investigated bronchial aspirates of patients admitted for suspected lung cancer with regard to the prevalence of aberrant methylation of potential marker genes. Applying quantitati...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.21090
更新日期：2005-09-20 00:00:00
abstract：:EBV-specific cytotoxic T cells (Tc) induced in vitro have continuously proliferated in vitro for over 9 months. The long-term maintenance of the Tc growth was dependent on periodic supplementation of both irrediated EBV-transformed autologous lymphoblastoid cell line (LCL) cels and conditioned medium. The latter was d...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910280205
更新日期：1981-08-15 00:00:00
abstract：:Monoclonal antibodies (MAbs) reactive with the ganglioside fucosyl GM1 (Fuc-GM1), an antigen associated with small-cell carcinoma of the lung (SCLC), were tested for their ability to mediate tumor-cell killing in vitro in conjunction with humoral and cellular effectors and to inhibit tumor engraftment in nude mice in ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910490619
更新日期：1991-12-02 00:00:00
abstract：:We analyzed the role of reproductive factors on the risk of endometrial cancer using data from a case-control study conducted in Italy. Cases were 752 women with histologically confirmed endometrial cancer < 75 years of age. Controls were 2,606 patients < 75 years of age admitted for acute, non-gynecological non-hormo...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19980610)76:6<784::aid-ijc
更新日期：1998-06-10 00:00:00
abstract：:A recent 2-dimensional gel electrophoresis study revealed several polypeptide differences between a strongly metastatic and a weakly metastatic clone from a single chemically induced murine fibrosarcoma (Jellum et al., 1984). To exclude the possibility that this was merely coincidental, the study is extended here to 2...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910410416
更新日期：1988-04-15 00:00:00
abstract：:By using a functional complementation approach, suppression of tumorigenicity was observed after transfer of intact or truncated copies of chromosome 3 into a nasopharyngeal carcinoma (NPC) HONE1 cell line. The extra exogenous chromosome 3 in the microcell hybrids (MCHs) significantly extended the lag period of tumor ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.23528
更新日期：2008-07-15 00:00:00
abstract：:Laboratory and epidemiological data have linked vitamin D to breast cancer prevention. Beside dietary intake, endogenous production of vitamin D substantially contributes to a subject's vitamin D status. Most studies, however, have assessed dietary intake only. Although differential effects of vitamin D on premenopaus...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.23904
更新日期：2009-01-01 00:00:00
abstract：:The effect of linoleic acid (LA) on growth and transformation of IEC6 intestinal cells was examined. IEC6 cells expressed mRNAs of 15-lipooxygenase (LOX15) and peroxisome proliferator-activated receptor (PPAR)gamma but not COX-2. Cell growth was suppressed by LA in a dose-dependent manner in IEC6 cells. Three-week tre...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.21393
更新日期：2006-02-01 00:00:00
abstract：:Neoplastic transformation is characterised by an imbalance in favour of cell growth over programmed cell death (apoptosis). The tumour-suppressor gene p53, responsible for maintaining cell-cycle control, is mutated in the majority of human cancers. Loss of function of the target genes of p53 are therefore important in...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：
更新日期：2000-11-01 00:00:00
abstract：:Smoking is a major contributor to all-cause mortality in Europe and accounts for one-fifth of the cancer-related deaths. Monitoring the tobacco epidemic via an analysis of lung cancer trends is essential in helping countries arrest the effects of tobacco epidemic in the region. The study aims to provide a comprehensiv...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.24855
更新日期：2010-03-15 00:00:00
abstract：:The specific aim of three-dimensional conformal radiotherapy is to deliver adequate therapeutic radiation dose to the target volume while concomitantly keeping the dose to surrounding and intervening normal tissues to a minimum. The objective of this study is to examine dose distributions produced by various radiother...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/1097-0215(20010220)96:1<55::aid-ijc6>3.0.c
更新日期：2001-02-20 00:00:00
abstract：:In order to clarify the frequency of p16 gene inactivation and its relationship with Rb expression, immunohistochemical analysis of p16 and Rb proteins was carried out on 82 paraffin-embedded sections of primary non-small cell lung cancers (NSCLCs). From immunohistochemical results, abnormal p16 expression was observe...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19980619)79:3<215::aid-ijc
更新日期：1998-06-19 00:00:00
abstract：:Leukocyte migration inhibition (LMI) assays were performed using 3 M KCI extracts to detect cell-mediated immune reactions against tumor-associated antigens (TAA) of swine melanoma. Positive LMI reactivity was 70% or greater in melanoma-bearing swine compared to 10% reactivity or less in normal swine tested with extra...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910310516
更新日期：1983-05-15 00:00:00
abstract：:It has become axiomatic that critical windows of susceptibility to genotoxins exist and that genetic damage in utero may be a trigger for later life cancers. Data supporting this critical window hypothesis are remarkably few. This study provides a quantitative bridge between DNA damage by the liver carcinogen aflatoxi...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.29102
更新日期：2015-03-15 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is the most common type of primary tumor in the liver and is a leading cause of cancer-related death worldwide. Activated hepatic stellate cells (HSCs) are key components of the HCC microenvironment and play an important role in the onset and progression of HCC through the secretion of g...
journal_title：International journal of cancer
pub_type： 杂志文章,评审
doi：10.1002/ijc.32899
更新日期：2020-09-15 00:00:00
