IGFBP-3 prolongs the p53 response and enhances apoptosis following UV irradiation.

abstract：:The lck gene encodes a lymphocyte-specific tyrosine protein kinase, p56lck, the expression of which is almost exclusive in T-cells. The expression of lck in human T-cell leukemia virus type I (HTLV-I)-transformed T-cell lines is closely associated with interleukin-2 (IL-2) dependence for their growth. That is, IL-2-de...

journal_title：International journal of cancer

authors： Nakamura K,Koga Y,Yoshida H,Kimura G,Nomoto K

更新日期：1991-07-09 00:00:00

abstract：:Pesticide exposure has been associated with non-Hodgkin lymphoma (NHL) risk in a number of studies, and two recent studies suggest that the increased risk may be confined to those with a history of asthma. We examined the interaction between occupational pesticide exposure and atopy on risk of NHL in an Australian pop...

journal_title：International journal of cancer

authors： Vajdic CM,Fritschi L,Grulich AE,Kaldor JM,Benke G,Kricker A,Hughes AM,Turner JJ,Milliken S,Goumas C,Armstrong BK

更新日期：2007-05-15 00:00:00

abstract：:Ionizing radiation remains a major therapeutic tool against human cancers, especially epithelial tumors, which account for the majority of human malignancies. Although Fas and Fas-L are essential determinants of apoptosis, few data support their role in the cytotoxic effect of ionizing radiation. Epstein-Barr-virus (E...

journal_title：International journal of cancer

authors： Abdulkarim B,Sabri S,Deutsch E,Vaganay S,Marangoni E,Vainchenker W,Bongrand P,Busson P,Bourhis J

更新日期：2000-04-15 00:00:00

abstract：:Fifty-two sporadic primary non-small-cell lung carcinomas (NSCLC) were examined for microsatellite instability. Six different microsatellite markers localized on chromosomes 2, 5, 8, 10, 11 and 17 were used. Genomic instability was observed in 35% (18/52) of NSCLC at single or multiple loci. The tumors were also analy...

journal_title：International journal of cancer

authors： Caligo MA,Ghimenti C,Marchetti A,Lonobile A,Buttitta F,Pellegrini S,Bevilacqua G

更新日期：1998-11-23 00:00:00

abstract：:We applied a strategy that utilized a combination of systematic gene expression analysis with various tissues and immunological detection with sera from melanoma patients to identify melanoma antigens expressed preferentially in melanoma and melanocytes. We selected 101 genes by comparing cDNA profiles obtained by Gen...

journal_title：International journal of cancer

authors： Inozume T,Matsuzaki Y,Kurihara S,Fujita T,Yamamoto A,Aburatani H,Shimada S,Kawakami Y

更新日期：2005-03-20 00:00:00

abstract：:C57BL/6J mice immunized with devitalized Ehrlich tumor (ET) cells produce high serum levels of IgM antibodies to ET cell-surface carbohydrates that are critical in the observed resistance against this tumor. However, this response is not found in ET-bearing mice at any stage of tumor development. Since previous studie...

journal_title：International journal of cancer

authors： Viñuela JE,Rodriguez R,Gil J,Coll J,De la Concha EG,Subiza JL

更新日期：1991-01-02 00:00:00

abstract：:In order to understand the expression and modulation of adhesion molecules (AMs) on the surface of different gastric cancers, we studied 4 gastric-cancer cell lines including SC-M1, KATO-III, AGS and AZ-521. The expression of E-cadherin, integrins (beta1, beta2 and beta3), ICAMs (1 and 2), and CD11 (a, b and c) on the...

journal_title：International journal of cancer

authors： Hsieh MC,Wu CW,Wu LH,Lui WY,P'eng FK,Yu CL

更新日期：1996-09-04 00:00:00

abstract：:Radiation therapy (RT) continues to be a cornerstone in the treatment for many cancers. Unfortunately, not all individuals respond effectively to RT resulting clinically in two groups consisting of nonresponders (progressive disease) and responders (tumor control/cure). The mechanisms that govern the outcome of radiot...

journal_title：International journal of cancer

authors： Gerber SA,Lim JY,Connolly KA,Sedlacek AL,Barlow ML,Murphy SP,Egilmez NK,Lord EM

更新日期：2014-05-15 00:00:00

abstract：:Cancer is an infrequent disease in childhood. However, it is responsible for 13.06% of child deaths between 1 and 14 years in Cuba. The aim of our work was to describe the incidence of childhood cancer in the period 1986 to 1990 using data reported to the National Cancer Registry (NCR) of Cuba. All cancer cases betwee...

journal_title：International journal of cancer

authors： Martín AA,Alert JA,Renó JS,Lonchong M,Grueiro S

更新日期：1997-08-07 00:00:00

abstract：:Generation of cytotoxic T lymphocytes (CTL) in vitro and tumor-rejection responses by sensitization of semi-syngeneic mice with tumor-antigen-reconstituted liposomes were investigated. Liposomes were prepared from a crude butanol extract (CBE) of BALBRVD leukemia cells and egg phosphatidylcholine (PC): 1,2-dimyristoyl...

journal_title：International journal of cancer

authors： Shibata R,Noguchi T,Sato T,Akiyoshi K,Sunamoto J,Shiku H,Nakayama E

更新日期：1991-05-30 00:00:00

abstract：:Thirty-one different long-term established human carcinoma culture cell lines were examined for the presence or absence of receptors for the Fc portion of immunoglobulin G (IgG) ("Fc receptors"), the third component of complement (C3 receptors), sheep erythrocytes and mouse erythrocytes. Included in the catalogue of l...

journal_title：International journal of cancer

authors： Kerbel RS,Pross HF,Leibovitz A

更新日期：1977-11-15 00:00:00

abstract：:Although tumor heterogeneity is widely accepted, the existence of cancer stem cells (CSCs) and their proposed role in tumor maintenance has always been challenged and remains a matter of debate. Recently, a path-breaking chapter was added to this saga when three independent groups reported the in vivo existence of CSC...

journal_title：International journal of cancer

authors： Singh AK,Arya RK,Maheshwari S,Singh A,Meena S,Pandey P,Dormond O,Datta D

更新日期：2015-05-01 00:00:00

abstract：:Circadian disruption has been classified as probably carcinogenic to humans by the World Health Organization's International Agency for Research on Cancer. The circadian clock is subject to environmental factors, particularly light exposure and food intake rhythms. However, the association between nutritional circadia...

journal_title：International journal of cancer

authors： Srour B,Plancoulaine S,Andreeva VA,Fassier P,Julia C,Galan P,Hercberg S,Deschasaux M,Latino-Martel P,Touvier M

更新日期：2018-11-15 00:00:00

abstract：:Increasing evidence indicates that breast cancer pathogenesis is linked with DNA double-strand break (DSB) repair dysfunction. This conclusion is based on advances in the study of functions of breast cancer susceptibility genes such as BRCA1 and BRCA2, on the identification of breast cancer-associated changes regardin...

journal_title：International journal of cancer

authors： Keimling M,Kaur J,Bagadi SA,Kreienberg R,Wiesmüller L,Ralhan R

更新日期：2008-08-01 00:00:00

abstract：:The site-specific relationship between melanoma and sun exposure was investigated in the high-risk region of New Zealand. Age and latitude of residence were used as biological and geographical proxy measures of exposure for the 16,117 newly incident cases and 3,150 death records reported between 1968 and 1993. Age-sta...

journal_title：International journal of cancer

authors： Bulliard JL

更新日期：2000-03-01 00:00:00

abstract：:The large geographic variations in the incidence of gastric cancer (GC) are likely due to differential environmental exposures, in particular to Helicobacter pylori (H. pylori) infection. We aimed to investigate the impact of H. pylori on the epigenome in normal gastric mucosa and methylation changes associated with c...

journal_title：International journal of cancer

authors： Woo HD,Fernandez-Jimenez N,Ghantous A,Degli Esposti D,Cuenin C,Cahais V,Choi IJ,Kim YI,Kim J,Herceg Z

更新日期：2018-08-01 00:00:00

abstract：:Immune cells in tumor microenvironment play a prominent role in tumor progression and metastasis. MicroRNA-155 (miR-155) represents an important player in innate and adaptive immunity by regulating differentiation, maturation and activation of macrophages, dendritic cells, B cells and T cells. However, the role of miR...

journal_title：International journal of cancer

authors： Wang J,Yu F,Jia X,Iwanowycz S,Wang Y,Huang S,Ai W,Fan D

更新日期：2015-03-15 00:00:00

abstract：:Obesity is a well-known risk factor for postmenopausal breast cancer. In contrast, the relationship between obesity and stage of breast cancer at diagnosis is less clear. We hypothesized that increased breast size in obese women may delay discovery of breast tumors. Thus, the purpose of our study was to examine whethe...

journal_title：International journal of cancer

authors： Cui Y,Whiteman MK,Flaws JA,Langenberg P,Tkaczuk KH,Bush TL

更新日期：2002-03-10 00:00:00

abstract：:The effects of combined administration of bombesin (40 micrograms/kg body weight) and the ornithine decarboxylase (ODC) inhibitor, 1,3-diaminopropane (DAP), on the development of large and small intestinal tumors and the incidence of their metastasis to the peritoneum induced by azoxymethane (AOM, 7.4 mg/kg body weigh...

journal_title：International journal of cancer

authors： Iishi H,Tatsuta M,Baba M,Uehara H,Nakaizumi A

更新日期：1994-08-15 00:00:00

abstract：:Metastasis continues to be the leading cause of mortality for patients with cancer. Several years ago, it became clear that chemokines and their receptors could control the tumor progress. CXCR3 has now been identified in many cancers including osteosarcoma and CXCR3 ligands were expressed by lungs that are the primar...

journal_title：International journal of cancer

authors： Pradelli E,Karimdjee-Soilihi B,Michiels JF,Ricci JE,Millet MA,Vandenbos F,Sullivan TJ,Collins TL,Johnson MG,Medina JC,Kleinerman ES,Schmid-Alliana A,Schmid-Antomarchi H

更新日期：2009-12-01 00:00:00

abstract：:Vascular endothelial growth factor-A (VEGF-A) plays an important role in tumour angiogenesis and cancer progression. VEGF gene variation may influence VEGF levels and therefore cancer susceptibility and progression. We studied the role of VEGF single nucleotide polymorphisms and haplotypes in breast cancer susceptibil...

journal_title：International journal of cancer

authors： Balasubramanian SP,Cox A,Cross SS,Higham SE,Brown NJ,Reed MW

更新日期：2007-09-01 00:00:00

abstract：:V79 cells incubated with di- or tetrasulfonated aluminium phthalocyanines (AlPcS2 or AlPcS4) showed a granular fluorescence pattern. Co-staining with the lysosomotropic dye acridine orange (AO) indicated that the granules that were stained by these photoactive phthalocyanines were identical to lysosomes. Small light e...

journal_title：International journal of cancer

authors： Moan J,Berg K,Anholt H,Madslien K

更新日期：1994-09-15 00:00:00

abstract：:Vaccination against oncogenic human papillomavirus (HPV) types is one key intervention for cervical cancer prevention. This follow-up study assessed the persistence of the systemic and mucosal immune responses together with the safety profile of the HPV-16/18 AS04-adjuvanted vaccine administered to young women aged 10...

journal_title：International journal of cancer

authors： Petäjä T,Pedersen C,Poder A,Strauss G,Catteau G,Thomas F,Lehtinen M,Descamps D

更新日期：2011-11-01 00:00:00

abstract：:Expression of the MDR1 (P-glycoprotein) gene confers resistance to several classes of chemotherapeutic drugs (multi-drug resistance). Colon carcinomas frequently express high levels of MDR1 mRNA and P-glycoprotein, presumably reflecting the origin of these tumors from MDR1-expressing normal colonic cells. In 4 colon c...

journal_title：International journal of cancer

authors： Frommel TO,Coon JS,Tsuruo T,Roninson IB

更新日期：1993-09-09 00:00:00

abstract：:Cultured murine hepatic tumor (HT) cells respond to the polar solvent dimethylsulfoxide (DMSO) with specific alterations in morphology, proliferative kinetics, and biochemical properties. These include entrance into a quiescent "Qi" substate (characterized by accumulation of cells in G1 phase and lowered cellular RNA ...

journal_title：International journal of cancer

authors： Ryan MP,Higgins PJ

更新日期：1988-08-15 00:00:00

abstract：:Embryonal tumors such as Wilms' tumor (WT), embryonal rhabdomyosarcoma (eRMS) and hepatoblastoma have been thought to have a common pathogenetic mechanism. H19 was found to be inactivated in WT and eRMS either by loss of heterozygosity or by hypermethylation of the maternal allele. We show here that the expression of ...

journal_title：International journal of cancer

authors： Fukuzawa R,Umezawa A,Ochi K,Urano F,Ikeda H,Hata J

更新日期：1999-08-12 00:00:00

abstract：:We report a population based case-control study of exposure to pesticides as risk factor for non-Hodgkin lymphoma (NHL). Male and female subjects aged 18-74 years living in Sweden were included during December 1, 1999, to April 30, 2002. Controls were selected from the national population registry. Exposure to differe...

journal_title：International journal of cancer

authors： Eriksson M,Hardell L,Carlberg M,Akerman M

更新日期：2008-10-01 00:00:00

abstract：:Childhood brain tumors (CBT) are the leading cause of cancer death in children, yet their etiology remains largely unknown. Tobacco smoke contains 61 known carcinogens and increases the risk of several adult cancers. This study investigated associations between parental smoking and risk of CBT in a population-based ca...

journal_title：International journal of cancer

authors： Milne E,Greenop KR,Scott RJ,Ashton LJ,Cohn RJ,de Klerk NH,Armstrong BK

更新日期：2013-07-01 00:00:00

abstract：:Spreading is a critical process involved in motility and growth of tumor cells during the metastatic cascade. Focal adhesion kinase, src-proteins and PKC have been reported to participate in the regulation of cytoskeleton organization in both normal and transformed cells during spreading. The role of other signaling e...

journal_title：International journal of cancer

authors： Aguirre Ghiso JA,Farías EF,Alonso DF,Arregui C,Bal de Kier Joffé E

更新日期：1997-05-29 00:00:00

abstract：:MAGE-1 and MAGE-3 or -6 are genes encoding melanoma-rejection antigens recognized by cytotoxic T lymphocytes in an HLA-A1 restriction manner. MAGE-1 and MAGE-3 or -6 were expressed in 5/14 (36%) and 6/14 (43%) neuroblastoma (NB) cell lines, and in 20/41 (49%) and 24/41 (59%) clinical NB-related tumors, respectively. A...

journal_title：International journal of cancer

authors： Ishida H,Matsumura T,Salgaller ML,Ohmizono Y,Kadono Y,Sawada T

更新日期：1996-10-21 00:00:00