Hepatitis B virus, tobacco smoking and ethanol consumption in the etiology of hepatocellular carcinoma.


:Tobacco smoking and alcohol drinking histories were obtained from 194 patients with hepatocellular carcinoma (HCC) and 456 hospital controls, and the results were analysed in conjunction with the results of serological determinations of hepatitis B surface antigen (HBsAg), antibody to HBsAg (anti-HBs) and antibody to hepatitis B core antigen (anti-HBc) in all subjects, as well as the presence or absence of cirrhosis in HCC patients. The relative risk (RR) of HCC (and 95% confidence interval) among HBsAg-positive subjects was 13.7 (8.0-23.5), whereas the excess risk among antibody-positive subjects was small and statistically non-significant. In the presence of cirrhosis the RR for HBsAg-positive subjects was considerably higher (30.7 vs. 7.1 among HBsAg-positive subjects without cirrhosis) indicating that HBV may affect the development of HCC through at least two different and potentially multiplicative mechanisms (DNA integration and liver regeneration). Moderate ethanol consumption does not affect the risk of HCC, but there is a statistically significant and dose-dependent association between tobacco smoking and HBsAg-negative HCC. In most of the developed countries of Europe and North America, where the prevalence of HBsAg carrier state is very low and tobacco smoking very common, more cases of HCC may be due to tobacco smoking than to HBV, even though the RR for HCC is much higher among HBsAg carriers than among tobacco smokers.


Int J Cancer


Trichopoulos D,Day NE,Kaklamani E,Tzonou A,Muñoz N,Zavitsanos X,Koumantaki Y,Trichopoulou A




Has Abstract


1987-01-15 00:00:00












  • Co-expression of heparin-binding EGF-like growth factor and related peptides in human gastric carcinoma.

    abstract::Heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) is a member of the EGF family of polypeptide growth factors, which includes EGF, transforming growth factor alpha(TGF-alpha), amphiregulin (AR) and betacellulin (BTC). To assess the potential role of HB-EGF in human gastric carcinomas, the expre...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Naef M,Yokoyama M,Friess H,Büchler MW,Korc M

    更新日期:1996-05-03 00:00:00

  • Antitumour immunity invoked by hepatic arterial infusion of first-line oxaliplatin predicts durable colorectal cancer control after liver metastasis ablation: 8-12 years of follow-up.

    abstract::In colorectal cancer (CRC), hepatic arterial infusion (HAI) chemotherapy may convert primarily unresectable CRC liver metastases (CLM) into resectability, although the risk of metastatic recurrence remains high after CLM ablation. We investigated the role of antitumour immunity invoked by first-line oxaliplatin-HAI fo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Abrahamsson H,Jensen BV,Berven LL,Nielsen DL,Šaltytė Benth J,Johansen JS,Larsen FO,Johansen JS,Ree AH

    更新日期:2020-04-01 00:00:00

  • Trends in childhood acute lymphoblastic leukemia in Western Australia, 1960-2006.

    abstract::Increases in the incidence of childhood acute lymphoblastic leukemia (ALL) have been reported in some countries, while other reports from similar geographical regions have indicated stable rates. The reasons for the discrepancies have been debated in the literature, with the focus on whether the observed increases are...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Milne E,Laurvick CL,de Klerk N,Robertson L,Thompson JR,Bower C

    更新日期:2008-03-01 00:00:00

  • Exosomal circRNA derived from gastric tumor promotes white adipose browning by targeting the miR-133/PRDM16 pathway.

    abstract::Cancer-related cachexia is a metabolic syndrome characterized by a wasting disorder of adipose and skeletal muscle and is accompanied by body weight loss and systemic inflammation. The treatment options for cancer cachexia are limited, and the molecular mechanism remains poorly understood. Circular RNAs (circRNAs) are...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zhang H,Zhu L,Bai M,Liu Y,Zhan Y,Deng T,Yang H,Sun W,Wang X,Zhu K,Fan Q,Li J,Ying G,Ba Y

    更新日期:2019-05-15 00:00:00

  • Possible role of Cdx2 in the serrated pathway of colorectal cancer characterized by BRAF mutation, high-level CpG Island methylator phenotype and mismatch repair-deficiency.

    abstract::Colorectal cancer is a heterogeneous disease at the histomorphological, clinical and molecular level. Approximately 20% of cases may progress through the "serrated" pathway characterized by BRAF mutation and high-level CpG Island Methylator Phenotype (CIMP). A large subgroup are additionally microsatellite instable (M...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Dawson H,Galván JA,Helbling M,Muller DE,Karamitopoulou E,Koelzer VH,Economou M,Hammer C,Lugli A,Zlobec I

    更新日期:2014-05-15 00:00:00

  • A cluster randomized controlled trial of visual, cytology and human papillomavirus screening for cancer of the cervix in rural India.

    abstract::The impact of screening by visual inspection with acetic acid (VIA), cytology or HPV testing on cervical cancer incidence and mortality is investigated in a cluster randomized controlled trial in India. We report findings after the screening phase, when 52 clusters, with a total of 142,701 women aged 30-59 years in Os...

    journal_title:International journal of cancer

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Sankaranarayanan R,Nene BM,Dinshaw KA,Mahe C,Jayant K,Shastri SS,Malvi SG,Chinoy R,Kelkar R,Budukh AM,Keskar V,Rajeshwarker R,Muwonge R,Kane S,Parkin DM,Chauhan MK,Desai S,Fontaniere B,Frappart L,Kothari A,Lucas E

    更新日期:2005-09-10 00:00:00

  • Heterotransplantation of small-cell carcinoma of the lung into nude mice: comparison of intracranial and subcutaneous routes.

    abstract::We compared and contrasted intracranial (i.c.) and subcutaneous (s.c.) heterotransplantation of small-cell carcinoma of the lung (SCCL) into athymic nude mice. Fresh human SCCL tumor specimens, tumor colonies grown in soft agarose and continuous cell lines were used. Tumors induced by the three types of specimens were...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Gazdar AF,Carney DN,Sims HL,Simmons A

    更新日期:1981-12-01 00:00:00

  • Breast cancer screening effect across breast density strata: A case-control study.

    abstract::Breast cancer screening is known to reduce breast cancer mortality. A high breast density may affect this reduction. We assessed the effect of screening on breast cancer mortality in women with dense and fatty breasts separately. Analyses were performed within the Nijmegen (Dutch) screening programme (1975-2008), whic...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: van der Waal D,Ripping TM,Verbeek AL,Broeders MJ

    更新日期:2017-01-01 00:00:00

  • Benign breast disease increases breast cancer risk independent of underlying familial risk profile: Findings from a Prospective Family Study Cohort.

    abstract::Benign breast disease (BBD) is an established breast cancer (BC) risk factor, but it is unclear whether the magnitude of the association applies to women at familial or genetic risk. This information is needed to improve BC risk assessment in clinical settings. Using the Prospective Family Study Cohort, we used Cox pr...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zeinomar N,Phillips KA,Daly MB,Milne RL,Dite GS,MacInnis RJ,Liao Y,Kehm RD,Knight JA,Southey MC,Chung WK,Giles GG,McLachlan SA,Friedlander ML,Weideman PC,Glendon G,Nesci S,kConFab Investigators.,Andrulis IL,Buys SS

    更新日期:2019-07-15 00:00:00

  • Infectious DNA recovered from avian tumor-virus-producing cells.

    abstract::A single treatment of chick embryo fibroblasts with DNA recovered from chick embryo fibroblasts productively infected and transformed with four different strains of RSV, or productively infected with two different strains of RAV, resulted in virus production and cell transformation (in the case of RSV) two or three p...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Vigier P,Montagnier L

    更新日期:1975-01-15 00:00:00

  • Food-frequency questionnaire-based estimates of total antioxidant capacity and risk of non-Hodgkin lymphoma.

    abstract::Antioxidants, primarily from fruits and vegetables, have been hypothesized to protect against non-Hodgkin lymphoma (NHL). The oxygen radical absorbance capacity (ORAC) assay, which measures total antioxidant capacity of individual foods and accounts for synergism, can be estimated using a food-frequency questionnaire ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Holtan SG,O'Connor HM,Fredericksen ZS,Liebow M,Thompson CA,Macon WR,Micallef IN,Wang AH,Slager SL,Habermann TM,Call TG,Cerhan JR

    更新日期:2012-09-01 00:00:00

  • Identification of TDE2 gene and its expression in non-small cell lung cancer.

    abstract::TDE2, a gene with sequence similarity to the mouse testicular tumor-differentially-expressed (Tde1/MUSTETU) gene, was identified by serial analysis of gene expression (SAGE) in nonsmall cell lung cancers (NSCLC). Here we characterized the TDE2 gene and determined its transcript levels in a panel of lung tumors, adjace...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Player A,Gillespie J,Fujii T,Fukuoka J,Dracheva T,Meerzaman D,Hong KM,Curran J,Attoh G,Travis W,Jen J

    更新日期:2003-11-01 00:00:00

  • Expression of p16(INK4A) and alterations of the 9p21-23 chromosome region in non-small-cell lung carcinomas: relationship with tumor growth parameters and ploidy status.

    abstract::The 9p21-23 chromosome region harbors a number of known and putative tumor-suppressor genes (TSGs). The best characterized gene in this area is p16(INK4A) (CDKN2A). Alterations of its product have been observed in various malignancies, including non-small-cell lung carcinomas (NSCLCs). We earlier investigated the mech...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mariatos G,Gorgoulis VG,Zacharatos P,Kotsinas A,Vogiatzi T,Rassidakis G,Foukas P,Liloglou T,Tiniakos D,Angelou N,Manolis EN,Veslemes M,Field JK,Kittas C

    更新日期:2000-03-20 00:00:00

  • Detection of occult tumour cells in lymph nodes of colorectal cancer patients using real-time quantitative RT-PCR for CEA and CK20 mRNAS.

    abstract::The purpose of our study was to develop specific, sensitive, objective assays for early detection of disseminated tumour cells in patients with colorectal cancer (CRC). Carcinoembryonic antigen (CEA) and cytokeratin 20 (CK20) were chosen as markers because they are selectively expressed in epithelial cells with mainta...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Oberg AN,Lindmark GE,Israelsson AC,Hammarström SG,Hammarström ML

    更新日期:2004-08-10 00:00:00

  • Murine osteosarcoma primary tumour growth and metastatic progression is maintained after marked suppression of serum insulin-like growth factor I.

    abstract::The insulin-like growth factor I (IGF-I) signaling pathway has been shown to play an important role in several aspects of cancer biology, including metastasis. The aim of this study was to define the contribution of serum (endocrine) and local (tumour microenvironment) IGF-I on osteosarcoma tumour growth and metastasi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hong SH,Briggs J,Newman R,Hoffman K,Mendoza A,LeRoith D,Helman L,Yakar S,Khanna C

    更新日期:2009-05-01 00:00:00

  • Cancer incidence in a cohort of Ontario and Quebec women having bilateral breast augmentation.

    abstract::The possibility that women, who receive breast implants for cosmetic purposes, have increased long-term risks of developing cancer continues to be debated. The objective of our study was to prospectively examine cancer incidence among women who received breast implants. A cohort was assembled of 24,558 women, 18 years...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Brisson J,Holowaty EJ,Villeneuve PJ,Xie L,Ugnat AM,Latulippe L,Mao Y

    更新日期:2006-06-01 00:00:00

  • Role of reproductive factors on the risk of endometrial cancer.

    abstract::We analyzed the role of reproductive factors on the risk of endometrial cancer using data from a case-control study conducted in Italy. Cases were 752 women with histologically confirmed endometrial cancer < 75 years of age. Controls were 2,606 patients < 75 years of age admitted for acute, non-gynecological non-hormo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Parazzini F,Negri E,La Vecchia C,Benzi G,Chiaffarino F,Polatti A,Francheschi S

    更新日期:1998-06-10 00:00:00

  • EGFR-TKIs plus local therapy demonstrated survival benefit than EGFR-TKIs alone in EGFR-mutant NSCLC patients with oligometastatic or oligoprogressive liver metastases.

    abstract::To investigate whether addition of local therapy to EGFR-TKIs could provide survival benefit than EGFR-TKIs alone in EGFR-mutant NSCLC patients with oligometastatic or oligoprogressive liver metastases (LM). Patients with EGFR-mutant NSCLC and oligometastatic or oligoprogressive LM who met inclusion criteria were retr...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Jiang T,Chu Q,Wang H,Zhou F,Gao G,Chen X,Li X,Zhao C,Xu Q,Li W,Wu F,Xiong A,Zhao J,Xu Y,Su C,Ren S,Zhou C,Hirsch FR

    更新日期:2019-05-15 00:00:00

  • Beta-galactoside alpha2,6 sialyltransferase in human colon cancer: contribution of multiple transcripts to regulation of enzyme activity and reactivity with Sambucus nigra agglutinin.

    abstract::Colon cancer tissues display an increased activity of beta-galactoside alpha2,6 sialyltransferase (ST6Gal.I) and an increased reactivity with the lectin from Sambucus nigra (SNA), specific for alpha2,6-sialyl-linkages. Experimental and clinical studies indicate a contribution of these alterations to tumor progression,...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Dall'Olio F,Chiricolo M,Ceccarelli C,Minni F,Marrano D,Santini D

    更新日期:2000-10-01 00:00:00

  • Mutational analysis of Bax and Bcl-2 in childhood acute lymphoblastic leukaemia.

    abstract::In childhood acute lymphoblastic leukaemia there are large interpatient variations in levels of the apoptosis-regulating proteins Bax and Bcl-2, but the molecular basis for this variation is unknown. Point-mutations in bax have been reported in cell lines derived from haematological malignancies. Frameshift mutations,...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Salomons GS,Buitenhuis CK,Martínez Muñoz C,Verwijs-Jassen M,Behrendt H,Zsiros J,Smets LA

    更新日期:1998-06-19 00:00:00

  • Isolation of a human prostate carcinoma cell line (DU 145).

    abstract::A long-term tissue culture cell line has been derived from a human prostate adenocarcinoma metastatic to the brain. The cell line, DU 145, has been passaged 90 times in vitro over a period of 2 years. The cells are epithelial, grow in isolated islands on plastic Petri dishes, and form colonies in soft agar suspension ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Stone KR,Mickey DD,Wunderli H,Mickey GH,Paulson DF

    更新日期:1978-03-15 00:00:00

  • Human sulphotransferases are involved in the activation of aristolochic acids and are expressed in renal target tissue.

    abstract::Use of herbal preparations containing Aristolochia species has led to progressive nephropathy and urothelial cancer in humans. Analysis of DNA adducts formed in human target tissues and studies in animal models have pointed out a major role of the secondary plant metabolites, aristolochic acids, in these effects. Only...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Meinl W,Pabel U,Osterloh-Quiroz M,Hengstler JG,Glatt H

    更新日期:2006-03-01 00:00:00

  • Enzymatic oxidation products of spermine induce greater cytotoxic effects on human multidrug-resistant colon carcinoma cells (LoVo) than on their wild-type counterparts.

    abstract::The occurrence of resistance to cytotoxic agents in tumor cells, associated with several phenotypic alterations, is one of the major obstacles to successful anticancer chemotherapy. A new strategy to overcome MDR of human cancer cells was studied, using BSAO, which generates cytotoxic products from spermine, H(2)O(2) ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Calcabrini A,Arancia G,Marra M,Crateri P,Befani O,Martone A,Agostinelli E

    更新日期:2002-05-01 00:00:00

  • Heat-resistant mutants of B-16 melanoma cells. I. Stepwise heating in vitro induces progressive increase in resistance to heat.

    abstract::Cloned lines from 4 different families of B-16 melanoma cells were heated repeatedly in tissue culture at 45 degrees C with step-up time intervals. These lines included the partially heat-resistant lines previously selected at 43 degrees C(HR 43 degrees) from wheat-germ-agglutinin-resistant mutant (WGAR, HR43 degrees)...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tao Tw

    更新日期:1985-09-15 00:00:00

  • Hot maté drinking and precancerous lesions of the oesophagus: an endoscopic survey in southern Brazil.

    abstract::Thermal injury resulting from drinking very hot beverages has been incriminated as a risk factor for oesophageal cancer, although no information is available on the lesions caused by this injury in human or experimental animals. The drinking of hot maté tea is very common in areas of moderately high incidence of oesop...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Muñoz N,Victora CG,Crespi M,Saul C,Braga NM,Correa P

    更新日期:1987-06-15 00:00:00

  • Colposcopy is not necessary to assess the risk to the cervix in HIV-positive women: an international cohort study of cervical pathology in HIV-1 positive women.

    abstract::The objectives of this prospective multicentre international cohort study are to describe the characteristics of a cohort of HIV-1 positive women and determine the best management system by comparing cervical pathology according to results of cytology, colposcopy and human papillomavirus (HPV) testing at baseline and ...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Kitchener H,Nelson L,Adams J,Mesher D,Sasieni P,Cubie H,Moore C,Heard I,Agarossi A,Casolati E,Denny L,Bradbeer C,Lyons F,Beattie G,Niemiec T

    更新日期:2007-12-01 00:00:00

  • Risk factors for renal-cell carcinoma in Denmark. III. Role of weight, physical activity and reproductive factors.

    abstract::A population-based case-control study of risk factors for renal-cell carcinoma was conducted in Denmark from 1989 to 1992. A total of 368 histologically verified cases and 396 controls were included. Information on weight, height, physical activity and reproductive factors were collected in a structured interview, alo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mellemgaard A,Engholm G,McLaughlin JK,Olsen JH

    更新日期:1994-01-02 00:00:00

  • MHC class I expression in HPV positive and negative tonsillar squamous cell carcinoma in correlation to clinical outcome.

    abstract::Human papillomavirus (HPV) is an important factor for the development of tonsillar squamous cell carcinoma (TSCC). In addition, patients with HPV-positive TSCC have a better clinical outcome than patients with HPV-negative TSCC. Although, HPV is an important prognostic marker, additional biomarkers are needed to bette...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Näsman A,Andersson E,Nordfors C,Grün N,Johansson H,Munck-Wikland E,Massucci G,Dalianis T,Ramqvist T

    更新日期:2013-01-01 00:00:00

  • Promoter -202 A/C polymorphism of insulin-like growth factor binding protein-3 gene and non-small cell lung cancer risk.

    abstract::Insulin-like growth factor binding protein-3 (IGFBP-3) inhibits the mitogenic and antiapoptotic activity of insulin-like growth factor (IGF) by blocking the binding of IGF to its receptor. However, under certain circumstances, IGFBP-3 can enhance the activity of IGF by protecting IGF from degradation. More than half o...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Moon JW,Chang YS,Ahn CW,Yoo KN,Shin JH,Kong JH,Kim YS,Chang J,Kim SK,Kim HJ,Kim SK

    更新日期:2006-01-15 00:00:00

  • Correlation of total VEGF mRNA and protein expression with histologic type, tumor angiogenesis, patient survival and timing of relapse in non-small-cell lung cancer.

    abstract::We have quantified the expression of all 4 isoforms of vascular endothelial growth factor (VEGF) mRNA in non-small-cell lung cancer (NSCLC) using a new kinetic quantitative PCR method, real-time quantitative (RTQ) RT-PCR, and investigated the association between VEGF expression at the mRNA and protein levels and the c...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yuan A,Yu CJ,Chen WJ,Lin FY,Kuo SH,Luh KT,Yang PC

    更新日期:2000-11-20 00:00:00