Hepatitis B virus, tobacco smoking and ethanol consumption in the etiology of hepatocellular carcinoma.


:Tobacco smoking and alcohol drinking histories were obtained from 194 patients with hepatocellular carcinoma (HCC) and 456 hospital controls, and the results were analysed in conjunction with the results of serological determinations of hepatitis B surface antigen (HBsAg), antibody to HBsAg (anti-HBs) and antibody to hepatitis B core antigen (anti-HBc) in all subjects, as well as the presence or absence of cirrhosis in HCC patients. The relative risk (RR) of HCC (and 95% confidence interval) among HBsAg-positive subjects was 13.7 (8.0-23.5), whereas the excess risk among antibody-positive subjects was small and statistically non-significant. In the presence of cirrhosis the RR for HBsAg-positive subjects was considerably higher (30.7 vs. 7.1 among HBsAg-positive subjects without cirrhosis) indicating that HBV may affect the development of HCC through at least two different and potentially multiplicative mechanisms (DNA integration and liver regeneration). Moderate ethanol consumption does not affect the risk of HCC, but there is a statistically significant and dose-dependent association between tobacco smoking and HBsAg-negative HCC. In most of the developed countries of Europe and North America, where the prevalence of HBsAg carrier state is very low and tobacco smoking very common, more cases of HCC may be due to tobacco smoking than to HBV, even though the RR for HCC is much higher among HBsAg carriers than among tobacco smokers.


Int J Cancer


Trichopoulos D,Day NE,Kaklamani E,Tzonou A,Muñoz N,Zavitsanos X,Koumantaki Y,Trichopoulou A




Has Abstract


1987-01-15 00:00:00












  • A mechanistic study on the metastasis inducing function of FUS-CHOP fusion protein in liposarcoma.

    abstract::The FUS-CHOP fusion protein has been found to be instrumental for specific oncogenic processes in liposarcoma, but its ability to induce metastasis and the underlying mechanisms by which this can be achieved remain unknown. To dissect its functional role in this context, we stably overexpressed this protein in SW872 l...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Patil N,Ahmed Kabeer Rasheed S,Abba M,Hendrik Leupold J,Schwarzbach M,Allgayer H

    更新日期:2014-06-15 00:00:00

  • Modification of the effect of C. parvum on macrophage activity and tumour growth by X-irradiation.

    abstract::The radiosensitivity of three forms of response to injection of C. parvum in mice has been investigated. The increase in phagocytin index evoked by IP or IV injection of 0.7 mg C. parvum (but not that evoked by 1.4 mg) was reduced but not abolished in mice given 350-500 rad whole-body irradiation 4 days before C. parv...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Woodruff MF,Ghaffar A,Whitehead VL

    更新日期:1976-05-15 00:00:00

  • Premature chromosome condensation: evidence for in vivo cell fusion in human malignant tumours.

    abstract::Premature chromosome condensation (PCC) was studied in direct preparations of tissues from patients with haematological diseases and carcinomas of various histological types. PCC was found in 6 out of 166 malignancies (128 haematological cases, 35 carcinomas and 3 malignant effusions) analysed with the GTG-technique. ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kovacs G

    更新日期:1985-12-15 00:00:00

  • Identification of Hodgkin and Sternberg-reed cells as a unique cell type derived from a newly-detected small-cell population.

    abstract::In this study the antigenic profile of Hodgkin (H) and Sternberg-Reed (SR) cells from cases of Hodgkin's disease was analysed using a large panel of monoclonal and polyclonal antibodies reactive with cells of lymphoid and haemotopoietic origin. The aim of this investigation was, firstly, to throw light on the origin o...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Stein H,Gerdes J,Schwab U,Lemke H,Mason DY,Ziegler A,Schienle W,Diehl V

    更新日期:1982-10-15 00:00:00

  • Presentation of native TROP-2 tumor antigens to human cytotoxic T lymphocytes by engineered antigen-presenting cells.

    abstract::Professional antigen-presenting cells (APC), e.g. dendritic cells, express immuno-proteasome components and process proteins for MHC presentation differently from non-immune cells. Thus, they induce reactivities against sets of peptides that do not overlap with those generated by non-professional APC, i.e., tumor cell...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mangino G,Grazia Capri M,Barnaba V,Alberti S

    更新日期:2002-10-01 00:00:00

  • Preservation of chromosome and DNA characteristics of human colorectal adenocarcinomas after passage in nude mice.

    abstract::Twenty-seven human colorectal adenocarcinomas were implanted s.c. into nude mice. A comparative study of chromosomes and DNA between fresh tumor (FT) and xenografted tumor cells (XT) could be performed in 9 cases. Losses or deletions were consistently found in FTs as well as in XTs, particularly on chromosomes 17 and/...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lefrançois D,Olschwang S,Delattre O,Muleris M,Dutrillaux AM,Thomas G,Dutrillaux B

    更新日期:1989-11-15 00:00:00

  • Interleukin-2 gene therapy of surgical minimal residual tumour disease.

    abstract::Our study was designed to examine the effects of IL-2 gene therapy in a surgical minimal residual tumour disease (SMRTD). Mice were inoculated s.c. with methylcholanthrene (MC)-induced MC12 sarcoma cells. When the tumours reached 8 to 12 mm in diameter, they were excised, either completely ("microscopic SMRTD") or inc...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Vlk V,Rössner P,Indrová M,Bubeník J,Sobota V

    更新日期:1998-03-30 00:00:00

  • Diagnosis of digestive system tumours.

    abstract::The WHO Classification of Tumours provides the international standards for the classification and diagnosis of tumours. It enables direct comparisons to be made between different countries. In the new fifth edition, the series has gone digital with the launch of a website as well as a series of books, known widely as ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Washington MK,Goldberg RM,Chang GJ,Limburg P,Lam AK,Salto-Tellez M,Arends MJ,Nagtegaal ID,Klimstra DS,Rugge M,Schirmacher P,Lazar AJ,Odze RD,Carneiro F,Fukayama M,Cree IA,WHO Classification of Tumours Editorial Board.

    更新日期:2021-03-01 00:00:00

  • Hospicells derived from ovarian cancer stroma inhibit T-cell immune responses.

    abstract::With metastatic disease at diagnosis for 70% of patients, ovarian cancer represents the most lethal gynecological malignancy. Ovarian carcinomas are aggressive malignancies that can evade immune surveillance and frequently develop into metastases. The tumor microenvironment is decisive for preventing immune attack but...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Martinet L,Poupot R,Mirshahi P,Rafii A,Fournié JJ,Mirshahi M,Poupot M

    更新日期:2010-05-01 00:00:00

  • Genetic features of multicentric/multifocal intramucosal gastric carcinoma.

    abstract::Chronic gastritis caused by Helicobacter pylori (H. pylori) infection could lead to the development of gastric cancer. The finding that multiple gastric cancers can develop synchronously and/or metachronously suggests the development of field cancerization in chronically inflamed, H. pylori-infected gastric mucosa. Th...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mizuguchi A,Takai A,Shimizu T,Matsumoto T,Kumagai K,Miyamoto S,Seno H,Marusawa H

    更新日期:2018-10-15 00:00:00

  • Three-dimensional radiotherapy of head and neck and esophageal carcinomas: a monoisocentric treatment technique to achieve improved dose distributions.

    abstract::The specific aim of three-dimensional conformal radiotherapy is to deliver adequate therapeutic radiation dose to the target volume while concomitantly keeping the dose to surrounding and intervening normal tissues to a minimum. The objective of this study is to examine dose distributions produced by various radiother...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ahmad M,Nath R

    更新日期:2001-02-20 00:00:00

  • Screening of human bladder tumors and urine sediments for the presence of H-ras mutations.

    abstract::A series of 111 human bladder tumors were screened using oligonucleotide mutant specific probes, restriction enzyme analysis and single-stranded confirmation polymorphism (SSCP) for the presence of H-ras activation events. Thirty-three tumors were found to harbor H-ras mutations where a glycine to valine (G-->T) chang...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Levesque P,Ramchurren N,Saini K,Joyce A,Libertino J,Summerhayes IC

    更新日期:1993-11-11 00:00:00

  • Different frequencies of p53 codon-249 hot-spot mutations in hepatocellular carcinomas in Jiang-su province of China.

    abstract::Environmental carcinogens often induce specific mutations in the p53 gene, apparent in tumors. The relation between aflatoxin B1 (AFB1 )-related hepatocellular carcinomas (HCCs) and hot spot at codon 249 of the p53 gene has received a great deal of attention, but its significance is still controversial. To clarify thi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Shimizu Y,Zhu JJ,Han F,Ishikawa T,Oda H

    更新日期:1999-07-19 00:00:00

  • Human papillomavirus-16 DNA methylation patterns support a causal association of the virus with oral squamous cell carcinomas.

    abstract::Infection with human papillomavirus-16 (HPV-16) is the cause of most anogenital carcinomas. This virus is also detected in about 20% of all head and neck squamous cell carcinomas. While there is strong evidence for a causal etiological role in the case of tonsillar carcinomas, causal association with malignant lesions...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Balderas-Loaeza A,Anaya-Saavedra G,Ramirez-Amador VA,Guido-Jimenez MC,Kalantari M,Calleja-Macias IE,Bernard HU,Garcia-Carranca A

    更新日期:2007-05-15 00:00:00

  • Prognostic and diagnostic potential of local and circulating levels of pentraxin 3 in lung cancer patients.

    abstract::There is a well-established link between inflammation and cancer of various organs, but little data are available on inflammation-associated markers of diagnostic and prognostic clinical utility in pulmonary malignancy. Blood samples were prospectively collected from 75 resectable lung cancer patients before surgery a...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Infante M,Allavena P,Garlanda C,Nebuloni M,Morenghi E,Rahal D,Roncalli M,Cavuto S,Pesce S,Monari M,Valaperta S,Montanelli A,Solomon D,Bottoni E,Errico V,Voulaz E,Bossi M,Chiesa G,Passera E,Mantovani A,Alloisio M

    更新日期:2016-02-15 00:00:00

  • Cytosine deaminase/5-fluorocytosine gene therapy can induce efficient anti-tumor effects and protective immunity in immunocompetent mice but not in athymic nude mice.

    abstract::Murine hepatocellular carcinoma cells were retrovirally transduced with the bacterial cytosine deaminase (CD) gene. CD-transduced cells exhibited more than 120-fold higher sensitivity to 5-fluorocytosine (5-FC) compared with parental cells. When syngeneic immunocompetent mice were inoculated s.c. with parental hepatoc...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kuriyama S,Kikukawa M,Masui K,Okuda H,Nakatani T,Sakamoto T,Yoshiji H,Fukui H,Ikenaka K,Mullen CA,Tsujii T

    更新日期:1999-05-17 00:00:00

  • LAGE-1, a new gene with tumor specificity.

    abstract::Representational difference analysis was used to identify genes that are expressed in a human melanoma cell line and not in normal skin. A cDNA clone that appeared to be specific for tumors was obtained and the corresponding gene was sequenced. This new gene was named LAGE-I. Using a LAGE-I probe to screen a cDNA libr...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lethé B,Lucas S,Michaux L,De Smet C,Godelaine D,Serrano A,De Plaen E,Boon T

    更新日期:1998-06-10 00:00:00

  • Malignant neoplasms in cyclosporin A-induced autoimmunity (CyA-AI).

    abstract::Lethally X-irradiated LEW rats reconstituted with syngeneic bone marrow and given low-dose Cyclosporine A (CyA) for 5 weeks develop, after withdrawal of CyA, symptoms of disease resembling graft-vs.-host disease (GVHD) as seen after allogeneic bone-marrow transplantation. Symptoms of disease may include acute dermatit...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wodzig KW,Beijleveld LJ,Damoiseaux JG,Arends JW,van Breda Vriesman PJ

    更新日期:1997-07-29 00:00:00

  • Cancer prevention by adult-onset calorie restriction after infant exposure to ionizing radiation in B6C3F1 male mice.

    abstract::Children are especially sensitive to ionizing radiation and chemical carcinogens, and limiting their cancer risk is of great public concern. Calorie restriction (CR) is a potent intervention for suppressing cancer. However, CR is generally not appropriate for children. This study, therefore, examined to see if adult-o...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Shang Y,Kakinuma S,Yamauchi K,Morioka T,Kokubo T,Tani S,Takabatake T,Kataoka Y,Shimada Y

    更新日期:2014-09-01 00:00:00

  • KSHV viral load and Interleukin-6 in HIV-associated pediatric Kaposi sarcoma-Exploring the role of lytic activation in driving the unique clinical features seen in endemic regions.

    abstract::Kaposi sarcoma (KS) is among the most common childhood malignancies in central, eastern, and southern Africa. Although its unique clinical features have been established, biological mechanisms related to the causative agent, KS-associated herpes-virus (KSHV), have yet to be explored in children. We performed a prospec...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: El-Mallawany NK,Mehta PS,Kamiyango W,Villiera J,Peckham-Gregory EC,Kampani C,Krysiak R,Sanders MK,Caro-Vegas C,Eason AB,Ahmed S,Schutze GE,Martin SC,Kazembe PN,Scheurer ME,Dittmer DP

    更新日期:2019-01-01 00:00:00

  • Poor oral health is associated with an increased risk of esophageal squamous cell carcinoma - a population-based case-control study in China.

    abstract::To further examine the association between oral hygiene and esophageal squamous cell carcinoma (ESCC) risk and the effect modification of other exposures, we conducted a population-based case-control study between 2010 and 2012 in Taixing, China, a high-risk area for ESCC. Cases were primarily recruited from endoscopy...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chen X,Yuan Z,Lu M,Zhang Y,Jin L,Ye W

    更新日期:2017-02-01 00:00:00

  • Isolation of a human prostate carcinoma cell line (DU 145).

    abstract::A long-term tissue culture cell line has been derived from a human prostate adenocarcinoma metastatic to the brain. The cell line, DU 145, has been passaged 90 times in vitro over a period of 2 years. The cells are epithelial, grow in isolated islands on plastic Petri dishes, and form colonies in soft agar suspension ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Stone KR,Mickey DD,Wunderli H,Mickey GH,Paulson DF

    更新日期:1978-03-15 00:00:00

  • Consistent expression of the stem cell renewal factor BMI-1 in primary and metastatic melanoma.

    abstract::Stem cell-like cells have recently been identified in melanoma cell lines, but their relevance for melanoma pathogenesis is controversial. To characterize the stem cell signature of melanoma, expression of stem cell markers BMI-1 and nestin was studied in 64 cutaneous melanomas, 165 melanoma metastases as well as 53 m...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mihic-Probst D,Kuster A,Kilgus S,Bode-Lesniewska B,Ingold-Heppner B,Leung C,Storz M,Seifert B,Marino S,Schraml P,Dummer R,Moch H

    更新日期:2007-10-15 00:00:00

  • Constitutive activating mutation of the FGFR3b in oral squamous cell carcinomas.

    abstract::A G to T mutation at nucleotide position 2128 in the human FGFR3b coding region resulting in a Cys for Gly substitution (G697C) in the tyrosine kinase domain was observed in 62% (44/71) of oral squamous cell carcinomas (OSCC) examined. Immunostained FGFR3b was found in the cytoplasm of prickle cells in normal epitheli...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zhang Y,Hiraishi Y,Wang H,Sumi KS,Hayashido Y,Toratani S,Kan M,Sato JD,Okamoto T

    更新日期:2005-10-20 00:00:00

  • Single nucleotide polymorphisms in the IGF-IRS pathway are associated with outcome in mCRC patients enrolled in the FIRE-3 trial.

    abstract::The Insulin-like growth factor (IGF)/IGF-receptor pathway with its scaffolding proteins Insulin Receptor Substrate (IRS)1 and IRS2 are crucial regulators of metabolism and progression in metastatic colorectal cancer (mCRC). The goal of the study was the identification of predictive and prognostic markers among IRS1, I...

    journal_title:International journal of cancer

    pub_type: 杂志文章,随机对照试验


    authors: Schirripa M,Zhang W,Heinemann V,Cao S,Okazaki S,Yang D,Loupakis F,Berger MD,Ning Y,Miyamoto Y,Suenaga M,Gopez RF,West JD,Hanna D,Barzi A,Falcone A,Stintzing S,Lenz HJ

    更新日期:2017-07-15 00:00:00

  • Thymidine kinase in epithelial ovarian cancer: relationship with the other pyrimidine pathway enzymes.

    abstract::TK is a pyrimidine metabolic pathway enzyme involved in salvage DNA synthesis. What roles TK may play in epithelial ovarian cancer and the relationships between TK and the other pyrimidine pathway enzymes remain unclear. We examined TK1 gene expression by RT-PCR and related it to gene expression of TS, TP and DPD in 6...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fujiwaki R,Hata K,Nakayama K,Moriyama M,Iwanari O,Katabuchi H,Okamura H,Sakai E,Miyazaki K

    更新日期:2002-05-20 00:00:00

  • Three exceptional IgH/myc-translocation-carrying rat immunocytomas have breakpoints 50 to 80 kb 5' of c-myc.

    abstract::The spontaneously arising immunocytoma of the Louvain rat (RIC) carries a consistent chromosomal translocation between chromosomes 6 and 7. This translocation juxtaposes immunoglobulin heavy chain and c-myc sequences. In an earlier study on 14 RIC tumors, we found that the translocation breakpoint is located within 1....

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Axelson H,Panda CK,Klein G

    更新日期:1994-02-01 00:00:00

  • Variations in sex hormone metabolism genes, postmenopausal hormone therapy and risk of endometrial cancer.

    abstract::We investigated whether variants in sex steroid hormone metabolism genes modify the effect of hormone therapy (HT) on endometrial cancer risk in postmenopausal non-Hispanic white women. A nested case-control study was conducted within the California Teachers Study (CTS). We genotyped htSNPs in six genes involved in th...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Razavi P,Lee E,Bernstein L,Van Den Berg D,Horn-Ross PL,Ursin G

    更新日期:2012-04-01 00:00:00

  • The ability of normal mouse cells to reduce the malignant potential of transformed mouse bladder epithelial cells depends on their somatic origin.

    abstract::Somatic cell hybrids have been made between a transformed mouse bladder carcinoma cell line and normal mouse bladder epithelium and mesenchyme. In the epithelial tumour/mesenchyme hybrids the malignant phenotype was expressed dominantly whereas in the carcinoma/normal epithelium hybrids the malignant potential was gre...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Cowell JK,Franks LM

    更新日期:1984-05-15 00:00:00

  • Cervicovaginal human papillomavirus (HPV)-infection before and after hysterectomy: evidence of different tissue tropism for oncogenic and nononcogenic HPV types in a cohort of HIV-positive and HIV-negative women.

    abstract::Human papillomavirus (HPV) is detected in nearly all cervical cancers and approximately half of vaginal cancers. However, vaginal cancer is an order of magnitude less common than cervical cancer, not only in the general population but also among women with HIV/AIDS. It is interesting therefore that recent studies foun...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: D'Souza G,Burk RD,Zhong Y,Minkoff H,Massad LS,Xue X,Watts DH,Anastos K,Palefsky JM,Levine AM,Colie C,Castle PE,Strickler HD

    更新日期:2012-09-15 00:00:00