Abstract:
:Complement-dependent cytotoxic antibodies to three cervical carcinoma cell lines (Me-180, SW-732 and HeLa) and to Herpes simplex virus type 2 (HSV-2)-infected cells were determined in a long-term study of women with cervical carcinoma. Cytolysis of surface antigens differed significantly between the cervical carcinoma cell lines and HSV-2. Regression of the tumor during treatment was accompanied by decreasing cytolysis in the cervical carcinoma lines, while tumor bearers and patients who became severely ill had high or increasing cytotoxic antibodies, The opposite was noted for the antibody response to HSV-2 infected cells: patients with less advanced cancer had significantly higher cytolytic activity than those who were severely ill or had advanced cancer; long-term survivors demonstrated high, stable lysis of HSV-2 infected cells. As a control of the cervical carcinoma cell lines, cytolytic activity was tested also on a lung carcinoma cell line, A-549. No significant differences were found between the patients with cervical cancer and the control women. Tumor bearers and patients treated for advanced cervical cancer showed a slight but non-significant increase in cytolytic activity on the A-549 line.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Christenson Bdoi
10.1002/ijc.2910200508subject
Has Abstractpub_date
1977-11-15 00:00:00pages
694-701issue
5eissn
0020-7136issn
1097-0215journal_volume
20pub_type
杂志文章abstract::Lung cancer is the leading cause of cancer mortality in the world. Although exposure to carcinogens is considered to be the main cause, genetic variation may contribute to lung cancer risk. Murine double minute 2, MDM2, is a key regulator of p53 activity and recently a polymorphism in the promoter region of the MDM2 g...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21872
更新日期:2006-08-01 00:00:00
abstract::Epigenetic alterations play a major role in cancer. Recently we reported that stem cell Polycomb group targets (PcGTs) are up to 12-fold more likely to have cancer-specific promoter DNA hypermethylation than nontargets. To identify potential, prognostic DNA methylation markers in ovarian cancer we analyzed the DNA met...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23563
更新日期:2008-08-01 00:00:00
abstract::Epidemiologic evidence on the association of antioxidant intake and prostate cancer incidence is inconsistent. Total antioxidant intake and prostate cancer incidence have not previously been examined. Using the ferric-reducing antioxidant potential (FRAP) assay, the total antioxidant content (TAC) of diet and suppleme...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28438
更新日期:2014-03-01 00:00:00
abstract::A clone of Cloudman S91 murine melanoma was fused in vitro with non-malignant hamster cheek pouch cells by means of lysolecithin, and the putative hybrid progeny cells, HCP-MM, were found to be highly malignant in hamster, but not in appropriate mice. A malignant clone of HCP-MM cells was shown to have hamster species...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910150214
更新日期:1975-02-15 00:00:00
abstract::Sunlight is essential for the production of vitamin D in the body. Evidence exists to suggest that vitamin D metabolites may have a role in tumor growth suppression. In this large study, involving over a million cancer patients from the United Kingdom, we have analyzed the role of season of diagnosis and sunlight expo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22052
更新日期:2006-10-01 00:00:00
abstract::Increasing evidences indicate that CXCR4/CXCL12 signaling pathway plays a pivotal role in the process of distant site metastasis that accounts for more than 90% of prostate cancer related deaths in patients. Thus, novel drugs that can downregulate CXCR4/CXCL12 axis have a great potential in the treatment of metastatic...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26120
更新日期:2011-10-01 00:00:00
abstract::T24 human bladder carcinoma cells reveal a high locomotor activity (70% locomoting cells) within a 3-dimensional collagen matrix. This high migratory activity is induced by an autocrine engagement of the interleukin-8 receptor A, as was shown by antibodies neutralizing the secreted interleukin-8. Treatment of the cell...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10424
更新日期:2002-06-10 00:00:00
abstract::A panel of conventional and monoclonal antibodies was used to examine the immunohistological characteristics of malignant epithelial cells and infiltrating lymphocytes in frozen sections of nasopharyngeal carcinoma (NPC) biopsies from 10 Tunisian patients. Three main categories of cells were identified. (1) Tumour cel...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910330616
更新日期:1984-06-15 00:00:00
abstract::Histone deacetylase inhibitors (HDACi) represent a promising new class of anticancer agents. In the current investigation, we examined the activity of the HDACi belinostat in preclinical models of prostate cancer. In vitro proliferation assays demonstrated that belinostat potently inhibited the growth of prostate canc...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23243
更新日期:2008-03-15 00:00:00
abstract::Mitotic and meiotic cell cycle regulation is essential for normal development and tumor prevention. The underlying molecular mechanisms are not completely characterized. The aim of our analysis was to derive a global expression map of cell cycle regulators in mitosis and meiosis. First, the expression of cyclins, CDKs...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21034
更新日期:2005-08-20 00:00:00
abstract::A major objective of peptide vaccination is the induction of tumor-reactive CD8+ T-cells. We have shown that HLA-A2 positive cancer patients frequently develop an antigen-specific CD8+ T-cell response after vaccination with NY-ESO-1 peptides p157-165/p157-167. These T-cells are highly reactive with the peptides used f...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22957
更新日期:2007-11-01 00:00:00
abstract::There are few published estimates of the risk of developing breast or ovarian cancer in women with a strong family history of ovarian cancer. As these women commonly present to family cancer clinics, accurate cancer risk estimates are needed. We have estimated these risks in women from families with 2 or more confirme...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20000701)87:1<110::aid-ijc16>3.0
更新日期:2000-07-01 00:00:00
abstract::Receptors for the third component of complement (C3) were demonstrated on the surface of established human lymphoid cell lines by a membrane fluorescence test with FITC- or TRITC-conjugated antibodies against human C3. Two-color fluorescence staining of EBV receptors and C3 receptors showed complete overlapping of gre...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910170602
更新日期:1976-06-15 00:00:00
abstract::MicroRNAs (mirs) are small noncoding RNA molecules (~22 nucleotides) that regulate posttranscriptional gene expression. Currently, there has not been a comprehensive study of their role in primary head and neck squamous cell carcinoma (HNSCC). To determine the role of mirs in HNSCC, we screened for altered microRNA ex...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23831
更新日期:2008-12-15 00:00:00
abstract::Primary cultures derived from pre-cancerous and cancerous human colon tissue are essential for understanding normal and abnormal growth function in the large intestine. Here presented are (i) the methodology for routine establishment of primary cultures of normal, adenoma- and carcinoma-derived cells, and (ii) data fo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980130)75:3<467::aid-ijc
更新日期:1998-01-30 00:00:00
abstract::The utility of EBV load as a tumor marker in nasopharyngeal carcinoma (NPC) patients suggests that it might also serve as a screening test for individuals who are at high risk for developing NPC. We previously demonstrated that unaffected individuals from high-risk families had elevated anti-EBV antibody levels compar...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/ijc.21396
更新日期:2006-02-01 00:00:00
abstract::Two factors potentially determining the consistent overexpression of sialyl-Le(x) antigen in colon carcinoma and metastases were investigated: (i) the expression of the mucins MUC1 and MUC2, known to carry sialyl-Le(x), by Northern blotting; (ii) the extent of sialic acid O-acetylation, by Western blotting and HPLC. R...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970717)72:2<258::aid-ijc
更新日期:1997-07-17 00:00:00
abstract::The EWS/Fli-1 fusion gene, a product of the translocation t(11;22, q24;q12), is detected in 85% of Ewing sarcomas and primitive neuroectodermal tumors. It is thought to be a transcriptional activator that plays a significant role in tumorigenesis. In this study, we developed a novel EWS/Fli-1 blockade system using RNA...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25564
更新日期:2011-01-01 00:00:00
abstract::Although a screening program for gastric cancer, using barium X-ray examination, has been carried out widely in Japan for the past 3 decades, there is insufficient evidence to confirm its effectiveness in terms of reducing mortality. To evaluate the effectiveness of the screening, a population-based case-control study...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910600106
更新日期:1995-01-03 00:00:00
abstract::von Willebrand factor (vWF), a glycoprotein produced uniquely by endothelial cells and megakaryocytes, is routinely used to identify vessels in tissue sections. Vessel density in tumor specimens, as determined by immuno-histochemical staining for vWF or other endothelial cell markers, is a negative prognostic factor f...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(20000115)85:2<281::aid-ijc
更新日期:2000-01-15 00:00:00
abstract::We established gastric cancer-specific CD8+ T-cell (T(CD8+)) lines derived from different lymphocyte sources in the same patients by repeated stimulation with mitomycin-C-treated autologous tumor cells with low-dose interleukin-2, and we compared recognition patterns among the T(CD8+) derived from solid tumor, lymph n...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970611)71:6<978::aid-ijc
更新日期:1997-06-11 00:00:00
abstract::To probe the potential contribution of beta-galactoside-contributing epitopes and receptor proteins (gal-1 and gal-3) to colon malignancy, we first examined the expression of galectins and binding sites in clinical specimens by lectin and immunohistochemistry. Sixty-seven colonic surgical resections were studied, incl...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10843
更新日期:2003-01-20 00:00:00
abstract::The distribution of aminoterminal propeptides of type-III procollagen (indicating the presence of type-III pN-collagen, i.e., type-III collagen molecule with a non-cleaved aminoterminal propeptide), laminin and type-IV collagen was studied by immunohistochemical methods. The results were compared with the distribution...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910410111
更新日期:1988-01-15 00:00:00
abstract::Thirty-one different long-term established human carcinoma culture cell lines were examined for the presence or absence of receptors for the Fc portion of immunoglobulin G (IgG) ("Fc receptors"), the third component of complement (C3 receptors), sheep erythrocytes and mouse erythrocytes. Included in the catalogue of l...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910200505
更新日期:1977-11-15 00:00:00
abstract::Diabetes refers to a group of metabolic diseases characterized by impaired insulin signalling and high blood glucose. A growing body of epidemiological evidence links diabetes to several types of cancer but the underlying molecular mechanisms are poorly understood. The signalling cascade connecting insulin and FOXO pr...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.30840
更新日期:2017-12-15 00:00:00
abstract::In Japan, cervical cancer incidence has increased since the late 1990s especially among young women, despite a decreasing trend in most developed countries. Here, we examined age, period and birth cohort trends in cervical cancer incidence rates from 1985 to 2012. Incidence rates were ascertained using three populatio...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32014
更新日期:2019-05-01 00:00:00
abstract::Promoter hypermethylation of various tumor-related genes is extremely frequent in gastric carcinoma (GC) associated with Epstein-Barr virus (EBV). To investigate the significance of the promoter methylation in this type of GC, we examined the methylation densities of the promoter regions of p14ARF and p16INK4A in EBV-...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20420
更新日期:2004-11-01 00:00:00
abstract::Data on the incidence of 15 cancers in the Jewish population of Israel from the period 1961-1981 have been studied with emphasis on the risk of disease in relation to birthplace, calendar time, and duration of residence in Israel. The results show wide variations in incidence by birthplace, from less than 2-fold for p...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910450407
更新日期:1990-04-15 00:00:00
abstract::In vivo TSTA induction in Syrian hamsters was studied with the use of SV40 ts mutants (A, B, C, BC and D). The ts A30, TS A239 and possibly also the ts BC210 mutants were defective in resistance-inducing activity in hamsters in contrast to wild type SV40 and other ts mutnats. At the permissive temperature ts A30 and t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910200420
更新日期:1977-10-15 00:00:00
abstract::We have surveyed the incidence of adult T-cell leukemia/lymphoma (ATLL) in an endemic area of 290,464 inhabitants for 7 years. We now revise our previous results on the basis of additional findings and estimate the age- and sex-specific cumulative rate for HTLV-I carriers, the adoption of which is recommended by curre...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910430618
更新日期:1989-06-15 00:00:00