Patterns of growth and differentiation in the colon carcinoma cell line LIM 1863.

abstract：:Galunisertib (LY2157299), a promising small-molecule inhibitor of the transforming growth factor-beta (TGF-β) receptor, is currently in mono- and combination therapy trials for various cancers including glioblastoma, hepatocellular carcinoma and breast cancer. Using genetically modified mouse models, we investigated t...

journal_title：International journal of cancer

authors： Li W,Tibben M,Wang Y,Lebre MC,Rosing H,Beijnen JH,Schinkel AH

更新日期：2020-03-15 00:00:00

abstract：:A functional promoter polymorphism in the progesterone receptor (PR) gene previously has been associated with an increased risk of postmenopausal breast cancer. Whether the relationship between genetic variation in PR and risk of breast cancer is modified by postmenopausal hormone (PMH) use is unknown. Thus, we conduc...

journal_title：International journal of cancer

authors： Kotsopoulos J,Tworoger SS,De Vivo I,Hankinson SE,Hunter DJ,Willett WC,Chen WY

更新日期：2009-10-01 00:00:00

abstract：:Bcl-2 expression is up-regulated in prostate cancer cells after androgen ablation and associated with development of androgen independence and chemoresistance. We recently reported that antisense Bcl-2 oligodeoxynucleotides (ODNs) delay progression to androgen independence in the androgen-dependent (AD) human LNCaP pr...

journal_title：International journal of cancer

authors： Leung S,Miyake H,Zellweger T,Tolcher A,Gleave ME

更新日期：2001-03-15 00:00:00

abstract：:An important method for silencing tumor suppressor genes in cancers is by aberrant methylation (referred to as methylation) of CpG islands in gene promoter regions. In lung cancer, methylation of the genes retinoic acid receptor beta-2 (RARbeta-2), CDH13 (H-cadherin), p16(INK4a) (p16), RASSF1A (RAS association domain ...

journal_title：International journal of cancer

authors： Zöchbauer-Müller S,Lam S,Toyooka S,Virmani AK,Toyooka KO,Seidl S,Minna JD,Gazdar AF

更新日期：2003-11-20 00:00:00

abstract：:Cancer is well established as an age-associated disease, and there is substantial overlap in the molecular, cellular and physiological changes observed with both ageing and the progression of cancer. Age-specific declines in resilience mechanisms such as DNA repair or epigenetic maintenance may contribute to the devel...

journal_title：International journal of cancer

authors： Lau CE,Robinson O

更新日期：2021-01-04 00:00:00

abstract：:Approximately 80% of bladder tumors are urothelial superficial papillary carcinomas (USPC). Despite a generally good prognosis, these tumors have a strong propensity to recur and about 1/3 of them compared to disease progression. Histological assessment of these superficial tumors is not sufficiently discriminator in ...

journal_title：International journal of cancer

authors： Santos L,Amaro T,Costa C,Pereira S,Bento MJ,Lopes P,Oliveira J,Criado B,Lopes C

更新日期：2003-06-10 00:00:00

abstract：:Lymphocyte blastogenesis induced by autologous tumor biopsy cells, by allogeneic lymphocytes and by PHA, was performed in the presence of autologous or allogeneic serum collected from normal blood donors. In 13 of the 15 cases lymphocyte stimulation by autologous tumor cells was inhibited in the presence of autologous...

journal_title：International journal of cancer

authors： Vánky F,Klein E,Stjernswärd J,Trempe G

更新日期：1975-11-15 00:00:00

abstract：:Hyaluronan (HA) has been shown to play crucial roles in the tumorigenicity of malignant tumors. Previous studies demonstrated that inhibition of HA suppressed the tumorigenicity of various malignant tumors including breast cancer. 4-methylumbelliferone (MU) has been reported to inhibit HA synthesis in several cell typ...

journal_title：International journal of cancer

authors： Urakawa H,Nishida Y,Wasa J,Arai E,Zhuo L,Kimata K,Kozawa E,Futamura N,Ishiguro N

更新日期：2012-01-15 00:00:00

abstract：:Loss of heterozygosity (LOH) on 10q is associated with late-stage events in urothelial neoplastic progression. The tumor suppressor gene PTEN, which is mutated or homozygously deleted in numerous cancers, maps to a region of 10q within the reported region of minimal loss in bladder tumors. In two recent studies altera...

journal_title：International journal of cancer

authors： Wang DS,Rieger-Christ K,Latini JM,Moinzadeh A,Stoffel J,Pezza JA,Saini K,Libertino JA,Summerhayes IC

更新日期：2000-11-15 00:00:00

abstract：:These studies were designed to examine the role of neutrophils in transplantation immunity to syngeneic rat tumors. We have earlier reported that specific transplantation immunity to syngeneic transplanted tumors is abrogated by selective depletion of peripheral-blood neutrophils by administration of a monoclonal anti...

journal_title：International journal of cancer

authors： Tanaka E,Sendo F

更新日期：1993-04-22 00:00:00

abstract：:CD4(+) T cells have been shown to be crucial for the induction and maintenance of cytotoxic T cell responses and to be also capable of mediating direct tumor rejection. Therefore, the anticancer therapeutic efficacy of peptide-based vaccines may be improved by addition of HLA class II epitopes to stimulate T helper c...

journal_title：International journal of cancer

authors： Widenmeyer M,Griesemann H,Stevanović S,Feyerabend S,Klein R,Attig S,Hennenlotter J,Wernet D,Kuprash DV,Sazykin AY,Pascolo S,Stenzl A,Gouttefangeas C,Rammensee HG

更新日期：2012-07-01 00:00:00

abstract：:Treatment of human colorectal tumor cells (LS174T, HT-29, and WiDr) with analogues of cyclic AMP (cAMP) (dibutyryl-cAMP and 8-Cl-cAMP) selectively enhances the expression of carcinoembryonic antigen (CEA). Dose and temporal kinetics results revealed that 8-Cl-cAMP was approximately 100-fold more potent than dibutyryl-...

journal_title：International journal of cancer

authors： Guadagni F,Tortora G,Roselli M,Clair T,Cho-Chung YS,Schlom J,Greiner JW

更新日期：1991-05-30 00:00:00

abstract：:Meibomian gland carcinoma (MGC) and basal cell carcinoma (BCC) are common eyelid carcinomas that exhibit highly dissimilar degrees of proliferation and prognoses. We address here the question of the differential mechanisms between these two eyelid cancers that explain their different outcome. A total of 102 confirmed ...

journal_title：International journal of cancer

authors： Zhang L,Huang X,Zhu X,Ge S,Gilson E,Jia R,Ye J,Fan X

更新日期：2016-03-15 00:00:00

abstract：:The paired-like homeodomain transcription factor 2 (PITX2), a downstream effector of wnt/β-catenin signaling, is well known to play critical role during normal embryonic development. However, the possible involvement of PITX2 in human tumorigenesis remains unclear. In this study, we extend its function in human esopha...

journal_title：International journal of cancer

authors： Zhang JX,Tong ZT,Yang L,Wang F,Chai HP,Zhang F,Xie MR,Zhang AL,Wu LM,Hong H,Yin L,Wang H,Wang HY,Zhao Y

更新日期：2013-06-01 00:00:00

abstract：:Germline mutation of the folliculin gene (BHD) at chromosome 17p11.2 is associated with the development of multiplex hamartomas of the hair follicles, chromophobe renal cell carcinomas (RCC) and renal oncocytomas (RO). We have analyzed the folliculin gene with sequencing for mutations and the chromosome 17p11.2 with m...

journal_title：International journal of cancer

authors： Nagy A,Zoubakov D,Stupar Z,Kovacs G

更新日期：2004-04-10 00:00:00

abstract：:Diabetes has been consistently associated with an increased risk of liver, pancreas and endometrial cancer and has been implicated as a risk factor for esophageal and gastric cancers, although this association has been less well studied. We sought to determine the role of diabetes in the etiology of esophageal, gastri...

journal_title：International journal of cancer

authors： Jiang X,Bernstein L,Tseng CC,Wu AH

更新日期：2012-09-15 00:00:00

abstract：:Cancer initiation is presumed to occur in utero for many childhood cancers and it has been hypothesized that advanced paternal age may have an impact due to the increasing number of mutations in the sperm DNA with increasing paternal age. We examined the association between paternal age and specific types of childhood...

journal_title：International journal of cancer

authors： Urhoj SK,Raaschou-Nielsen O,Hansen AV,Mortensen LH,Andersen PK,Nybo Andersen AM

更新日期：2017-06-01 00:00:00

abstract：:p27Kip1, one of the cyclin-dependent kinase (CDK) inhibitors (CDKIs), blocks progression from G1 to S phase by binding cyclin D1-CDK4 and/or cyclin E-CDK2 and inhibiting their activities. Reflecting the function of p27 as a CDKI in vitro, a reduced expression of protein p27 has recently been reported to be associated ...

journal_title：International journal of cancer

authors： Anayama T,Furihata M,Ishikawa T,Ohtsuki Y,Ogoshi S

更新日期：1998-08-21 00:00:00

abstract：:Intratumoural (i.t.) injection of radio-iododeoxyuridine (IdUrd), a thymidine (dThd) analogue, is envisaged for targeted Auger electron- or beta-radiation therapy of glioblastoma. Here, biodistribution of [(125)I]IdUrd was evaluated 5 hr after i.t. injection in subcutaneous human glioblastoma xenografts LN229 after di...

journal_title：International journal of cancer

authors： Buchegger F,Adamer F,Schaffland AO,Kosinski M,Grannavel C,Dupertuis YM,de Tribolet N,Mach JP,Delaloye AB

更新日期：2004-05-20 00:00:00

abstract：:Variants of human papillomavirus (HPV) type 31 have been shown to be related both to risk of cervical lesions and racial composition of a population. It is largely undetermined whether variants differ in their likelihood of persistence. Study subjects were women who participated in the ASCUS-LSIL Triage Study and who ...

journal_title：International journal of cancer

authors： Xi LF,Schiffman M,Koutsky LA,He Z,Winer RL,Hulbert A,Lee SK,Ke Y,Kiviat NB

更新日期：2013-02-01 00:00:00

abstract：:A marked increase in natural killer (NK) activity is observed with lymphoid cells prepared from SJL/J mouse spleen and lymph nodes, in which a transplantable reticulum-cell neoplasm (RCN) is growing. The killer cells are non-adherent, non-phagocytic, relatively resistant to X-ray, and scarcely or only partially inacti...

journal_title：International journal of cancer

authors： Chang KS,Log T

更新日期：1980-03-15 00:00:00

abstract：:The Be Clear on Cancer (BCoC) campaigns have run in England since 2010. They aim to raise awareness of possible cancer symptoms, encouraging people to consult a general practice with these symptoms. Our study provides an overview of the impact of 11 national campaigns, for bowel, lung, bladder and kidney, breast and o...

journal_title：International journal of cancer

authors： Lai J,Mak V,Bright CJ,Lyratzopoulos G,Elliss-Brookes L,Gildea C

更新日期：2021-03-01 00:00:00

abstract：:Occupational data from 5 case-control studies in the United States involving 2,973 male cases and 3,210 controls were analyzed to estimate the percentage of lung cancer attributable to well-known and suspected lung carcinogens. The studies were conducted in areas heterogeneous in terms of industrial activities. The pe...

journal_title：International journal of cancer

authors： Vineis P,Thomas T,Hayes RB,Blot WJ,Mason TJ,Pickle LW,Correa P,Fontham ET,Schoenberg J

更新日期：1988-12-15 00:00:00

abstract：:Tumor toxins are recombinant, bifunctional proteins which comprise a tumor-cell-specific recognition domain and an enzymatic toxin domain. We have evaluated the in vivo effects of a tumor toxin that specifically recognizes the erbB-3 and erbB-4 receptors (HRG beta 1-ETA). High doses of HRG beta 1-ETA administered syst...

journal_title：International journal of cancer

authors： Groner B,Wick B,Jeschke M,Fiebig HH,Dengler W,Runau T,Mihatsch M,Kahl R,Schmidt M,Wels W,Stöcklin E

更新日期：1997-03-17 00:00:00

abstract：:A human papillomavirus (HPV) was cloned from a patient with multiple squamous cell carcinomas (SCCs) and identified as HPV88, recently categorized into a new species within the genus Gamma. The HPV88 viral load in an SCC of the index patient exceeded 1 million copies/cell. By contrast, a survey of 447 skin lesions (79...

journal_title：International journal of cancer

authors： Kullander J,Handisurya A,Forslund O,Geusau A,Kirnbauer R,Dillner J

更新日期：2008-01-15 00:00:00

abstract：:E-cadherin mutations are found in 50% of diffuse-type gastric carcinoma, but not in intestinal gastric carcinoma. Because cell-cell adhesion mediated by E-cadherin plays an important role in epithelial cell survival, E-cadherin mutations could alter the apoptotic behavior of tumor cells. p53 and Bcl-2 family members a...

journal_title：International journal of cancer

authors： Fricke E,Keller G,Becker I,Rosivatz E,Schott C,Plaschke S,Rudelius M,Hermannstädter C,Busch R,Höfler H,Becker KF,Luber B

更新日期：2003-03-10 00:00:00

abstract：:The effect of linoleic acid (LA) on growth and transformation of IEC6 intestinal cells was examined. IEC6 cells expressed mRNAs of 15-lipooxygenase (LOX15) and peroxisome proliferator-activated receptor (PPAR)gamma but not COX-2. Cell growth was suppressed by LA in a dose-dependent manner in IEC6 cells. Three-week tre...

journal_title：International journal of cancer

authors： Sasaki T,Yoshida K,Shimura H,Ichiba M,Sasahira T,Shimomoto T,Denda A,Kuniyasu H

更新日期：2006-02-01 00:00:00

abstract：:To assess long-term trends in the prevalence of oncogenic human papillomavirus (HPV) infection, we performed a cross-sectional serosurvey of the seroprevalence of the major oncogenic HPV type, HPV16, among 3,512 pregnant women undergoing population-based serological screening at the first trimester of pregnancy in the...

journal_title：International journal of cancer

authors： af Geijersstam V,Wang Z,Lewensohn-Fuchs I,Eklund C,Schiller JT,Forsgren M,Dillner J

更新日期：1998-05-04 00:00:00

abstract：:Human 8-oxoguanine DNA glycosylase 1 (hOGG1) plays a major role in the repair of 8-hydroxyguanine, one of the major forms of DNA damage generated by reactive oxygen species in tobacco smoke. If left unrepaired by hOGG1, 8-hydroxyguanine can produce G:C-to-T:A transversions. Recent studies have suggested that the hOGG1...

journal_title：International journal of cancer

authors： Hu YC,Ahrendt SA

更新日期：2005-04-10 00:00:00

abstract：:The influence of viremia on hepatic injury in patients infected with hepatitis C virus was examined by analysis of the relationship between alanine aminotransferase activity and the amount of hepatitis C virus RNA in sequential serum samples from I untreated patient with acute hepatitis C and 3 untreated patients with...

journal_title：International journal of cancer

authors： Gunji T,Kato N,Mori S,Ootsuyama Y,Hijikata M,Imawari M,Shimotohno K

更新日期：1992-11-11 00:00:00