Production of T-cell lines with inhibitory or stimulatory activity against syngeneic tumors in vivo. A preliminary report.


:We obtained Thy-I-positive cells directly from growing methylcholanthrene-induced (MCA-1510) sarcomas using fluorescence-activated cell sorting, then cultured these lymphocytes in medium containing Interleukin-2 and tested their activity in vivo against various MCA-sarcoma lines with the Winn assay. We found that cultured T cells from small MCA-1510 tumors (17 days after transplantation) significantly inhibited the growth of that particular sarcoma, but not of three other MCA-tumor lines tested, while cultured T cells from large MCA-1510 sarcomas (41 days after transplantation) significantly enhanced the growth of that tumor, but not of an unrelated tumor, MCA-1460. The former cells were primarily Lyt-1+, 2+ while the latter were primarily Lyt-1+, 2+.


Int J Cancer


Mulé JJ,Forstrom JW,George E,Hellström I,Hellström KE




Has Abstract


1981-11-15 00:00:00












  • Over-expression of p53 protein in human laryngeal carcinoma.

    abstract::We examined the expression of tumor-suppressor protein p53 in a variety of laryngeal carcinomas from 43 patients (25 primary, 13 metastatic and 5 recurrent cases), 13 normal laryngeal tissues and 7 benign laryngeal nodule biopsy specimens, using the polyclonal antibody CM-1. Previously we have reported a high incidenc...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Anwar K,Nakakuki K,Imai H,Naiki H,Inuzuka M

    更新日期:1993-04-01 00:00:00

  • Overexpression of RbAp46 facilitates stress-induced apoptosis and suppresses tumorigenicity of neoplastigenic breast epithelial cells.

    abstract::We have found previously that the retinoblastoma (Rb) suppressor associated protein 46 (RbAp46) is a gene upregulated by the Wilms' tumor suppressor, WT1, and functions as a potent growth inhibitor. To investigate the effect of RbAp46 overexpression on early development of breast cancer, we established stable cell lin...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Li GC,Guan LS,Wang ZY

    更新日期:2003-07-20 00:00:00

  • KIF14 mRNA expression is a predictor of grade and outcome in breast cancer.

    abstract::Gain of chromosome 1q is a hallmark of breast cancer, and likely reflects oncogene amplification. We previously identified mitotic kinesin KIF14 (kinesin family member 14) as an overexpressed candidate oncogene in the 1q31.3-1q32.1 minimal region of genomic gain in breast cancer cell lines. KIF14 also showed high expr...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Corson TW,Gallie BL

    更新日期:2006-09-01 00:00:00

  • GD2-mediated melanoma cell targeting and cytotoxicity of liposome-entrapped fenretinide.

    abstract::Melanoma is a highly malignant and increasingly common neoplasm. Because metastatic melanoma remains incurable, new treatment approaches are needed. Immunoliposomes have been previously shown to enhance the selective localization of immunoliposome-entrapped drugs to solid tumors with improvements in the therapeutic in...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Pagnan G,Montaldo PG,Pastorino F,Raffaghello L,Kirchmeier M,Allen TM,Ponzoni M

    更新日期:1999-04-12 00:00:00

  • A prospective study of the independent effects of parity and age at first birth on breast cancer incidence in England and Wales.

    abstract::The independent effects of parity and age at first birth on breast cancer incidence are investigated in a 1% sample of women aged 16 to 59 from the 1971 Census of England and Wales. Over the period 1971-81, 1,003 breast cancer cases occurred in the cohort of 113,263 women who were either married, widowed or divorced a...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Leon DA

    更新日期:1989-06-15 00:00:00

  • Berberine-induced apoptosis of human leukemia HL-60 cells is associated with down-regulation of nucleophosmin/B23 and telomerase activity.

    abstract::The steady-state level of nucleophosmin/B23 mRNA decreased during berberine-induced (25 microg/ml, 24 to 96 hr) apoptosis of human leukemia HL-60 cells. A decline in telomerase activity was also observed in HL-60 cells treated with berberine. A stable clone of nucleophosmin/B23 overexpressed in HL-60 cells was selecte...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wu HL,Hsu CY,Liu WH,Yung BY

    更新日期:1999-06-11 00:00:00

  • V-ATPase inhibition by archazolid leads to lysosomal dysfunction resulting in impaired cathepsin B activation in vivo.

    abstract::The myxobacterial agent archazolid inhibits the vacuolar proton pump V-ATPase. V-ATPases are ubiquitously expressed ATP-dependent proton pumps, which are known to regulate the pH in endomembrane systems and thus play a crucial role in endo- and exocytotic processes of the cell. As cancer cells depend on a highly activ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kubisch R,Fröhlich T,Arnold GJ,Schreiner L,von Schwarzenberg K,Roidl A,Vollmar AM,Wagner E

    更新日期:2014-05-15 00:00:00

  • Establishment and characterization of a thymic carcinoma cell line (Ty-82) carrying t(15;19)(q15;p13) chromosome abnormality.

    abstract::A new human cell line, designated Ty-82, was established from the pleural effusion of a 22-year-old woman with undifferentiated thymic carcinoma. This cell line consisted of primitive cells that were positive for alpha-naphthyl butyrate esterase and acid phosphatase. The cells were shown to express epithelial membrane...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kuzume T,Kubonishi I,Takeuchi S,Takeuchi T,Iwata J,Sonobe H,Ohtsuki Y,Miyoshi I

    更新日期:1992-01-21 00:00:00

  • The bisphosphonate zoledronic acid has antimyeloma activity in vivo by inhibition of protein prenylation.

    abstract::Nitrogen-containing bisphosphonates (N-BPs) are effective antiosteolytic agents in patients with multiple myeloma. Preclinical studies have also demonstrated that these agents have direct antitumor effects in vitro and can reduce tumor burden in a variety of animal models, although it is not clear whether such effects...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Guenther A,Gordon S,Tiemann M,Burger R,Bakker F,Green JR,Baum W,Roelofs AJ,Rogers MJ,Gramatzki M

    更新日期:2010-01-01 00:00:00

  • Plasma 25-hydroxyvitamin D and premenopausal breast cancer risk in a German case-control study.

    abstract::Laboratory and epidemiological data have linked vitamin D to breast cancer prevention. Beside dietary intake, endogenous production of vitamin D substantially contributes to a subject's vitamin D status. Most studies, however, have assessed dietary intake only. Although differential effects of vitamin D on premenopaus...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Abbas S,Chang-Claude J,Linseisen J

    更新日期:2009-01-01 00:00:00

  • International osteosarcoma incidence patterns in children and adolescents, middle ages and elderly persons.

    abstract::Osteosarcoma incidence rates in the United States peak in adolescence and in the elderly. The international patterns of osteosarcoma incidence in children have been described, whereas those for young, middle age or elderly adults have not. Using the Cancer Incidence in Five Continents, International Agency for Cancer ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mirabello L,Troisi RJ,Savage SA

    更新日期:2009-07-01 00:00:00

  • Microsatellite instability and pathological aspects of breast cancer.

    abstract::Genomic instability plays a key role in hereditary nonpolyposis colorectal cancer and in a significant sub-set of non-hereditary colorectal tumors. Recent evidence suggests that microsatellite instability also occurs in various sub-sets of common, non-hereditary forms of extra-colorectal carcinoma. To investigate the ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Contegiacomo A,Palmirotta R,De Marchis L,Pizzi C,Mastranzo P,Delrio P,Petrella G,Figliolini M,Bianco AR,Frati L

    更新日期:1995-08-22 00:00:00

  • alpha-fetoprotein-containing cells in the early stages of liver carcinogenesis induced by 3'-methyl-4-dimethyl-aminoazobenzene and 2-acetylaminofluorene.

    abstract::The morphology of rat liver cells containing alpha-feto-protein (AFP) during early stages of carcinogenesis induced by 3'methyl-4-dimethylaminoazobenzene and 2-acetylaminofluorene was investigated. Indirect immunofluorescence was used to detect AFP. AFP was not found in the cells of hyperplastic nodules but was presen...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tchipysheva TA,Guelstein VI,Bannikov GA

    更新日期:1977-09-15 00:00:00

  • Herceptest: HER2 expression and gene amplification in non-small cell lung cancer.

    abstract::HER2 is an erbB/HER type 1 tyrosine kinase receptor that is frequently over-expressed in malignant epithelial tumours. Herceptin, a humanised mouse monoclonal antibody to HER2, is proven therapeutically in the management of metastatic breast cancer, significantly prolonging survival when combined with cytotoxic chemot...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Cox G,Vyberg M,Melgaard B,Askaa J,Oster A,O'Byrne KJ

    更新日期:2001-05-15 00:00:00

  • Dietary catechins and epithelial cancer incidence: the Zutphen elderly study.

    abstract::The flavonoids, a group of more than 4,000 polyphenolic antioxidants, are potential cancer preventive components of fruits and vegetables. Catechins, one of the 6 major groups of flavonoids, are present in high concentrations in tea as well. Our objective was to evaluate the association between intake of catechins and...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Arts IC,Hollman PC,Bueno De Mesquita HB,Feskens EJ,Kromhout D

    更新日期:2001-04-15 00:00:00

  • Bacterial surface display of endoglin by antigen 43 induces antitumor effectiveness via bypassing immunotolerance and inhibition of angiogenesis.

    abstract::Various angiogenesis-related self-molecules have been considered to be therapeutic targets. However, the direct use of self-molecules as vaccines is not recommended because of the inherent ability of the host to develop immune tolerance. Antigen 43 (Ag43) is a surface protein found in E. coli and contains an α and a β...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Huang FY,Li L,Liu Q,Li YN,Bai RZ,Huang YH,Zhao HG,Guo JL,Zhou SL,Wang H,Lin YY,Tan GH

    更新日期:2014-04-15 00:00:00

  • Persistence of newly detected human papillomavirus type 31 infection, stratified by variant lineage.

    abstract::Variants of human papillomavirus (HPV) type 31 have been shown to be related both to risk of cervical lesions and racial composition of a population. It is largely undetermined whether variants differ in their likelihood of persistence. Study subjects were women who participated in the ASCUS-LSIL Triage Study and who ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Xi LF,Schiffman M,Koutsky LA,He Z,Winer RL,Hulbert A,Lee SK,Ke Y,Kiviat NB

    更新日期:2013-02-01 00:00:00

  • Prognostic value of phospho-Akt in patients with non-small cell lung carcinoma: a meta-analysis.

    abstract::Previous studies have been inconsistent with respect to the reported associations between phospho-Akt (p-Akt) overexpression and lung cancer prognosis. In this study, we conducted a systematic review and meta-analysis to assess the prognostic value of p-Akt in patients with non-small cell lung carcinoma (NSCLC). Relev...

    journal_title:International journal of cancer

    pub_type: 杂志文章,meta分析,评审


    authors: Yang Y,Luo J,Zhai X,Fu Z,Tang Z,Liu L,Chen M,Zhu Y

    更新日期:2014-09-15 00:00:00

  • P-glycoprotein expression in the Golgi apparatus of multidrug-resistant cells.

    abstract::The surface and intracellular expression of mdrI-P-glycoprotein in parental drug-sensitive human breast cancer cells (MCF-7) and their multidrug-resistant (MDR) variants has been studied by using the monoclonal antibodies (MAbs) MM4.17 and MRK-16, which recognize 2 different epitopes of the drug efflux pump molecule. ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Molinari A,Cianfriglia M,Meschini S,Calcabrini A,Arancia G

    更新日期:1994-12-15 00:00:00

  • APE1 genotype and risk of bladder cancer: evidence for effect modification by smoking.

    abstract::Apurinic/apyrimidinic (AP) sites are common mutagenic and cytotoxic DNA lesions that arise from the loss of normal bases. APE1, the major AP endonuclease of human cells, plays a central role in the repair of AP sites through both its endonuclease and phosphodiesterase activities. A common APE1 polymorphism, a T-->G tr...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Terry PD,Umbach DM,Taylor JA

    更新日期:2006-06-15 00:00:00

  • Body mass and stage of breast cancer at diagnosis.

    abstract::Obesity is a well-known risk factor for postmenopausal breast cancer. In contrast, the relationship between obesity and stage of breast cancer at diagnosis is less clear. We hypothesized that increased breast size in obese women may delay discovery of breast tumors. Thus, the purpose of our study was to examine whethe...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Cui Y,Whiteman MK,Flaws JA,Langenberg P,Tkaczuk KH,Bush TL

    更新日期:2002-03-10 00:00:00

  • Distinct immune evasion in APOBEC-enriched, HPV-negative HNSCC.

    abstract::Immune checkpoint inhibition leads to response in some patients with head and neck squamous cell carcinoma (HNSCC). Robust biomarkers are lacking to date. We analyzed viral status, gene expression signatures, mutational load and mutational signatures in whole exome and RNA-sequencing data of the HNSCC TCGA dataset (n ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Messerschmidt C,Obermayer B,Klinghammer K,Ochsenreither S,Treue D,Stenzinger A,Glimm H,Fröhling S,Kindler T,Brandts CH,Schulze-Osthoff K,Weichert W,Tinhofer I,Klauschen F,Keilholz U,Beule D,Rieke DT

    更新日期:2020-10-15 00:00:00

  • Role of multileaf collimator in replacing shielding blocks in radiation therapy.

    abstract::To facilitate the use of multileaf collimator (MLC) in field shaping, we tested the hypothesis that the changes in the penumbra due to MLC replacing a Cerrobend block can be related to a change in the margin of the block. We also investigated if it is possible to estimate the effect of MLC replacing a block in terms o...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Cheng CW,Das IJ,Steinberg T

    更新日期:2001-12-20 00:00:00

  • Long-term risk of cervical cancer following conization of cervical intraepithelial neoplasia grade 3-A Danish nationwide cohort study.

    abstract::Using nationwide Danish registries we examined the long-term risk of cervical cancer in women diagnosed with cervical intraepithelial neoplasia grade 3 (CIN3) (including adenocarcinoma in situ (AIS)) on the cone compared to women with a normal cytology test. Initially, we identified women born 1918-1990, who were reco...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sand FL,Frederiksen K,Munk C,Jensen SM,Kjaer SK

    更新日期:2018-05-01 00:00:00

  • Selective occlusion of tumor blood vessels by targeted delivery of an antibody-photosensitizer conjugate.

    abstract::The irregular vasculature and high interstitial pressure of solid tumors hinder the delivery of cytotoxic agents to cancer cells. As a consequence, the doses of chemotherapy necessary to achieve complete tumor eradication are associated with unacceptably high toxicities. The selective thrombosis of tumor blood vessels...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fabbrini M,Trachsel E,Soldani P,Bindi S,Alessi P,Bracci L,Kosmehl H,Zardi L,Neri D,Neri P

    更新日期:2006-04-01 00:00:00

  • Identification of Hodgkin and Sternberg-reed cells as a unique cell type derived from a newly-detected small-cell population.

    abstract::In this study the antigenic profile of Hodgkin (H) and Sternberg-Reed (SR) cells from cases of Hodgkin's disease was analysed using a large panel of monoclonal and polyclonal antibodies reactive with cells of lymphoid and haemotopoietic origin. The aim of this investigation was, firstly, to throw light on the origin o...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Stein H,Gerdes J,Schwab U,Lemke H,Mason DY,Ziegler A,Schienle W,Diehl V

    更新日期:1982-10-15 00:00:00

  • Transcription factor co-repressors in cancer biology: roles and targeting.

    abstract::Normal transcription displays a high degree of flexibility over the choice, timing and magnitude of mRNA expression levels that tend to oscillate and cycle. These processes allow for combinatorial actions, feedback control and fine-tuning. A central role has emerged for the transcriptional co-repressor proteins such a...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Battaglia S,Maguire O,Campbell MJ

    更新日期:2010-06-01 00:00:00

  • Prenatal exposure of mice to the human liver carcinogen aflatoxin B1 reveals a critical window of susceptibility to genetic change.

    abstract::It has become axiomatic that critical windows of susceptibility to genotoxins exist and that genetic damage in utero may be a trigger for later life cancers. Data supporting this critical window hypothesis are remarkably few. This study provides a quantitative bridge between DNA damage by the liver carcinogen aflatoxi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chawanthayatham S,Thiantanawat A,Egner PA,Groopman JD,Wogan GN,Croy RG,Essigmann JM

    更新日期:2015-03-15 00:00:00

  • Abrogation of tumor-inhibitory MRC-OX8+ (CD8+) effector T-cell generation in rats by selective depletion of neutrophils in vivo using a monoclonal antibody.

    abstract::These studies were designed to examine the role of neutrophils in transplantation immunity to syngeneic rat tumors. We have earlier reported that specific transplantation immunity to syngeneic transplanted tumors is abrogated by selective depletion of peripheral-blood neutrophils by administration of a monoclonal anti...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tanaka E,Sendo F

    更新日期:1993-04-22 00:00:00

  • Allelic loss of chromosome 13q14.3 in human oral cancer: correlation with lymph node metastasis.

    abstract::To evaluate the role of chromosome 13 deletions in oral squamous cell carcinoma (SCC) progression and to define the precise localization of putative tumor suppressor genes, we studied tumors from 34 unrelated patients with oral SCC by the polymerase chain reaction (PCR)-loss of heterozygosity (LOH) assay, using 18 dif...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ogawara K,Miyakawa A,Shiba M,Uzawa K,Watanabe T,Wang XL,Sato T,Kubosawa H,Kondo Y,Tanzawa H

    更新日期:1998-08-21 00:00:00