Abstract:
:We obtained Thy-I-positive cells directly from growing methylcholanthrene-induced (MCA-1510) sarcomas using fluorescence-activated cell sorting, then cultured these lymphocytes in medium containing Interleukin-2 and tested their activity in vivo against various MCA-sarcoma lines with the Winn assay. We found that cultured T cells from small MCA-1510 tumors (17 days after transplantation) significantly inhibited the growth of that particular sarcoma, but not of three other MCA-tumor lines tested, while cultured T cells from large MCA-1510 sarcomas (41 days after transplantation) significantly enhanced the growth of that tumor, but not of an unrelated tumor, MCA-1460. The former cells were primarily Lyt-1+, 2+ while the latter were primarily Lyt-1+, 2+.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Mulé JJ,Forstrom JW,George E,Hellström I,Hellström KEdoi
10.1002/ijc.2910280513subject
Has Abstractpub_date
1981-11-15 00:00:00pages
611-4issue
5eissn
0020-7136issn
1097-0215journal_volume
28pub_type
杂志文章abstract::Lytically infected EBV-positive lymphoblastoid cells enhance the growth of early-passage, but not late-passage, EBV-immortalized lymphoblastoid cell lines (LCLs) in SCID mice and have enhanced IL-6 secretion. Here, we have examined the importance of IL-6 for the growth of early-passage LCLs (EPL) in SCID mice, identif...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22839
更新日期:2007-09-15 00:00:00
abstract::Although tobacco smoking, pan chewing and alcohol drinking are important risk factors for head and neck cancer (HNC), the HNC risks conferred by products available in Nepal for these habits are unknown. We assessed the associations of tobacco smoking, chewing habits, and alcohol drinking with HNC risk in Nepal. A case...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32823
更新日期:2020-08-01 00:00:00
abstract::The mutated in colorectal cancer (MCC) is a multifunctional gene showing loss of expression in colorectal and liver cancers. MCC mutations can drive colon carcinogenesis in the mouse and in vitro experiments suggest that loss of MCC function promotes cancer through several important cellular pathways. In particular, t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28967
更新日期:2015-01-01 00:00:00
abstract::Angiogenesis inhibitors have been used to treat some cancers, but the therapeutic potential of these agents for gastric cancer has remained unclear. To investigate their therapeutic potential, we examined the effect of ZD6474, an agent that selectively targets vascular endothelial growth factor receptor-2 (VEGFR-2; KD...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21340
更新日期:2006-01-15 00:00:00
abstract::The growth properties of a human melanoma cell line (MeWo) and of a variant (MeWo-LC1) endowed with higher metastatic potential in nude mice were compared using hormonally-defined serum-free media. The two cell lines failed to arrest in G0 following serum deprivation, and responded to INS and MSA but not to EGF, PDGF ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910370120
更新日期:1986-01-15 00:00:00
abstract::OCT-4 (also known as POU5F1) is a key regulator of self-renewal in embryonic stem cells. Regarding the new cancer stem cell concept, the expression of such genes is potentially correlated with tumorigenesis and can affect some aspects of tumor behavior, such as tumor recurrence or resistance to therapies. Although OCT...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22508
更新日期:2007-04-01 00:00:00
abstract::The cell-cycle regulator p16 inhibits the complex cdk4-cyclin D1 and controls G1-S transition. In human tumors, p16 inactivation is often accomplished by homozygous deletion (HD) of its encoding gene, CDKN2A. Methylation of the 5' CpG island promoter has been proposed as an alternative mechanism of inactivation. Expre...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20001115)88:4<554::aid-ijc6>3.0.
更新日期:2000-11-15 00:00:00
abstract::We investigated whether cilengitide could amplify the antitumor effects of radiotherapy in an orthotopic rat glioma xenograft model. Cilengitide is a specific inhibitor of alphav series integrins, and acts as an antiangiogenic. U251 human glioma cells express alphavbeta3 and alphavbeta5 integrins. We used in vitro ass...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24240
更新日期:2009-06-01 00:00:00
abstract::It is well known that the functions of reproductive organs are regulated by sex steroids and their receptors and it is hypothesized that the progression of neoplasms that originate from the reproductive organs is influenced by them. However, the correlation between sex steroids and tumor progression, especially tumor ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10504
更新日期:2002-08-01 00:00:00
abstract::A population-based case-control study was conducted to examine the effect of ingestion of vitamin C, carotenoids and retinol on risk of pharyngeal cancer. Data were available from 166 cases of pharyngeal cancer or their next-of-kin, and from 547 controls similar in age and sex to the cases. Odds ratios (ORs) relating ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910440406
更新日期:1989-10-15 00:00:00
abstract::Endometrial serous adenocarcinoma (ESC) is aggressive and carries a poor prognosis. p53 is frequently mutated in ESC. microRNAs (miRNAs) are a direct p53 target and have been implicated in cancer cell behavior. In this study, we compared miRNA expression levels in ESC with the levels in endometrial endometrioid adenoc...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27345
更新日期:2012-08-15 00:00:00
abstract::Gefitinib has shown meaningful antitumor activity with tolerable toxicity in chemotherapy-refractory NSCLC in previous studies. Moreover, EGFR expression failed to show a correlation with response. In an attempt to identify predictive markers of response, we have investigated the tumoral expression of key signaling mo...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1002/ijc.20550
更新日期:2005-01-01 00:00:00
abstract::A long-term tissue culture cell line has been derived from a human prostate adenocarcinoma metastatic to the brain. The cell line, DU 145, has been passaged 90 times in vitro over a period of 2 years. The cells are epithelial, grow in isolated islands on plastic Petri dishes, and form colonies in soft agar suspension ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910210305
更新日期:1978-03-15 00:00:00
abstract::The steady-state mRNA level of nucleophosmin/B23 in HeLa cells increased after UV irradiation. Nucleophosmin/B23 antisense transfection potentiated ultraviolet (UV)-induced cell killing. A block in G(2)/M phase, larger peak of apoptotic cells and higher caspase-3 in vitro activity were noted in nucleophosmin/B23 antis...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1606
更新日期:2002-01-20 00:00:00
abstract::Our previous clinicopathologic study revealed an inverse association of liver metastasis of colorectal cancer and stromal expression of matrix metalloproteinase-9 (MMP-9) or urokinase receptor (uPAR). This suggests that host cells, particularly macrophages, expressing matrix-degrading enzymes/factors could be protecti...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(20000401)86:1<24::aid-ijc4
更新日期:2000-04-01 00:00:00
abstract::A-kinase anchoring protein 3 (AKAP3) is a sperm protein and its expression appears to be restricted to the testis in normal adult tissues. We investigated AKAP3 mRNA expression in 20 normal ovaries and 54 ovarian cancers of different histological types, grades and stages by reverse transcription-polymerase chain react...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11565
更新日期:2004-01-01 00:00:00
abstract::Immune cells in tumor microenvironment play a prominent role in tumor progression and metastasis. MicroRNA-155 (miR-155) represents an important player in innate and adaptive immunity by regulating differentiation, maturation and activation of macrophages, dendritic cells, B cells and T cells. However, the role of miR...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29151
更新日期:2015-03-15 00:00:00
abstract::Epigenetic alterations play an important role in carcinogenesis. Recent studies suggested that global histone modifications are predictors of cancer recurrence in various tumor entities. Our study was performed to evaluate histone H3 lysine 4 mono-methyl (H3K4me1), -di-methyl (H3K4me2) and -trimethyl (H3K4me3) pattern...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25250
更新日期:2010-11-15 00:00:00
abstract::Cord blood transplantation (CBT) is an effective option for treating hematological malignancies, but graft failure (GF) remains the primary cause of therapy failure. Thus, based on myeloablative conditioning (MAC) of busulfan with cyclophosphamide (Bu/Cy) or total body irradiation with Cy (TBI/Cy), fludarabine (Flu) w...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31339
更新日期:2018-08-01 00:00:00
abstract::Neoplasms constituted an enormous burden and contributed to an estimated 8.2 million deaths in 2012 worldwide. FOXO1 (forkhead box O1), a member of the forkhead box (FOX) family, is a transcriptional factor involved in diverse cellular functions. Herein, we concentrate on recent studies of the antineoplastic roles of ...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.31338
更新日期:2018-10-01 00:00:00
abstract::Heme oxygenase (HO)-1 catalyzes the degradation of cytotoxic heme into biliverdin and blocks antitumor immune responses, thus protecting cancer against host defense. Whether this scenario also applies to neuroblastoma (NB), the most common extracranial solid childhood tumor, is not known. Here, we demonstrate for the ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29933
更新日期:2016-04-15 00:00:00
abstract::Colonic tumors of human origin produce abundant transforming growth factor (TGF)-beta suggesting that TGF-beta is critical to their growth. Dietary lipids regulate a number of growth factors including TGF-beta. Whether elevated TGF-beta levels are consistently expressed in colonic tumors irrespective of the environmen...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10522
更新日期:2002-08-20 00:00:00
abstract::A case-control study involving interviews with 227 lung-cancer cases and 227 matched hospital controls was conducted in Heilongjiang Province in northeast China to examine the influence of dietary factors on the risk of developing lung cancer. Lung-cancer cases were all incident cases judged to be suitable candidates ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970611)71:6<924::aid-ijc
更新日期:1997-06-11 00:00:00
abstract::APC10.1 is a new intestinal cell line derived from ApcMin/+ mice that retains both the heterozygous Apc genotype and a nonactivated Wnt signaling pathway and displays an early neoplastic phenotype. Although tumorigenic both in immunodepressed and in immunocompetent syngeneic mice, it requires a high cell dose and a lo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11690
更新日期:2004-03-20 00:00:00
abstract::Dendritic cells (DCs) cross-present antigen (Ag) to initiate T-cell immunity against most infections and tumors. Natural killer (NK) cells are innate cytolytic lymphocytes that have emerged as key modulators of multiple DC functions. Here, we show that human NK cells promote cross-presentation of tumor cell-derived Ag...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29087
更新日期:2015-03-01 00:00:00
abstract::Epidemiologic studies indicate that human T-cell lymphotropic virus type I (HTLV-I), the causative agent of most cases of adult T-cell leukemia/lymphoma (ATLL) in Southeast Japan and the Caribbean islands and the probable cause of a progressive neurological disorder often referred to as tropical spastic paraparesis, o...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910420103
更新日期:1988-07-15 00:00:00
abstract::We have established 3 new EBV-negative cell lines, designated Sc-1, Ri-1 and Ci-1, from patients with B-cell lymphoma/leukemia. We characterized them by cytogenetics and by study of surface membrane antigens with a panel of monoclonal antibodies (MAbs), surface and cytoplasmic immunoglobulin (Ig) expression and Ig hea...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910390116
更新日期:1987-01-15 00:00:00
abstract::Six oncogenic cell lines were established from primary sarcomas that had been induced in thymectomized, aged, BALB/cSt mice by the injection of 3-methylcholanthrene. Of these lines, three produced B-tropic murine leukemia virus (MuLV), i.e. MuLV that would patently infect fibroblasts of BALB/c origin but not those fro...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910210216
更新日期:1978-02-15 00:00:00
abstract::In a retrospective analysis of 203 patients with small cell lung cancer (SCLC), we examined the prognostic value of c-kit expression on survival. Expression of c-kit was examined immunohistochemically in formalin-fixed, paraffin-embedded tissue sections. c-kit was observed in 87.7% of SCLC tumors. Using the Kaplan-Mei...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20252
更新日期:2004-08-20 00:00:00
abstract::Human papillomavirus (HPV) infections and HPV-associated penile lesions are frequently found in male sexual partners of women with cervical intraepithelial neoplasia (CIN). To determine the significance of these findings, we studied the prevalence of HPV and HPV associated penile lesions in a male hospital population ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20502
更新日期:2005-01-01 00:00:00