Abstract:
:Using morphometric and immunohistological techniques, we investigated the distribution of T lymphocytes and subsets, B lymphocytes, macrophages and plasma cells in sections of human breast tissue. In normal lobules and ducts, leukocytes were found in greater density in the epithelium than in the stroma. The intra-epithelial cells consisted largely of suppressor/cytotoxic T lymphocytes with a smaller number of macrophages; inducer T cells were seen in only 1 out of 10 subjects and were present in very low numbers. In the stroma, there were roughly equal numbers of suppressor/cytotoxic cells, macrophages and plasma cells containing IgA or IgM. Small numbers of stromal inducer lymphocytes were seen in only 2 cases. Although the density of suppressor/cytotoxic cells in the epithelium was considerably greater than in the stroma, macrophages were present in roughly similar density in both locations. In carcinoma, the ratio of epithelial to stromal leukocyte density was reversed, due to a marked reduction in intra-epithelial cells and to an increase in those in the stroma. Between 10% and 30% of lymphocytes expressed activation markers in contrast to the normal breast in which virtually all were negative. Inducer lymphocytes were identified in 9/10 carcinomas. The possible relationship of inducer cells to breast carcinoma and pre-neoplasia is discussed and warrants further investigation. No alteration in stromal plasma cell numbers was observed.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Lwin KY,Zuccarini O,Sloane JP,Beverley PCdoi
10.1002/ijc.2910360404subject
Has Abstractpub_date
1985-10-15 00:00:00pages
433-8issue
4eissn
0020-7136issn
1097-0215journal_volume
36pub_type
杂志文章abstract::We have recently shown in the BDII rat model of human endometrial adenocarcinoma (EAC), rat chromosome 10 (RNO10) is frequently involved in chromosomal aberrations. In the present study, we investigated the association between RNO10 deletions, allelic imbalance (AI) at RNO10q24 and Tp53 mutation in 27 rat EAC tumors. ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22533
更新日期:2007-04-01 00:00:00
abstract::A population-based case-control study of gastric cancer was conducted in areas with contrasting incidence rates in Sweden. Face-to-face interviews were carried out with 338 (74.1%) of all eligible cases and 679 (77.3%) of the selected controls. Consumption of selected nutrients during adolescence and 20 years prior to...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910570505
更新日期:1994-06-01 00:00:00
abstract::Cervical carcinogenesis is a consequence of persistent infection with high-risk human papillomaviruses (HPVs). Recent studies indicate that HPV-transformed cells actively instruct their microenvironment to promote carcinogenesis. Here, we demonstrate that cervical cancer cells activate monocytes to produce their own C...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28549
更新日期:2014-05-01 00:00:00
abstract::Ocimum sp. is a traditionally used medicinal herb, which shows anti-oxidant, anti-carcinogenic, radio-protective and free radical scavenging properties. So far no detailed studies have been reported on its effects on human cancers. Thus, we analyzed its effects on human breast cancer utilizing in vitro and in vivo met...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22733
更新日期:2007-08-15 00:00:00
abstract::We analyzed the biodistribution of the 111In-labelled murine anti-tenascin-C MAb BC-2 after intralesional injection in 15 glioblastoma patients. The activated ligand DTPA was conjugated via the isothiocyanato-benzyl group onto BC-2. Conjugates were labelled with 111In, displaying immunoreactivity greater than 90% and ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970529)71:5<810::aid-ijc
更新日期:1997-05-29 00:00:00
abstract::Epigenetic silencing of MLH1 is the most common cause of defective DNA mismatch repair in endometrial and colorectal cancers. We hypothesized that variation in the MLH1 gene might contribute to the risk for MLH1 methylation and epigenetic silencing. We undertook a case-control study to test for the association between...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22406
更新日期:2007-04-15 00:00:00
abstract::Two HLA-A2 restricted epitopes have recently been identified from the broadly expressed tumor antigen survivin, and several vaccination trials in cancer patients based on these survivin-derived peptides have been initiated. Consequently, there is a crucial need for the identification of survivin epitopes restricted to...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11634
更新日期:2004-03-01 00:00:00
abstract::Glioma invasion into the surrounding brain tissue is still a major obstacle for any therapeutical approach. As in other solid tumors, matrix-metalloproteases (MMPs) have been suggested as being involved. The aim of this study was to evaluate whether the use of MMP inhibitors to target the protease-mediated invasion pr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990301)80:5<764::aid-ijc
更新日期:1999-03-01 00:00:00
abstract::Rat yolk-sac tumors were induced by intraperitoneal (i.p.) displacement of the visceral yolk sac in fetectomized W/Fu rats. Serum was obtained from each female rat prior to the pregnancy preceding the tumor-inducing procedure and then once a month during the induction period. The sera were analyzed for the presence of...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910400118
更新日期:1987-07-15 00:00:00
abstract::We use the population-based Family-Cancer Database from Sweden to study familial breast cancer. The size of the population and the nation-wide registration of cancer offer unique possibilities for epidemiological studies of familial cancer, including complete and unbiased identification of cases in the probands and in...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980729)77:3<386::aid-ijc
更新日期:1998-07-29 00:00:00
abstract::Caveolae have been indicated as a center of cytoskeleton regulation for Src kinase/Rho GTPase signaling. In addition, Src recruitment on intact cortical actin cytoskeleton appears to be required for bFGF/FGFR signal activation. Recently, we established a relationship between caveolin-1 (Cav-1) expression and cell migr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26092
更新日期:2012-03-15 00:00:00
abstract::To identify characteristics of gastric cancer associated with hereditary non-polyposis colorectal cancer (HNPCC), we gathered clinical data and tumor samples relating to patients recorded in the Finnish HNPCC registry. Our series included 51 families with a characterized mutation and/or that met the Amsterdam criteria...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19971021)74:5<551::aid-ijc
更新日期:1997-10-21 00:00:00
abstract::Both epigallocatechin gallate (EGCG) and curcumin have shown efficacy in various in vivo and in vitro models of cancer. This study was designed to determine the efficacy of these naturally derived polyphenolic compounds in vitro and in vivo, when given in combination. Studies in MDA-MB-231 cells demonstrated that EGCG...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23328
更新日期:2008-05-01 00:00:00
abstract::We have found previously that the retinoblastoma (Rb) suppressor associated protein 46 (RbAp46) is a gene upregulated by the Wilms' tumor suppressor, WT1, and functions as a potent growth inhibitor. To investigate the effect of RbAp46 overexpression on early development of breast cancer, we established stable cell lin...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11148
更新日期:2003-07-20 00:00:00
abstract::We evaluated whether regular mammographic screening of women aged 65 years or older affected breast cancer mortality. In Nijmegen, a population-based screening program for breast cancer was started in 1975, with biennial mammography for women aged 35-64 years. Since 1977, elderly women have also been participating. Fo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960611)66:6<727::AID-IJC
更新日期:1996-06-11 00:00:00
abstract::Studies have shown that the calcium-sensing receptor (CaSR) mediates the antitumorigenic effects of calcium against colorectal cancer (CRC). Expression of the CaSR in colorectal tumors is often reduced. We have reported previously that silencing of CaSR in CRC is caused in part by methylation of CaSR promoter 2 and lo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29681
更新日期:2016-01-01 00:00:00
abstract::A general concern exists that cervical cancer screening using human papillomavirus (HPV) testing may lead to considerable overtreatment. We evaluated the trade-off between benefits and overtreatment among different screening strategies differing by primary tests (cytology, p16/Ki-67, HPV alone or in combinations), int...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32849
更新日期:2020-08-15 00:00:00
abstract::Cytoskeleton and extracellular matrix-related proteins (CECMPs) represent the most common class of cancer mutants, owing to the large size of their coding regions and the randomness of mutagenesis. We used a bioinformatics approach to assess the impact of amino acid (AA) substitutions on the sensitivity of CECMPs to p...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31111
更新日期:2018-03-01 00:00:00
abstract::Family history (FH) of lung cancer is an established risk factor for lung cancer, but the modifying effect of smoking in relatives has been rarely examined. Also, the role of FH of nonmalignant lung diseases on lung cancer risk is not well known. We examined the role of FH of cancer and nonmalignant lung diseases in l...
journal_title:International journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/ijc.24283
更新日期:2009-07-01 00:00:00
abstract::Owing to their role in controlling the efflux of toxic compounds, transporters are central players in the process of detoxification and elimination of xenobiotics, which in turn is related to cancer risk. Among these transporters, ATP-binding cassette B1/multidrug resistance 1 (ABCB1/MDR1), ABCC2/multidrug resistance ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26436
更新日期:2012-08-15 00:00:00
abstract::Tumors can induce the generation and accumulation of immunosuppressive cells such as myeloid-derived suppressor cells (MDSCs) in a tumor microenvironment, contributing to tumor escape from immunological attack. Although dendritic cell-based cancer vaccines can initiate antitumor immune responses, tumor-educated dendri...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30002
更新日期:2016-06-01 00:00:00
abstract::Ultraviolet radiation, and in particular UVA (320-400 nm), induces significant oxidative stress to human skin. Ferritin and glutathione have been shown to be among the more important molecules within human skin cells providing protection against this damage, the presence of lower levels of these anti-oxidants giving r...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960729)67:3<430::AID-IJC
更新日期:1996-07-29 00:00:00
abstract::The occurrence of resistance to cytotoxic agents in tumor cells, associated with several phenotypic alterations, is one of the major obstacles to successful anticancer chemotherapy. A new strategy to overcome MDR of human cancer cells was studied, using BSAO, which generates cytotoxic products from spermine, H(2)O(2) ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10310
更新日期:2002-05-01 00:00:00
abstract::The causes of childhood cancers are largely unknown. Birth order has been used as a proxy for prenatal and postnatal exposures, such as frequency of infections and in utero hormone exposures. We investigated the association between birth order and childhood cancers in a pooled case-control dataset. The subjects were d...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.25593
更新日期:2011-06-01 00:00:00
abstract::Oncogenic activation of MYC occurs often in breast carcinoma and is associated with poor prognosis. Loss or inactivation of mechanisms that restrain MYC may therefore be involved in tumor progression. In this study, we show that the MYC-interacting adaptor protein BIN1 is frequently missing in malignant breast cells a...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:
更新日期:2000-02-01 00:00:00
abstract::Mammalian LIM kinase 1 (LIMK1) phosphorylates and inactivates the actin-binding and -depolymerizing factor cofilin and induces actin cytoskeletal changes. LIMK1 is reported to play an important role in cell motility, but the mechanism of induction of cell motility and the role of LIMK1 in tumor growth, angiogenesis an...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21650
更新日期:2006-06-01 00:00:00
abstract::Polyclonal and monoclonal antibodies were used to characterize human milk fat globule (HMFG) membrane antigens, using gel filtration, ion exchange chromatography and western blotting. Although originally generated against HMFG, monoclonal antibodies also reacted with skim milk. In western blotting, several antigen mol...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910350207
更新日期:1985-02-15 00:00:00
abstract::Rabbit V2 carcinoma cells and normal rabbit skin fibroblasts produced cysteine proteinases with properties similar to those of purified rabbit liver cathepsin B. Both cell types secreted into the culture medium enzymes with an apparent Mr of 43,000, which reacted with synthetic substrates commonly used for cathepsin B...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910380520
更新日期:1986-11-15 00:00:00
abstract::Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with high proliferative and metastatic phenotypes. CDCA7, a new member of the cell division cycle associated family of genes, is involved in embryonic development and dysregulated in various types of human cancer. However, the biologi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31766
更新日期:2018-11-15 00:00:00
abstract::The relationship between breast cancer-associated fatty acid synthase (FAS; oncogenic antigen-519) and chemotherapy-induced cell damage has not been studied. We examined the ability of C75, a synthetic slow-binding inhibitor of FAS activity, to modulate the cytotoxic activity of the microtubule-interfering agent Taxol...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20754
更新日期:2005-05-20 00:00:00