Abstract:
:Ultraviolet radiation, and in particular UVA (320-400 nm), induces significant oxidative stress to human skin. Ferritin and glutathione have been shown to be among the more important molecules within human skin cells providing protection against this damage, the presence of lower levels of these anti-oxidants giving rise to increased cellular sensitivity to stress. We compared endogenous levels of ferritin and glutathione in human melanoma cells with normal human skin fibroblasts and keratinocytes, also the response of melanoma cells to oxidative stress with fibroblasts and keratinocytes. Ferritin levels were heterogenous in the untreated melanoma cell lines tested and remained the same following oxidative stress (UVA radiation) or hemin treatment. Epidermal keratinocytes were unaffected, as were the melanoma cell lines, but skin fibroblasts showed dose-dependent ferritin depletion. Similar results were seen for glutathione alterations resulting from UVA radiation: melanoma cell lines and epidermal skin keratinocytes remained unchanged following UVA radiation, while skin fibroblasts showed dose-dependent depletion. Our results show that human melanoma cells have low ferritin and glutathione levels, yet are resistant to oxidative stress.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Applegate LA,Scaletta C,Labidi F,Vile GF,Frenk Edoi
10.1002/(SICI)1097-0215(19960729)67:3<430::AID-IJCsubject
Has Abstractpub_date
1996-07-29 00:00:00pages
430-4issue
3eissn
0020-7136issn
1097-0215pii
10.1002/(SICI)1097-0215(19960729)67:3<430::AID-IJCjournal_volume
67pub_type
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