Prospective study of body size throughout the life-course and the incidence of endometrial cancer among premenopausal and postmenopausal women.

abstract：:Pathological deregulation of the transforming growth factor, beta 1 (TGFB1) pathway has been implicated in the development of several major diseases, including cancers. Regulatory variation in the TGFB1 gene may lead to altered TGFB1 expression and activity, and thus, modulate an individual's susceptibility to disease...

journal_title：International journal of cancer

authors： Healy J,Dionne J,Bélanger H,Larivière M,Beaulieu P,Labuda D,Sinnett D

更新日期：2009-09-15 00:00:00

abstract：:Paclitaxel has antiangiogenic properties, but the mechanisms for the enhanced sensitivity of endothelial cells (ECs) to this drug are not established. The aims of our study were to compare the distribution of paclitaxel into ECs with other cell types, to assess the effects of low doses of paclitaxel on Cox-2 expressio...

journal_title：International journal of cancer

authors： Merchan JR,Jayaram DR,Supko JG,He X,Bubley GJ,Sukhatme VP

更新日期：2005-01-20 00:00:00

abstract：:The insulin-like growth factor I (IGF-I) signaling pathway has been shown to play an important role in several aspects of cancer biology, including metastasis. The aim of this study was to define the contribution of serum (endocrine) and local (tumour microenvironment) IGF-I on osteosarcoma tumour growth and metastasi...

journal_title：International journal of cancer

authors： Hong SH,Briggs J,Newman R,Hoffman K,Mendoza A,LeRoith D,Helman L,Yakar S,Khanna C

更新日期：2009-05-01 00:00:00

abstract：:Malignant mesothelioma of the pleura (MPM) is a highly aggressive neoplasm with a poor prognosis and limited treatment options. A better understanding of its pathogenesis is essential to developing alternative therapeutic strategies. We previously demonstrated that the Wnt signaling pathway is activated in MPM through...

journal_title：International journal of cancer

authors： Mazieres J,You L,He B,Xu Z,Twogood S,Lee AY,Reguart N,Batra S,Mikami I,Jablons DM

更新日期：2005-11-01 00:00:00

abstract：:The c-KIT protooncogene encodes a tyrosine kinase receptor, KIT, that is expressed in many normal and cancerous tissues. In this study, we have examined the expression of c-KIT and its ligand, stem cell factor (SCF), in human epithelial ovarian tumors, in normal ovaries and in cultured ovarian surface epithelium (OSE)...

journal_title：International journal of cancer

authors： Tonary AM,Macdonald EA,Faught W,Senterman MK,Vanderhyden BC

更新日期：2000-05-20 00:00:00

abstract：:Using morphometric and immunohistological techniques, we investigated the distribution of T lymphocytes and subsets, B lymphocytes, macrophages and plasma cells in sections of human breast tissue. In normal lobules and ducts, leukocytes were found in greater density in the epithelium than in the stroma. The intra-epit...

journal_title：International journal of cancer

authors： Lwin KY,Zuccarini O,Sloane JP,Beverley PC

更新日期：1985-10-15 00:00:00

abstract：:Several lines of evidence suggest that long-term treatment with non-steroidal anti-inflammatory drugs may reduce the risk of colon cancer and the size and number of colonic polyps in patients with familial adenomatous polyposis. Aspirin has also been shown to inhibit cell proliferation in human tumor cell lines and to...

journal_title：International journal of cancer

authors： Ricchi P,Pignata S,Di Popolo A,Memoli A,Apicella A,Zarrilli R,Acquaviva AM

更新日期：1997-12-10 00:00:00

abstract：:Because renal-cell carcinoma (RCC) is considered relatively resistant to radio- and chemotherapy, RCC patients may benefit from new treatment modalities, e.g. immunotherapy. In vitro and in vivo studies suggest that combinations of cytokines such as interferon gamma or interferon alpha (IFN-gamma, IFN-alpha) and tumor...

journal_title：International journal of cancer

authors： van Dijk J,Uemura H,Beniers AJ,Peelen WP,Zegveld ST,Fleuren GJ,Warnaar SO,Oosterwijk E

更新日期：1994-01-15 00:00:00

abstract：:To identify characteristics of gastric cancer associated with hereditary non-polyposis colorectal cancer (HNPCC), we gathered clinical data and tumor samples relating to patients recorded in the Finnish HNPCC registry. Our series included 51 families with a characterized mutation and/or that met the Amsterdam criteria...

journal_title：International journal of cancer

authors： Aarnio M,Salovaara R,Aaltonen LA,Mecklin JP,Järvinen HJ

更新日期：1997-10-21 00:00:00

abstract：:Tonsillar squamous cell carcinoma (TSCC) is frequently associated with human papillomavirus (HPV) and chromosome instability. Data from cellular model systems are, however, controversial concerning a relation between HPV and chromosome instability development. Here we studied this association in 77 primary TSCC with k...

journal_title：International journal of cancer

authors： Mooren JJ,Kremer B,Claessen SM,Voogd AC,Bot FJ,Peter Klussmann J,Huebbers CU,Hopman AH,Ramaekers FC,Speel EJ

更新日期：2013-04-15 00:00:00

abstract：:Risks of 2nd primary cancer were assessed in all patients with cutaneous melanoma (12,460) and all patients with ocular melanoma (2,018) incident in Denmark from 1943 to 1989 and followed for totals of 88,667 person-years and 16,045 person-years, respectively. After cutaneous melanoma, 972 2nd cancers occurred. The ri...

journal_title：International journal of cancer

authors： Swerdlow AJ,Storm HH,Sasieni PD

更新日期：1995-06-09 00:00:00

abstract：:Breast cancer is one of the leading causes of cancer death in women. It is a complex and heterogeneous disease with different clinical outcomes. Stratifying patients into subgroups with different outcomes could help guide clinical decision making. In this study, we used two opposing groups of genes, Yin and Yang, to d...

journal_title：International journal of cancer

authors： Xu W,Jia G,Cai N,Huang S,Davie JR,Pitz M,Banerji S,Murphy L

更新日期：2017-03-15 00:00:00

abstract：:The Eph receptor A2 (EphA2) is overexpressed in a range of human epithelial cancers, a phenotype that is associated with cancer cell proliferation, progression and angiogenesis. Mouse models of mammary neoplasia have confirmed the role of EphA2 as mice carrying a knockout allele of EphA2 were resistant to breast cance...

journal_title：International journal of cancer

authors： Bogan C,Chen J,O'Sullivan MG,Cormier RT

更新日期：2009-03-15 00:00:00

abstract：:Cytoskeleton and extracellular matrix-related proteins (CECMPs) represent the most common class of cancer mutants, owing to the large size of their coding regions and the randomness of mutagenesis. We used a bioinformatics approach to assess the impact of amino acid (AA) substitutions on the sensitivity of CECMPs to p...

journal_title：International journal of cancer

authors： Callahan BM,Patel JS,Fawcett TJ,Blanck G

更新日期：2018-03-01 00:00:00

abstract：:Ninety-seven Japanese patients with so-called primary non-Hodgkin's lymphoma of the central nervous system (CNS-NHL), unrelated to the acquired immunodeficiency syndrome (AIDS) or organ transplantation, were reviewed. The patients' ages ranged from 1 to 87 years (median: 58 years) with a male to female ratio of 1.77:1...

journal_title：International journal of cancer

authors： Aozasa K,Ohsawa M,Yamabe H,Shima N,Kirimoto K,Yamane T,Tsujimoto M,Kobayashi Y,Kurata A,Osada H

更新日期：1990-04-15 00:00:00

abstract：:Progression from an androgen-dependent to an androgen-independent state often occurs in patients with prostate cancer (PCa) who undergo hormonal therapy. We have investigated whether inhibition of the epidermal growth factor receptor (EGFR) signaling pathway affects the antitumor effect of a nonsteroidal antiandrogen....

journal_title：International journal of cancer

authors： Festuccia C,Gravina GL,Angelucci A,Millimaggi D,Muzi P,Vicentini C,Bologna M

更新日期：2005-07-01 00:00:00

abstract：:In order to gain new insights into the risk factors influencing human-T-cell-leukemia/lymphoma-virus-type-I (HTLV-I) mother-to-child transmission, a retrospective study of HTLV-I infection among children born to HTLV-I-seropositive women was carried out in a highly HTLV-I-endemic population of African origin living in...

journal_title：International journal of cancer

authors： Ureta-Vidal A,Angelin-Duclos C,Tortevoye P,Murphy E,Lepère JF,Buigues RP,Jolly N,Joubert M,Carles G,Pouliquen JF,de Thé G,Moreau JP,Gessain A

更新日期：1999-09-09 00:00:00

abstract：:TP63 gene is a member of TP53 tumor suppressor gene family that encodes several protein isoforms involved in the process of epithelial stratification and in epithelial-mesenchyme interactions. TP63 is amplified in a significant proportion of squamous cell carcinoma of the esophagus (ESCC), resulting in the hyper-expre...

journal_title：International journal of cancer

authors： Thépot A,Hautefeuille A,Cros MP,Abedi-Ardekani B,Pétré A,Damour O,Krutovskikh V,Hainaut P

更新日期：2010-11-01 00:00:00

abstract：:Dimethylbenzanthracene (DMBA)-induced rat mammary tumors were analyzed for the structure and expression of the oncogenes c-Ha-ras and neu and the effects of anti-estrogen treatment. Tumor samples were divided into 3 groups, the first consisting of untreated tumors, the second of anti-estrogen (toremifene)-treated unre...

journal_title：International journal of cancer

authors： Vuorio T,Wärri A,Sandberg M,Alitalo K,Vuorio E

更新日期：1988-11-15 00:00:00

abstract：:Many tumors are impervious to anticancer agents. Resistance due to lack of cytotoxic penetration into the tumor is often overlooked but can play a significant role in undermining therapy. Insufficient and irregular vascularization of tumors is a possible barrier to drug delivery, but there are others, e.g., impaired v...

journal_title：International journal of cancer

authors： Wildiers H,Guetens G,de Boeck G,Landuyt W,Verbeken E,Highley M,de Bruijn EA,van Oosterom AT

更新日期：2002-06-01 00:00:00

abstract：:The human polyomaviruses JC virus (JCV) and BK virus (BKV) are oncogenic in experimental systems and commonly infect humans. JCV DNA has been reported to be present in human colon mucosa and in colorectal cancers. To investigate whether the risk for colorectal cancer is associated with JCV or BKV infection, we perform...

journal_title：International journal of cancer

authors： Lundstig A,Stattin P,Persson K,Sasnauskas K,Viscidi RP,Gislefoss RE,Dillner J

更新日期：2007-09-01 00:00:00

abstract：:A population-based case-control study of gastric cancer was conducted in areas with contrasting incidence rates in Sweden. Face-to-face interviews were carried out with 338 (74.1%) of all eligible cases and 679 (77.3%) of the selected controls. Consumption of selected nutrients during adolescence and 20 years prior to...

journal_title：International journal of cancer

authors： Hansson LE,Nyrén O,Bergström R,Wolk A,Lindgren A,Baron J,Adami HO

更新日期：1994-06-01 00:00:00

abstract：:Mucin-associated sialylated Lewis antigens are implicated in tumor cell metastasis and are used in several tests for pancreatic cancer. Despite their clinical importance, little is known about the structures of the oligosaccharides of pancreatic cancer mucins or about the regulation of their synthesis or of the synthe...

journal_title：International journal of cancer

authors： Yamashita Y,Ho JJ,Cheng S,Siddiki B,Chung YS,Sowa M,Kim YS

更新日期：1997-07-29 00:00:00

abstract：:Dendritic cells (DCs) cross-present antigen (Ag) to initiate T-cell immunity against most infections and tumors. Natural killer (NK) cells are innate cytolytic lymphocytes that have emerged as key modulators of multiple DC functions. Here, we show that human NK cells promote cross-presentation of tumor cell-derived Ag...

journal_title：International journal of cancer

authors： Deauvieau F,Ollion V,Doffin AC,Achard C,Fonteneau JF,Verronese E,Durand I,Ghittoni R,Marvel J,Dezutter-Dambuyant C,Walzer T,Vie H,Perrot I,Goutagny N,Caux C,Valladeau-Guilemond J

更新日期：2015-03-01 00:00:00

abstract：:We have studied the production and release of cholecystokinin (CCK) forms by rat medullary thyroid cancer (MTC) in vivo. MTC cells were inoculated s.c. into 8 Wag-Rij rats. One month later, after i.v. injection of calcium plasma levels of CCK, calcitonin and tissue contents of gastrin and calcitonin were determined by...

journal_title：International journal of cancer

authors： Poston GJ,Draviam EJ,Seitz PK,Rajaraman S,Alexander RW,Cooper CW,Townsend CM Jr,Thompson JC

更新日期：1991-07-09 00:00:00

abstract：:Our case-control study was conducted to investigate whether residential and occupational exposure to magnetic fields increased the risk for brain tumours in adults. Data from an occupational exposure matrix was also evaluated. The study population in this nested case-control study was made up of subjects aged 16 years...

journal_title：International journal of cancer

authors： Klaeboe L,Blaasaas KG,Haldorsen T,Tynes T

更新日期：2005-05-20 00:00:00

abstract：:There is limited research on the effect of dietary quality on hepatocellular carcinoma (HCC) risk in populations with relatively high risk of HCC. Using data from Singapore Chinese Health Study, a prospective cohort study, of 63 257 Chinese aged 45 to 74, we assessed four diet-quality index (DQI) scores: the Alternati...

journal_title：International journal of cancer

authors： Luu HN,Neelakantan N,Geng TT,Wang R,Goh GB,Clemente JC,Jin A,van Dam RM,Jia W,Behari J,Koh WP,Yuan JM

更新日期：2020-10-31 00:00:00

abstract：:As Phase 0 studies have proven to be reasonably predictive of therapeutic dose pharmacokinetics, the application of microdosing has expanded into metabolism, drug-drug interactions and now diagnostics. One potentially serious issue with this application of microdosing that has not been previously discussed is the poss...

journal_title：International journal of cancer

authors： Wurz GT,DeGregorio MW

更新日期：2015-04-01 00:00:00

abstract：:Aberrant methylation of CpG islands (CGI) not only plays a role in gene silencing, but is also a potential cancer biomarker. To identify more CGI aberrantly methylated in human breast cancers, we carried out a genome-wide search for aberrant methylation, using methylation-sensitive-representational difference analysis...

journal_title：International journal of cancer

authors： Miyamoto K,Fukutomi T,Akashi-Tanaka S,Hasegawa T,Asahara T,Sugimura T,Ushijima T

更新日期：2005-09-01 00:00:00

abstract：:Peripheral blood T cells from a patient with T-cell chronic lymphocytic leukemia (T-CLL) failed to respond to mitogenic lectins or alloantigens but could be induced to proliferate by the addition of exogenous interleukin-2 (IL-2). The T-CLL cells also proliferated in response to 12-O-tetradecanoyl phorbol-13-acetate (...

journal_title：International journal of cancer

authors： Vyth-Dreese FA,de Vries JE

更新日期：1983-07-15 00:00:00