Therapeutic effects of monoclonal antibody G250, interferons and tumor necrosis factor, in mice with renal-cell carcinoma xenografts.

abstract：:A deficit in colorectal cancer survival in Denmark and in the UK compared to Sweden, Norway and Finland was found in the EUROCARE studies. We set out to explore if these differences still exist. Patients diagnosed with colorectal cancer as their first invasive cancer at age 15-89 in the period 1994-2000 were identifie...

journal_title：International journal of cancer

authors： Engholm G,Kejs AM,Brewster DH,Gaard M,Holmberg L,Hartley R,Iddenden R,Møller H,Sankila R,Thomson CS,Storm HH

更新日期：2007-09-01 00:00:00

abstract：:Metastasis-associated protein MTA1 and histone deacetylase form a protein complex with histone deacetylase activity that plays an important role in histone deacetylation, alteration of chromatin structure and transcriptional control. The precise role of the MTA1 protein in the malignant progression of human cancers re...

journal_title：International journal of cancer

authors： Toh Y,Ohga T,Endo K,Adachi E,Kusumoto H,Haraguchi M,Okamura T,Nicolson GL

更新日期：2004-06-20 00:00:00

abstract：:V79 cells incubated with di- or tetrasulfonated aluminium phthalocyanines (AlPcS2 or AlPcS4) showed a granular fluorescence pattern. Co-staining with the lysosomotropic dye acridine orange (AO) indicated that the granules that were stained by these photoactive phthalocyanines were identical to lysosomes. Small light e...

journal_title：International journal of cancer

authors： Moan J,Berg K,Anholt H,Madslien K

更新日期：1994-09-15 00:00:00

abstract：:The impact of a human papillomavirus (HPV) vaccine on development of cervical intraepithelial neoplasia grade 2-3 or adenocarcinoma in situ (CIN2-3/AIS) in women with ongoing HPV16 or 18 infections prevaccination is reported. Seventeen thousand six-hundred and twenty-two women aged 16-26 were enrolled in 1 of 2 random...

journal_title：International journal of cancer

authors： Haupt RM,Wheeler CM,Brown DR,Garland SM,Ferris DG,Paavonen JA,Lehtinen MO,Steben M,Joura EA,Giacoletti KE,Radley DR,James MK,Saah AJ,Sings HL,FUTURE I and II Investigators.

更新日期：2011-12-01 00:00:00

abstract：:This study was aimed at comparing screen-detected and symptomatic breast carcinomas with regard to the prevalence of positive immunostaining for c-erb-B-2 oncoprotein. Paraffin sections of 81 breast carcinomas detected through the National Screening Programme were examined for the over-expression of c-erbB-2 oncoprote...

journal_title：International journal of cancer

authors： Soomro S,Taylor P,Shepard HM,Feldmann M,Sinnett HD,Shousha S

更新日期：1993-08-19 00:00:00

abstract：:We have studied the in vitro invasive properties of 3 cell lines derived from the co-transfection of rat embryo fibroblasts (REF) with EIA genes deficient in exon 2 and T24-ras. All 3 cell lines showed invasive properties at passage 10 after isolation. Invasive cells expressed elevated levels of stromelysin-1 and redu...

journal_title：International journal of cancer

authors： Engel G,Popowicz P,Marshall H,Norling G,Svensson C,Auer G,Akusjärvi G,Linder S

更新日期：1992-07-09 00:00:00

abstract：:Physiological concentrations of insulin support the in vitro growth of LB T-cell lymphoma. We could not detect similar insulin dependence in other tumor cell lines. This study reports that insulin also enhances the growth of LB cells in vivo. Mice treated with Streptozotocin (SZ) developed partial resistance to LB lym...

journal_title：International journal of cancer

authors： Sharon R,Pillemer G,Ish-Shalom D,Kalman R,Ziv E,Berry EM,Naor D

更新日期：1993-03-12 00:00:00

abstract：:Obesity is a well-known risk factor for postmenopausal breast cancer. In contrast, the relationship between obesity and stage of breast cancer at diagnosis is less clear. We hypothesized that increased breast size in obese women may delay discovery of breast tumors. Thus, the purpose of our study was to examine whethe...

journal_title：International journal of cancer

authors： Cui Y,Whiteman MK,Flaws JA,Langenberg P,Tkaczuk KH,Bush TL

更新日期：2002-03-10 00:00:00

abstract：:Our group has conducted two previous studies on the association between vitamin D binding protein (DBP) and renal cell carcinoma (RCC), the most common form of kidney cancer, finding strong inverse associations. We undertook the current analysis to replicate our findings in a different study population that included w...

journal_title：International journal of cancer

authors： Kratzer TB,Weinstein SJ,Albanes D,Mondul AM

更新日期：2020-08-01 00:00:00

abstract：:Telomerase appears to be an important factor for the control of cellular proliferation capacity and for tumorigenesis. Enzyme activity is highly increased in almost all human tumors and distinguishes them from benign lesions. Besides its diagnostic value, telomerase activity appears to be associated with tumor progres...

journal_title：International journal of cancer

authors： Hoos A,Hepp HH,Kaul S,Ahlert T,Bastert G,Wallwiener D

更新日期：1998-02-20 00:00:00

abstract：:Isothiocyanates (ITC) in cruciferous vegetables may be chemopreventive against gastric cancer development. Glutathione S-transferases (GSTs) may modify the chemopreventive effect of ITC. The relationship between urinary total ITC and risk of gastric cancer was prospectively examined. Between 1986 and 1989, 18,244 midd...

journal_title：International journal of cancer

authors： Moy KA,Yuan JM,Chung FL,Wang XL,Van Den Berg D,Wang R,Gao YT,Yu MC

更新日期：2009-12-01 00:00:00

abstract：:Messenger RNA differential display was used to study liver-gene expression in paired tumor and non-tumor tissues from hepatocellular carcinoma (HCC) patients. mRNA differential display and Northern-blot analyses showed that a 0.8-kb cDNA fragment was diminished or absent from the tumorous tissues of 7 HCC patients. Th...

journal_title：International journal of cancer

authors： Chen YM,Shiu JY,Tzeng SJ,Shih LS,Chen YJ,Lui WY,Chen PH

更新日期：1998-03-02 00:00:00

abstract：:Mouse and human lymphoid cells were cultivated in the presence of T-cell growth factor (TCGF) and evaluated for their in vivo anti-tumor effect in mice. Cultured spleen cells of normal BALB/c mice or of mice bearing the M109 tumor had a high level of cytotoxic activity in vitro against a variety of tumor target cells ...

journal_title：International journal of cancer

authors： Gorelik E,Kedar E,Sredni B,Herberman R

更新日期：1981-08-15 00:00:00

abstract：:Inactivation of the tumor-suppressor gene p16 (MTS1/ CDKN2/INK4a) has been described in various human malignancies. Although p16 deletion has been found in various ovarian tumor cell lines, p16 inactivation by homozygous deletion or mutation has been reported only sporadically in primary ovarian carcinomas. In a compr...

journal_title：International journal of cancer

authors： Milde-Langosch K,Ocon E,Becker G,Löning T

更新日期：1998-02-20 00:00:00

abstract：:The insulin-like growth factors (IGF-I and IGF-II) play a key role in cellular proliferation and are involved in cellular transformation. The expression of the IGF-I receptor has been demonstrated in a variety of human tumor cell lines including ovarian cancer cells. Phosphorothioate antisense oligodeoxynucleotides (S...

journal_title：International journal of cancer

authors： Müller M,Dietel M,Turzynski A,Wiechen K

更新日期：1998-08-12 00:00:00

abstract：:During the course of a mechanism-based screening program aimed at identifying new antimitotic agents, a novel microtubule depolymerizing piperazine derivative, 1-(5-chloro-2-methoxybenzoyl)-4-(3-chlorophenyl) piperazine, was identified. The compound, designated CB694, caused inhibition of proliferation of a wide range...

journal_title：International journal of cancer

authors： Weiderhold KN,Randall-Hlubek DA,Polin LA,Hamel E,Mooberry SL

更新日期：2006-02-15 00:00:00

abstract：:Transforming growth factor-beta (TGFbeta1) enhances human MDA-MB-231 breast tumour cell invasion of reconstituted basement membrane in vitro but does not inhibit proliferation of this cell line. In contrast to basal invasion, which is plasmin-, urokinase (uPA)-, tissue-type plasminogen activator (t-PA)-, matrix metall...

journal_title：International journal of cancer

authors： Farina AR,Coppa A,Tiberio A,Tacconelli A,Turco A,Colletta G,Gulino A,Mackay AR

更新日期：1998-03-02 00:00:00

abstract：:Most breast cancer patients in sub-Saharan Africa are diagnosed at advanced stages after prolonged symptomatic periods. In the multicountry African Breast Cancer-Disparities in Outcomes cohort, we dissected the diagnostic journey to inform downstaging interventions. At hospital presentation for breast cancer, women re...

journal_title：International journal of cancer

authors： Foerster M,McKenzie F,Zietsman A,Galukande M,Anele A,Adisa C,Parham G,Pinder L,Schüz J,McCormack V,Dos-Santos-Silva I

更新日期：2021-01-15 00:00:00

abstract：:Human malignant glioma cell lines and clones were incubated with various concentrations of recombinant human TNF-alpha, either alone or in combination with recombinant human IFN-gamma. The surface expression of HLA-ABC (class I) antigens and beta 2-microglobulin, was significantly enhanced by TNF-alpha alone on every ...

journal_title：International journal of cancer

authors： Zuber P,Accolla RS,Carrel S,Diserens AC,de Tribolet N

更新日期：1988-11-15 00:00:00

abstract：:The SIL gene expression is increased in multiple cancers and correlates with the expression of mitotic spindle checkpoint genes and with increased metastatic potential. SIL regulates mitotic entry, organization of the mitotic spindle and cell survival. The E2F transcription factors regulate cell cycle progression by c...

journal_title：International journal of cancer

authors： Erez A,Chaussepied M,Castiel A,Colaizzo-Anas T,Aplan PD,Ginsberg D,Izraeli S

更新日期：2008-10-01 00:00:00

abstract：:Regression of EB-virus-induced transformation occurs exclusively in cultures of leukocytes from seropositive donors. Studies have shown that the strength of regression could be assayed in terms of the proportion of T cells which must be added to the autologous EB virus-infected T-cell-depleted population in order to e...

journal_title：International journal of cancer

authors： Rickinson AB,Moss DJ,Pope JH

更新日期：1979-05-15 00:00:00

abstract：:In 584 consecutive patients with no previous history of cancer or polypectomy, 769 adenomas were excised endoscopically and classified retrospectively according to the following parameters: macroscopic growth pattern, size, histological type, grade of dysplasia, anatomical site, presence of adenocarcinoma (ADK), numbe...

journal_title：International journal of cancer

authors： Gatteschi B,Costantini M,Bruzzi P,Merlo F,Torcoli R,Nicolo G

更新日期：1991-10-21 00:00:00

abstract：:T cell responses against malignant cells play a major role in maintaining remission and prolonging overall survival in patients after allogeneic stem cell transplantation and donor lymphocyte infusion (DLI) due to graft-versus-leukemia effect. For better characterization of the T cell responses, we assessed frequency ...

journal_title：International journal of cancer

authors： Hofmann S,Schmitt M,Götz M,Döhner H,Wiesneth M,Bunjes D,Greiner J

更新日期：2019-03-01 00:00:00

abstract：:Treatment of mouse Lewis lung carcinoma with razoxane or dacarbazine was protracted for 10 transplant generations. While the capacity of the treated tumors to grow locally in immuno-competent or in immuno-depressed hosts was retained and not significantly modified, the metastatic phenotype was eliminated when the trea...

journal_title：International journal of cancer

authors： Garbisa S,Onisto M,Peron A,Perissin L,Rapozzi V,Zorzet S,Giraldi T

更新日期：1997-09-17 00:00:00

abstract：:Vaccination strategies based on repeated injections of NY-ESO-1 protein formulated in ISCOMATRIX particles (NY-ESO-1 ISCOMATRIX) have shown to elicit combined NY-ESO-1 specific antibody and T cell responses. However, it remains unclear whether heterologous prime-boost strategies based on the combination with NY-ESO-1 ...

journal_title：International journal of cancer

authors： Chen JL,Dawoodji A,Tarlton A,Gnjatic S,Tajar A,Karydis I,Browning J,Pratap S,Verfaille C,Venhaus RR,Pan L,Altman DG,Cebon JS,Old LL,Nathan P,Ottensmeier C,Middleton M,Cerundolo V

更新日期：2015-03-15 00:00:00

abstract：:Due to the large scale use of asbestos (more than 3.5 million tons produced or imported until its definitive banning in 1992), a specific national surveillance system of mesothelioma incident cases is active in Italy, with direct and individual anamnestic etiological investigation. In the period between 1993 and 2004,...

journal_title：International journal of cancer

authors： Marinaccio A,Binazzi A,Marzio DD,Scarselli A,Verardo M,Mirabelli D,Gennaro V,Mensi C,Riboldi L,Merler E,Zotti RD,Romanelli A,Chellini E,Silvestri S,Pascucci C,Romeo E,Menegozzo S,Musti M,Cavone D,Cauzillo G,Tumino

更新日期：2012-05-01 00:00:00

abstract：:The Insulin-like growth factor (IGF)/IGF-receptor pathway with its scaffolding proteins Insulin Receptor Substrate (IRS)1 and IRS2 are crucial regulators of metabolism and progression in metastatic colorectal cancer (mCRC). The goal of the study was the identification of predictive and prognostic markers among IRS1, I...

journal_title：International journal of cancer

authors： Schirripa M,Zhang W,Heinemann V,Cao S,Okazaki S,Yang D,Loupakis F,Berger MD,Ning Y,Miyamoto Y,Suenaga M,Gopez RF,West JD,Hanna D,Barzi A,Falcone A,Stintzing S,Lenz HJ

更新日期：2017-07-15 00:00:00

abstract：:To better inform the next clinical trials of vascular disrupting agent combretastatin-A4-phosphate (CA4P) in patients with hepatic malignancies, this preclinical study aimed at evaluating CA4P therapeutic efficacy in rats with primary hepatocellular carcinomas (HCCs) of a full spectrum of differentiation and vasculari...

journal_title：International journal of cancer

authors： Liu Y,De Keyzer F,Wang Y,Wang F,Feng Y,Chen F,Yu J,Liu J,Song S,Swinnen J,Bormans G,Oyen R,Huang G,Ni Y

更新日期：2018-10-01 00:00:00

abstract：:The relationship between breast cancer and radiation treatment for cervical cancer was evaluated in an international study of 953 women who subsequently developed breast cancer and 1,806 matched controls. Radiation doses to the breast (average 0.31 Gy) and ovaries (average 32 Gy) were reconstructed for exposed subject...

journal_title：International journal of cancer

authors： Boice JD Jr,Blettner M,Kleinerman RA,Engholm G,Stovall M,Lisco H,Austin DF,Bosch A,Harlan L,Krementz ET,Latouret HB,Merril JA,Petters LJ,Schulz MD,Wactawski J,Storm HH,Björkholm E,Pettersson F,Bell CM,Coleman MP,F

更新日期：1989-07-15 00:00:00

abstract：:Cancer vaccines directed against tumor associate antigen (TAA) have produced encouraging results in preclinical models but not in cancer patients. A major limitation of this strategy is the relative degree of tolerance to these antigens and the low and heterogeneous tumor cell expression of TAA and major histocompatib...

journal_title：International journal of cancer

authors： Correale P,Aquino A,Giuliani A,Pellegrini M,Micheli L,Cusi MG,Nencini C,Petrioli R,Prete SP,De Vecchis L,Turriziani M,Giorgi G,Bonmassar E,Francini G

更新日期：2003-04-20 00:00:00