Functional impact of sequence variation in the promoter region of TGFB1.

Abstract:

:Pathological deregulation of the transforming growth factor, beta 1 (TGFB1) pathway has been implicated in the development of several major diseases, including cancers. Regulatory variation in the TGFB1 gene may lead to altered TGFB1 expression and activity, and thus, modulate an individual's susceptibility to disease. Here, we performed a study of the functional relevance of cis-acting regulatory variation in the proximal promoter region of the TGFB1 gene. In a previous study, 9 promoter polymorphisms were identified in the 2kb region upstream of the transcription start site and 9 distinct promoter haplotypes were inferred from a panel of individuals from 5 distinct continental population groups. Following experimental validation, we found that the 2 major haplotypes significantly influenced TGFB1 transcriptional activity in an allele-specific manner and that 3 of the SNPs (-1886G>A, -509C>T and -1550DEL/AGG) altered DNA-protein complex formation. Though the biological relevance of these findings remains to be verified, our study suggests that polymorphisms in the TGFB1 promoter could indeed influence gene expression and potentially contribute to the pathogenesis of TGFB1 related diseases.

journal_name

Int J Cancer

authors

Healy J,Dionne J,Bélanger H,Larivière M,Beaulieu P,Labuda D,Sinnett D

doi

10.1002/ijc.24526

subject

Has Abstract

pub_date

2009-09-15 00:00:00

pages

1483-9

issue

6

eissn

0020-7136

issn

1097-0215

journal_volume

125

pub_type

杂志文章
  • Serial transplantation of an HTLV-I-transformed hamster lymphoid cell line into hamsters.

    abstract::A hamster lymphoid cell line, HCT-2, transformed by human T-cell leukemia virus type I (HTLV-I) was serially transplanted for 9 passages in newborn hamsters. A total of 34 newborn hamsters inoculated intraperitoneally (i.p.) with 0.2-2 X 10(7) HCT-2 cells developed fatal lymphomas with dissemination to various organs ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910410617

    authors: Eguchi T,Kubonishi I,Daibata M,Yano S,Imamura J,Ohtsuki Y,Miyoshi I

    更新日期:1988-06-15 00:00:00

  • CpG methylation of viral DNA in EBV-associated tumours.

    abstract::In EBV-immortalized lymphoblastoid cell lines (LCLs) a small number of "latent" proteins are expressed. These are the EBV nuclear antigens, EBNAs 1-6, and a latent membrane protein, LMP. We have investigated the expression of these proteins in a variety of EBV-associated tumours and cell lines. Whereas transplant and ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910450623

    authors: Allday MJ,Kundu D,Finerty S,Griffin BE

    更新日期:1990-06-15 00:00:00

  • Distinct clinical features associated with microsatellite instability in colorectal cancers of young patients.

    abstract::The Hong Kong Chinese population has an unusually high incidence of colorectal cancer in the young, suggestive of hereditary susceptibility. To search for a genetic basis for this predisposition, we studied the incidence of microsatellite instability (MSI) in paraffin-embedded colectomy specimens of 124 young (<50 yea...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0215(20000720)89:4<356::aid-ijc7>3.0.

    authors: Ho JW,Yuen ST,Chung LP,Kwan KY,Chan TL,Leung SY,Chan AS,Tse Cw,Lam PW,Luk IS

    更新日期:2000-07-20 00:00:00

  • Candidate regions of tumor suppressor locus on chromosome 9q31.1 in gastric cancer.

    abstract::Loss of heterozygosity (LOH) is an important event of tumorigenesis. In gastric cancer, we found a novel region of LOH in chromosome 9q having about 800 kb deletions at 9q31.1. The microsatellite marker D9S938 in that region exhibiting the highest LOH frequency, 56.5%. In addition, the LOH at 9q31.1 did not show any r...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.11674

    authors: Kakinuma N,Kohu K,Sato M,Yamada T,Nakajima M,Akiyama T,Ohwada S,Shibanaka Y

    更新日期:2004-03-01 00:00:00

  • Expression of MAGE-1, MAGE-2, MAGE-3/-6 and MAGE-4a/-4b genes in ovarian tumors.

    abstract::MAGE genes encoding tumor-rejection antigens recognized by cytotoxic T lymphocytes are expressed at the mRNA level in various malignant tumors. We have investigated the expression of genes MAGE-1, -2, -3/-6 and -4a/-4b at the mRNA level in malignant and non-malignant ovarian tumors as well as in normal ovaries by reve...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910640607

    authors: Yamada A,Kataoka A,Shichijo S,Kamura T,Imai Y,Nishida T,Itoh K

    更新日期:1995-12-20 00:00:00

  • Mixed lymphocyte/tumor-cell interaction in a murine sarcoma virus (Moloney)-induced tumor system. Comparison between lymphoproliferation and lymphocyte cytotoxicity.

    abstract::Studies of the MLTI were performed in a primary MSV-induced tumor system. Reactivity against mitomycin-C-treated RBL-5 cells could be detected during a limited period at about 14 days after virus injection. The degree of reactivity of MSV 14 spleen cells was quite variable; stimulation indices ranged from 2.2 to 9.4. ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910170313

    authors: Kirchner H,Glaser M,Holden HT,Herberman RB

    更新日期:1976-03-15 00:00:00

  • Mammary tumor latency is increased in mice lacking the inducible nitric oxide synthase.

    abstract::Nitric oxide (NO) and its metabolites are implicated in carcinogenesis and metastasis. Both stimulatory and inhibitory effects of NO have been reported in relation to breast cancer and its role in the development of malignancies and metastasis remains uncertain. We have used the polyomavirus middle T antigen (PyV-mT) ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.11178

    authors: Ellies LG,Fishman M,Hardison J,Kleeman J,Maglione JE,Manner CK,Cardiff RD,MacLeod CL

    更新日期:2003-08-10 00:00:00

  • Binding of some metastatic tumor cell lines to fibrous elastin and elastin peptides.

    abstract::Recent suggestions that tumor-cell targeting of elastin-rich tissues (e.g., lung) correlates with the presence of surface elastin receptors have been investigated. Receptors for insoluble (fibrous) elastin and for soluble elastin peptides have been implemented in these correlations. A rapid assay for binding of insolu...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910530520

    authors: Svitkina TM,Parsons DF

    更新日期:1993-03-12 00:00:00

  • Trends in hysterectomy-corrected uterine cancer mortality rates during 2002 to 2015: mortality of nonendometrioid cancer on the rise?

    abstract::Corpus uteri cancer is the most common gynecological malignancy in most developed countries. The disease is typically diagnosed at an early stage, is of endometrioid histologic subtype, and has a fairly good prognosis. Here, we describe hysterectomy-corrected mortality rates of corpus uteri cancer, overall and stratif...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.33219

    authors: Gustafson LW,Booth BB,Kahlert J,Ørtoft G,Mejlgaard E,Clarke MA,Wentzensen N,Rositch AF,Hammer A

    更新日期:2021-02-01 00:00:00

  • Dietary supplement use and colorectal cancer risk: a systematic review and meta-analyses of prospective cohort studies.

    abstract::Use of dietary supplements is rising in countries where colorectal cancer is prevalent. We conducted a systematic literature review and meta-analyses of prospective cohort studies on dietary supplement use and colorectal cancer risk. We identified relevant studies in Medline, Embase and Cochrane up to January 2013. Or...

    journal_title:International journal of cancer

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/ijc.29277

    authors: Heine-Bröring RC,Winkels RM,Renkema JM,Kragt L,van Orten-Luiten AC,Tigchelaar EF,Chan DS,Norat T,Kampman E

    更新日期:2015-05-15 00:00:00

  • Tamoxifen modulation of cisplatin cytotoxicity in human malignancies.

    abstract::Recent clinical trials have indicated that addition of tamoxifen (TAM) to a combination of cisplatin (DDP), carmustine and dacarbazine markedly increases the overall objective response rate of patients with metastatic malignant melanoma. Previous studies have determined that there is remarkable synergy between TAM and...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910550623

    authors: McClay EF,Albright KD,Jones JA,Christen RD,Howell SB

    更新日期:1993-12-02 00:00:00

  • Functional variant of MTOR rs2536 and survival of Chinese gastric cancer patients.

    abstract::We previously reported that some single nucleotide polymorphisms (SNPs) of candidate genes involved in the MTOR complex1 (MTORC1) were associated with risk of gastric cancer (GCa). In the present study, we further evaluated associations of eight potentially functional SNPs of MTOR, MLST8 and RPTOR with survival of 100...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.31656

    authors: Cheng L,Qiu L,Zhang R,Qian D,Wang M,Sun M,Zhu X,Wang Y,Guo W,Wei Q

    更新日期:2019-01-15 00:00:00

  • Inverse regulation of neuronal cellular adhesion molecule (NCAM) by IFN-gamma in melanoma cell cultures established from CNS lesions.

    abstract::In advanced stages of malignant melanoma (MM), metastases to the CNS are frequently observed. Few results are available on trophic factors and immunological features involved in the process of invasion and adhesion of circulating metastatic cells into the CNS. A direct comparison of remote metastases found in differen...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0215(19990924)83:1<135::aid-ijc

    authors: Geertsen R,Zenklusen R,Kamarashev J,Burg G,Dummer R

    更新日期:1999-09-24 00:00:00

  • Mutation analysis of the MYH gene in an Australian series of colorectal polyposis patients with or without germline APC mutations.

    abstract::The MYH gene has recently been shown to be associated with a recessive form of colorectal adenomatous polyposis. Two common mutations in the MYH gene have been identified that lend themselves to rapid screening. We have examined a series of 302 individuals comprising 120 control subjects, 120 patients diagnosed with a...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.20983

    authors: Kairupan CF,Meldrum CJ,Crooks R,Milward EA,Spigelman AD,Burgess B,Groombridge C,Kirk J,Tucker K,Ward R,Williams R,Scott RJ

    更新日期:2005-08-10 00:00:00

  • Plasma microRNAs as biomarkers of pancreatic cancer risk in a prospective cohort study.

    abstract::Noninvasive biomarkers for early pancreatic ductal adenocarcinoma (PDAC) diagnosis and disease risk stratification are greatly needed. We conducted a nested case-control study within the Prospective Investigation into Cancer and Nutrition (EPIC) cohort to evaluate prediagnostic microRNAs (miRs) as biomarkers of subseq...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.30790

    authors: Duell EJ,Lujan-Barroso L,Sala N,Deitz McElyea S,Overvad K,Tjonneland A,Olsen A,Weiderpass E,Busund LT,Moi L,Muller D,Vineis P,Aune D,Matullo G,Naccarati A,Panico S,Tagliabue G,Tumino R,Palli D,Kaaks R,Katzke VA,

    更新日期:2017-09-01 00:00:00

  • Expression of activation-induced cytidine deaminase in human hepatocytes during hepatocarcinogenesis.

    abstract::Activation-induced cytidine deaminase (AID) plays a role as a genome mutator in activated B cells, and inappropriate expression of AID has been implicated in the immunopathological phenotype of human B-cell malignancies. Notably, we found that the transgenic mice overexpressing AID developed lung adenocarcinoma and he...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.22292

    authors: Kou T,Marusawa H,Kinoshita K,Endo Y,Okazaki IM,Ueda Y,Kodama Y,Haga H,Ikai I,Chiba T

    更新日期:2007-02-01 00:00:00

  • Epstein-Barr herpesvirus infection: inhibition by immunologically induced mediators with interferon-like properties.

    abstract::When sensitized leukocytes were re-exposed to EBV antigen or to tuberculin-purified protein derivatives, they produced lymphokines, including the migration inhibition factor, which inhibited the migration of guinea-pig peritoneal exudate cells, and other lymphokines with the characteristics of interferon, which inhibi...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910200106

    authors: Lai PK,Alpers MP,MacKay-Scollay EM

    更新日期:1977-07-15 00:00:00

  • Dietary catechins and epithelial cancer incidence: the Zutphen elderly study.

    abstract::The flavonoids, a group of more than 4,000 polyphenolic antioxidants, are potential cancer preventive components of fruits and vegetables. Catechins, one of the 6 major groups of flavonoids, are present in high concentrations in tea as well. Our objective was to evaluate the association between intake of catechins and...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0215(200102)9999:9999<::aid-ijc1187>3

    authors: Arts IC,Hollman PC,Bueno De Mesquita HB,Feskens EJ,Kromhout D

    更新日期:2001-04-15 00:00:00

  • Overexpression of the oncogenic signal transducer Gab2 occurs early in breast cancer development.

    abstract::Gab2, a docking-type signaling protein with demonstrated oncogenic potential, is overexpressed in breast cancer, but its prognostic significance and role in disease evolution remain unclear. Immunohistochemical detection of Gab2 in a large cohort of primary human breast cancers of known outcome revealed that while Gab...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.25172

    authors: Fleuren ED,O'Toole S,Millar EK,McNeil C,Lopez-Knowles E,Boulghourjian A,Croucher DR,Schramek D,Brummer T,Penninger JM,Sutherland RL,Daly RJ

    更新日期:2010-09-01 00:00:00

  • Toward a real liquid biopsy in metastatic breast and prostate cancer: Diagnostic LeukApheresis increases CTC yields in a European prospective multicenter study (CTCTrap).

    abstract::Frequently, the number of circulating tumor cells (CTC) isolated in 7.5 mL of blood is too small to reliably determine tumor heterogeneity and to be representative as a "liquid biopsy". In the EU FP7 program CTCTrap, we aimed to validate and optimize the recently introduced Diagnostic LeukApheresis (DLA) to screen lit...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ijc.31752

    authors: Andree KC,Mentink A,Zeune LL,Terstappen LWMM,Stoecklein NH,Neves RP,Driemel C,Lampignano R,Yang L,Neubauer H,Fehm T,Fischer JC,Rossi E,Manicone M,Basso U,Marson P,Zamarchi R,Loriot Y,Lapierre V,Faugeroux V,Oulhen

    更新日期:2018-11-15 00:00:00

  • Efficacy of dendrimer-mediated angiostatin and TIMP-2 gene delivery on inhibition of tumor growth and angiogenesis: in vitro and in vivo studies.

    abstract::Gene transfer is an attractive approach to fight cancer by targeting cancer cells or their vasculature. Our study reports the inhibition of tumor growth and angiogenesis by a nonviral method using dendrimers associated with 36-mer anionic oligomers (ON36) for delivering angiostatin (Kringle 1-3) and tissue inhibitor o...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.11105

    authors: Vincent L,Varet J,Pille JY,Bompais H,Opolon P,Maksimenko A,Malvy C,Mirshahi M,Lu H,Vannier JP,Soria C,Li H

    更新日期:2003-06-20 00:00:00

  • Adenovirus-mediated wild-type-p53-gene expression sensitizes TNF-resistant tumor cells to TNF-induced cytotoxicity by altering the cellular redox state.

    abstract::We have shown that the loss of p53 function contributed to resistance of tumor cells to TNF-induced cytotoxicity. In the present study, we evaluated the effect of wild-type p53 (wt-p53) expression on TNF sensitivity, by introducing wt-p53 into MCF7/Adr cells in which p53 was deleted, via a recombinant adenovirus encod...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0215(20000101)85:1<93::aid-ijc1

    authors: Shatrov VA,Ameyar M,Bouquet C,Cai Z,Stancou R,Haddada H,Chouaib S

    更新日期:2000-01-01 00:00:00

  • Promiscuous survivin peptide induces robust CD4+ T-cell responses in the majority of vaccinated cancer patients.

    abstract::CD4(+) T cells have been shown to be crucial for the induction and maintenance of cytotoxic T cell responses and to be also capable of mediating direct tumor rejection. Therefore, the anticancer therapeutic efficacy of peptide-based vaccines may be improved by addition of HLA class II epitopes to stimulate T helper c...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.26365

    authors: Widenmeyer M,Griesemann H,Stevanović S,Feyerabend S,Klein R,Attig S,Hennenlotter J,Wernet D,Kuprash DV,Sazykin AY,Pascolo S,Stenzl A,Gouttefangeas C,Rammensee HG

    更新日期:2012-07-01 00:00:00

  • Cross-reactions between tumor cells and allogeneic normal tissues. Inhibition of a syngeneic lymphoma outgrowth in H-2 and non-H-2 alloimmune BALB/c mice.

    abstract::To test whether alloimmunization with H-2 or/and non-H-2 different normal tissues may increase the immunity to syngeneic tumors, groups of BALB/c (H-2d) mice were immunized with a series of allogeneic lymphoid cells and then challenged i.p. with syngeneic lymphoma cells. The outgrowth of otherwise lethal doses of the ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910290316

    authors: Parmiani G,Sensi ML,Carbone G,Colombo M,Pierotti M,Ballinari D,Hilgers J,Hilkens J

    更新日期:1982-03-15 00:00:00

  • Diverse expression patterns of the EMT suppressor grainyhead-like 2 (GRHL2) in normal and tumour tissues.

    abstract::The transcription factor grainyhead-like 2 (GRHL2) plays a crucial role in various developmental processes. Although GRHL2 recently has attracted considerable interest in that it could be identified as a novel suppressor of the epithelial-to-mesenchymal transition, evidence is emerging that GRHL2 also exhibits tumour-...

    journal_title:International journal of cancer

    pub_type: 杂志文章,meta分析

    doi:10.1002/ijc.29841

    authors: Riethdorf S,Frey S,Santjer S,Stoupiec M,Otto B,Riethdorf L,Koop C,Wilczak W,Simon R,Sauter G,Pantel K,Assmann V

    更新日期:2016-02-15 00:00:00

  • The methylthioadenosine phosphorylase gene is frequently co-deleted with the p16INK4a gene in acute type adult T-cell leukemia.

    abstract::Adult T-cell leukemia (ATL) is a retrovirus-associated leukemia with poor prognosis and often has deletions of the p16INK4a and p15INK4b genes on chromosome 9p21. The gene for methylthioadenosine phosphorylase (MTAP), a purine and methionine metabolic enzyme, resides approximately 100 Kb telomeric to the p16INK4a gene...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0215(19980105)75:1<51::aid-ijc9

    authors: Hori Y,Hori H,Yamada Y,Carrera CJ,Tomonaga M,Kamihira S,Carson DA,Nobori T

    更新日期:1998-01-05 00:00:00

  • MicroRNA-31 expression in relation to BRAF mutation, CpG island methylation and colorectal continuum in serrated lesions.

    abstract::The CpG island methylator phenotype (CIMP) is a distinct form of epigenomic instability. Many CIMP-high colorectal cancers (CRCs) with BRAF mutation are considered to arise from serrated pathway. We recently reported that microRNA-31 (miR-31) is associated with BRAF mutation in colorectal tumors. Emerging new approach...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.28920

    authors: Ito M,Mitsuhashi K,Igarashi H,Nosho K,Naito T,Yoshii S,Takahashi H,Fujita M,Sukawa Y,Yamamoto E,Takahashi T,Adachi Y,Nojima M,Sasaki Y,Tokino T,Baba Y,Maruyama R,Suzuki H,Imai K,Yamamoto H,Shinomura Y

    更新日期:2014-12-01 00:00:00

  • An immunohistochemical study of laminin, type-IV collagen and type-III pN-collagen with relation to reticular fibres in Hodgkin's disease.

    abstract::The distribution of aminoterminal propeptides of type-III procollagen (indicating the presence of type-III pN-collagen, i.e., type-III collagen molecule with a non-cleaved aminoterminal propeptide), laminin and type-IV collagen was studied by immunohistochemical methods. The results were compared with the distribution...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910410111

    authors: Karttunen T,Alavaikko M,Apaja-Sarkkinen M,Autio-Harmainen H

    更新日期:1988-01-15 00:00:00

  • Multidirectional differentiation in a newly established human epithelioid sarcoma cell line (GRU-1) with co-expression of vimentin, cytokeratins and neurofilament proteins.

    abstract::A new permanent cell line (GRU-1) derived from the lymph-node metastasis of a human epithelioid sarcoma was established in tissue culture. Immunohistochemically, the original tumor had exhibited an intriguing potential for multidirectional differentiation with features of mesenchymal, epithelial and neural differentia...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910450126

    authors: Gerharz CD,Moll R,Ramp U,Mellin W,Gabbert HE

    更新日期:1990-01-15 00:00:00

  • High cell kinetics is associated with amplification of the int-2, bcl-1, myc and erbB-2 proto-oncogenes and loss of heterozygosity at the DF3 locus in primary breast cancers.

    abstract::Cell kinetics is a predictive parameter of breast-cancer aggressiveness, and mutations occurring in mammary tumorigenesis may favor uncontrolled cell proliferation. In this study, cell kinetics, clinico-pathological characteristics and genetic alterations at the int-2, bcl-1, c-myc, c-erbB-2, and DF3 loci were analyze...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910610102

    authors: Contegiacomo A,Pizzi C,De Marchis L,Alimandi M,Delrio P,Di Palma E,Petrella G,Ottini L,French D,Frati L

    更新日期:1995-03-29 00:00:00