Functional impact of sequence variation in the promoter region of TGFB1.


:Pathological deregulation of the transforming growth factor, beta 1 (TGFB1) pathway has been implicated in the development of several major diseases, including cancers. Regulatory variation in the TGFB1 gene may lead to altered TGFB1 expression and activity, and thus, modulate an individual's susceptibility to disease. Here, we performed a study of the functional relevance of cis-acting regulatory variation in the proximal promoter region of the TGFB1 gene. In a previous study, 9 promoter polymorphisms were identified in the 2kb region upstream of the transcription start site and 9 distinct promoter haplotypes were inferred from a panel of individuals from 5 distinct continental population groups. Following experimental validation, we found that the 2 major haplotypes significantly influenced TGFB1 transcriptional activity in an allele-specific manner and that 3 of the SNPs (-1886G>A, -509C>T and -1550DEL/AGG) altered DNA-protein complex formation. Though the biological relevance of these findings remains to be verified, our study suggests that polymorphisms in the TGFB1 promoter could indeed influence gene expression and potentially contribute to the pathogenesis of TGFB1 related diseases.


Int J Cancer


Healy J,Dionne J,Bélanger H,Larivière M,Beaulieu P,Labuda D,Sinnett D




Has Abstract


2009-09-15 00:00:00












  • Differential survival of γδT cells, αβT cells and NK cells upon engagement of NKG2D by NKG2DL-expressing leukemic cells.

    abstract::Herein, we show that γδT, CD8(+) αβT lymphocytes and natural killer (NK) cells display a different sensitivity to survival signals delivered via NKG2D surface receptor. All the three effector cell populations activate Akt1/PKBalpha through the engagement of this molecule. Upon binding to leukemic cells expressing NKG2...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Poggi A,Zancolli M,Boero S,Catellani S,Musso A,Zocchi MR

    更新日期:2011-07-15 00:00:00

  • Prospective study of oral microbiome and colorectal cancer risk in low-income and African American populations.

    abstract::Oral microbiome may play an important role in cancer pathogenesis. However, no study has prospectively investigated the association of the oral microbiome with subsequent risk of developing colorectal cancer (CRC). We conducted a nested case-control study including 231 incident CRC cases and 462 controls within the So...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yang Y,Cai Q,Shu XO,Steinwandel MD,Blot WJ,Zheng W,Long J

    更新日期:2019-05-15 00:00:00

  • Expression and localization of human multidrug resistance protein (ABCC) family members in pancreatic carcinoma.

    abstract::Pancreatic ductal adenocarcinoma is among the top 10 causes of death from cancer in industrialized countries. In comparison with other gastrointestinal malignancies, pancreatic cancer is one of the tumors most resistant to chemotherapy. An important mechanism of tumor multidrug resistance is increased drug efflux medi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: König J,Hartel M,Nies AT,Martignoni ME,Guo J,Büchler MW,Friess H,Keppler D

    更新日期:2005-06-20 00:00:00

  • Increased incidence of mouse mammary tumor virus-related antigen in Tunisian patients with breast cancer.

    abstract::Biopsies obtained from 74 Tunisian women with breast cancer (33 cases), benign breast disease (17 cases), and cervical cancer (24 cases) were assayed for the presence of an antigen cross-reacting with gp52 of the mouse mammary tumor virus (MMTV) in order to determine the frequency and possible prognostic significance ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Levine PH,Mesa-Tejada R,Keydar I,Tabbane F,Spiegelman S,Mourali N

    更新日期:1984-03-15 00:00:00

  • Urine estrogens and breast cancer risk factors among post-menopausal women.

    abstract::Creatinine-adjusted levels of estrone, estradiol and estriol were determined in overnight urine specimens from 220 post-menopausal women, aged 54 to 66 years, from Boston (121 women) and Athens (99 women). The associations of individual and total estrogens with various characteristics of the women (age at menopause, y...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Trichopoulos D,Brown J,MacMahon B

    更新日期:1987-12-15 00:00:00

  • Significance of the expression of major histocompatibility complex class II antigen, HLA-DR and -DQ, with recurrence of papillary thyroid cancer.

    abstract::Normal thyroid epithelial cells lack major histocompatibility complex (MHC) Class II antigen. Oncogenic kinases involved in papillary thyroid carcinoma (PTC) trigger the expression of Class II transactivator and MHC Class II complex. However, the relationship between MHC Class II antigen expression and clinical outcom...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Jo YS,Lee JC,Li S,Choi YS,Bai YS,Kim YJ,Lee IS,Rha SY,Ro HK,Kim JM,Shong M

    更新日期:2008-02-15 00:00:00

  • Epigenetic silencing of the candidate tumor suppressor gene PROX1 in sporadic breast cancer.

    abstract::Extensive hypermethylation and consecutive transcriptional silencing of tumorsuppressor genes have been documented in multiple tumor entities including breast cancer. In a microarray based genome-wide methylation analysis of five sporadic breast carcinomas we identified a hypermethylated CpG island within the first in...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Versmold B,Felsberg J,Mikeska T,Ehrentraut D,Köhler J,Hampl JA,Röhn G,Niederacher D,Betz B,Hellmich M,Pietsch T,Schmutzler RK,Waha A

    更新日期:2007-08-01 00:00:00

  • No evidence for simian virus 40 DNA sequences in malignant non-Hodgkin lymphomas.

    abstract::DNA sequences coding for simian virus 40 (SV40) large T antigen have been detected at different frequencies in human non-Hodgkin's lymphomas (NHL) by PCR techniques as well as immunohistochemistry. A highly sensitive quantitative real-time PCR specific for a sequence of SV40 large T antigen was established to test whe...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Schüler F,Dölken SC,Hirt C,Dölken MT,Mentel R,Gürtler LG,Dölken G

    更新日期:2006-01-15 00:00:00

  • Blood monocytes sample MelanA/MART1 antigen for long-lasting cross-presentation to CD8+ T cells after differentiation into dendritic cells.

    abstract::Human blood monocytes are very potent to take up antigens. Like macrophages in tissue, they efficiently degrade exogenous protein and are less efficient than dendritic cells (DCs) at cross-presenting antigens to CD8+ T cells. Although it is generally accepted that DCs take up tissue antigens and then migrate to lymph ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Faure F,Jouve M,Lebhar-Peguillet I,Sadaka C,Sepulveda F,Lantz O,Berre S,Gaudin R,Sánchez-Ramón S,Amigorena S

    更新日期:2018-01-01 00:00:00

  • Oxidative inhibition of Hsp90 disrupts the super-chaperone complex and attenuates pancreatic adenocarcinoma in vitro and in vivo.

    abstract::Pancreatic cancer is almost always fatal, in part because of its delayed diagnosis, poor prognosis, rapid progression and chemoresistance. Oncogenic proteins are stabilized by the Hsp90, making it a potential therapeutic target. We investigated the oxidative stress-mediated dysfunction of Hsp90 and the hindrance of it...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sarkar S,Dutta D,Samanta SK,Bhattacharya K,Pal BC,Li J,Datta K,Mandal C,Mandal C

    更新日期:2013-02-01 00:00:00

  • Surface markers on human B and T-lymphocytes. IX. Two-color immunofluorescence studies on the association between ebv receptors and complement receptors on the surface of lymphoid cell lines.

    abstract::Receptors for the third component of complement (C3) were demonstrated on the surface of established human lymphoid cell lines by a membrane fluorescence test with FITC- or TRITC-conjugated antibodies against human C3. Two-color fluorescence staining of EBV receptors and C3 receptors showed complete overlapping of gre...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yefenof E,Klein G,Jondal M,Oldstone MB

    更新日期:1976-06-15 00:00:00

  • Potential lives saved in 73 countries by adopting multi-cohort vaccination of 9-14-year-old girls against human papillomavirus.

    abstract::Up to 2016, low- and middle-income countries mostly introduced routine human papillomavirus (HPV) vaccination for just a single age-cohort of girls each year. However, high-income countries have reported large reductions in HPV prevalence following "catch-up" vaccination of multiple age-cohorts in the year of HPV vacc...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Jit M,Brisson M

    更新日期:2018-07-15 00:00:00

  • Role of the genetic background of rats in infection by HTLV-I and HTLV-II and in the development of associated diseases.

    abstract::Three aspects of the rat model of HTLV-I/II infection were investigated. (i) The efficacy of HTLV-I-transformed rat cell lines in infecting different strains of rats: WKY and Lewis HTLV-I-transformed cell lines were injected into adult WKY, Lewis and Brown Norway rats, representing syngeneic and allogeneic combination...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kazanji M,Ibrahim F,Fiette L,Bomford R,De Thé G

    更新日期:1997-09-26 00:00:00

  • Activity of retinoic acid receptor-gamma selectively binding retinoids alone and in combination with interferon-gamma in breast cancer cell lines.

    abstract::Retinoids modulate several cell functions and especially inhibit the growth of a wide variety of cells including breast cancer. Retinoic acid receptor-gamma (RAR-gamma) has been shown to mediate the antiproliferative activity of retinoids. To further test this hypothesis we examined the effects of different RAR-gamma ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Widschwendter M,Daxenbichler G,Culig Z,Michel S,Zeimet AG,Mörtl MG,Widschwendter A,Marth C

    更新日期:1997-05-02 00:00:00

  • Angiogenin promotes colorectal cancer metastasis via tiRNA production.

    abstract::Metastasis of colorectal cancer (CRC) is the leading cause of CRC-associated mortality. Angiogenin (ANG), a member of the ribonuclease A superfamily, not only activates endothelial cells to induce tumor angiogenesis, but also targets tumor cells to promote cell survival, proliferation and/or migration. However, its cl...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Li S,Shi X,Chen M,Xu N,Sun D,Bai R,Chen H,Ding K,Sheng J,Xu Z

    更新日期:2019-09-01 00:00:00

  • Human sulphotransferases are involved in the activation of aristolochic acids and are expressed in renal target tissue.

    abstract::Use of herbal preparations containing Aristolochia species has led to progressive nephropathy and urothelial cancer in humans. Analysis of DNA adducts formed in human target tissues and studies in animal models have pointed out a major role of the secondary plant metabolites, aristolochic acids, in these effects. Only...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Meinl W,Pabel U,Osterloh-Quiroz M,Hengstler JG,Glatt H

    更新日期:2006-03-01 00:00:00

  • Risk factors for endometrial cancer according to familial susceptibility.

    abstract::Endometrial cancer (EC) shares some environmental or genetic risk factors with colorectal cancer (CRC). It represents a risk factor for CRC. Furthermore, EC is the most frequent extracolonic neoplasm in HNPCC (hereditary nonpolyposis colorectal cancer) and, in this syndrome, it has the same inheritance pattern as CRC....

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fornasarig M,Campagnutta E,Talamini R,Franceschi S,Boz G,Scarabelli C,Andreaus CM,Scozzari G,Valentini M

    更新日期:1998-07-03 00:00:00

  • Ki-67 index enhances the prognostic accuracy of the urothelial superficial bladder carcinoma risk group classification.

    abstract::Approximately 80% of bladder tumors are urothelial superficial papillary carcinomas (USPC). Despite a generally good prognosis, these tumors have a strong propensity to recur and about 1/3 of them compared to disease progression. Histological assessment of these superficial tumors is not sufficiently discriminator in ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Santos L,Amaro T,Costa C,Pereira S,Bento MJ,Lopes P,Oliveira J,Criado B,Lopes C

    更新日期:2003-06-10 00:00:00

  • The MTHFR C677T and DeltaDNMT3B C-149T polymorphisms confer different risks for right- and left-sided colorectal cancer.

    abstract::Etiological risk factors for proximal (right-sided) colon cancers may be different to those of distal colon and rectal (left-sided) cancers if these tumors develop along distinct pathways. The CpG Island Methylator Phenotype (CIMP+) occurs in approximately 15% of colorectal cancers (CRC) and predominantly in the proxi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Iacopetta B,Heyworth J,Girschik J,Grieu F,Clayforth C,Fritschi L

    更新日期:2009-07-01 00:00:00

  • Heterogeneity of colon and rectum cancer incidence across 612 SEER counties, 2000-2014.

    abstract::Recent analyses have suggested decreases over time in colorectal cancer incidence at older ages (≥55 years) but increases at younger ages (20-54 years). Understanding the geographic heterogeneity of incidence facilitates resource allocation for potential interventions and advances our knowledge of differential etiolog...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chernyavskiy P,Kennerley VM,Jemal A,Little MP,Rosenberg PS

    更新日期:2019-04-15 00:00:00

  • The prevalence of antibody to p42 of HTLV-I among ATLL patients in comparison with healthy carriers in Japan.

    abstract::A gene product (p42) of the long open reading frame, now termed tax, of the viral genome of human T-cell leukemia virus type I (HTLV-I) may be related to the transformation of T cells in adult T-cell leukemia-lymphoma (ATLL). To evaluate its association with the disease, we compared the prevalence of antibody to p42 i...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yokota T,Cho MJ,Tachibana N,McLane MF,Takatsuki K,Lee TH,Mueller N,Essex M

    更新日期:1989-06-15 00:00:00

  • The effects of telomerase inhibition on prostate tumor-initiating cells.

    abstract::Prostate cancer is the most common malignancy in men, and patients with metastatic disease have poor outcome even with the most advanced therapeutic approaches. Most cancer therapies target the bulk tumor cells, but may leave intact a small population of tumor-initiating cells (TICs), which are believed to be responsi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Marian CO,Wright WE,Shay JW

    更新日期:2010-07-15 00:00:00

  • Knockout of the tetraspanin Cd9 in the TRAMP model of de novo prostate cancer increases spontaneous metastases in an organ-specific manner.

    abstract::Prostate cancer is an extremely heterogeneous disease; patients that do progress to late-stage metastatic prostate cancer have limited treatment options, mostly palliative. Molecules involved in the metastatic cascade may prove beneficial in stratifying patients to assign appropriate treatment modalities and may also ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Copeland BT,Bowman MJ,Boucheix C,Ashman LK

    更新日期:2013-10-15 00:00:00

  • Fractional allelic imbalance in human breast cancer increases with tetraploidization and chromosome loss.

    abstract::We have previously reported a complete allelotype study of 86 primary breast carcinomas, in which each non-acrocentric chromosome arm was studied with at least one polymorphic DNA-marker for the presence of allelic imbalance (AI, allelic loss or allelic gain) in the tumor. Here we report the statistical analysis of th...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Cornelisse CJ,Kuipers-Dijkshoorn N,van Vliet M,Hermans J,Devilee P

    更新日期:1992-02-20 00:00:00

  • Nutritional factors and pancreatic cancer in the francophone community in Montréal, Canada.

    abstract::In a population-based case-control study of dietary risk factors for pancreatic cancer, a total of 179 cases and 239 controls were interviewed between 1984 and 1988. This study demonstrated an increased risk of pancreas cancer associated with high levels of reported energy intake. After adjustment for age, sex, respon...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ghadirian P,Simard A,Baillargeon J,Maisonneuve P,Boyle P

    更新日期:1991-01-02 00:00:00

  • Circadian organization of thymidylate synthase activity in normal tissues: a possible basis for 5-fluorouracil chronotherapeutic advantage.

    abstract::Fluoropyrimidines induce cytotoxicity, in part, by inhibiting the proliferation-coordinated enzyme thymidylate synthase (TS), which is essential for DNA synthesis. Tumor TS levels are clinically predictive of post-surgical tumor recurrence and of response to fluoropyrimidine chemotherapy. Fluoropyrimidine drug toxicit...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lincoln DW 2nd,Hrushesky WJ,Wood PA

    更新日期:2000-11-01 00:00:00

  • Impact of p53-based immunization on primary chemically-induced tumors.

    abstract::In mice as well as humans, cytotoxic T lymphocytes (CTL) specific for wild-type-sequence (wt) p53 peptides have been shown to react against a wide range of tumors, but not normal cells. As such, they are attractive candidates for developing broadly applicable cancer vaccines. Of particular interest is the potential of...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Cicinnati VR,Dworacki G,Albers A,Beckebaum S,Tüting T,Kaczmarek E,DeLeo AB

    更新日期:2005-03-01 00:00:00

  • Evaluation of circulating EBV microRNA BART2-5p in facilitating early detection and screening of nasopharyngeal carcinoma.

    abstract::Nasopharyngeal carcinoma is an Epstein-Barr Virus (EBV) associated malignancy which is highly prevalent in Southeast Asia. EBV-related antibodies have been widely used as screening markers for early nasopharyngeal carcinoma (NPC) detection. However, due to its low positive predictive rate, it is essential to develop n...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Jiang C,Chen J,Xie S,Zhang L,Xiang Y,Lung M,Kam NW,Kwong DL,Cao S,Guan XY

    更新日期:2018-12-15 00:00:00

  • H-Ras selectively up-regulates MMP-9 and COX-2 through activation of ERK1/2 and NF-kappaB: an implication for invasive phenotype in rat liver epithelial cells.

    abstract::One of the most frequent events in carcinogenesis is uncontrolled activation of Ras signaling pathway. A previous study demonstrated that the introduction of H-Ras into the normal WB-F344 rat liver epithelial (WB) cell line and adult male F344 rats resulted in tumorigenicity. The present study investigated whether H-R...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lee KW,Kim MS,Kang NJ,Kim DH,Surh YJ,Lee HJ,Moon A

    更新日期:2006-10-15 00:00:00

  • Concomitant increase of LMP1 and CD25 (IL-2-receptor alpha) expression induced by IL-10 in the EBV-positive NK lines SNK6 and KAI3.

    abstract::Extranodal, nasal NK/T-cell lymphomas are regularly Epstein-Barr virus (EBV)-positive, with a type II latency pattern, expressing thus EBNA-1 and LMP1. The contribution of EBV to the tumor development is not known. Similarly to normal natural killer (NK) cells, cell lines derived from malignancies with a NK phenotype ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Takahara M,Kis LL,Nagy N,Liu A,Harabuchi Y,Klein G,Klein E

    更新日期:2006-12-15 00:00:00