Abstract:
:Monocytes from the peripheral blood of 10 normal adult human donors were tested for their cytolytic activity on untransformed or SV40-transformed, early passage, human fibroblasts. Two pairs of human fibroblast lines (2303 and SV40-2303, 2931 and SV40-2931) were used and lysis was assessed in terms of release of [3H]thymidine from prelabelled target cells over a 72-h incubation period. High levels of cytolytic activity were consistently observed on transformed fibroblasts at attacker to target cell (A:T) ratios ranging from 5:1 to 40:1. Low, but significant, lysis of untransformed cells was observed only with two donors at the highest (40:1) A:T ratio tested. With all donors, the cytolytic activity on transformed lines was significantly greater than on untransformed fibroblasts. Thus natural human monocyte-mediated cytotoxicity is preferentially expressed on transformed, as compared to untransformed, cells although sparing of the latter is not absolute.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Mantovani A,Tagliabue A,Dean JH,Jerrells TR,Herberman RBdoi
10.1002/ijc.2910230106subject
Has Abstractpub_date
1979-01-15 00:00:00pages
28-31issue
1eissn
0020-7136issn
1097-0215journal_volume
23pub_type
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