Loss of expression of the tumour suppressor gene AIMP3 predicts survival following radiotherapy in muscle-invasive bladder cancer.


:The aim of this study was to test the utility of AIMP3, an upstream regulator of DNA damage response following genotoxic stress, as a clinical biomarker in muscle-invasive bladder cancer (MIBC). AIMP3 was identified from a meta-analysis of a global gene-expression dataset. AIMP3 protein expression was determined by immunohistochemistry on a customised bladder cancer tissue-microarray (TMA). The mechanism of gene silencing was probed using methylation-specific PCR. The association between AIMP3 expression, Tp53 transactivity and genomic stability was analysed. In vitro AIMP3 translocation to the nucleus in response to ionising radiation was demonstrated using immunofluorescence. Radiosensitisation effects of siRNA-mediated AIMP3-knockdown were measured using colony forming assays. TMAs derived from patients enrolled in BCON, a Phase III multicentre radiotherapy trial in bladder cancer (ISRCTN45938399) were used to evaluate the association between AIMP3 expression and survival. The prognostic value of AIMP3 expression was determined in a TMA derived from patients treated by radical cystectomy. Loss of AIMP3 expression was frequent in MIBC and associated with impaired Tp53 transactivity and genomic instability. AIMP3-knockdown was associated with an increase in radioresistance. Loss of AIMP3 expression was associated with survival in MIBC patients following radiotherapy (HR = 0.53; 95% CI: 0.36 to 0.78, p = 0.002) but was not prognostic in the cystectomy set. In conclusion, AIMP3 expression is lost in a subset of bladder cancers and is significantly predictive of survival following radiotherapy in MIBC patients.


Int J Cancer


Gurung PM,Veerakumarasivam A,Williamson M,Counsell N,Douglas J,Tan WS,Feber A,Crabb SJ,Short SC,Freeman A,Powles T,Hoskin PJ,West CM,Kelly JD




Has Abstract


2015-02-01 00:00:00












  • Selective occlusion of tumor blood vessels by targeted delivery of an antibody-photosensitizer conjugate.

    abstract::The irregular vasculature and high interstitial pressure of solid tumors hinder the delivery of cytotoxic agents to cancer cells. As a consequence, the doses of chemotherapy necessary to achieve complete tumor eradication are associated with unacceptably high toxicities. The selective thrombosis of tumor blood vessels...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fabbrini M,Trachsel E,Soldani P,Bindi S,Alessi P,Bracci L,Kosmehl H,Zardi L,Neri D,Neri P

    更新日期:2006-04-01 00:00:00

  • Transactivation of MCP-1/CCL2 by beta-catenin/TCF-4 in human breast cancer cells.

    abstract::The loss of E-cadherin expression and the translocation of beta-catenin to the nucleus are frequently associated with the metastatic conversion of epithelial cells. In the nucleus, beta-catenin binds to the TCF/LEF-1 (T-cell factor/ lymphoid enhancer factor) transcription factor family resulting in the activation of s...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mestdagt M,Polette M,Buttice G,Noël A,Ueda A,Foidart JM,Gilles C

    更新日期:2006-01-01 00:00:00

  • Methodological issues in international comparison of interval breast cancers.

    abstract::International comparisons of interval cancers (IC) are important to better understand the relationship between programmes' performance and screening practices. In this respect, differences in (i) definition, (ii) identification and (iii) quantification of IC have received little attention. To examine these 3 comparabi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bulliard JL,Sasieni P,Klabunde C,De Landtsheer JP,Yankaskas BC,Fracheboud J

    更新日期:2006-09-01 00:00:00

  • Cell cycle-related kinase supports ovarian carcinoma cell proliferation via regulation of cyclin D1 and is a predictor of outcome in patients with ovarian carcinoma.

    abstract::Our previous study has suggested that the cell cycle-related kinase (CCRK) is a putative candidate oncogene in glioblastoma tumorigenesis. The potential oncogenic role of CCRK and its clinical/prognostic significance, however, in ovarian carcinoma are unclear. In this study, CCRK expression was examined by immunohisto...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wu GQ,Xie D,Yang GF,Liao YJ,Mai SJ,Deng HX,Sze J,Guan XY,Zeng YX,Lin MC,Kung HF

    更新日期:2009-12-01 00:00:00

  • FGF-2 isoforms of 18 and 22.5 kDa differentially modulate t-PA and PAI-1 expressions on the pancreatic carcinoma cells AR4-2J: consequences on cell spreading and invasion.

    abstract::Pancreatic tumors overexpress FGF-2 and t-PA, but the implication of the growth factor in t-PA synthesis and t-PA-dependent tumor invasion remains unknown. FGF-2 is present in different isoforms: The 18 kDa FGF-2 is secreted, while the 22.5 kDa one is nuclearized and exerts intracrine regulations bypassing cell-surfac...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Escaffit F,Estival A,Bertrand C,Vaysse N,Hollande E,Clemente F

    更新日期:2000-02-15 00:00:00

  • PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.

    abstract::ERK and RSK2 drive proliferation and invasion of many cancers. Phosphoprotein enriched in astrocytes 15 (PEA15) binds ERK and RSK2 and high PEA15 levels can impair ERK- and RSK2-dependent transcription. PEA15 expression also inversely correlates with cell motility and invasiveness. We therefore tested PEA15 effects on...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Gawecka JE,Geerts D,Koster J,Caliva MJ,Sulzmaier FJ,Opoku-Ansah J,Wada RK,Bachmann AS,Ramos JW

    更新日期:2012-10-01 00:00:00

  • Enhanced cathepsin L expression is mediated by different Ras effector pathways in fibroblasts and epithelial cells.

    abstract::Ras expression induces increased expression and altered targeting of lysosomal proteases in multiple cell types, but the specific downstream cytoplasmic signaling pathways mediating these changes have not been identified. In this study, we compared the involvement of 3 major Ras effectors, Raf, phosphatidylinositol 3-...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Collette J,Ulku AS,Der CJ,Jones A,Erickson AH

    更新日期:2004-11-01 00:00:00

  • DNA flow cytometry, nuclear morphometry, mitotic indices and steroid receptors as independent prognostic factors in female breast cancer.

    abstract::Clinical features, 8 histological variables, 7 nuclear morphometric variables, 2 mitotic indices, oestrogen-receptor (ER) and progesterone-receptor content (PR), DNA ploidy and S-phase fraction (SPF) were entered in a Cox's model to assess their independent predictive value in 216 breast-cancer patients followed up fo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Eskelinen M,Lipponen P,Papinaho S,Aaltomaa S,Kosma VM,Klemi P,Syrjänen K

    更新日期:1992-06-19 00:00:00

  • Pesticide exposure as risk factor for non-Hodgkin lymphoma including histopathological subgroup analysis.

    abstract::We report a population based case-control study of exposure to pesticides as risk factor for non-Hodgkin lymphoma (NHL). Male and female subjects aged 18-74 years living in Sweden were included during December 1, 1999, to April 30, 2002. Controls were selected from the national population registry. Exposure to differe...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Eriksson M,Hardell L,Carlberg M,Akerman M

    更新日期:2008-10-01 00:00:00

  • Ultrastructural evidence of collagenolytic activity in ductal infiltrating carcinoma of the human breast.

    abstract::The stroma of ductal infiltrating carcinoma of the human breast shows characteristic and localized areas of collagen rarefaction and fragmentation. This finding has been correlated with a peculiar type of fibrillar damage, observed in a small percentage of collagen fibrils isolated in the native state from the tumour ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Pucci-Minafra I,Luparello C,Schillaci R,Sciarrino S

    更新日期:1987-05-15 00:00:00

  • Enhancement by TPA of phenotypes associated with transformation in carcinogen-treated human cells: evidence for a selective mechanism.

    abstract::The tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) was found to increase the incidence of phenotypic alterations induced by the direct-acting carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in human endometrial stromal cells. Following carcinogen treatment, changes in saturation density, gamma-glutam...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Siegfried JM,Kaufman DG

    更新日期:1983-10-15 00:00:00

  • Differential expression of sphingolipids in MRP1 overexpressing HT29 cells.

    abstract::We have obtained a novel multidrug resistant cell line, derived from HT29 G(+) human colon carcinoma cells, by selection with gradually increasing concentrations of the anti-mitotic, microtubule-disrupting agent colchicine. This HT29(col) cell line displayed a 25-fold increase in colchicine resistance and exhibited cr...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kok JW,Veldman RJ,Klappe K,Koning H,Filipeanu CM,Müller M

    更新日期:2000-07-15 00:00:00

  • Physical activity and risk of renal cell cancer.

    abstract::The relation between physical activity and renal cell cancer is unclear. High occupational physical activity has been associated with a decreased risk of renal cell cancer among men-but not among women-in two previous studies, while no association has been found for leisure time physical activity. Our aim was to inves...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bergström A,Terry P,Lindblad P,Lichtenstein P,Ahlbom A,Feychting M,Wolk A

    更新日期:2001-04-01 00:00:00

  • Expression, subcellular localization and putative function of platelet-type 12-lipoxygenase in human prostate cancer cell lines of different metastatic potential.

    abstract::The involvement of 12-lipoxygenase (12-LOX) expression and function in tumor metastasis has been demonstrated in several murine tumor cell lines. In addition, 12-LOX expression was detected in human prostatic tumors and correlated to the clinical stage of disease. Here we provide data that human prostate cancer cell l...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Timár J,Rásó E,Döme B,Li L,Grignon D,Nie D,Honn KV,Hagmann W

    更新日期:2000-07-01 00:00:00

  • Apoptotic body-loaded dendritic cells efficiently cross-prime cytotoxic T lymphocytes specific for NA17-A antigen but not for Melan-A/MART-1 antigen.

    abstract::DCs hold promise for cancer immunotherapy due to their functional ambivalence: iDCs internalize antigens, then mDCs trigger naive T-cell activation. However, no consensus has been reached concerning the optimal mode of antigen acquisition for efficient cross-priming of TAA-specific CTLs, and this remains a field of in...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Labarrière N,Bretaudeau L,Gervois N,Bodinier M,Bougras G,Diez E,Lang F,Gregoire M,Jotereau F

    更新日期:2002-09-20 00:00:00

  • Evaluation of circulating EBV microRNA BART2-5p in facilitating early detection and screening of nasopharyngeal carcinoma.

    abstract::Nasopharyngeal carcinoma is an Epstein-Barr Virus (EBV) associated malignancy which is highly prevalent in Southeast Asia. EBV-related antibodies have been widely used as screening markers for early nasopharyngeal carcinoma (NPC) detection. However, due to its low positive predictive rate, it is essential to develop n...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Jiang C,Chen J,Xie S,Zhang L,Xiang Y,Lung M,Kam NW,Kwong DL,Cao S,Guan XY

    更新日期:2018-12-15 00:00:00

  • Enhanced expression of human T-cell leukemia/lymphoma virus in neoplastic T cells induced to proliferate by phorbol ester and interleukin-2.

    abstract::Peripheral blood T cells from a patient with T-cell chronic lymphocytic leukemia (T-CLL) failed to respond to mitogenic lectins or alloantigens but could be induced to proliferate by the addition of exogenous interleukin-2 (IL-2). The T-CLL cells also proliferated in response to 12-O-tetradecanoyl phorbol-13-acetate (...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Vyth-Dreese FA,de Vries JE

    更新日期:1983-07-15 00:00:00

  • Potentiation of the anti-tumor effect of actinomycin D by tumor necrosis factor alpha in mice: correlation between in vitro and in vivo results.

    abstract::The anti-tumor effects of actinomycin D (Act D) and recombinant human tumor necrosis factor (TNF)-alpha have been studied on 4 established murine tumor cell lines: MmB16 melanoma, Lewis lung (LL/2) carcinoma, L1 sarcoma and L1210 leukemia. During short-term incubation (24 hr) Act D produced dose-dependent cytostatic/c...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lasek W,Giermasz A,Kuc K,Wańkowicz A,Feleszko W,Gołab J,Zagozdzon R,Stokłosa T,Jakóbisiak M

    更新日期:1996-05-03 00:00:00

  • Global trends in oral and pharyngeal cancer incidence and mortality.

    abstract::To provide an up-to-date overview of recent trends in mortality from oral and pharyngeal cancer, we analyzed death certification data for 61 countries worldwide provided by the World Health Organization in 2010-2015, and, for selected most populous countries, over the period 1970-2016. For 12 largest countries, we ana...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bosetti C,Carioli G,Santucci C,Bertuccio P,Gallus S,Garavello W,Negri E,La Vecchia C

    更新日期:2020-08-15 00:00:00

  • Expression of the macrophage antigen CD163 in rectal cancer cells is associated with early local recurrence and reduced survival time.

    abstract::Expression of the macrophage antigen CD163 in breast cancer cells is recently shown to be related to early distant recurrence and shortened survival. In this study, 163 patients with rectal cancer, included in the Swedish rectal cancer trial and followed up for a median of 71 months, were examined for the expression o...

    journal_title:International journal of cancer

    pub_type: 杂志文章,随机对照试验


    authors: Shabo I,Olsson H,Sun XF,Svanvik J

    更新日期:2009-10-15 00:00:00

  • HS3ST2 modulates breast cancer cell invasiveness via MAP kinase- and Tcf4 (Tcf7l2)-dependent regulation of protease and cadherin expression.

    abstract::Heparan sulfate 3-O-sulfotransferase 2 (HS3ST2), an enzyme mediating 3-O-sulfation of heparan sulfate (HS), is silenced by hypermethylation in breast cancer. As HS has an important co-receptor function for numerous signal transduction pathways, the phenotypical changes due to HS3ST2 reexpression were investigated in v...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Vijaya Kumar A,Salem Gassar E,Spillmann D,Stock C,Sen YP,Zhang T,Van Kuppevelt TH,Hülsewig C,Koszlowski EO,Pavao MS,Ibrahim SA,Poeter M,Rescher U,Kiesel L,Koduru S,Yip GW,Götte M

    更新日期:2014-12-01 00:00:00

  • Hypermethylation of the MYF-3 gene in colorectal cancers: associations with pathological features and with microsatellite instability.

    abstract::Myf-3 is the human homologue of the murine Myo-D1 gene involved in muscle-cell differentiation. Using Southern blot analysis, we examined methylation of Myf-3 in histologically normal colonic mucosae, adenomas and carcinomas from a large series of patients with primary colorectal cancer. Hypermethylation of this gene ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Shannon B,Kay P,House A,Iacopetta B

    更新日期:1999-04-20 00:00:00

  • Inhibition of nuclear factor kappab activity by genistein is mediated via Notch-1 signaling pathway in pancreatic cancer cells.

    abstract::Pancreatic cancer remains the fourth most common cause of cancer related death in the United States. Therefore, novel strategies for the prevention and treatment are urgently needed. Genistein is a prominent isoflavonoid found in soy products and has been proposed to be responsible for lowering the rate of pancreatic ...

    journal_title:International journal of cancer

    pub_type: 杂志文章,收录出版


    authors: Wang Z,Zhang Y,Banerjee S,Li Y,Sarkar FH

    更新日期:2006-04-15 00:00:00

  • Isolation and analysis of two strongly transforming isoforms of the Epstein-Barr-Virus(EBV)-encoded latent membrane protein-1 (LMP1) from a single Hodgkin's lymphoma.

    abstract::Two genes encoding the latent membrane protein 1 (LMP1) of the Epstein-Barr virus (EBV) were isolated from a single case of Hodgkin's disease (HD) and were tested for their biological activities. The LMP1 gene from the Reed-Sternberg cells contained point mutations relative to the prototype LMP1 gene, leading to amino...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mehl AM,Fischer N,Rowe M,Hartmann F,Daus H,Trümper L,Pfreundschuh M,Müller-Lantzsch N,Grässer FA

    更新日期:1998-04-13 00:00:00

  • Pharmacokinetics, pharmacodynamics and efficacy on pediatric tumors of the glioma radiosensitizer KU60019.

    abstract::We have recently reported that glioblastoma (GB)-initiating cells (GIC) with low expression and/or mutation of TP53 and high expression of PI3K ("responder" genetic profile) can be effectively and safely radiosensitized by the ATM inhibitor KU60019. We report here on drug's diffusion and elimination from the animal bo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Vecchio D,Daga A,Carra E,Marubbi D,Raso A,Mascelli S,Nozza P,Garrè ML,Pitto F,Ravetti JL,Vagge S,Corvò R,Profumo A,Baio G,Marcello D,Frosina G

    更新日期:2015-03-15 00:00:00

  • New pharmacological effect of fulvestrant to prevent oxaliplatin-induced neurodegeneration and mechanical allodynia in rats.

    abstract::Oxaliplatin, which is widely used as chemotherapy for certain solid cancers, frequently causes peripheral neuropathy. Commonly described neuropathic symptoms include aberrant sensations such as mechanical allodynia (hypersensitivity to normally innocuous stimuli). Although oxaliplatin neuropathy is a dose-limiting tox...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yamamoto S,Yamashita T,Ito M,Caaveiro JMM,Egashira N,Tozaki-Saitoh H,Tsuda M

    更新日期:2019-10-15 00:00:00

  • Colibactin-positive Escherichia coli induce a procarcinogenic immune environment leading to immunotherapy resistance in colorectal cancer.

    abstract::Colibactin-producing E. coli (CoPEC) are frequently detected in colorectal cancer (CRC) and exhibit procarcinogenic properties. Because increasing evidence show the role of immune environment and especially of antitumor T-cells in CRC development, we investigated the impact of CoPEC on these cells in human CRC and in ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lopès A,Billard E,Casse AH,Villéger R,Veziant J,Roche G,Carrier G,Sauvanet P,Briat A,Pagès F,Naimi S,Pezet D,Barnich N,Dumas B,Bonnet M

    更新日期:2020-06-01 00:00:00

  • HSP90 inhibitor AUY922 abrogates up-regulation of RTKs by mTOR inhibitor AZD8055 and potentiates its antiproliferative activity in human breast cancer.

    abstract::mTOR inhibition led to activation of upstream receptor tyrosine kinases (RTKs) and AKT, which may attenuate the efficacy of mTOR kinase inhibitors. We sought to discover efficient drug combination with mTOR inhibitors by elucidating the survival feedback loops induced by mTOR inhibition in breast cancer. The feedback ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chen SM,Guo CL,Shi JJ,Xu YC,Chen Y,Shen YY,Su Y,Ding J,Meng LH

    更新日期:2014-11-15 00:00:00

  • Antagonism of chemokine receptor CXCR3 inhibits osteosarcoma metastasis to lungs.

    abstract::Metastasis continues to be the leading cause of mortality for patients with cancer. Several years ago, it became clear that chemokines and their receptors could control the tumor progress. CXCR3 has now been identified in many cancers including osteosarcoma and CXCR3 ligands were expressed by lungs that are the primar...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Pradelli E,Karimdjee-Soilihi B,Michiels JF,Ricci JE,Millet MA,Vandenbos F,Sullivan TJ,Collins TL,Johnson MG,Medina JC,Kleinerman ES,Schmid-Alliana A,Schmid-Antomarchi H

    更新日期:2009-12-01 00:00:00

  • Microsatellite alterations and p53, TGFbetaRII, IGFIIR and BAX mutations in sporadic non-small-cell lung cancer.

    abstract::Fifty-two sporadic primary non-small-cell lung carcinomas (NSCLC) were examined for microsatellite instability. Six different microsatellite markers localized on chromosomes 2, 5, 8, 10, 11 and 17 were used. Genomic instability was observed in 35% (18/52) of NSCLC at single or multiple loci. The tumors were also analy...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Caligo MA,Ghimenti C,Marchetti A,Lonobile A,Buttitta F,Pellegrini S,Bevilacqua G

    更新日期:1998-11-23 00:00:00