An in vitro model of intra-epithelial expansion of transformed urothelial cells.

abstract：:Antitumor immunity in chronic lymphocytic leukemia (CLL) is hampered by highly dysfunctional T-cells. Although certain T-cell subsets have been reported to be of prognostic significance in this disease, their interplay is complex and it remains incompletely understood which of these subsets significantly drive CLL pro...

journal_title：International journal of cancer

authors： Rissiek A,Schulze C,Bacher U,Schieferdecker A,Thiele B,Jacholkowski A,Flammiger A,Horn C,Haag F,Tiegs G,Zirlik K,Trepel M,Tolosa E,Binder M

更新日期：2014-11-15 00:00:00

abstract：:Proteins can be detected by South-western analyses of human tumour-cell extracts binding to double-stranded oligonucleotide DNA treated in vitro with the chemotherapeutic drug cis-diamminedichloroplatinum (II) (CDDP), but not to untreated DNA. The relative molecular masses of proteins binding to the CDDP-treated doubl...

journal_title：International journal of cancer

authors： McLaughlin K,Coren G,Masters J,Brown R

更新日期：1993-02-20 00:00:00

abstract：:Thymidylate synthase (TYMS) is an important enzyme for 5-fluorouracil (5-FU) metabolism in metastatic colorectal cancer (mCRC) patients. The search for this enzyme in circulating tumor cells (CTCs) can be a powerful tool to follow-up cancer patients. mCRC patients were enrolled before the beginning of 5-FU-based chemo...

journal_title：International journal of cancer

authors： Abdallah EA,Fanelli MF,Buim ME,Machado Netto MC,Gasparini Junior JL,Souza E Silva V,Dettino AL,Mingues NB,Romero JV,Ocea LM,Rocha BM,Alves VS,Araújo DV,Chinen LT

更新日期：2015-09-15 00:00:00

abstract：:In an ongoing case-control study in Athens on the etiology of hepatocellular carcinoma (HCC), an analysis was made in order to assess whether HCV genotype 1b is associated with hepatocellular carcinoma (HCC). The HCV genotype was determined in 17 HCC patients, 87 patients with chronic hepatitis C (CHC) without cirrhos...

journal_title：International journal of cancer

authors： Hatzakis A,Katsoulidou A,Kaklamani E,Touloumi G,Koumantaki Y,Tassopoulos NC,Karvountzis G,Gioustozi A,Hadziyannis S,Trichopoulos D

更新日期：1996-09-27 00:00:00

abstract：:Homeobox-containing genes are a network of genes encoding DNA-binding proteins highly conserved throughout evolution. They are involved in the control of normal development as well as in the regulation of gene expression in adult differentiating systems, including hematopoiesis. Aberrant expression of homeobox-contain...

journal_title：International journal of cancer

authors： Celetti A,Barba P,Cillo C,Rotoli B,Boncinelli E,Magli MC

更新日期：1993-01-21 00:00:00

abstract：:Current evidence suggests poor identification and referral of Lynch syndrome patients. This study evaluated the strategies by which patients with endometrial cancer were referred to genetics services. Data from clinic-based patients with endometrial cancer enrolled through the Australian National Endometrial Cancer po...

journal_title：International journal of cancer

authors： Tan YY,McGaughran J,Ferguson K,Walsh MD,Buchanan DD,Young JP,Webb PM,Obermair A,Spurdle AB,ANECS Group.

更新日期：2013-06-15 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in variety of cancer cells without affecting most normal cells, which makes it a promising agent for cancer therapy. However, TRAIL therapy is clinically not effective due to resistance induction. To identify novel regulators of TRAIL th...

journal_title：International journal of cancer

authors： Thapa B,Bahadur Kc R,Uludağ H

更新日期：2018-02-01 00:00:00

abstract：:There is little long-term follow-up information about how the number of melanoma deaths and case fatality vary over time according to the measured thickness of melanoma at diagnosis. This population-based longitudinal cohort study examines patterns and trends in case fatality among 44,531 people in Queensland (Austral...

journal_title：International journal of cancer

authors： Baade PD,Whiteman DC,Janda M,Cust AE,Neale RE,Smithers BM,Green AC,Khosrotehrani K,Mar V,Soyer HP,Aitken JF

更新日期：2020-09-01 00:00:00

abstract：:Chicken anemia virus viral protein 3 (VP3 or apoptin) localizes more efficiently in the nucleus of transformed than nontransformed cells. Although previous studies implicate the C-terminus of apoptin as being responsible, the molecular basis is controversial, and the extent to which altered nuclear transport efficienc...

journal_title：International journal of cancer

authors： Kuusisto HV,Wagstaff KM,Alvisi G,Jans DA

更新日期：2008-12-15 00:00:00

abstract：:We analyzed the role of reproductive factors on the risk of endometrial cancer using data from a case-control study conducted in Italy. Cases were 752 women with histologically confirmed endometrial cancer < 75 years of age. Controls were 2,606 patients < 75 years of age admitted for acute, non-gynecological non-hormo...

journal_title：International journal of cancer

authors： Parazzini F,Negri E,La Vecchia C,Benzi G,Chiaffarino F,Polatti A,Francheschi S

更新日期：1998-06-10 00:00:00

abstract：:To assess long-term trends in the prevalence of oncogenic human papillomavirus (HPV) infection, we performed a cross-sectional serosurvey of the seroprevalence of the major oncogenic HPV type, HPV16, among 3,512 pregnant women undergoing population-based serological screening at the first trimester of pregnancy in the...

journal_title：International journal of cancer

authors： af Geijersstam V,Wang Z,Lewensohn-Fuchs I,Eklund C,Schiller JT,Forsgren M,Dillner J

更新日期：1998-05-04 00:00:00

abstract：:High BMI is a well-known risk factor for postmenopausal breast cancer. There have been some reports of excess risk in association with weight gain and WHR, but little is known about the influence of body fatness per se. Using data from the Malmö Diet and Cancer Study, a prospective cohort study, 12,159 postmenopausal ...

journal_title：International journal of cancer

authors： Lahmann PH,Lissner L,Gullberg B,Olsson H,Berglund G

更新日期：2003-01-10 00:00:00

abstract：:Seven human ocular melanoma cell lines were established in vitro and 3 of these, GU-4, LLN-40 and its subline C17-11, were characterized. Mice were immunized with these ocular melanoma cell lines, and 2 hybridomas producing monoclonal IgG1 antibodies (MAb) were produced. MAb 2/10SN recognizes a 44-kDa monomeric protei...

journal_title：International journal of cancer

authors： Safi N,Kantor RR,Atkinson B,Moratz C,Wilt AR,Pancake S,Reba R,Mathieson BJ,Desgrez A

更新日期：1992-07-09 00:00:00

abstract：:A cyclin-dependent kinase inhibitor CDKN2A (p16/Ink4a) is a tumor suppressor and upregulated in cellular senescence. CDKN2A promoter methylation and gene silencing are associated with the CpG island methylator phenotype (CIMP) in colon cancer. However, prognostic significance of CDKN2A methylation or loss of CDKN2A (p...

journal_title：International journal of cancer

authors： Shima K,Nosho K,Baba Y,Cantor M,Meyerhardt JA,Giovannucci EL,Fuchs CS,Ogino S

更新日期：2011-03-01 00:00:00

abstract：:Using differential screening of a breast cancer cDNA library, we isolated a cDNA encoding the psoriasin (S100A7) protein, previously identified in psoriatic epidermis. In the present study, we demonstrate that the psoriasin gene is expressed in breast cancer cell lines and in cancer cells of some breast carcinomas but...

journal_title：International journal of cancer

authors： Moog-Lutz C,Bouillet P,Régnier CH,Tomasetto C,Mattei MG,Chenard MP,Anglard P,Rio MC,Basset P

更新日期：1995-10-09 00:00:00

abstract：:In a series of 135 patients with renal-cell carcinomas (followed up for a mean of 9.5 years), a variety of clinical and histological factors were analyzed in relation to morphometric measurements of the nuclear parameters in the primary tumours to establish their value as prognostic factors. Clinical, histological and...

journal_title：International journal of cancer

authors： Eskelinen M,Lipponen P,Aitto-Oja L,Hall O,Syrjänen K

更新日期：1993-10-21 00:00:00

abstract：:Bladder cancer-associated protein (BLCAP) is a highly conserved protein among species, and it is considered a novel candidate tumor suppressor gene originally identified from human bladder carcinoma. However, little is known about the regulation or the function of this protein. Here, we show that the human BLCAP trans...

journal_title：International journal of cancer

authors： Galeano F,Leroy A,Rossetti C,Gromova I,Gautier P,Keegan LP,Massimi L,Di Rocco C,O'Connell MA,Gallo A

更新日期：2010-07-01 00:00:00

abstract：:There is growing evidence suggesting that cytotoxic activity of cisplatin is closely associated with increased generation of reactive oxygen species (ROS). Therefore, this study was undertaken to examine oxidative DNA damage, which arises as a result of chemotherapy with cisplatin. Using HPLC prepurification/isotope d...

journal_title：International journal of cancer

authors： Siomek A,Tujakowski J,Gackowski D,Rozalski R,Foksinski M,Dziaman T,Roszkowski K,Olinski R

更新日期：2006-11-01 00:00:00

abstract：:We report the relative frequency of sucrase-isomaltase (SI) antigen expression in human colonic adenocarcinoma (22/57), in peritumoral mucosa taken next to the tumor (31/41) or distant from it (29/42) as well as in 21/23 polyps. Our results are based on indirect immunofluorescence with a monoclonal antibody (MAb) spec...

journal_title：International journal of cancer

authors： Czernichow B,Simon-Assmann P,Kedinger M,Arnold C,Parache M,Marescaux J,Zweibaum A,Haffen K

更新日期：1989-08-15 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta1) is a potent negative regulator of cell growth that transduces signals through interactions with type I and II receptors. Abnormal expression and mutational alterations of these receptors have been observed in several human malignancies. In this study, we investigated the exp...

journal_title：International journal of cancer

authors： Guo Y,Jacobs SC,Kyprianou N

更新日期：1997-05-16 00:00:00

abstract：:The aim of our study was to develop and validate a machine learning algorithm to predict response of individual HER2-amplified colorectal cancer liver metastases (lmCRC) undergoing dual HER2-targeted therapy. Twenty-four radiomics features were extracted after 3D manual segmentation of 141 lmCRC on pretreatment portal...

journal_title：International journal of cancer

authors： Giannini V,Rosati S,Defeudis A,Balestra G,Vassallo L,Cappello G,Mazzetti S,De Mattia C,Rizzetto F,Torresin A,Sartore-Bianchi A,Siena S,Vanzulli A,Leone F,Zagonel V,Marsoni S,Regge D

更新日期：2020-12-01 00:00:00

abstract：:Risk factors for pancreatic cancer, other than smoking and diabetes, are not well-established, especially for women. In a cohort of 1.3 million middle-aged women, followed for 9.2 million person-years for cancer incidence and 11.5 million person-years for mortality, there were 1,338 incident pancreatic cancer cases an...

journal_title：International journal of cancer

authors： Stevens RJ,Roddam AW,Spencer EA,Pirie KL,Reeves GK,Green J,Beral V,Million Women Study Collaborators.

更新日期：2009-05-15 00:00:00

abstract：:Tobacco-related carcinogens cause a variety of DNA damage that is repaired by different enzymatic pathways, suggesting that DNA repair plays an important role in tobacco-induced carcinogenesis. In a large hospital-based case-control study, we investigated DNA repair capacity (DRC) as a biomarker for susceptibility to ...

journal_title：International journal of cancer

authors： Shen H,Spitz MR,Qiao Y,Guo Z,Wang LE,Bosken CH,Amos CI,Wei Q

更新日期：2003-10-20 00:00:00

abstract：:MicroRNAs (mirs) are small noncoding RNA molecules (~22 nucleotides) that regulate posttranscriptional gene expression. Currently, there has not been a comprehensive study of their role in primary head and neck squamous cell carcinoma (HNSCC). To determine the role of mirs in HNSCC, we screened for altered microRNA ex...

journal_title：International journal of cancer

authors： Chang SS,Jiang WW,Smith I,Poeta LM,Begum S,Glazer C,Shan S,Westra W,Sidransky D,Califano JA

更新日期：2008-12-15 00:00:00

abstract：:Changes in the expression of a cell membrane antigen during hepatocarcinogenesis and in the developing liver were analyzed by HAM.4, a monoclonal antibody (MAb) against a membrane glycoprotein of normal rat hepatocyte. Of the precancerous lesions observed during hepatocarcinogenesis induced by diethylnitrosamine, 2-ac...

journal_title：International journal of cancer

authors： Matsumoto M,Tamakoshi K,Kanai K,Kako M,Fukumoto T

更新日期：1988-04-15 00:00:00

abstract：:The red bone marrow (BM) is an important indicator organ of hematogenous micrometastatic spread of carcinomas. Characterization of biological properties specific for BM micrometastatic cells, however, is technically challenging due to the limited number of target cells usually available for the purpose. This report pr...

journal_title：International journal of cancer

authors： Ree AH,Engebraaten O,Hovig E,Fodstad Ø

更新日期：2002-01-01 00:00:00

abstract：:Specific estrogen, progesterone and androgen receptors were determined in 19 well-characterized squamous-cell carcinoma (SCC) cell lines. Ten of the lines were derived from patients with SCC of the larynx and nine were from patients with SCC originating in other areas of the head and neck. Estrogen receptors (ER) were...

journal_title：International journal of cancer

authors： Virolainen E,Vanharanta R,Carey TE

更新日期：1984-01-15 00:00:00

abstract：:The inhibitory effects of novel prodrugs, inclusion complexes of 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid (GOFA) and auraptene (AUR) with beta-cyclodextrin (CD), on colon carcinogenesis were investigated using an azoxymethane (AOM)/dextran sodium sulfate (DSS) model. Male CD-1 (ICR) mice initiated wit...

journal_title：International journal of cancer

authors： Tanaka T,de Azevedo MB,Durán N,Alderete JB,Epifano F,Genovese S,Tanaka M,Tanaka T,Curini M

更新日期：2010-02-15 00:00:00

abstract：:Human germ cell tumors comprise a heterogeneous group of neoplasms. Those of the adult testis, known as TGCTs, originate from carcinoma in situ (CIS), which are initiated during intra-uterine development. We present here a molecular model for the development of TGCTs, including various parameters, such as apoptosis, c...

journal_title：International journal of cancer

authors： Looijenga LH,de Munnik H,Oosterhuis JW

更新日期：1999-12-10 00:00:00

abstract：:In order to evaluate whether the SCID mouse can provide the microenvironment for the growth of human immature T-cell leukemias and if in vivo growth alters their phenotype, we examined the behavior of 3 well-characterized T-cell acute lymphoblastic leukemia (T-ALL)-derived T-cell lines which are at different stages of...

journal_title：International journal of cancer

authors： Uittenbogaart CH,Anisman DJ,Tary-Lehmann M,Vollger LW,Breit TM,Van Dongen JJ,Saxon A

更新日期：1994-02-15 00:00:00