Abstract:
:There is growing evidence suggesting that cytotoxic activity of cisplatin is closely associated with increased generation of reactive oxygen species (ROS). Therefore, this study was undertaken to examine oxidative DNA damage, which arises as a result of chemotherapy with cisplatin. Using HPLC prepurification/isotope dilution GC/MS methodology, we examined the amount of 8-oxoGua and 8-oxodG excreted into urine in cancer patients (n = 66) who received chemotherapy with cisplatin. One day after the infusion of the drug, significant increase in the amount of 8-oxoGua and 8-oxodG in urine of the patients was observed, when compared to the initial value (78%, p < 0.0001 and 22%, p = 0.0051). In the "nadir days" (when the most distinct cell death based on hematological cell counts can be observed), the level of modified base and nucleoside decreased in comparison with the aforementioned time point. These results, for the first time, indicate that oxidatively damaged DNA may be, at least in part, responsible for cisplatin induced cytotoxicity. Our results also demonstrate that cell death does not contribute to urinary 8-oxoGua and 8-oxodG in humans.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Siomek A,Tujakowski J,Gackowski D,Rozalski R,Foksinski M,Dziaman T,Roszkowski K,Olinski Rdoi
10.1002/ijc.22088subject
Has Abstractpub_date
2006-11-01 00:00:00pages
2228-30issue
9eissn
0020-7136issn
1097-0215journal_volume
119pub_type
杂志文章abstract::We examined cancer-associated fibroblasts (CAFs) and a panel of immunohistochemical markers of epithelial-mesenchymal transition (EMT) in 19 pair-matched oral tongue squamous cell carcinoma (SCC) and metastatic tumors to regional lymph nodes (RLNs). alpha-Smooth muscle actin (alpha-SMA) was studied to identify CAFs. E...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25358
更新日期:2010-09-01 00:00:00
abstract::Incidence of upper gastrointestinal cancers of the oesophagus and stomach show a strong unexplained male predominance. Hormonal and reproductive factors have been associated with upper gastrointestinal cancers in women but there is little available data on men. To investigate this, we included 219,425 men enrolled in ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31375
更新日期:2018-08-15 00:00:00
abstract::Our objective was to examine whether parental exposure to atomic bomb radiation has led to increased cancer and/or noncancer mortality rates among the offspring. We studied 41,010 subjects born from May 1946 through December 1984 (i.e., conceived between 1 month and 38 years after the bombings) and surviving for at le...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11400
更新日期:2003-11-01 00:00:00
abstract::Immunohistochemical and/or indirect immunofluorescence analysis with monoclonal antibody (MAb) H19 demonstrated the expression of protectin (CD59) in 54 surgically removed metastatic melanoma lesions and on 8 out of 12 melanoma cell lines. CD59 expression had a low degree of intra- and intertumor heterogeneity. SDS-PA...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910610420
更新日期:1995-05-16 00:00:00
abstract::We have studied the production and release of cholecystokinin (CCK) forms by rat medullary thyroid cancer (MTC) in vivo. MTC cells were inoculated s.c. into 8 Wag-Rij rats. One month later, after i.v. injection of calcium plasma levels of CCK, calcitonin and tissue contents of gastrin and calcitonin were determined by...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910480510
更新日期:1991-07-09 00:00:00
abstract::Infection with human papillomavirus-16 (HPV-16) is the cause of most anogenital carcinomas. This virus is also detected in about 20% of all head and neck squamous cell carcinomas. While there is strong evidence for a causal etiological role in the case of tonsillar carcinomas, causal association with malignant lesions...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22563
更新日期:2007-05-15 00:00:00
abstract::Invasive pituitary adenomas (PAs) are generally refractory to conventional therapy and salvage treatment with temozolomide (TMZ). In addition to antiprotozoan effects, pyrimethamine (PYR) has recently shown its strong antitumor activity as an antineoplastic agent or in combination with TMZ in metastatic melanoma cells...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28199
更新日期:2013-10-15 00:00:00
abstract::These studies were designed to examine the role of neutrophils in transplantation immunity to syngeneic rat tumors. We have earlier reported that specific transplantation immunity to syngeneic transplanted tumors is abrogated by selective depletion of peripheral-blood neutrophils by administration of a monoclonal anti...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910540121
更新日期:1993-04-22 00:00:00
abstract::Idiotypic protein (Id) produced by myeloma cells is clone-specific and may be a suitable tumor-specific antigen for immune targeting. Advances in dendritic cell (DC) technology suggest the opportunity for using this potent antigen presentation system to deliver myeloma Id to the autologous host to elicit anti-tumor im...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1097-0215(19991008)83:2<215::aid-ijc
更新日期:1999-10-08 00:00:00
abstract::Cancers occurring at the gastroesophageal junction (GEJ) are classified as predominantly esophageal or gastric, which is often difficult to decipher. We hypothesized that the transcriptomic profile might reveal molecular subgroups which could help to define the tumor origin and behavior beyond anatomical location. The...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32384
更新日期:2019-12-15 00:00:00
abstract::Extracts were made from Walker 256 carcinoma, spontaneous rat mammary adenocarcinoma, Wilms' tumour, human neuroblastoma and human haemangioma. Chromatography of the extracts on Sephadex G-100 yielded four fractions, A, B, C and D. Injection of fractions B and C resulted in the growth of new capillaries in the subcuta...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910170502
更新日期:1976-05-15 00:00:00
abstract::Both retinoids and anti-estrogens inhibit breast cancer cell proliferation with accumulation of cells in the G1 phase of the cell cycle, but the effect of retinoids is delayed compared to that of anti-estrogens. To determine whether this temporal difference is due to a simple delay in the action of retinoids on a comm...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970127)70:3<291::aid-ijc
更新日期:1997-01-27 00:00:00
abstract::Familial atypical multiple mole melanoma (FAMMM) is an autosomal dominant disease characterized by the familial occurrence of malignant melanoma of the skin and multiple atypical precursor lesions. Germline mutations in the p16 (CDKN2A) gene have been reported in at least a quarter of such families. An association has...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:
更新日期:2000-09-15 00:00:00
abstract::Cell populations resistant to high doses (30 microM) of 6-thioguanine (6-TG, 6-TG(r) cells) were selected from a human colon carcinoma cell line, LoVo. This cell line, which lacks hMSH2, a component of the human mismatch binding heterodimer hMutSalpha, is resistant to low doses of 6-TG. The level of activity of hypoxa...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990812)82:4<556::aid-ijc
更新日期:1999-08-12 00:00:00
abstract::The recently described PGM-2 leukemia displays a hierarchical structure with bipotential stem cells, B-lymphocyte and macrophage progenitor cells, and post-mitotic end cells. Because the different cell types can easily be identified in vitro by clonal culture assays and simple staining procedures, this leukemia is a u...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910600515
更新日期:1995-03-03 00:00:00
abstract::Polymorphisms in DNA repair genes may be associated with differences in the repair capacity of DNA damage and may thereby influence an individual's susceptibility to smoking-related cancer. We investigated the association between the -93G-->A polymorphism in the hMLH1 gene and the risk of lung cancer in a Korean popul...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20359
更新日期:2004-11-20 00:00:00
abstract::Although childhood exposure to ionizing radiation is a well-established risk factor for thyroid cancer, the risk associated with adulthood exposure remains unclear. We prospectively examined the association between cumulative, low-to-moderate dose occupational radiation exposure to the thyroid and thyroid cancer incid...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31270
更新日期:2018-11-01 00:00:00
abstract::Urinary bladder cancer is a heterogeneous disease with tumors ranging from papillary noninvasive (stage Ta) to solid muscle infiltrating tumors (stage T2+). The risk of progression and death for the most frequent diagnosed type, Ta, is low, but the high incidence of recurrences has a significant effect on the patients...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24954
更新日期:2010-03-15 00:00:00
abstract::Previous studies reported an inverse relationship between body mass index (BMI) and upper aerodigestive tract (UADT) cancers. Examining change in BMI over time may clarify these previous observations. We used data from 2,048 cases and 2,173 hospital- and population-based controls from ten European countries (alcohol-r...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.25468
更新日期:2011-03-15 00:00:00
abstract::The 1100delC mutation of the cell cycle checkpoint kinase 2 (CHEK2) gene confers an increased risk for breast cancer, but the clinical impact of other CHEK2 gene variants remains unclear. We determined the frequency of two functionally relevant CHEK2 gene mutations, I157T and IVS2+1G > A, in two large series of breast...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21022
更新日期:2005-08-20 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) represents the eighth frequent solid tumor and fourth leading cause of cancer death. Because current treatments against PDAC are still unsatisfactory, new anticancer strategies are required, including oncolytic viruses. Among these, autonomous parvoviruses (PV), like MVMp (minut...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24992
更新日期:2010-06-15 00:00:00
abstract::Loss of heterozygosity (LOH) at the site of the retinoblastoma (RB1) gene, at 13q14, has been shown to occur in a high proportion of ovarian cancer patients. Based on this, RB1 gene inactivation was studied in primary tumor cells from 15 patients with ovarian cancer. Structural changes as well as expression of the RB1...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910580508
更新日期:1994-09-01 00:00:00
abstract::Activating Ras mutations are involved in a significant fraction of human tumors. A suppressor screen using a retroviral mouse fibroblast cDNA library was performed to identify novel factors in Ras-mediated transformation. We identified a novel potent inhibitor of Ras-mediated morphological transformation encoded by a ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22373
更新日期:2007-03-01 00:00:00
abstract::To understand the mechanisms underlying increased expression of Myc protein in human urinary bladder cancer, expression of c-myc mRNA and the copy number of the c-myc gene were determined. Expression of mRNA was measured by quantitative RT-PCR in 40 urothelial carcinomas and in 18 histologically normal mucosae. Mean e...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990420)84:2<169::aid-ijc
更新日期:1999-04-20 00:00:00
abstract::Human epidemiological studies suggest that 1,25(OH)2 D3 deficiency might increase cancer incidence, but no spontaneous tumors have been reported in mice lacking 1,25(OH)2 D3 or deficient in its receptor. In our study, we detected, for the first time, diverse types of spontaneous tumors in l,25(OH)2 D3 deficient mice m...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31317
更新日期:2018-07-15 00:00:00
abstract::In a cohort of 11,663 participants in a breast-cancer screening program, height, weight, waist circumference and hip circumference were measured, and information about menstrual and reproductive history was obtained by questionnaire. After exclusion of 83 women with unclear menopausal status, the subjects were divided...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980529)76:5<647::aid-ijc
更新日期:1998-05-29 00:00:00
abstract::Oral squamous cell carcinoma (OSCC) is the most common malignancy representing 90% of all forms of oral cancer worldwide. Although great efforts have been made in the past decades, the 5-year survival rate of OSCC patients is no more than 60% due to tumor metastasis and subsequent recurrence. The metastasis from the p...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.33352
更新日期:2020-10-22 00:00:00
abstract::Evidence indicates that acquired resistance of cancers to chemotherapeutic agents can occur via epigenetic mechanisms. Down-regulation of expression of argininosuccinate synthetase (ASS1), the rate-limiting enzyme in the biosynthesis of arginine, has been associated with the development of platinum resistance in ovari...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24546
更新日期:2009-09-15 00:00:00
abstract::Benign breast disease (BBD) is an established breast cancer (BC) risk factor, but it is unclear whether the magnitude of the association applies to women at familial or genetic risk. This information is needed to improve BC risk assessment in clinical settings. Using the Prospective Family Study Cohort, we used Cox pr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32112
更新日期:2019-07-15 00:00:00
abstract::We describe the selection of 3 new multidrug-resistant cell lines derived from tumor cells of different metastatic phenotypes within the Dunning R3327 model of rat prostatic carcinoma. Cell lines of weak (AT2) and strong (AT3 and MAT-LyLu) metastatic behavior were cultured in vitro and challenged with doxorubicin at p...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910570519
更新日期:1994-06-01 00:00:00